GREMLIN Database
PSUG - Pseudouridine-5'-phosphate glycosidase
UniProt: P33025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12033
Length: 312 (298)
Sequences: 1083 (701)
Seq/√Len: 40.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A300_A3.7891.00
53_E57_K3.6151.00
187_G205_V3.6081.00
237_I288_S3.5451.00
172_G203_F3.5451.00
12_Q71_V3.3071.00
192_A202_P3.2581.00
45_A85_G3.1551.00
151_Q181_F3.0331.00
49_I78_K2.9161.00
72_M119_I2.6211.00
50_E294_F2.5781.00
258_E276_R2.5511.00
191_K208_R2.4991.00
192_A200_T2.4621.00
36_S110_A2.4461.00
140_A173_L2.4351.00
94_V109_G2.3871.00
69_G83_L2.3831.00
58_Q302_E2.3671.00
219_M307_Y2.2741.00
16_E56_R2.2721.00
121_A157_N2.2551.00
213_S306_E2.2341.00
21_L27_V2.2281.00
54_T294_F2.2121.00
140_A144_F2.1800.99
73_K80_E2.1660.99
275_A279_E2.1640.99
12_Q73_K2.1370.99
43_Q46_Q2.0830.99
245_E249_N2.0560.99
94_V102_V2.0450.99
19_D23_N2.0250.99
233_V303_I2.0240.99
251_A281_T2.0110.99
49_I81_I2.0100.99
34_I293_V1.9950.99
77_S80_E1.9660.99
55_I60_A1.9430.99
187_G190_T1.9340.99
18_Q22_K1.9330.99
276_R280_L1.9170.99
159_T219_M1.9130.99
219_M231_L1.8910.98
117_M156_T1.8520.98
13_I27_V1.8360.98
165_A171_L1.8150.98
249_N253_D1.8080.98
60_A301_S1.8080.98
74_V119_I1.7920.98
209_L218_A1.7720.98
162_C232_V1.7700.98
144_F173_L1.7570.97
212_A302_E1.7050.97
83_L108_N1.6990.97
215_I233_V1.6940.97
262_Q272_F1.6920.97
159_T233_V1.6490.96
235_N299_L1.6440.96
222_K229_G1.6430.96
138_R256_V1.6260.96
69_G108_N1.6240.96
211_S214_E1.6040.96
247_T284_D1.6030.96
215_I303_I1.5980.96
276_R279_E1.5960.96
298_I302_E1.5910.95
95_S114_A1.5900.95
209_L215_I1.5890.95
117_M158_V1.5890.95
188_Y212_A1.5550.95
35_I85_G1.5440.95
157_N222_K1.5350.94
13_I21_L1.5330.94
258_E262_Q1.5190.94
254_Q280_L1.5120.94
67_I94_V1.5090.94
43_Q287_K1.4970.94
171_L193_L1.4970.94
32_S35_I1.4790.93
96_R118_I1.4760.93
32_S66_A1.4580.93
186_I218_A1.4580.93
291_Q294_F1.4550.93
39_M51_V1.4460.92
141_E173_L1.4260.92
257_A261_A1.4250.92
281_T285_S1.4200.92
58_Q298_I1.4130.92
100_P222_K1.4040.91
199_R239_E1.3850.91
220_V224_Q1.3400.89
175_T203_F1.3260.89
191_K204_D1.3230.89
133_I165_A1.3010.88
186_I209_L1.2940.88
165_A193_L1.2930.88
284_D287_K1.2760.87
67_I99_L1.2680.86
154_A181_F1.2590.86
106_G217_R1.2490.86
105_A214_E1.2490.86
127_V161_V1.2470.86
51_V297_A1.2310.85
159_T223_W1.2230.84
241_F291_Q1.2210.84
72_M103_V1.2170.84
171_L203_F1.2110.84
