YEIR - ECOLI - GREMLIN Contacts

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YEIR - Uncharacterized protein YeiR

UniProt:	P33030	Sequences: MTRTNLITGFLGSGKTTSILHLLAHKDPNEKWAVLVNEFGEVGIDGALLADSGALLKEIPGGCMCCVNGLPMQVGLNTLLRQGKPDRLLIEPTGLGHPKQILDLLTAPVYEPWIDLRATLCILDPRLLLDEKSASNENFRDQLAAADIIVANKSDRTTPESEQALQRWWQQNGGDRQLIHSEHGKVDGHLLDLPRRNLAELPASAAHSHQHVVKKGLAALSLPEHQRWRRSLNSGQGYQACGWIFDADTVFDTIGILEWARLAPVERVKGVLRIPEGLVRINRQGDDLHIETQNVAPPDSRIELISSSEADWNALQSALLKLRLATTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12104
Length:	328 (298)
Sequences:	5524 (3493)
Seq/√Len:	202.3

ECOLI - YEIR YJIA
BACSU - YCIC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
166_Q	180_H	5.710	1.00
312_W	316_Q	5.019	1.00
150_V	181_S	4.345	1.00
158_T	161_S	3.773	1.00
292_T	296_A	3.616	1.00
125_P	157_T	3.491	1.00
245_F	320_L	3.227	1.00
152_N	181_S	2.975	1.00
155_D	182_E	2.912	1.00
125_P	151_A	2.771	1.00
316_Q	320_L	2.648	1.00
149_I	169_W	2.638	1.00
122_I	152_N	2.563	1.00
259_W	318_A	2.550	1.00
166_Q	170_Q	2.511	1.00
268_V	281_I	2.349	1.00
88_L	114_I	2.319	1.00
21_H	185_K	2.297	1.00
162_E	180_H	2.293	1.00
173_G	176_R	2.273	1.00
252_D	255_G	2.213	1.00
7_I	19_I	2.204	1.00
22_L	89_L	2.176	1.00
311_D	314_A	2.151	1.00
292_T	295_V	2.142	1.00
157_T	162_E	2.103	1.00
30_E	87_R	2.041	1.00
161_S	164_A	2.031	1.00
21_H	25_H	2.028	1.00
256_I	274_I	2.013	1.00
31_K	86_D	1.997	1.00
154_S	180_H	1.989	1.00
162_E	166_Q	1.966	1.00
163_Q	167_R	1.949	1.00
159_P	163_Q	1.948	1.00
33_A	79_L	1.940	1.00
76_L	88_L	1.935	1.00
154_S	162_E	1.881	1.00
246_D	299_D	1.856	1.00
313_N	317_S	1.853	1.00
246_D	301_R	1.833	1.00
25_H	28_P	1.823	1.00
293_Q	296_A	1.772	1.00
124_D	153_K	1.734	1.00
80_L	114_I	1.696	1.00
22_L	188_G	1.683	1.00
2_T	88_L	1.681	1.00
133_S	168_W	1.680	1.00
43_G	58_E	1.677	1.00
23_L	34_V	1.660	1.00
181_S	184_G	1.647	1.00
38_E	43_G	1.610	1.00
43_G	46_G	1.602	1.00
8_T	119_T	1.595	1.00
5_N	117_R	1.587	1.00
243_W	315_L	1.577	1.00
97_H	141_D	1.575	1.00
13_S	122_I	1.574	1.00
265_V	304_L	1.570	1.00
250_V	273_R	1.549	1.00
18_S	184_G	1.548	1.00
128_L	143_L	1.544	1.00
170_Q	178_L	1.539	1.00
182_E	185_K	1.526	1.00
118_A	148_I	1.499	1.00
76_L	114_I	1.496	1.00
165_L	169_W	1.494	1.00
118_A	193_L	1.491	1.00
257_L	261_R	1.486	1.00
