GREMLIN Database
YADV - Probable fimbrial chaperone YadV
UniProt: P33128 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11973
Length: 246 (215)
Sequences: 2898 (2177)
Seq/√Len: 148.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_S205_M3.1621.00
61_L144_L3.1081.00
167_S176_R3.0101.00
184_Y207_A2.9721.00
37_K40_Q2.8831.00
108_R209_F2.8691.00
178_T211_D2.8541.00
207_A210_S2.8101.00
111_V205_M2.7971.00
164_W177_V2.7881.00
29_I142_I2.6701.00
163_K178_T2.6131.00
104_L112_F2.5831.00
176_R213_V2.4881.00
34_V43_V2.4791.00
176_R211_D2.4611.00
55_L118_E2.4061.00
34_V114_F2.3691.00
157_E160_L2.3461.00
145_F205_M2.3301.00
34_V96_L2.3281.00
39_D149_D2.3131.00
174_S213_V2.3111.00
52_N89_K2.2321.00
168_G174_S2.2031.00
165_F176_R2.1611.00
177_V214_M2.1061.00
54_P87_D2.0651.00
145_F184_Y2.0611.00
62_D141_R2.0611.00
234_N240_I2.0421.00
162_L177_V1.9731.00
60_W115_N1.9521.00
162_L185_V1.8681.00
37_K43_V1.8311.00
117_L139_R1.8051.00
105_P110_S1.7651.00
59_S94_I1.7351.00
54_P85_R1.7241.00
161_A181_T1.6801.00
151_L183_Y1.6761.00
79_A94_I1.6741.00
77_F96_L1.6351.00
115_N141_R1.6161.00
62_D115_N1.6111.00
167_S174_S1.6071.00
29_I116_V1.5871.00
154_N157_E1.5811.00
158_A185_V1.5621.00
87_D90_R1.5461.00
158_A232_A1.5391.00
111_V145_F1.5311.00
45_V114_F1.4761.00
165_F178_T1.4761.00
61_L75_V1.4641.00
169_S174_S1.4561.00
98_Y102_T1.4541.00
185_V232_A1.4371.00
38_S106_K1.4231.00
189_S231_Y1.4121.00
36_Y43_V1.4091.00
105_P108_R1.3831.00
162_L187_F1.3641.00
234_N238_G1.3601.00
42_S95_K1.3311.00
206_I212_E1.3101.00
57_V84_S1.3091.00
155_P158_A1.3071.00
46_R91_G1.2981.00
191_D229_H1.2401.00
51_G118_E1.2401.00
77_F144_L1.2161.00
182_P209_F1.2091.00
111_V186_S1.2081.00
34_V142_I1.2081.00
47_L86_I1.1881.00
79_A96_L1.1841.00
191_D198_R1.1781.00
186_S232_A1.1761.00
174_S215_K1.1611.00
63_T73_I1.1571.00
29_I45_V1.1511.00
38_S149_D1.1461.00
96_L144_L1.1431.00
188_S239_A1.1401.00
60_W141_R1.1300.99
27_I86_I1.1300.99
98_Y146_Y1.1240.99
164_W230_F1.1150.99
114_F144_L1.1040.99
31_G45_V1.0780.99
62_D66_D1.0700.99
123_P133_L1.0700.99
175_L216_V1.0640.99
232_A240_I1.0550.99
113_W141_R1.0450.99
28_V31_G1.0420.99
167_S213_V1.0400.99
123_P135_Q1.0360.99
98_Y103_S1.0270.99
30_S46_R1.0230.99
26_D118_E1.0070.99
84_S92_Q1.0060.99
60_W117_L1.0030.99
48_E91_G1.0010.99
159_P230_F0.9880.99
164_W190_G0.9780.99
187_F206_I0.9770.98
79_A114_F0.9770.98
159_P185_V0.9760.98
63_T71_G0.9750.98
118_E138_F0.9680.98
94_I114_F0.9680.98
36_Y97_M0.9670.98
38_S146_Y0.9540.98
27_I57_V0.9450.98
161_A180_P0.9380.98
94_I116_V0.9320.98
62_D113_W0.9320.98
13_F16_C0.9240.98
187_F232_A0.9220.98
92_Q117_L0.9140.98
109_E147_R0.9020.97
30_S91_G0.8960.97
33_R147_R0.8920.97
137_A164_W0.8820.97
150_G153_G0.8810.97
29_I47_L0.8730.97
191_D196_G0.8710.97
51_G55_L0.8550.97
34_V45_V0.8530.96
143_K233_I0.8510.96
86_I91_G0.8480.96
178_T209_F0.8350.96
20_S24_I0.8310.96
113_W117_L0.8270.96
36_Y77_F0.8260.96
163_K180_P0.8230.96
169_S213_V0.8190.96
231_Y239_A0.8110.95
9_T17_M0.8100.95
26_D50_K0.8090.95
61_L79_A0.8050.95
115_N139_R0.7920.95
59_S79_A0.7910.95
107_D209_F0.7910.95
59_S116_V0.7880.94
155_P159_P0.7870.94
175_L190_G0.7840.94
184_Y208_P0.7840.94
92_Q118_E0.7820.94
153_G183_Y0.7820.94
195_S223_A0.7800.94
36_Y98_Y0.7690.94
47_L57_V0.7680.94
86_I92_Q0.7630.94
125_A131_Q0.7600.93
19_F24_I0.7580.93
35_I147_R0.7570.93
84_S94_I0.7550.93
31_G34_V0.7520.93
26_D55_L0.7520.93
111_V184_Y0.7490.93
106_K150_G0.7490.93
108_R148_P0.7480.93
11_L14_V0.7460.93
159_P232_A0.7440.93
14_V17_M0.7410.92
