GREMLIN Database
PSUT - Putative pseudouridine transporter
UniProt: P33024 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12032
Length: 416 (399)
Sequences: 1653 (930)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_Y278_G5.0591.00
315_D349_E4.6321.00
313_W316_A4.2171.00
277_N295_E3.8751.00
383_R386_E3.8551.00
295_E337_S3.7261.00
23_N26_S3.7121.00
105_I262_V3.6751.00
337_S340_P3.4891.00
319_A356_I3.3601.00
175_T214_I3.3311.00
22_V393_R3.1601.00
170_R389_Q2.9391.00
284_G292_A2.9211.00
161_V168_M2.8991.00
319_A352_T2.8971.00
12_V308_I2.8331.00
20_L396_A2.7561.00
10_M404_M2.7461.00
392_L396_A2.6761.00
77_I267_M2.6261.00
256_L260_A2.6001.00
123_L127_I2.5911.00
309_M403_L2.5621.00
212_G401_S2.4841.00
114_L244_F2.4791.00
22_V221_S2.4691.00
18_F24_K2.4221.00
35_A215_L2.4081.00
166_D382_K2.4001.00
165_I380_S2.3811.00
252_A268_A2.3511.00
325_Q337_S2.2731.00
17_A219_I2.2651.00
57_E61_L2.2321.00
366_F392_L2.2301.00
22_V170_R2.0951.00
253_M261_G2.0470.99
338_F351_K2.0420.99
114_L248_A2.0330.99
66_V111_L2.0270.99
117_Y241_P2.0100.99
17_A216_F1.9770.99
72_A75_A1.9620.99
118_I244_F1.9550.99
148_T160_I1.9370.99
201_Y358_F1.9370.99
309_M407_T1.9140.99
258_I261_G1.9100.99
303_A320_G1.8990.99
248_A272_I1.8890.99
7_V11_V1.8840.99
71_D100_R1.8230.99
209_A405_S1.8100.99
51_P55_A1.7970.99
131_I135_A1.7830.99
220_L397_A1.7700.98
170_R386_E1.7660.98
358_F405_S1.7450.98
364_A402_N1.7420.98
142_E218_R1.7410.98
169_N223_A1.7140.98
138_I143_S1.7030.98
296_S300_Y1.7000.98
257_K260_A1.6970.98
220_L396_A1.6930.98
327_L399_T1.6660.98
44_G412_F1.6460.98
32_V215_L1.6460.98
127_I130_S1.6070.97
155_N258_I1.6030.97
5_R307_W1.5840.97
294_L298_F1.5780.97
171_N223_A1.5760.97
45_I49_F1.5710.97
209_A212_G1.5680.97
20_L220_L1.5620.97
283_I287_F1.5600.97
307_W313_W1.5510.96
17_A400_L1.5480.96
154_Q372_V1.5450.96
102_L263_A1.5340.96
154_Q368_S1.5230.96
33_G37_L1.5200.96
108_V152_L1.5030.96
119_G122_G1.4990.96
113_S117_Y1.4860.96
93_A96_I1.4840.95
123_L126_R1.4820.95
129_G140_K1.4790.95
173_L386_E1.4700.95
4_M8_V1.4620.95
70_S74_S1.4450.95
8_V307_W1.4410.95
18_F27_I1.4390.95
364_A399_T1.4290.94
392_L395_L1.4200.94
174_F397_A1.4100.94
154_Q367_G1.4070.94
292_A297_I1.4000.94
328_A366_F1.3990.94
55_A58_Q1.3900.94
181_M372_V1.3900.94
64_H68_S1.3860.93
275_L279_I1.3820.93
193_A199_I1.3770.93
157_I179_S1.3620.93
259_A263_A1.3610.93
303_A313_W1.3550.93
27_I219_I1.3540.93
155_N261_G1.3470.92