78_T	82_Q	1.479	1.00
143_L	149_I	1.454	1.00
8_T	121_C	1.446	1.00
42_V	244_I	1.435	1.00
252_D	275_P	1.433	1.00
128_L	165_L	1.430	1.00
146_A	149_I	1.419	1.00
183_H	289_H	1.413	1.00
126_R	287_D	1.401	1.00
253_T	257_L	1.393	1.00
148_I	177_Q	1.389	1.00
5_N	87_R	1.358	1.00
63_C	66_C	1.348	1.00
268_V	283_R	1.335	1.00
245_F	251_F	1.314	1.00
280_R	291_E	1.293	1.00
93_T	96_G	1.281	1.00
33_A	85_P	1.280	1.00
20_L	24_A	1.274	1.00
32_W	87_R	1.274	1.00
18_S	122_I	1.270	1.00
248_D	299_D	1.266	1.00
21_H	24_A	1.265	1.00
166_Q	178_L	1.262	1.00
126_R	156_R	1.254	1.00
292_T	298_P	1.237	1.00
102_L	119_T	1.231	1.00
157_T	165_L	1.224	1.00
241_C	312_W	1.214	1.00
126_R	161_S	1.208	1.00
163_Q	166_Q	1.205	1.00
38_E	46_G	1.198	1.00
77_N	81_R	1.193	1.00
36_V	49_L	1.190	1.00
256_I	272_L	1.187	1.00
245_F	319_L	1.183	1.00
130_D	134_A	1.173	1.00
268_V	304_L	1.169	1.00
146_A	173_G	1.167	1.00
313_N	316_Q	1.161	1.00
59_I	68_N	1.161	1.00
92_P	101_I	1.161	1.00
64_M	90_I	1.160	1.00
274_I	279_V	1.160	1.00
243_W	316_Q	1.152	1.00
102_L	116_L	1.149	1.00
143_L	169_W	1.148	1.00
152_N	184_G	1.147	1.00
272_L	300_S	1.141	1.00
283_R	288_L	1.136	1.00
251_F	256_I	1.132	1.00
314_A	318_A	1.131	1.00
151_A	180_H	1.130	1.00
243_W	312_W	1.120	1.00
317_S	321_K	1.119	1.00
306_S	310_A	1.115	1.00
30_E	189_H	1.111	1.00
39_F	242_G	1.106	1.00
43_G	60_P	1.086	1.00
152_N	183_H	1.083	1.00
6_L	105_L	1.081	1.00
159_P	180_H	1.080	1.00
80_L	113_W	1.080	1.00
273_R	298_P	1.078	1.00
160_E	163_Q	1.076	1.00
205_A	208_S	1.074	1.00
21_H	184_G	1.064	1.00
253_T	274_I	1.059	1.00
72_M	90_I	1.055	1.00
148_I	179_I	1.053	1.00
254_I	258_E	1.042	1.00
204_S	208_S	1.039	1.00
204_S	207_H	1.031	1.00
273_R	278_L	1.031	1.00
239_Q	242_G	1.020	1.00
179_I	186_V	1.016	1.00
67_V	93_T	1.006	1.00
318_A	321_K	1.004	1.00
70_L	74_V	1.004	1.00
150_V	179_I	1.004	1.00
274_I	277_G	1.000	1.00
271_V	280_R	0.996	1.00
202_P	205_A	0.995	1.00
35_L	75_G	0.988	1.00
48_L	280_R	0.985	1.00
64_M	72_M	0.979	1.00
121_C	146_A	0.969	1.00
232_L	235_G	0.964	0.99
247_A	320_L	0.962	0.99
158_T	162_E	0.959	0.99
175_D	200_E	0.958	0.99
253_T	276_E	0.951	0.99
122_I	184_G	0.950	0.99
20_L	49_L	0.950	0.99
157_T	161_S	0.950	0.99
149_I	176_R	0.947	0.99
125_P	162_E	0.934	0.99
317_S	320_L	0.927	0.99
228_W	231_S	0.915	0.99
22_L	190_L	0.912	0.99
