GREMLIN Database
YEIR - Uncharacterized protein YeiR
UniProt: P33030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12104
Length: 328 (298)
Sequences: 5524 (3493)
Seq/√Len: 202.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_Q180_H5.7101.00
312_W316_Q5.0191.00
150_V181_S4.3451.00
158_T161_S3.7731.00
292_T296_A3.6161.00
125_P157_T3.4911.00
245_F320_L3.2271.00
152_N181_S2.9751.00
155_D182_E2.9121.00
125_P151_A2.7711.00
316_Q320_L2.6481.00
149_I169_W2.6381.00
122_I152_N2.5631.00
259_W318_A2.5501.00
166_Q170_Q2.5111.00
268_V281_I2.3491.00
88_L114_I2.3191.00
21_H185_K2.2971.00
162_E180_H2.2931.00
173_G176_R2.2731.00
252_D255_G2.2131.00
7_I19_I2.2041.00
22_L89_L2.1761.00
311_D314_A2.1511.00
292_T295_V2.1421.00
157_T162_E2.1031.00
30_E87_R2.0411.00
161_S164_A2.0311.00
21_H25_H2.0281.00
256_I274_I2.0131.00
31_K86_D1.9971.00
154_S180_H1.9891.00
162_E166_Q1.9661.00
163_Q167_R1.9491.00
159_P163_Q1.9481.00
33_A79_L1.9401.00
76_L88_L1.9351.00
154_S162_E1.8811.00
246_D299_D1.8561.00
313_N317_S1.8531.00
246_D301_R1.8331.00
25_H28_P1.8231.00
293_Q296_A1.7721.00
124_D153_K1.7341.00
80_L114_I1.6961.00
22_L188_G1.6831.00
2_T88_L1.6811.00
133_S168_W1.6801.00
43_G58_E1.6771.00
23_L34_V1.6601.00
181_S184_G1.6471.00
38_E43_G1.6101.00
43_G46_G1.6021.00
8_T119_T1.5951.00
5_N117_R1.5871.00
243_W315_L1.5771.00
97_H141_D1.5751.00
13_S122_I1.5741.00
265_V304_L1.5701.00
250_V273_R1.5491.00
18_S184_G1.5481.00
128_L143_L1.5441.00
170_Q178_L1.5391.00
182_E185_K1.5261.00
118_A148_I1.4991.00
76_L114_I1.4961.00
165_L169_W1.4941.00
118_A193_L1.4911.00
257_L261_R1.4861.00
78_T82_Q1.4791.00
143_L149_I1.4541.00
8_T121_C1.4461.00
42_V244_I1.4351.00
252_D275_P1.4331.00
128_L165_L1.4301.00
146_A149_I1.4191.00
183_H289_H1.4131.00
126_R287_D1.4011.00
253_T257_L1.3931.00
148_I177_Q1.3891.00
5_N87_R1.3581.00
63_C66_C1.3481.00
268_V283_R1.3351.00
245_F251_F1.3141.00
280_R291_E1.2931.00
93_T96_G1.2811.00
33_A85_P1.2801.00
20_L24_A1.2741.00
32_W87_R1.2741.00
18_S122_I1.2701.00
248_D299_D1.2661.00
21_H24_A1.2651.00
166_Q178_L1.2621.00
126_R156_R1.2541.00
292_T298_P1.2371.00
102_L119_T1.2311.00
157_T165_L1.2241.00
241_C312_W1.2141.00
126_R161_S1.2081.00
163_Q166_Q1.2051.00
38_E46_G1.1981.00
77_N81_R1.1931.00
36_V49_L1.1901.00
256_I272_L1.1871.00
245_F319_L1.1831.00
130_D134_A1.1731.00
268_V304_L1.1691.00
146_A173_G1.1671.00
313_N316_Q1.1611.00
