GREMLIN Database
YEIQ - Uncharacterized oxidoreductase YeiQ
UniProt: P33029 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12036
Length: 488 (453)
Sequences: 2431 (1694)
Seq/√Len: 79.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D92_I3.9891.00
320_D479_H3.8701.00
60_I111_I3.6681.00
109_A171_R3.1601.00
311_F320_D3.0491.00
44_T273_W3.0441.00
472_Q481_A3.0391.00
328_R351_D2.9531.00
25_S58_C2.9071.00
234_D237_L2.8281.00
241_S247_N2.8271.00
46_R92_I2.7671.00
116_C171_R2.7571.00
58_C114_K2.6791.00
99_E114_K2.6301.00
196_K200_L2.6261.00
262_V278_V2.5911.00
173_R209_E2.5881.00
117_E120_V2.5331.00
27_I44_T2.4671.00
193_H222_G2.4321.00
204_E215_K2.4271.00
329_T333_D2.3901.00
107_S110_A2.3641.00
317_C323_F2.2861.00
113_E175_R2.2671.00
82_L91_V2.2251.00
23_L56_G2.2131.00
167_E171_R2.2051.00
304_Y373_G2.1321.00
301_F401_G2.1301.00
388_H393_T2.1241.00
203_A214_I2.0861.00
121_A270_R2.0821.00
324_R358_A2.0681.00
199_V220_F2.0511.00
364_H368_Q2.0411.00
219_S267_V2.0411.00
28_V120_V2.0331.00
180_F218_V2.0051.00
170_K174_E1.9931.00
402_V462_F1.9861.00
160_S163_G1.9761.00
115_F168_A1.9521.00
465_A469_A1.9441.00
238_V242_Q1.9421.00
305_L404_G1.9421.00
171_R175_R1.9371.00
43_L258_I1.9341.00
332_L350_A1.9331.00
99_E110_A1.9211.00
272_A275_V1.9171.00
62_L164_I1.9111.00
73_R77_H1.9061.00
109_A113_E1.8731.00
36_H40_Q1.8711.00
78_L93_I1.8681.00
83_E254_C1.8651.00
170_K206_R1.8541.00
212_G216_E1.8301.00
134_I198_A1.8041.00
56_G98_H1.8011.00
315_S319_Q1.7921.00
182_V195_V1.7591.00
324_R328_R1.7541.00
307_Y419_I1.7531.00
58_C99_E1.7471.00
301_F330_L1.7461.00
25_S99_E1.7321.00
25_S120_V1.7181.00
273_W278_V1.7091.00
70_S74_A1.7081.00
219_S265_N1.7071.00
42_L81_V1.6981.00
28_V60_I1.6951.00
298_S327_A1.6871.00
406_M445_L1.6791.00
305_L400_L1.6751.00
190_D193_H1.6721.00
473_I481_A1.6621.00
336_A350_A1.6581.00
24_Q119_Q1.6571.00
81_V94_V1.6551.00
204_E211_A1.6511.00
45_D49_N1.6391.00
385_I402_V1.6281.00
59_E97_V1.6171.00
294_M331_M1.6071.00
294_M350_A1.5991.00
314_I369_I1.5911.00
298_S331_M1.5811.00
101_L111_I1.5791.00
325_H329_T1.5751.00
25_S98_H1.5651.00
306_G317_C1.5621.00
181_T267_V1.5570.99
183_L262_V1.5540.99
312_A316_D1.5500.99
135_D138_T1.5450.99
127_I161_A1.5170.99
387_I390_G1.5170.99
26_R121_A1.5150.99
460_P464_Q1.5140.99
190_D285_L1.5120.99
173_R207_S1.5070.99
27_I57_I1.5050.99
150_H154_T1.5010.99
413_D417_N1.4940.99
