GREMLIN Database
HTRE - Outer membrane usher protein HtrE
UniProt: P33129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11972
Length: 865 (772)
Sequences: 2685 (2009)
Seq/√Len: 72.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_C127_C5.0841.00
659_A675_S4.6361.00
251_E265_R4.5681.00
701_A731_L4.3831.00
690_S727_V4.3231.00
795_A827_I4.2981.00
331_I343_T4.2091.00
295_A336_E4.1951.00
360_G385_Y4.0891.00
287_I299_I4.0611.00
183_L200_A4.0581.00
779_A819_I4.0491.00
360_G387_Y4.0371.00
264_I380_L3.9951.00
522_G547_Y3.7751.00
661_S673_S3.7501.00
335_E341_K3.6801.00
704_Q770_D3.5821.00
680_F689_F3.4331.00
333_T341_K3.3941.00
296_K335_E3.3611.00
682_L687_L3.3171.00
210_A238_R3.2971.00
63_V79_S3.2891.00
823_G842_Y3.2791.00
292_N340_S3.2111.00
797_I814_A3.1531.00
364_I383_A3.0441.00
525_Y546_G2.9521.00
334_I342_R2.9291.00
300_T305_K2.9271.00
549_N556_Y2.9211.00
628_S648_Y2.9131.00
69_Y147_R2.8911.00
66_V141_Y2.8711.00
783_I840_A2.8411.00
600_T612_L2.8171.00
797_I825_I2.8031.00
630_N646_G2.8011.00
700_L766_V2.7871.00
213_L234_R2.7231.00
183_L198_I2.7091.00
298_T305_K2.6571.00
292_N342_R2.6491.00
658_L676_T2.6191.00
425_D445_R2.6061.00
213_L236_V2.6061.00
797_I827_I2.5911.00
217_G229_Y2.5901.00
205_G214_R2.5621.00
548_S557_S2.5201.00
656_G676_T2.5031.00
66_V82_F2.5011.00
824_N839_L2.4951.00
176_A766_V2.4871.00
688_T721_D2.4811.00
431_V477_A2.4671.00
140_R149_D2.4621.00
185_G198_I2.4581.00
783_I827_I2.4261.00
139_V150_I2.4241.00
174_I702_V2.4171.00
683_H688_T2.3831.00
175_N206_M2.3821.00
142_D145_D2.3631.00
65_D79_S2.3571.00
704_Q768_F2.3561.00
252_S264_I2.3491.00
840_A860_I2.3421.00
680_F687_L2.3311.00
530_W541_S2.3281.00
63_V81_T2.3111.00
240_I243_L2.3001.00
129_N132_E2.2861.00
300_T331_I2.2821.00
34_E37_H2.2591.00
288_H317_V2.2421.00
649_A660_G2.2331.00
206_M213_L2.2261.00
82_F93_A2.2241.00
408_A427_T2.2221.00
187_H196_E2.2131.00
824_N841_H2.2131.00
248_I270_Y2.2021.00
526_L545_I2.1941.00
785_R791_I2.1831.00
562_R572_D2.1421.00
298_T335_E2.1331.00
130_L137_A2.1181.00
177_A206_M2.1061.00
701_A739_I2.1031.00
179_L204_G2.0901.00
684_S768_F2.0871.00
679_G690_S2.0811.00
737_N761_P2.0791.00
300_T333_T2.0731.00
679_G696_D2.0711.00
106_N109_D2.0691.00
705_A708_A2.0501.00
181_Y678_G2.0191.00
273_S361_R2.0031.00
297_V334_I1.9991.00
799_D803_N1.9951.00
68_V80_I1.9721.00
164_Y167_P1.9621.00
134_I137_A1.9591.00
559_S575_Y1.9501.00
702_V725_Y1.9411.00
825_I840_A1.9371.00
428_H442_Q1.9311.00
259_F398_G1.9191.00
696_D700_L1.8881.00