23_N224_T1.3440.92
72_A274_A1.3290.92
256_L264_T1.3240.92
261_G265_V1.3240.92
244_F248_A1.3200.92
70_S271_A1.3150.92
271_A367_G1.3130.91
354_A413_I1.3110.91
169_N225_E1.3100.91
165_I379_I1.2900.91
78_F98_A1.2810.90
74_S99_F1.2790.90
258_I262_V1.2790.90
198_P342_L1.2780.90
15_A19_L1.2700.90
28_S31_T1.2680.90
155_N375_A1.2670.90
110_A248_A1.2610.90
169_N172_E1.2590.90
65_K69_Y1.2500.89
300_Y317_N1.2470.89
294_L328_A1.2290.89
175_T179_S1.2270.88
247_A251_G1.2250.88
65_K68_S1.2220.88
127_I131_I1.2210.88
303_A317_N1.1950.87
315_D348_L1.1930.87
322_L341_Y1.1920.87
246_E384_A1.1880.87
279_I282_G1.1810.86
351_K355_I1.1810.86
246_E250_S1.1800.86
97_F367_G1.1760.86
148_T152_L1.1740.86
49_F52_G1.1720.86
306_A323_I1.1660.86
314_S318_L1.1630.86
104_A187_S1.1540.85
145_V157_I1.1500.85
402_N405_S1.1410.84
38_L135_A1.1380.84
80_S96_I1.1280.84
81_L96_I1.1230.84
110_A252_A1.1220.83
276_I294_L1.1160.83
187_S258_I1.1030.82
80_S93_A1.0900.82
128_L150_I1.0860.81
295_E325_Q1.0820.81
42_I212_G1.0810.81
292_A296_S1.0800.81
16_I305_L1.0770.81
268_A370_G1.0750.81
338_F356_I1.0740.81
45_I51_P1.0700.80
395_L399_T1.0690.80
158_P180_G1.0670.80
409_A412_F1.0620.80
311_V319_A1.0570.80
154_Q371_V1.0570.80
329_I333_V1.0570.80
209_A358_F1.0540.79
341_Y347_T1.0540.79
376_F387_I1.0490.79
16_I396_A1.0440.79
191_G332_F1.0430.79
401_S405_S1.0420.79
125_I164_F1.0410.79
19_L24_K1.0390.78
16_I379_I1.0340.78
313_W320_G1.0320.78
369_I372_V1.0240.77
40_I408_I1.0210.77
330_N367_G1.0170.77
61_L64_H1.0160.77
145_V179_S1.0140.77
273_I329_I1.0140.77
384_A398_A1.0070.76
14_L32_V1.0050.76
335_Y361_C1.0040.76
342_L353_I1.0000.76
216_F397_A0.9970.75
43_G352_T0.9940.75
283_I286_W0.9880.75
195_M336_L0.9850.75
154_Q327_L0.9840.74
395_L398_A0.9830.74
14_L219_I0.9820.74
80_S84_P0.9800.74
6_S351_K0.9790.74
43_G320_G0.9760.74
293_S296_S0.9690.73
21_S219_I0.9640.73
321_S325_Q0.9630.73
149_T183_S0.9630.73
120_V350_V0.9630.73
62_G65_K0.9560.72
30_R34_A0.9530.72
366_F395_L0.9510.72
5_R8_V0.9470.72
261_G375_A0.9460.72
189_M202_L0.9440.71
67_M190_I0.9430.71
44_G48_Y0.9430.71
152_L160_I0.9360.71
284_G293_S0.9360.71
59_A62_G0.9360.71
132_F136_L0.9350.71
118_I121_M0.9350.71
74_S271_A0.9330.70
169_N224_T0.9250.70
175_T217_A0.9230.70
167_R228_Q0.9210.69
266_V270_V0.9200.69
165_I176_A0.9170.69
83_G96_I0.9140.69
326_K332_F0.9140.69
13_L404_M0.9100.69
160_I262_V0.9060.68
13_L216_F0.9050.68
114_L272_I0.9030.68