123_V180_F1.4910.99
385_I462_F1.4790.99
457_P463_V1.4590.99
115_F180_F1.4580.99
58_C120_V1.4570.99
281_V286_P1.4470.99
179_P218_V1.4450.99
234_D238_V1.4370.99
167_E170_K1.4310.99
140_A201_G1.4240.99
395_W399_A1.4210.99
443_T463_V1.4170.99
305_L473_I1.4100.99
209_E212_G1.4060.99
200_L215_K1.4050.99
447_S457_P1.4000.99
345_D348_Q1.3980.99
28_V168_A1.3940.99
407_R470_W1.3890.99
389_Q459_N1.3780.99
166_V214_I1.3710.99
410_S433_V1.3690.99
48_L53_G1.3670.99
386_R454_D1.3540.99
110_A113_E1.3500.99
303_A370_A1.3430.98
214_I220_F1.3400.98
312_A365_K1.3390.98
112_I171_R1.3300.98
322_A479_H1.3250.98
449_R458_D1.3210.98
354_I358_A1.3140.98
407_R474_V1.3100.98
329_T397_L1.3070.98
239_E243_H1.3020.98
140_A197_N1.2950.98
400_L481_A1.2950.98
425_L428_K1.2910.98
44_T57_I1.2870.98
399_A466_I1.2860.98
170_K207_S1.2840.98
167_E206_R1.2760.98
166_V199_V1.2710.98
208_P212_G1.2670.98
318_M324_R1.2580.98
19_D22_Q1.2540.98
84_K236_S1.2530.98
396_S465_A1.2510.98
211_A214_I1.2470.98
41_A57_I1.2450.98
332_L351_D1.2370.97
166_V202_M1.2240.97
204_E212_G1.2220.97
150_H159_H1.2210.97
125_L161_A1.2190.97
471_Q475_Q1.2110.97
472_Q476_F1.2090.97
232_A237_L1.2080.97
348_Q352_K1.2060.97
46_R50_A1.2060.97
307_Y408_Y1.2030.97
80_T91_V1.2030.97
232_A251_A1.2020.97
80_T93_I1.1970.97
328_R332_L1.1960.97
309_S323_F1.1880.97
386_R453_G1.1860.97
42_L94_V1.1850.97
314_I317_C1.1840.97
430_R434_A1.1840.97
301_F326_A1.1830.97
204_E208_P1.1820.97
165_L199_V1.1740.96
367_W408_Y1.1730.96
123_V165_L1.1700.96
294_M336_A1.1640.96
78_L95_G1.1600.96
32_F97_V1.1500.96
152_L202_M1.1490.96
86_A360_P1.1370.96
130_K375_Q1.1310.96
180_F267_V1.1280.96
165_L182_V1.1280.96
212_G215_K1.1250.95
112_I167_E1.1220.95
178_T268_A1.1220.95
75_Q248_D1.1190.95
77_H100_C1.1190.95
302_L323_F1.1160.95
293_R387_I1.1140.95
32_F59_E1.1050.95
141_L201_G1.1040.95
77_H99_E1.1010.95
108_L164_I1.0960.95
19_D23_L1.0950.95
183_L223_T1.0870.95
113_E116_C1.0850.94
476_F480_Q1.0780.94
427_D431_E1.0750.94
463_V467_E1.0720.94
294_M353_L1.0710.94
314_I366_T1.0680.94
289_E340_Q1.0570.94
30_F161_A1.0560.94
30_F115_F1.0560.94
400_L473_I1.0520.94
307_Y366_T1.0510.93
69_M73_R1.0480.93
197_N201_G1.0470.93
283_D286_P1.0440.93
307_Y367_W1.0340.93
428_K448_L1.0340.93
331_M350_A1.0320.93
168_A180_F1.0290.93
300_S376_K1.0240.93
200_L211_A1.0240.93
315_S363_K1.0200.92
163_G202_M1.0170.92
182_V220_F1.0160.92