59_I68_N1.1611.00
92_P101_I1.1611.00
64_M90_I1.1601.00
274_I279_V1.1601.00
243_W316_Q1.1521.00
102_L116_L1.1491.00
143_L169_W1.1481.00
152_N184_G1.1471.00
272_L300_S1.1411.00
283_R288_L1.1361.00
251_F256_I1.1321.00
314_A318_A1.1311.00
151_A180_H1.1301.00
243_W312_W1.1201.00
317_S321_K1.1191.00
306_S310_A1.1151.00
30_E189_H1.1111.00
39_F242_G1.1061.00
43_G60_P1.0861.00
152_N183_H1.0831.00
6_L105_L1.0811.00
159_P180_H1.0801.00
80_L113_W1.0801.00
273_R298_P1.0781.00
160_E163_Q1.0761.00
205_A208_S1.0741.00
21_H184_G1.0641.00
253_T274_I1.0591.00
72_M90_I1.0551.00
148_I179_I1.0531.00
254_I258_E1.0421.00
204_S208_S1.0391.00
204_S207_H1.0311.00
273_R278_L1.0311.00
239_Q242_G1.0201.00
179_I186_V1.0161.00
67_V93_T1.0061.00
318_A321_K1.0041.00
70_L74_V1.0041.00
150_V179_I1.0041.00
274_I277_G1.0001.00
271_V280_R0.9961.00
202_P205_A0.9951.00
35_L75_G0.9881.00
48_L280_R0.9851.00
64_M72_M0.9791.00
121_C146_A0.9691.00
232_L235_G0.9640.99
247_A320_L0.9620.99
158_T162_E0.9590.99
175_D200_E0.9580.99
253_T276_E0.9510.99
122_I184_G0.9500.99
20_L49_L0.9500.99
157_T161_S0.9500.99
149_I176_R0.9470.99
125_P162_E0.9340.99
317_S320_L0.9270.99
228_W231_S0.9150.99
22_L190_L0.9120.99
92_P96_G0.9080.99
168_W171_Q0.9080.99
22_L32_W0.9060.99
35_L88_L0.9000.99
154_S182_E0.8930.99
256_I288_L0.8890.99
167_R171_Q0.8850.99
54_A57_K0.8830.99
201_L206_A0.8760.99
201_L204_S0.8760.99
117_R194_P0.8700.99
25_H188_G0.8660.99
39_F96_G0.8640.99
165_L168_W0.8580.99
2_T80_L0.8510.99
39_F95_L0.8490.99
48_L271_V0.8480.99
126_R157_T0.8440.99
265_V268_V0.8440.99
19_I89_L0.8410.99
74_V78_T0.8400.99
75_G78_T0.8370.99
264_P308_S0.8360.99
54_A71_P0.8350.99
38_E96_G0.8350.99
123_L128_L0.8330.98
200_E204_S0.8330.98
4_T88_L0.8300.98
270_G302_I0.8240.98
163_Q180_H0.8230.98
119_T147_D0.8210.98
36_V45_D0.8200.98
239_Q309_E0.8180.98
202_P206_A0.8180.98
43_G111_E0.8150.98
71_P74_V0.8140.98
230_R233_N0.8120.98
248_D297_P0.8100.98
77_N113_W0.8070.98
6_L119_T0.8030.98
164_A167_R0.8010.98
155_D184_G0.7970.98
45_D49_L0.7970.98
252_D276_E0.7920.98
229_R232_L0.7880.98
38_E93_T0.7850.98
128_L139_F0.7850.98
150_V186_V0.7800.98
18_S150_V0.7790.98
4_T105_L0.7760.98
36_V43_G0.7740.98
5_N120_L0.7720.98
262_L318_A0.7720.98
177_Q195_R0.7650.97
247_A316_Q0.7610.97
125_P165_L0.7610.97
21_H188_G0.7600.97
247_A251_F0.7590.97
82_Q85_P0.7580.97
153_K156_R0.7570.97
99_K103_D0.7540.97