9_T12_C0.7350.92
175_L228_V0.7290.92
55_L117_L0.7290.92
192_L228_V0.7280.92
28_V50_K0.7270.92
187_F238_G0.7270.92
65_D72_S0.7250.92
58_Q117_L0.7240.92
64_G113_W0.7230.92
33_R143_K0.7160.91
159_P181_T0.7140.91
186_S203_V0.7090.91
15_T20_S0.7080.91
55_L59_S0.7060.91
107_D147_R0.7040.90
164_W175_L0.7040.90
86_I90_R0.6990.90
10_A13_F0.6970.90
112_F146_Y0.6970.90
115_N143_K0.6940.90
190_G214_M0.6920.90
46_R83_V0.6890.90
54_P121_P0.6870.89
37_K145_F0.6810.89
33_R148_P0.6730.88
21_S241_E0.6730.88
188_S233_I0.6720.88
116_V142_I0.6710.88
96_L114_F0.6710.88
82_P119_V0.6700.88
12_C15_T0.6670.88
143_K186_S0.6660.88
20_S23_S0.6610.88
61_L119_V0.6590.87
83_V91_G0.6550.87
63_T74_T0.6520.87
28_V140_T0.6490.87
27_I55_L0.6460.86
110_S146_Y0.6440.86
174_S216_V0.6420.86
21_S24_I0.6390.86
153_G157_E0.6360.85
113_W143_K0.6350.85
166_W218_G0.6350.85
63_T75_V0.6300.85
77_F146_Y0.6300.85
19_F23_S0.6290.85
14_V21_S0.6280.85
50_K121_P0.6280.85
57_V86_I0.6260.85
132_S135_Q0.6250.84
203_V214_M0.6220.84
159_P162_L0.6160.84
95_K120_P0.6150.83
113_W186_S0.6140.83
191_D197_K0.6120.83
59_S84_S0.6110.83
155_P185_V0.6100.83
124_D163_K0.6090.83
159_P180_P0.6080.83
118_E137_A0.6070.83
169_S196_G0.6020.82
56_L117_L0.6020.82
107_D110_S0.6020.82
153_G158_A0.6000.82
138_F203_V0.5960.82
231_Y241_E0.5950.81
29_I50_K0.5940.81
32_T147_R0.5940.81
192_L227_K0.5920.81
143_K147_R0.5920.81
36_Y40_Q0.5920.81
60_W140_T0.5910.81
113_W116_V0.5900.81
33_R235_D0.5890.81
189_S198_R0.5850.80
169_S215_K0.5830.80
46_R136_L0.5830.80
16_C200_P0.5810.80
164_W228_V0.5780.80
10_A18_A0.5770.79
59_S92_Q0.5770.79
206_I210_S0.5750.79
197_K223_A0.5740.79
47_L121_P0.5730.79
64_G141_R0.5690.79
27_I47_L0.5690.79
76_P110_S0.5680.78
100_A103_S0.5680.78
47_L116_V0.5680.78
184_Y210_S0.5680.78
64_G111_V0.5670.78
44_N54_P0.5600.77
217_N223_A0.5590.77
154_N183_Y0.5590.77
61_L112_F0.5580.77
149_D152_K0.5580.77
41_K130_N0.5570.77
120_P137_A0.5570.77
62_D136_L0.5550.77
164_W205_M0.5500.76
175_L213_V0.5490.76
24_I175_L0.5490.76
191_D231_Y0.5480.76
29_I140_T0.5470.76
199_Y216_V0.5460.76
73_I76_P0.5460.76
51_G117_L0.5430.75
139_R164_W0.5430.75
190_G216_V0.5430.75
134_L141_R0.5410.75
36_Y41_K0.5410.75
21_S165_F0.5400.75
42_S60_W0.5400.75
44_N136_L0.5390.75
29_I56_L0.5320.74
147_R183_Y0.5320.74
104_L107_D0.5320.74
11_L52_N0.5300.74
9_T14_V0.5300.74
91_G206_I0.5290.73
56_L183_Y0.5290.73
13_F24_I0.5290.73
122_K135_Q0.5280.73
55_L86_I0.5280.73
59_S96_L0.5260.73
51_G113_W0.5240.73
11_L15_T0.5240.73
190_G217_N0.5230.73
104_L110_S0.5230.73
157_E161_A0.5210.72
177_V206_I0.5210.72
166_W169_S0.5200.72
118_E186_S0.5200.72
148_P208_P0.5200.72
60_W113_W0.5190.72
30_S51_G0.5170.72
118_E230_F0.5170.72
97_M208_P0.5170.72
187_F230_F0.5160.72
212_E215_K0.5160.72
78_T97_M0.5140.71
73_I122_K0.5140.71
147_R208_P0.5130.71
62_D117_L0.5120.71
187_F190_G0.5110.71
206_I226_A0.5090.71
19_F196_G0.5080.70
31_G117_L0.5070.70
166_W224_N0.5040.70
110_S151_L0.5040.70
210_S223_A0.5030.70
39_D134_L0.5020.69
118_E139_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q48A 1 0.7886 100 0.169 Contact Map
2co7B 1 0.7967 100 0.178 Contact Map
1klfA 1 0.8211 100 0.187 Contact Map
1l4iA 2 0.7724 100 0.19 Contact Map
2xg5A 1 0.8252 100 0.2 Contact Map
3gfuC 1 0.8008 100 0.209 Contact Map
4ay0A 2 0.7724 100 0.219 Contact Map
4djmA 1 0.8089 100 0.222 Contact Map
4ncdA 2 0.7886 100 0.272 Contact Map
1mspA 3 0.4797 95.4 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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