309_S320_D1.0120.92
318_M327_A1.0110.92
431_E434_A1.0110.92
123_V182_V1.0090.92
377_L401_G1.0080.92
318_M354_I1.0070.92
408_Y421_V1.0030.92
232_A252_I1.0020.92
399_A462_F1.0020.92
316_D319_Q1.0010.92
28_V123_V1.0010.92
154_T157_E1.0000.92
42_L92_I0.9950.91
443_T447_S0.9920.91
240_I244_L0.9900.91
313_H316_D0.9890.91
313_H363_K0.9880.91
16_P95_G0.9850.91
227_R254_C0.9830.91
330_L398_L0.9820.91
384_G398_L0.9780.91
42_L46_R0.9770.91
367_W422_R0.9760.91
169_L213_W0.9720.90
50_A275_V0.9720.90
116_C168_A0.9690.90
91_V244_L0.9690.90
365_K368_Q0.9690.90
43_L276_A0.9680.90
432_L448_L0.9670.90
387_I391_R0.9670.90
428_K450_E0.9650.90
121_A269_G0.9640.90
328_R354_I0.9610.90
270_R274_E0.9590.90
213_W217_H0.9580.90
367_W419_I0.9570.90
443_T467_E0.9550.90
374_S451_V0.9540.90
46_R258_I0.9460.89
158_P167_E0.9450.89
35_F185_C0.9440.89
40_Q124_S0.9430.89
166_V203_A0.9430.89
64_S67_Q0.9430.89
407_R414_D0.9360.89
69_M105_L0.9360.89
374_S405_W0.9320.89
428_K432_L0.9310.88
193_H196_K0.9310.88
465_A468_Q0.9270.88
336_A346_L0.9250.88
113_E171_R0.9250.88
428_K431_E0.9200.88
27_I122_I0.9190.88
346_L350_A0.9160.88
326_A397_L0.9160.88
331_M354_I0.9090.87
114_K117_E0.9090.87
441_R447_S0.9080.87
44_T278_V0.9070.87
222_G263_E0.9060.87
477_G481_A0.9030.87
72_L77_H0.9010.87
448_L451_V0.8990.87
375_Q425_L0.8950.86
73_R99_E0.8910.86
294_M335_Q0.8890.86
395_W461_H0.8850.86
74_A249_P0.8840.86
83_E90_Q0.8840.86
61_S68_L0.8840.86
314_I327_A0.8780.85
25_S114_K0.8770.85
351_D354_I0.8760.85
80_T246_V0.8750.85
173_R210_L0.8740.85
49_N92_I0.8730.85
385_I399_A0.8650.85
171_R174_E0.8650.85
130_K380_R0.8620.84
239_E242_Q0.8590.84
18_Y45_D0.8560.84
85_G256_P0.8550.84
316_D366_T0.8550.84
124_S223_T0.8520.84
47_V276_A0.8500.83
348_Q351_D0.8470.83
352_K355_A0.8460.83
332_L336_A0.8460.83
402_V466_I0.8400.83
45_D96_A0.8390.83
347_T351_D0.8380.83
194_V197_N0.8380.83
311_F316_D0.8360.82
335_Q398_L0.8340.82
439_E467_E0.8330.82
70_S105_L0.8260.82
40_Q185_C0.8250.82
364_H380_R0.8220.81
257_F260_W0.8220.81
122_I270_R0.8210.81
335_Q384_G0.8210.81
468_Q472_Q0.8190.81
273_W280_M0.8160.81
46_R276_A0.8150.81
118_P177_L0.8140.81
364_H369_I0.8130.81
371_M422_R0.8110.81
125_L184_S0.8110.81
331_M353_L0.8090.80
81_V362_L0.8080.80
134_I194_V0.8070.80
169_L182_V0.8040.80
298_S357_F0.8010.80
381_M401_G0.7990.80
330_L335_Q0.7950.79
203_A211_A0.7940.79
17_R98_H0.7920.79
115_F123_V0.7920.79