248_I252_S1.8741.00
396_Y425_D1.8671.00
685_G768_F1.8651.00
400_Q474_L1.8461.00
291_A311_V1.8451.00
683_H725_Y1.8341.00
783_I814_A1.8321.00
632_G644_Y1.8261.00
620_S624_R1.8051.00
142_D149_D1.7891.00
69_Y149_D1.7821.00
334_I344_F1.7731.00
736_E758_V1.7681.00
237_Q246_Q1.7631.00
264_I365_S1.7631.00
212_R762_R1.7601.00
653_S658_L1.7471.00
563_S573_S1.7291.00
331_I345_S1.7251.00
698_D763_Q1.7251.00
599_D615_S1.7201.00
749_D777_Q1.7141.00
785_R789_K1.7071.00
777_Q821_Q1.7041.00
59_A91_A1.7031.00
604_S609_N1.7011.00
69_Y74_P1.6941.00
600_T614_V1.6911.00
558_V576_L1.6881.00
629_V647_G1.6811.00
239_D246_Q1.6751.00
685_G704_Q1.6731.00
718_S726_G1.6621.00
238_R247_L1.6591.00
278_P735_H1.6581.00
389_L395_G1.6561.00
424_F446_V1.6551.00
239_D734_Y1.6541.00
521_Y547_Y1.6521.00
368_Q379_N1.6451.00
332_V346_Q1.6441.00
215_A234_R1.6401.00
215_A231_F1.6370.99
443_S465_R1.6330.99
388_G394_T1.6290.99
791_I827_I1.6270.99
70_V157_V1.6250.99
245_S362_W1.6250.99
59_A143_V1.6230.99
783_I791_I1.6230.99
782_N859_G1.6220.99
219_Y227_S1.6160.99
240_I269_L1.6140.99
264_I268_R1.6130.99
420_G448_W1.6070.99
172_N241_A1.6070.99
274_R763_Q1.6050.99
705_A773_T1.6040.99
430_N438_T1.5990.99
332_V344_F1.5960.99
67_S77_N1.5910.99
265_R370_L1.5880.99
299_I318_I1.5860.99
784_T790_N1.5860.99
407_T430_N1.5800.99
96_T99_N1.5800.99
653_S656_G1.5760.99
557_S577_S1.5730.99
443_S467_S1.5690.99
252_S365_S1.5670.99
795_A829_W1.5640.99
679_G700_L1.5580.99
602_I610_N1.5560.99
177_A682_L1.5530.99
393_L415_L1.5510.99
273_S359_V1.5430.99
664_A670_R1.5240.99
333_T343_T1.5170.99
784_T859_G1.5170.99
711_A720_I1.4940.99
647_G662_I1.4900.99
554_G578_F1.4810.99
178_M700_L1.4720.99
296_K308_E1.4650.99
97_L101_L1.4600.99
753_K772_E1.4580.99
258_T410_L1.4570.99
174_I768_F1.4560.99
298_T308_E1.4560.99
80_I93_A1.4560.99
249_L267_I1.4550.99
781_M858_N1.4500.99
178_M766_V1.4490.99
182_N677_D1.4300.99
287_I330_L1.4180.99
239_D762_R1.4110.98
363_D384_S1.4060.98
822_Q843_Q1.4020.98
430_N440_Q1.3950.98
269_L364_I1.3940.98
82_F91_A1.3900.98
268_R363_D1.3890.98
551_T556_Y1.3890.98
560_A574_V1.3780.98
99_N103_F1.3730.98
797_I816_V1.3710.98
657_T677_D1.3710.98
260_D473_G1.3680.98
556_Y576_L1.3650.98
346_Q354_M1.3650.98
681_V702_V1.3580.98
329_D345_S1.3530.98
204_G215_A1.3400.98
368_Q377_E1.3340.98
704_Q725_Y1.3300.98
515_K520_D1.3300.98
782_N813_Q1.3280.98
396_Y412_G1.3260.98
713_I728_T1.3250.98
106_N158_M1.3230.98
151_D312_P1.3210.98
681_V700_L1.3180.98
625_V651_Y1.3150.98
460_N507_T1.3090.98
826_S839_L1.3080.98