92_P	96_G	0.908	0.99
168_W	171_Q	0.908	0.99
22_L	32_W	0.906	0.99
35_L	88_L	0.900	0.99
154_S	182_E	0.893	0.99
256_I	288_L	0.889	0.99
167_R	171_Q	0.885	0.99
54_A	57_K	0.883	0.99
201_L	206_A	0.876	0.99
201_L	204_S	0.876	0.99
117_R	194_P	0.870	0.99
25_H	188_G	0.866	0.99
39_F	96_G	0.864	0.99
165_L	168_W	0.858	0.99
2_T	80_L	0.851	0.99
39_F	95_L	0.849	0.99
48_L	271_V	0.848	0.99
126_R	157_T	0.844	0.99
265_V	268_V	0.844	0.99
19_I	89_L	0.841	0.99
74_V	78_T	0.840	0.99
75_G	78_T	0.837	0.99
264_P	308_S	0.836	0.99
54_A	71_P	0.835	0.99
38_E	96_G	0.835	0.99
123_L	128_L	0.833	0.98
200_E	204_S	0.833	0.98
4_T	88_L	0.830	0.98
270_G	302_I	0.824	0.98
163_Q	180_H	0.823	0.98
119_T	147_D	0.821	0.98
36_V	45_D	0.820	0.98
239_Q	309_E	0.818	0.98
202_P	206_A	0.818	0.98
43_G	111_E	0.815	0.98
71_P	74_V	0.814	0.98
230_R	233_N	0.812	0.98
248_D	297_P	0.810	0.98
77_N	113_W	0.807	0.98
6_L	119_T	0.803	0.98
164_A	167_R	0.801	0.98
155_D	184_G	0.797	0.98
45_D	49_L	0.797	0.98
252_D	276_E	0.792	0.98
229_R	232_L	0.788	0.98
38_E	93_T	0.785	0.98
128_L	139_F	0.785	0.98
150_V	186_V	0.780	0.98
18_S	150_V	0.779	0.98
4_T	105_L	0.776	0.98
36_V	43_G	0.774	0.98
5_N	120_L	0.772	0.98
262_L	318_A	0.772	0.98
177_Q	195_R	0.765	0.97
247_A	316_Q	0.761	0.97
125_P	165_L	0.761	0.97
21_H	188_G	0.760	0.97
247_A	251_F	0.759	0.97
82_Q	85_P	0.758	0.97
153_K	156_R	0.757	0.97
99_K	103_D	0.754	0.97
138_N	141_D	0.752	0.97
87_R	117_R	0.747	0.97
30_E	192_D	0.746	0.97
94_G	269_K	0.744	0.97
117_R	192_D	0.744	0.97
201_L	207_H	0.742	0.97
273_R	297_P	0.735	0.97
278_L	296_A	0.732	0.97
131_E	136_N	0.732	0.97
96_G	101_I	0.730	0.97
132_K	139_F	0.728	0.96
42_V	45_D	0.723	0.96
152_N	182_E	0.723	0.96
20_L	40_G	0.723	0.96
47_A	301_R	0.720	0.96
18_S	181_S	0.720	0.96
61_G	65_C	0.720	0.96
248_D	300_S	0.717	0.96
151_A	165_L	0.716	0.96
5_N	118_A	0.714	0.96
264_P	309_E	0.713	0.96
79_L	85_P	0.712	0.96
203_A	207_H	0.708	0.96
131_E	134_A	0.706	0.96
200_E	203_A	0.702	0.96
80_L	88_L	0.701	0.96
243_W	304_L	0.700	0.96
121_C	149_I	0.698	0.96
32_W	89_L	0.697	0.95
91_E	94_G	0.697	0.95
110_Y	114_I	0.694	0.95
181_S	186_V	0.693	0.95
11_L	14_G	0.685	0.95
61_G	105_L	0.685	0.95
304_L	319_L	0.685	0.95
129_L	164_A	0.684	0.95
228_W	233_N	0.684	0.95
123_L	149_I	0.684	0.95
23_L	32_W	0.683	0.95