266_F270_R0.7890.79
427_D430_R0.7880.79
25_S119_Q0.7840.78
440_Q443_T0.7840.78
382_L402_V0.7840.78
473_I478_A0.7820.78
449_R454_D0.7820.78
200_L214_I0.7780.78
182_V218_V0.7760.78
230_P349_Y0.7750.77
406_M466_I0.7750.77
26_R55_W0.7720.77
290_M344_V0.7710.77
302_L366_T0.7700.77
399_A465_A0.7670.77
309_S322_A0.7660.77
35_F40_Q0.7630.76
69_M100_C0.7630.76
196_K215_K0.7610.76
306_G366_T0.7610.76
181_T270_R0.7600.76
103_A164_I0.7580.76
36_H41_A0.7570.76
124_S260_W0.7550.76
435_G444_A0.7550.76
61_S102_N0.7520.75
307_Y312_A0.7490.75
116_C175_R0.7480.75
52_G272_A0.7470.75
71_Q249_P0.7460.75
124_S183_L0.7460.75
207_S211_A0.7440.75
310_G320_D0.7430.74
24_Q54_D0.7410.74
32_F62_L0.7380.74
170_K210_L0.7380.74
104_K108_L0.7360.74
117_E177_L0.7340.74
52_G275_V0.7330.73
304_Y408_Y0.7330.73
44_T47_V0.7320.73
256_P355_A0.7300.73
185_C349_Y0.7300.73
328_R350_A0.7270.73
185_C257_F0.7240.72
289_E387_I0.7220.72
152_L205_K0.7210.72
61_S100_C0.7210.72
414_D478_A0.7200.72
314_I376_K0.7200.72
300_S373_G0.7190.72
101_L110_A0.7190.72
203_A210_L0.7180.72
274_E280_M0.7180.72
372_D424_P0.7180.72
302_L317_C0.7170.72
174_E207_S0.7170.72
16_P19_D0.7130.71
136_P140_A0.7130.71
447_S463_V0.7120.71
382_L385_I0.7120.71
177_L217_H0.7110.71
322_A325_H0.7110.71
71_Q250_C0.7080.71
32_F61_S0.7040.70
446_L462_F0.7030.70
238_V241_S0.7020.70
305_L323_F0.7020.70
312_A413_D0.7000.70
17_R49_N0.7000.70
180_F203_A0.6980.70
343_D347_T0.6970.70
102_N105_L0.6970.70
181_T266_F0.6940.69
224_M284_V0.6940.69
181_T221_P0.6940.69
407_R411_G0.6930.69
93_I246_V0.6930.69
60_I101_L0.6930.69
201_G205_K0.6910.69
237_L251_A0.6900.69
438_S474_V0.6890.69
333_D397_L0.6880.69
334_E397_L0.6870.69
58_C98_H0.6870.69
25_S56_G0.6850.68
322_A482_L0.6850.68
385_I398_L0.6840.68
294_M298_S0.6820.68
333_D394_D0.6810.68
236_S239_E0.6760.67
67_Q70_S0.6750.67
321_R325_H0.6730.67
290_M346_L0.6720.67
57_I96_A0.6720.67
166_V206_R0.6710.67
46_R49_N0.6710.67
389_Q461_H0.6690.66
69_M102_N0.6690.66
375_Q379_Q0.6680.66
300_S304_Y0.6670.66
355_A360_P0.6660.66
414_D419_I0.6620.66
368_Q422_R0.6610.66
477_G480_Q0.6610.66
409_V421_V0.6600.65
473_I477_G0.6600.65
30_F168_A0.6580.65
18_Y95_G0.6580.65
124_S185_C0.6570.65
112_I164_I0.6560.65
75_Q78_L0.6560.65
150_H157_E0.6550.65
26_R48_L0.6530.65
374_S423_D0.6530.65
323_F482_L0.6520.64
42_L258_I0.6520.64
130_K372_D0.6510.64
300_S371_M0.6500.64
284_V288_E0.6480.64