138_N141_D0.7520.97
87_R117_R0.7470.97
30_E192_D0.7460.97
94_G269_K0.7440.97
117_R192_D0.7440.97
201_L207_H0.7420.97
273_R297_P0.7350.97
278_L296_A0.7320.97
131_E136_N0.7320.97
96_G101_I0.7300.97
132_K139_F0.7280.96
42_V45_D0.7230.96
152_N182_E0.7230.96
20_L40_G0.7230.96
47_A301_R0.7200.96
18_S181_S0.7200.96
61_G65_C0.7200.96
248_D300_S0.7170.96
151_A165_L0.7160.96
5_N118_A0.7140.96
264_P309_E0.7130.96
79_L85_P0.7120.96
203_A207_H0.7080.96
131_E134_A0.7060.96
200_E203_A0.7020.96
80_L88_L0.7010.96
243_W304_L0.7000.96
121_C149_I0.6980.96
32_W89_L0.6970.95
91_E94_G0.6970.95
110_Y114_I0.6940.95
181_S186_V0.6930.95
11_L14_G0.6850.95
61_G105_L0.6850.95
304_L319_L0.6850.95
129_L164_A0.6840.95
228_W233_N0.6840.95
123_L149_I0.6840.95
23_L32_W0.6830.95
45_D56_L0.6810.95
12_G15_K0.6810.95
121_C142_Q0.6800.95
314_A317_S0.6800.95
259_W315_L0.6790.95
4_T90_I0.6780.95
138_N238_Y0.6770.95
199_A203_A0.6740.95
20_L48_L0.6730.95
123_L143_L0.6730.95
237_G240_A0.6690.94
77_N80_L0.6690.94
258_E262_L0.6680.94
103_D106_T0.6680.94
9_G12_G0.6670.94
12_G16_T0.6670.94
115_D192_D0.6660.94
34_V37_N0.6660.94
36_V44_I0.6630.94
201_L205_A0.6620.94
85_P88_L0.6610.94
198_L204_S0.6610.94
198_L201_L0.6610.94
77_N109_V0.6610.94
104_L256_I0.6600.94
281_I302_I0.6580.94
63_C67_V0.6560.94
272_L281_I0.6540.94
281_I288_L0.6530.94
199_A202_P0.6530.94
254_I257_L0.6530.94
37_N40_G0.6510.94
92_P147_D0.6490.93
125_P169_W0.6490.93
151_A154_S0.6470.93
151_A178_L0.6470.93
231_S234_S0.6460.93
59_I75_G0.6460.93
137_E140_R0.6430.93
10_F266_E0.6430.93
123_L165_L0.6430.93
57_K75_G0.6430.93
198_L205_A0.6380.93
26_K89_L0.6380.93
251_F319_L0.6380.93
283_R286_D0.6370.93
109_V112_P0.6370.93
11_L37_N0.6370.93
44_I47_A0.6340.93
24_A28_P0.6340.93
10_F142_Q0.6330.93
267_R270_G0.6330.93
9_G15_K0.6320.93
154_S157_T0.6300.92
6_L116_L0.6280.92
202_P207_H0.6240.92
203_A206_A0.6230.92
200_E207_H0.6200.92
38_E58_E0.6200.92
208_S230_R0.6190.92
28_P32_W0.6180.92
256_I260_A0.6180.92
304_L310_A0.6160.92
273_R300_S0.6140.91
231_S235_G0.6130.91
155_D183_H0.6120.91
167_R170_Q0.6120.91
6_L283_R0.6120.91
129_L133_S0.6110.91
8_T92_P0.6110.91
129_L161_S0.6100.91
108_P112_P0.6100.91
18_S146_A0.6100.91
228_W232_L0.6090.91
21_H181_S0.6090.91
151_A162_E0.6080.91
62_G65_C0.6070.91
5_N190_L0.6070.91
46_G58_E0.6060.91
161_S165_L0.6040.91
255_G259_W0.6040.91
127_L285_G0.6030.91
132_K140_R0.6030.91