141_Y148_L1.3070.97
596_Q616_S1.3000.97
357_P391_N1.2970.97
505_Q531_S1.2930.97
189_E670_R1.2820.97
272_D763_Q1.2810.97
216_S233_N1.2780.97
761_P767_V1.2780.97
318_I321_L1.2710.97
151_D313_P1.2660.97
175_N766_V1.2530.97
100_L105_I1.2390.97
175_N208_L1.2340.96
185_G674_L1.2280.96
211_W238_R1.2270.96
321_L324_S1.2270.96
298_T333_T1.2270.96
294_N336_E1.2190.96
781_M814_A1.2150.96
299_I309_T1.2100.96
443_S534_W1.2080.96
178_M205_G1.2070.96
712_R745_D1.2070.96
240_I247_L1.2050.96
442_Q468_T1.1970.96
141_Y146_Q1.1940.96
792_P829_W1.1940.96
720_I724_G1.1920.96
605_D609_N1.1880.96
783_I808_V1.1860.96
388_G420_G1.1860.96
779_A844_Q1.1830.95
709_Q722_R1.1780.95
508_V526_L1.1750.95
827_I840_A1.1720.95
175_N684_S1.1700.95
634_T638_A1.1680.95
823_G844_Q1.1580.95
180_S203_N1.1560.95
455_T512_Q1.1500.95
61_P84_A1.1490.95
393_L413_L1.1470.95
68_V78_Q1.1460.95
80_I148_L1.1420.95
251_E370_L1.1400.94
781_M816_V1.1380.94
169_L736_E1.1370.94
101_L158_M1.1370.94
286_I317_V1.1360.94
820_E823_G1.1290.94
159_K319_D1.1260.94
295_A338_D1.1240.94
503_K534_W1.1240.94
162_Q322_S1.1230.94
688_T723_W1.1140.94
366_G379_N1.1120.94
98_K102_Q1.1080.94
504_N532_D1.1060.94
705_A711_A1.1060.94
134_I156_W1.1030.93
781_M840_A1.1020.93
426_V444_Y1.1020.93
792_P795_A1.1010.93
157_V312_P1.0990.93
85_I92_Q1.0950.93
522_G549_N1.0950.93
476_D479_T1.0910.93
554_G580_I1.0880.93
762_R765_S1.0870.93
329_D347_P1.0820.93
826_S837_S1.0810.93
152_V157_V1.0810.93
67_S74_P1.0810.93
683_H686_G1.0800.93
296_K310_T1.0800.93
652_E657_T1.0800.93
72_D149_D1.0770.93
355_L360_G1.0760.93
688_T725_Y1.0660.92
172_N210_A1.0650.92
265_R368_Q1.0620.92
796_D804_V1.0600.92
435_D439_Y1.0540.92
681_V766_V1.0530.92
262_V400_Q1.0530.92
560_A572_D1.0490.92
604_S610_N1.0450.91
679_G727_V1.0440.91
299_I307_Y1.0420.91
203_N216_S1.0420.91
70_V75_I1.0370.91
511_N525_Y1.0360.91
633_Y643_S1.0360.91
759_A767_V1.0320.91
212_R764_G1.0290.91
524_F547_Y1.0290.91
174_I766_V1.0280.91
720_I778_S1.0220.91
185_G196_E1.0220.91
32_L55_E1.0210.90
78_Q102_Q1.0130.90
137_A152_V1.0040.90
561_Q573_S1.0030.90
284_A356_R1.0000.90
268_R365_S0.9990.89
37_H41_M0.9980.89
244_R276_L0.9970.89
598_I614_V0.9960.89
527_S544_S0.9930.89
514_L522_G0.9920.89
648_Y661_S0.9910.89
211_W236_V0.9890.89
303_G331_I0.9860.89
369_V478_L0.9850.89
473_G476_D0.9850.89
652_E691_N0.9820.89
355_L385_Y0.9800.89
650_S657_T0.9780.88
293_T340_S0.9760.88
580_I608_G0.9740.88
753_K774_V0.9740.88
85_I90_N0.9700.88
397_T410_L0.9680.88
688_T702_V0.9630.88