259_Q349_Y0.6480.64
404_G478_A0.6480.64
16_P20_R0.6470.64
400_L469_A0.6470.64
478_A482_L0.6460.64
375_Q380_R0.6450.64
193_H447_S0.6440.64
293_R338_T0.6430.63
86_A355_A0.6420.63
396_S468_Q0.6410.63
290_M341_I0.6410.63
99_E113_E0.6400.63
162_P202_M0.6390.63
133_C160_S0.6390.63
389_Q462_F0.6380.63
177_L180_F0.6380.63
194_V198_A0.6380.63
85_G361_A0.6370.63
395_W459_N0.6370.63
227_R258_I0.6360.63
84_K227_R0.6360.63
85_G360_P0.6360.63
426_S430_R0.6350.62
230_P260_W0.6330.62
338_T384_G0.6320.62
274_E278_V0.6320.62
306_G311_F0.6310.62
165_L195_V0.6310.62
429_I445_L0.6310.62
349_Y353_L0.6300.62
20_R95_G0.6290.62
313_H362_L0.6290.62
219_S268_A0.6280.62
433_V441_R0.6260.61
125_L165_L0.6260.61
374_S429_I0.6250.61
189_P288_E0.6240.61
118_P178_T0.6230.61
334_E382_L0.6230.61
30_F67_Q0.6220.61
445_L451_V0.6210.61
383_A387_I0.6210.61
20_R23_L0.6210.61
476_F481_A0.6210.61
189_P297_G0.6190.60
305_L478_A0.6170.60
28_V115_F0.6170.60
383_A386_R0.6150.60
411_G414_D0.6140.60
141_L174_E0.6130.60
63_F127_I0.6120.60
464_Q468_Q0.6110.59
293_R384_G0.6090.59
109_A156_E0.6060.59
453_G457_P0.6060.59
53_G56_G0.6060.59
35_F39_H0.6060.59
389_Q395_W0.6050.59
439_E471_Q0.6050.59
61_S69_M0.6030.58
410_S474_V0.6020.58
400_L478_A0.6000.58
198_A201_G0.5990.58
183_L278_V0.5990.58
141_L198_A0.5980.58
32_F100_C0.5970.58
63_F67_Q0.5970.58
200_L362_L0.5960.58
377_L381_M0.5950.57
334_E388_H0.5950.57
402_V452_F0.5940.57
36_H39_H0.5940.57
330_L397_L0.5880.57
230_P359_N0.5880.57
84_K253_S0.5880.57
79_Y227_R0.5880.57
384_G387_I0.5850.56
238_V247_N0.5840.56
334_E398_L0.5830.56
304_Y317_C0.5820.56
470_W473_I0.5810.56
178_T217_H0.5800.56
378_P453_G0.5790.55
126_T288_E0.5780.55
286_P339_L0.5780.55
112_I116_C0.5770.55
183_L273_W0.5770.55
260_W359_N0.5760.55
265_N282_N0.5760.55
61_S64_S0.5750.55
50_A276_A0.5750.55
266_F269_G0.5730.55
153_Q458_D0.5730.55
42_L385_I0.5720.55
204_E214_I0.5720.55
311_F323_F0.5720.55
445_L448_L0.5720.55
338_T388_H0.5700.54
386_R390_G0.5690.54
129_E371_M0.5680.54
113_E117_E0.5660.54
235_E238_V0.5640.54
107_S112_I0.5630.53
257_F278_V0.5620.53
151_D158_P0.5620.53
130_K368_Q0.5610.53
409_V419_I0.5610.53
229_V244_L0.5610.53
130_K424_P0.5600.53
381_M398_L0.5600.53
30_F111_I0.5590.53
228_I260_W0.5580.53
255_E359_N0.5570.53
221_P264_D0.5570.53
478_A481_A0.5570.53
134_I139_G0.5570.53
108_L111_I0.5560.52
370_A375_Q0.5560.52
169_L218_V0.5560.52