66_A76_L1.2050.83
259_A272_F1.2000.83
258_E280_L1.1940.83
46_Q50_E1.1880.83
167_S172_G1.1860.83
87_E91_V1.1840.82
113_V133_I1.1660.81
175_T193_L1.1570.81
139_G260_E1.1470.80
197_F278_A1.1420.80
97_R197_F1.1350.80
96_R152_E1.1210.79
52_E64_T1.1080.78
126_K223_W1.1080.78
212_A303_I1.0990.77
173_L177_Y1.0980.77
215_I299_L1.0900.77
87_E90_N1.0870.77
146_I177_Y1.0780.76
218_A231_L1.0770.76
15_P77_S1.0750.76
244_P247_T1.0680.75
33_T37_H1.0630.75
117_M152_E1.0620.75
39_M286_L1.0580.75
84_L91_V1.0570.75
277_V285_S1.0530.74
122_L225_S1.0510.74
99_L119_I1.0500.74
104_A218_A1.0500.74
198_C243_M1.0490.74
254_Q276_R1.0490.74
238_P295_N1.0450.74
96_R182_G1.0440.74
45_A81_I1.0430.74
50_E54_T1.0350.73
140_A146_I1.0260.72
29_A120_A1.0240.72
152_E156_T1.0240.72
199_R242_A1.0200.72
171_L195_A1.0180.72
247_T251_A1.0080.71
212_A299_L1.0030.71
60_A305_K1.0000.70
47_T51_V0.9970.70
92_T107_K0.9840.69
158_V230_G0.9710.68
237_I241_F0.9690.68
257_A260_E0.9650.68
11_L123_A0.9600.67
193_L234_A0.9510.66
167_S203_F0.9510.66
16_E61_V0.9490.66
95_S148_A0.9450.66
66_A73_K0.9410.66
168_I273_L0.9390.65
34_I51_V0.9370.65
58_Q301_S0.9320.65
68_I108_N0.9320.65
146_I173_L0.9290.65
151_Q193_L0.9270.64
167_S197_F0.9250.64
187_G206_S0.9190.64
141_E144_F0.9170.64
189_Q299_L0.9150.63
190_T205_V0.9120.63
19_D25_K0.9100.63
251_A277_V0.8940.62
47_T293_V0.8780.60
186_I215_I0.8780.60
103_V221_V0.8750.60
158_V184_P0.8700.59
186_I231_L0.8680.59
195_A201_S0.8630.59
39_M47_T0.8600.59
51_V290_I0.8580.58
55_I301_S0.8540.58
126_K220_V0.8540.58
162_C165_A0.8530.58
91_V110_A0.8460.57
39_M290_I0.8440.57
177_Y181_F0.8420.57
101_F209_L0.8420.57
275_A278_A0.8400.57
219_M223_W0.8390.57
157_N223_W0.8330.56
66_A84_L0.8320.56
267_K273_L0.8300.56
114_A148_A0.8300.56
65_I120_A0.8270.56
74_V81_I0.8250.55
222_K227_L0.8210.55
45_A82_E0.8170.55
15_P18_Q0.8130.54
155_N228_N0.8120.54
127_V307_Y0.8050.54
91_V108_N0.8020.53
55_I297_A0.7990.53
48_A64_T0.7940.53
250_A254_Q0.7900.52
47_T290_I0.7890.52
188_Y299_L0.7840.52
102_V107_K0.7820.51
65_I125_I0.7820.51
34_I39_M0.7740.51
101_F218_A0.7730.51
28_V60_A0.7690.50
118_I227_L0.7640.50
167_S232_V0.7560.49
96_R117_M0.7550.49
100_P225_S0.7510.49
198_C242_A0.7500.48
198_C244_P0.7440.48
36_S278_A0.7430.48
47_T85_G0.7420.48
51_V294_F0.7410.48
254_Q258_E0.7410.48
189_Q210_D0.7380.47
44_N48_A0.7330.47
131_G274_L0.7310.47
159_T231_L0.7310.47
87_E108_N0.7290.47