45_D	56_L	0.681	0.95
12_G	15_K	0.681	0.95
121_C	142_Q	0.680	0.95
314_A	317_S	0.680	0.95
259_W	315_L	0.679	0.95
4_T	90_I	0.678	0.95
138_N	238_Y	0.677	0.95
199_A	203_A	0.674	0.95
20_L	48_L	0.673	0.95
123_L	143_L	0.673	0.95
237_G	240_A	0.669	0.94
77_N	80_L	0.669	0.94
258_E	262_L	0.668	0.94
103_D	106_T	0.668	0.94
9_G	12_G	0.667	0.94
12_G	16_T	0.667	0.94
115_D	192_D	0.666	0.94
34_V	37_N	0.666	0.94
36_V	44_I	0.663	0.94
201_L	205_A	0.662	0.94
85_P	88_L	0.661	0.94
198_L	204_S	0.661	0.94
198_L	201_L	0.661	0.94
77_N	109_V	0.661	0.94
104_L	256_I	0.660	0.94
281_I	302_I	0.658	0.94
63_C	67_V	0.656	0.94
272_L	281_I	0.654	0.94
281_I	288_L	0.653	0.94
199_A	202_P	0.653	0.94
254_I	257_L	0.653	0.94
37_N	40_G	0.651	0.94
92_P	147_D	0.649	0.93
125_P	169_W	0.649	0.93
151_A	154_S	0.647	0.93
151_A	178_L	0.647	0.93
231_S	234_S	0.646	0.93
59_I	75_G	0.646	0.93
137_E	140_R	0.643	0.93
10_F	266_E	0.643	0.93
123_L	165_L	0.643	0.93
57_K	75_G	0.643	0.93
198_L	205_A	0.638	0.93
26_K	89_L	0.638	0.93
251_F	319_L	0.638	0.93
283_R	286_D	0.637	0.93
109_V	112_P	0.637	0.93
11_L	37_N	0.637	0.93
44_I	47_A	0.634	0.93
24_A	28_P	0.634	0.93
10_F	142_Q	0.633	0.93
267_R	270_G	0.633	0.93
9_G	15_K	0.632	0.93
154_S	157_T	0.630	0.92
6_L	116_L	0.628	0.92
202_P	207_H	0.624	0.92
203_A	206_A	0.623	0.92
200_E	207_H	0.620	0.92
38_E	58_E	0.620	0.92
208_S	230_R	0.619	0.92
28_P	32_W	0.618	0.92
256_I	260_A	0.618	0.92
304_L	310_A	0.616	0.92
273_R	300_S	0.614	0.91
231_S	235_G	0.613	0.91
155_D	183_H	0.612	0.91
167_R	170_Q	0.612	0.91
6_L	283_R	0.612	0.91
129_L	133_S	0.611	0.91
8_T	92_P	0.611	0.91
129_L	161_S	0.610	0.91
108_P	112_P	0.610	0.91
18_S	146_A	0.610	0.91
228_W	232_L	0.609	0.91
21_H	181_S	0.609	0.91
151_A	162_E	0.608	0.91
62_G	65_C	0.607	0.91
5_N	190_L	0.607	0.91
46_G	58_E	0.606	0.91
161_S	165_L	0.604	0.91
255_G	259_W	0.604	0.91
127_L	285_G	0.603	0.91
132_K	140_R	0.603	0.91
243_W	249_T	0.603	0.91
14_G	17_T	0.602	0.91
272_L	279_V	0.598	0.90
46_G	49_L	0.598	0.90
43_G	139_F	0.596	0.90
192_D	197_N	0.594	0.90
129_L	165_L	0.593	0.90
310_A	315_L	0.593	0.90
168_W	172_N	0.593	0.90
120_L	150_V	0.592	0.90
80_L	110_Y	0.592	0.90
265_V	310_A	0.590	0.90
200_E	208_S	0.590	0.90
76_L	105_L	0.589	0.90
33_A	83_G	0.589	0.90
235_G	238_Y	0.589	0.90
250_V	275_P	0.586	0.89
8_T	118_A	0.584	0.89