625_V649_A0.9550.87
615_S646_G0.9530.87
277_P388_G0.9520.87
36_D39_F0.9510.87
207_N214_R0.9500.87
247_L269_L0.9500.87
381_F401_I0.9480.87
67_S147_R0.9480.87
231_F251_E0.9470.87
51_S54_S0.9470.87
598_I616_S0.9440.87
174_I684_S0.9410.86
270_Y363_D0.9400.86
252_S268_R0.9400.86
210_A762_R0.9390.86
43_Q46_S0.9380.86
200_A204_G0.9370.86
779_A818_G0.9350.86
615_S628_S0.9330.86
232_K370_L0.9330.86
514_L521_Y0.9330.86
439_Y470_N0.9270.86
212_R765_S0.9270.86
553_W584_K0.9260.86
271_S362_W0.9240.85
289_G316_F0.9200.85
215_A229_Y0.9190.85
645_V664_A0.9170.85
253_Y263_S0.9160.85
738_R756_S0.9160.85
423_S447_S0.9130.85
68_V334_I0.9110.85
631_T645_V0.9100.85
457_T510_I0.9100.85
417_T422_F0.9080.84
50_L54_S0.9080.84
602_I612_L0.9060.84
681_V727_V0.9060.84
235_Y764_G0.9030.84
691_N718_S0.8920.83
622_N625_V0.8880.83
777_Q845_S0.8870.83
787_D790_N0.8870.83
757_A769_A0.8840.83
138_S151_D0.8810.83
171_E174_I0.8810.83
351_V361_R0.8810.83
316_F336_E0.8780.82
613_N628_S0.8750.82
620_S623_A0.8750.82
294_N313_P0.8730.82
352_V380_L0.8720.82
254_T264_I0.8710.82
155_A317_V0.8640.81
742_D745_D0.8630.81
236_V249_L0.8620.81
355_L359_V0.8610.81
107_S578_F0.8600.81
405_N432_R0.8590.81
380_L474_L0.8590.81
702_V768_F0.8570.81
783_I860_I0.8570.81
328_S388_G0.8560.81
354_M388_G0.8550.81
355_L386_Y0.8550.81
679_G682_L0.8540.81
857_L860_I0.8520.80
178_M679_G0.8510.80
731_L735_H0.8510.80
245_S269_L0.8490.80
644_Y670_R0.8490.80
130_L134_I0.8470.80
750_V775_Q0.8460.80
297_V311_V0.8460.80
615_S630_N0.8450.80
285_P289_G0.8420.80
416_N421_A0.8420.80
656_G690_S0.8410.80
281_A735_H0.8410.80
476_D502_M0.8410.80
221_W227_S0.8410.80
472_L480_L0.8400.80
697_S733_P0.8380.79
798_Y828_K0.8360.79
432_R459_L0.8330.79
747_E750_V0.8320.79
601_Q613_N0.8320.79
703_V728_T0.8260.78
281_A322_S0.8260.78
80_I299_I0.8260.78
551_T615_S0.8250.78
380_L400_Q0.8230.78
439_Y472_L0.8230.78
710_G719_T0.8220.78
364_I385_Y0.8220.78
395_G842_Y0.8210.78
244_R273_S0.8210.78
562_R565_N0.8200.78
457_T466_Y0.8190.78
701_A767_V0.8190.78
432_R438_T0.8190.78
38_T42_G0.8180.78
321_L356_R0.8170.78
365_S382_Q0.8170.78
163_N279_T0.8170.78
209_G238_R0.8160.78
357_P390_N0.8160.78
778_S817_R0.8150.77
754_S757_A0.8140.77
173_G686_G0.8140.77
678_G838_C0.8130.77
366_G381_F0.8110.77
721_D724_G0.8110.77
821_Q825_I0.8090.77
451_L456_S0.8080.77
292_N336_E0.8080.77
181_Y289_G0.8070.77
49_D52_R0.8040.76
137_A597_S0.8030.76
32_L89_K0.8020.76
180_S700_L0.8010.76
161_Y279_T0.8000.76
58_P91_A0.7990.76
273_S281_A0.7990.76