54_T58_Q0.7270.46
295_N299_L0.7250.46
99_L115_S0.7240.46
139_G143_T0.7220.46
113_V160_V0.7220.46
60_A297_A0.7210.46
104_A221_V0.7210.46
53_E79_E0.7160.45
197_F243_M0.7130.45
18_Q27_V0.7130.45
271_P274_L0.7080.45
243_M247_T0.7030.44
133_I232_V0.6990.44
161_V300_A0.6990.44
193_L205_V0.6980.44
66_A81_I0.6930.43
26_P305_K0.6890.43
33_T271_P0.6860.43
92_T102_V0.6850.43
96_R148_A0.6830.42
200_T245_E0.6770.42
106_G257_A0.6750.42
161_V233_V0.6750.42
92_T101_F0.6730.41
66_A293_V0.6730.41
68_I80_E0.6710.41
288_S291_Q0.6710.41
248_I251_A0.6670.41
138_R177_Y0.6670.41
235_N293_V0.6640.41
12_Q15_P0.6630.41
36_S232_V0.6590.40
252_I272_F0.6560.40
243_M288_S0.6540.40
110_A256_V0.6530.40
193_L202_P0.6520.40
115_S256_V0.6520.40
255_A259_A0.6480.39
214_E217_R0.6480.39
223_W231_L0.6470.39
27_V74_V0.6470.39
54_T298_I0.6470.39
151_Q154_A0.6450.39
171_L187_G0.6450.39
261_A272_F0.6420.39
154_A296_N0.6420.39
215_I218_A0.6410.39
45_A49_I0.6400.39
290_I294_F0.6380.38
163_A300_A0.6380.38
286_L290_I0.6370.38
172_G202_P0.6360.38
114_A297_A0.6350.38
219_M233_V0.6340.38
25_K61_V0.6320.38
247_T250_A0.6320.38
40_P286_L0.6310.38
14_S27_V0.6310.38
198_C248_I0.6300.38
251_A285_S0.6280.37
35_I48_A0.6270.37
133_I195_A0.6260.37
41_F45_A0.6240.37
168_I225_S0.6220.37
290_I295_N0.6210.37
11_L293_V0.6210.37
94_V254_Q0.6200.37
246_H257_A0.6190.37
36_S205_V0.6180.37
155_N175_T0.6170.37
259_A269_S0.6160.36
96_R114_A0.6160.36
94_V207_I0.6150.36
116_T271_P0.6110.36
171_L175_T0.6110.36
71_V103_V0.6100.36
101_F207_I0.6080.36
288_S295_N0.6070.36
157_N229_G0.6070.36
270_T289_N0.6060.36
171_L200_T0.6010.35
188_Y211_S0.6000.35
55_I58_Q0.6000.35
71_V119_I0.5980.35
105_A161_V0.5980.35
97_R167_S0.5970.35
140_A143_T0.5970.35
302_E305_K0.5970.35
133_I160_V0.5960.35
28_V297_A0.5940.35
32_S110_A0.5940.35
296_N301_S0.5940.35
55_I305_K0.5930.34
152_E182_G0.5920.34
35_I168_I0.5910.34
274_L292_L0.5900.34
13_I18_Q0.5870.34
74_V125_I0.5870.34
183_V230_G0.5870.34
92_T267_K0.5860.34
48_A85_G0.5860.34
101_F186_I0.5810.33
98_D109_G0.5800.33
177_Y242_A0.5790.33
77_S257_A0.5760.33
24_K308_Q0.5760.33
165_A234_A0.5760.33
21_L124_G0.5740.33
192_A204_D0.5730.33
258_E279_E0.5720.33
129_A241_F0.5720.33
69_G106_G0.5710.33
78_K82_E0.5680.32
220_V307_Y0.5680.32
82_E86_R0.5680.32
131_G292_L0.5670.32
154_A221_V0.5650.32
256_V298_I0.5650.32
94_V163_A0.5650.32
49_I85_G0.5640.32
10_L224_Q0.5610.32