292_L380_R0.5560.52
208_P411_G0.5550.52
29_H124_S0.5550.52
162_P380_R0.5540.52
223_T285_L0.5520.52
233_T236_S0.5510.52
370_A408_Y0.5510.52
91_V240_I0.5510.52
309_S479_H0.5500.52
216_E238_V0.5500.52
300_S369_I0.5500.52
32_F63_F0.5500.52
122_I273_W0.5490.52
341_I344_V0.5480.51
366_T369_I0.5480.51
380_R466_I0.5470.51
240_I243_H0.5470.51
40_Q260_W0.5460.51
310_G413_D0.5460.51
152_L206_R0.5430.51
300_S368_Q0.5430.51
388_H395_W0.5430.51
305_L401_G0.5410.51
83_E258_I0.5410.51
395_W465_A0.5410.51
212_G458_D0.5400.50
16_P93_I0.5390.50
81_V254_C0.5380.50
454_D458_D0.5370.50
230_P252_I0.5360.50
150_H153_Q0.5350.50
407_R473_I0.5340.50
219_S266_F0.5340.50
319_Q324_R0.5330.50
46_R321_R0.5330.50
461_H465_A0.5330.50
229_V362_L0.5310.49
236_S253_S0.5310.49
134_I205_K0.5300.49
47_V52_G0.5290.49
162_P364_H0.5290.49
45_D95_G0.5280.49
58_C101_L0.5270.49
266_F271_P0.5270.49
311_F408_Y0.5270.49
39_H185_C0.5270.49
178_T219_S0.5260.49
63_F102_N0.5260.49
382_L386_R0.5250.48
158_P400_L0.5240.48
109_A391_R0.5240.48
362_L381_M0.5240.48
28_V161_A0.5240.48
155_P206_R0.5230.48
104_K164_I0.5220.48
431_E480_Q0.5220.48
224_M261_V0.5220.48
158_P163_G0.5210.48
470_W474_V0.5210.48
28_V114_K0.5210.48
208_P211_A0.5200.48
313_H369_I0.5180.48
69_M72_L0.5180.48
16_P23_L0.5180.48
237_L250_C0.5180.48
173_R213_W0.5180.48
34_A253_S0.5170.47
72_L185_C0.5170.47
163_G308_L0.5170.47
50_A458_D0.5160.47
47_V53_G0.5160.47
269_G280_M0.5160.47
439_E443_T0.5160.47
242_Q460_P0.5160.47
297_G381_M0.5150.47
26_R53_G0.5150.47
235_E363_K0.5130.47
44_T280_M0.5130.47
35_F254_C0.5120.47
167_E180_F0.5120.47
273_W360_P0.5090.46
24_Q53_G0.5090.46
126_T186_D0.5080.46
44_T53_G0.5080.46
207_S212_G0.5070.46
57_I122_I0.5060.46
367_W420_D0.5050.46
261_V284_V0.5050.46
472_Q475_Q0.5040.46
376_K380_R0.5040.46
266_F274_E0.5030.46
385_I389_Q0.5030.46
312_A417_N0.5030.46
221_P263_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4im7A 1 0.9877 100 0.071 Contact Map
1lj8A 1 0.9939 100 0.079 Contact Map
3h2zA 2 0.7582 100 0.361 Contact Map
2ew2A 2 0.625 93.4 0.962 Contact Map
3wfiA 2 0.6168 93.2 0.963 Contact Map
3hn2A 2 0.6004 92.7 0.963 Contact Map
3i83A 2 0.6189 90.6 0.965 Contact Map
2qytA 1 0.5697 86.6 0.968 Contact Map
3hwrA 2 0.6045 82.2 0.969 Contact Map
4ol9A 2 0.6025 56.3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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