71_P	104_L	0.583	0.89
77_N	112_P	0.581	0.89
202_P	208_S	0.578	0.89
253_T	277_G	0.578	0.89
149_I	178_L	0.577	0.89
115_D	194_P	0.577	0.89
278_L	282_N	0.572	0.88
261_R	288_L	0.571	0.88
68_N	72_M	0.571	0.88
30_E	86_D	0.569	0.88
252_D	274_I	0.569	0.88
120_L	148_I	0.568	0.88
151_A	166_Q	0.568	0.88
148_I	193_L	0.568	0.88
9_G	14_G	0.567	0.88
147_D	195_R	0.567	0.88
248_D	273_R	0.566	0.88
32_W	86_D	0.564	0.88
159_P	204_S	0.560	0.87
206_A	228_W	0.560	0.87
59_I	69_G	0.557	0.87
315_L	318_A	0.557	0.87
99_K	141_D	0.557	0.87
197_N	200_E	0.556	0.87
48_L	53_G	0.555	0.87
293_Q	298_P	0.553	0.87
270_G	281_I	0.553	0.87
3_R	115_D	0.547	0.86
143_L	293_Q	0.546	0.86
124_D	127_L	0.546	0.86
11_L	15_K	0.540	0.85
152_N	186_V	0.537	0.85
26_K	29_N	0.536	0.85
159_P	162_E	0.535	0.85
16_T	48_L	0.535	0.85
167_R	255_G	0.535	0.85
206_A	229_R	0.532	0.84
73_Q	107_A	0.530	0.84
200_E	206_A	0.529	0.84
78_T	185_K	0.529	0.84
108_P	111_E	0.528	0.84
11_L	16_T	0.527	0.84
248_D	251_F	0.526	0.84
38_E	41_E	0.524	0.84
117_R	191_L	0.523	0.83
26_K	30_E	0.523	0.83
239_Q	245_F	0.522	0.83
38_E	97_H	0.521	0.83
100_Q	104_L	0.521	0.83
2_T	114_I	0.520	0.83
259_W	289_H	0.519	0.83
37_N	65_C	0.519	0.83
235_G	239_Q	0.518	0.83
75_G	265_V	0.517	0.83
36_V	46_G	0.517	0.83
201_L	208_S	0.516	0.83
93_T	110_Y	0.515	0.82
194_P	197_N	0.514	0.82
57_K	61_G	0.514	0.82
182_E	313_N	0.513	0.82
156_R	183_H	0.513	0.82
64_M	71_P	0.512	0.82
4_T	69_G	0.511	0.82
258_E	261_R	0.511	0.82
177_Q	193_L	0.508	0.82
159_P	166_Q	0.506	0.81
11_L	94_G	0.506	0.81
55_L	78_T	0.506	0.81
16_T	37_N	0.505	0.81
59_I	63_C	0.505	0.81
26_K	188_G	0.503	0.81
235_G	240_A	0.503	0.81
281_I	290_I	0.502	0.81
230_R	235_G	0.502	0.81
5_N	147_D	0.501	0.81
167_R	189_H	0.501	0.81
130_D	171_Q	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nijA	1	0.9085	100	0.406	Contact Map
4ehxA	1	0.7713	99.9	0.709	Contact Map
2wsmA	2	0.5488	99.9	0.728	Contact Map
2hf9A	2	0.564	99.9	0.743	Contact Map
4hi0E	2	0.5579	99.8	0.76	Contact Map
1yrbA	2	0.6768	99.8	0.761	Contact Map
4lpsA	1	0.5793	99.8	0.762	Contact Map
1xjcA	2	0.4207	99.8	0.774	Contact Map
4xc8A	2	0.8567	99.7	0.794	Contact Map
2qm8A	2	0.6524	99.7	0.796	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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