18_Q21_L0.5600.32
175_T225_S0.5600.32
47_T50_E0.5600.32
39_M293_V0.5590.32
213_S246_H0.5590.32
15_P25_K0.5570.32
165_A187_G0.5570.32
19_D306_E0.5560.31
292_L297_A0.5560.31
118_I154_A0.5550.31
288_S292_L0.5540.31
127_V233_V0.5530.31
35_I64_T0.5500.31
163_A189_Q0.5500.31
194_P234_A0.5490.31
83_L87_E0.5490.31
72_M99_L0.5490.31
197_F297_A0.5470.31
255_A277_V0.5470.31
157_N228_N0.5460.31
163_A241_F0.5460.31
104_A107_K0.5460.31
131_G271_P0.5450.31
184_P229_G0.5430.30
133_I207_I0.5430.30
254_Q268_E0.5420.30
114_A127_V0.5380.30
243_M251_A0.5380.30
202_P245_E0.5380.30
65_I119_I0.5370.30
130_T271_P0.5370.30
205_V208_R0.5360.30
105_A126_K0.5350.30
255_A279_E0.5350.30
126_K262_Q0.5330.30
248_I277_V0.5330.30
241_F287_K0.5320.30
270_T274_L0.5320.30
79_E220_V0.5320.30
76_L81_I0.5310.30
96_R230_G0.5310.30
13_I308_Q0.5300.29
200_T246_H0.5300.29
252_I259_A0.5300.29
43_Q248_I0.5290.29
182_G227_L0.5280.29
235_N248_I0.5280.29
84_L252_I0.5280.29
114_A118_I0.5270.29
27_V308_Q0.5260.29
116_T130_T0.5260.29
47_T297_A0.5250.29
43_Q290_I0.5250.29
138_R244_P0.5250.29
95_S156_T0.5240.29
118_I122_L0.5230.29
96_R156_T0.5220.29
33_T131_G0.5220.29
129_A297_A0.5210.29
202_P306_E0.5200.29
23_N305_K0.5200.29
188_Y210_D0.5190.29
248_I293_V0.5180.29
26_P188_Y0.5180.29
129_A197_F0.5180.29
34_I37_H0.5180.29
95_S98_D0.5170.28
34_I285_S0.5160.28
163_A215_I0.5150.28
252_I277_V0.5150.28
123_A184_P0.5120.28
191_K210_D0.5110.28
101_F107_K0.5090.28
238_P292_L0.5080.28
198_C252_I0.5070.28
151_Q229_G0.5070.28
14_S77_S0.5070.28
175_T202_P0.5070.28
47_T82_E0.5070.28
274_L289_N0.5060.28
173_L223_W0.5050.28
131_G296_N0.5050.28
295_N298_I0.5050.28
167_S271_P0.5050.28
68_I73_K0.5050.28
221_V231_L0.5040.27
13_I213_S0.5040.27
13_I74_V0.5030.27
171_L205_V0.5020.27
268_E300_A0.5020.27
228_N233_V0.5010.27
159_T218_A0.5010.27
154_A184_P0.5010.27
253_D260_E0.5000.27
48_A52_E0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gimA 3 0.984 100 0.02 Contact Map
4ex8A 3 0.9615 100 0.07 Contact Map
1vkmA 5 0.9359 100 0.101 Contact Map
2gp4A 2 0.6378 76.3 0.967 Contact Map
2w6rA 1 0.4327 75.9 0.967 Contact Map
1mzhA 2 0.5032 68.9 0.968 Contact Map
3pffA 2 0.6731 63.1 0.97 Contact Map
1vquA 2 0.7853 62.7 0.97 Contact Map
2obnA 2 0.6859 53.7 0.971 Contact Map
2qjgA 6 0.6538 51.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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