394_T420_G0.7980.76
243_L269_L0.7980.76
180_S696_D0.7970.76
698_D733_P0.7950.76
33_V38_T0.7940.76
662_I670_R0.7930.76
289_G678_G0.7920.75
94_C354_M0.7900.75
838_C862_C0.7890.75
172_N239_D0.7880.75
353_Q414_G0.7850.75
358_G388_G0.7850.75
208_L422_F0.7850.75
49_D53_Y0.7830.75
186_Y671_Q0.7830.75
791_I829_W0.7820.74
71_N724_G0.7820.74
473_G509_S0.7810.74
297_V578_F0.7810.74
401_I800_E0.7790.74
474_L477_A0.7780.74
199_Y218_N0.7760.74
282_S324_S0.7720.74
808_V814_A0.7720.74
72_D655_W0.7690.73
224_D713_I0.7680.73
32_L54_S0.7680.73
188_S667_D0.7680.73
262_V474_L0.7670.73
389_L413_L0.7670.73
254_T736_E0.7670.73
172_N762_R0.7660.73
777_Q856_I0.7660.73
349_S354_M0.7630.73
36_D56_G0.7630.73
656_G691_N0.7630.73
41_M47_N0.7620.73
182_N713_I0.7610.72
33_V39_F0.7600.72
706_P770_D0.7590.72
272_D583_E0.7590.72
93_A575_Y0.7550.72
447_S460_N0.7550.72
688_T727_V0.7550.72
498_N728_T0.7520.72
819_I823_G0.7520.72
776_G818_G0.7500.71
809_G813_Q0.7500.71
459_L510_I0.7490.71
718_S729_S0.7490.71
702_V766_V0.7490.71
531_S540_R0.7490.71
143_V146_Q0.7460.71
403_D470_N0.7460.71
369_V474_L0.7450.71
240_I560_A0.7430.71
106_N816_V0.7430.71
309_T318_I0.7420.71
383_A399_I0.7410.70
505_Q751_E0.7410.70
248_I264_I0.7410.70
509_S527_S0.7400.70
441_G468_T0.7400.70
245_S271_S0.7400.70
743_I755_T0.7390.70
52_R55_E0.7390.70
285_P291_A0.7370.70
336_E340_S0.7370.70
46_S49_D0.7360.70
805_I816_V0.7360.70
474_L478_L0.7360.70
222_M225_S0.7350.70
678_G771_F0.7340.70
80_I102_Q0.7340.70
625_V629_V0.7330.70
278_P281_A0.7330.70
823_G843_Q0.7330.70
285_P388_G0.7320.70
178_M214_R0.7310.69
180_S679_G0.7310.69
691_N717_N0.7300.69
701_A728_T0.7300.69
198_I202_F0.7290.69
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359_V647_G0.5020.42
596_Q618_G0.5020.42
783_I795_A0.5020.42
42_G48_I0.5020.42
31_E55_E0.5020.42
746_L752_L0.5020.42
376_D440_Q0.5010.42
613_N630_N0.5010.42
239_D342_R0.5010.42
524_F607_K0.5010.42
354_M460_N0.5010.42
178_M752_L0.5000.42
72_D193_R0.5000.42
656_G689_F0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfzB 2 0.8844 100 0.073 Contact Map
3fipA 1 0.5052 100 0.462 Contact Map
3fcgA 2 0.0867 100 0.842 Contact Map
4b0mA 1 0.1491 99.9 0.848 Contact Map
3bwuD 1 0.1399 99.9 0.86 Contact Map
2xetA 1 0.1006 99.6 0.901 Contact Map
3l48A 1 0.1006 99.5 0.909 Contact Map
3e8vA 1 0.0867 93.7 0.966 Contact Map
4oq1A 1 0.2069 92.2 0.968 Contact Map
4u3sB 1 0.1006 80.9 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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