243_W249_T0.6030.91
14_G17_T0.6020.91
272_L279_V0.5980.90
46_G49_L0.5980.90
43_G139_F0.5960.90
192_D197_N0.5940.90
129_L165_L0.5930.90
310_A315_L0.5930.90
168_W172_N0.5930.90
120_L150_V0.5920.90
80_L110_Y0.5920.90
265_V310_A0.5900.90
200_E208_S0.5900.90
76_L105_L0.5890.90
33_A83_G0.5890.90
235_G238_Y0.5890.90
250_V275_P0.5860.89
8_T118_A0.5840.89
71_P104_L0.5830.89
77_N112_P0.5810.89
202_P208_S0.5780.89
253_T277_G0.5780.89
149_I178_L0.5770.89
115_D194_P0.5770.89
278_L282_N0.5720.88
261_R288_L0.5710.88
68_N72_M0.5710.88
30_E86_D0.5690.88
252_D274_I0.5690.88
120_L148_I0.5680.88
151_A166_Q0.5680.88
148_I193_L0.5680.88
9_G14_G0.5670.88
147_D195_R0.5670.88
248_D273_R0.5660.88
32_W86_D0.5640.88
159_P204_S0.5600.87
206_A228_W0.5600.87
59_I69_G0.5570.87
315_L318_A0.5570.87
99_K141_D0.5570.87
197_N200_E0.5560.87
48_L53_G0.5550.87
293_Q298_P0.5530.87
270_G281_I0.5530.87
3_R115_D0.5470.86
143_L293_Q0.5460.86
124_D127_L0.5460.86
11_L15_K0.5400.85
152_N186_V0.5370.85
26_K29_N0.5360.85
159_P162_E0.5350.85
16_T48_L0.5350.85
167_R255_G0.5350.85
206_A229_R0.5320.84
73_Q107_A0.5300.84
200_E206_A0.5290.84
78_T185_K0.5290.84
108_P111_E0.5280.84
11_L16_T0.5270.84
248_D251_F0.5260.84
38_E41_E0.5240.84
117_R191_L0.5230.83
26_K30_E0.5230.83
239_Q245_F0.5220.83
38_E97_H0.5210.83
100_Q104_L0.5210.83
2_T114_I0.5200.83
259_W289_H0.5190.83
37_N65_C0.5190.83
235_G239_Q0.5180.83
75_G265_V0.5170.83
36_V46_G0.5170.83
201_L208_S0.5160.83
93_T110_Y0.5150.82
194_P197_N0.5140.82
57_K61_G0.5140.82
182_E313_N0.5130.82
156_R183_H0.5130.82
64_M71_P0.5120.82
4_T69_G0.5110.82
258_E261_R0.5110.82
177_Q193_L0.5080.82
159_P166_Q0.5060.81
11_L94_G0.5060.81
55_L78_T0.5060.81
16_T37_N0.5050.81
59_I63_C0.5050.81
26_K188_G0.5030.81
235_G240_A0.5030.81
281_I290_I0.5020.81
230_R235_G0.5020.81
5_N147_D0.5010.81
167_R189_H0.5010.81
130_D171_Q0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nijA 1 0.9085 100 0.406 Contact Map
4ehxA 1 0.7713 99.9 0.709 Contact Map
2wsmA 2 0.5488 99.9 0.728 Contact Map
2hf9A 2 0.564 99.9 0.743 Contact Map
4hi0E 2 0.5579 99.8 0.76 Contact Map
1yrbA 2 0.6768 99.8 0.761 Contact Map
4lpsA 1 0.5793 99.8 0.762 Contact Map
1xjcA 2 0.4207 99.8 0.774 Contact Map
4xc8A 2 0.8567 99.7 0.794 Contact Map
2qm8A 2 0.6524 99.7 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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