179_S210_I0.9010.68
106_I255_G0.9000.68
55_A59_A0.8980.68
284_G291_N0.8950.67
195_M369_I0.8940.67
369_I391_G0.8890.67
138_I214_I0.8870.67
125_I184_I0.8840.66
188_M367_G0.8830.66
40_I412_F0.8830.66
28_S33_G0.8780.66
206_S209_A0.8760.66
8_V162_K0.8750.65
280_I292_A0.8740.65
18_F219_I0.8740.65
35_A136_L0.8740.65
369_I387_I0.8640.65
68_S71_D0.8620.64
170_R221_S0.8540.64
147_V191_G0.8530.63
70_S104_A0.8450.63
215_L402_N0.8430.63
14_L411_F0.8420.62
129_G143_S0.8400.62
116_Y163_P0.8380.62
35_A48_Y0.8360.62
10_M212_G0.8360.62
54_W57_E0.8350.62
249_A253_M0.8320.62
6_S203_L0.8280.61
155_N188_M0.8280.61
80_S83_G0.8260.61
369_I395_L0.8260.61
348_L353_I0.8240.61
314_S349_E0.8220.61
34_A136_L0.8180.60
170_R390_L0.8170.60
49_F53_K0.8150.60
12_V15_A0.8130.60
76_F97_F0.8120.60
59_A203_L0.8100.59
42_I112_I0.8090.59
181_M398_A0.8070.59
295_E340_P0.8040.59
355_I404_M0.8040.59
265_V366_F0.8010.59
318_L341_Y0.8000.59
10_M405_S0.8000.59
120_V301_V0.7990.58
146_A214_I0.7980.58
98_A263_A0.7980.58
242_K389_Q0.7970.58
37_L308_I0.7970.58
101_V259_A0.7930.58
99_F103_P0.7850.57
39_Q212_G0.7820.57
209_A402_N0.7760.56
299_G321_S0.7740.56
281_G313_W0.7730.56
28_S136_L0.7720.56
274_A278_G0.7660.55
28_S137_N0.7650.55
350_V353_I0.7650.55
43_G341_Y0.7640.55
121_M125_I0.7610.55
136_L176_A0.7600.55
189_M193_A0.7570.54
365_N368_S0.7560.54
173_L383_R0.7550.54
259_A320_G0.7540.54
168_M176_A0.7530.54
121_M163_P0.7530.54
219_I308_I0.7520.54
167_R295_E0.7520.54
132_F395_L0.7510.54
149_T189_M0.7510.54
34_A37_L0.7500.54
254_T257_K0.7470.53
358_F409_A0.7460.53
212_G405_S0.7450.53
141_I168_M0.7450.53
318_L348_L0.7440.53
13_L309_M0.7430.53
355_I393_R0.7410.53
112_I121_M0.7400.53
41_A44_G0.7350.52
305_L403_L0.7350.52
129_G132_F0.7350.52
141_I157_I0.7340.52
327_L364_A0.7340.52
350_V354_A0.7320.52
112_I152_L0.7310.52
309_M355_I0.7310.52
108_V269_F0.7300.52
69_Y275_L0.7300.52
154_Q259_A0.7290.52
38_L253_M0.7280.51
371_V374_G0.7280.51
216_F370_G0.7260.51
112_I183_S0.7260.51
113_S241_P0.7260.51
58_Q62_G0.7250.51
184_I302_L0.7230.51
171_N218_R0.7220.51
265_V371_V0.7170.50
78_F103_P0.7170.50
185_A188_M0.7160.50
179_S351_K0.7150.50
171_N210_I0.7130.50
84_P220_L0.7130.50
27_I59_A0.7120.50
154_Q249_A0.7040.49
15_A18_F0.7020.49
183_S198_P0.7010.49
189_M206_S0.6980.49
53_K57_E0.6970.48
75_A80_S0.6940.48
184_I188_M0.6930.48
111_L264_T0.6910.48
273_I321_S0.6900.48
164_F398_A0.6900.48
7_V385_P0.6890.48
358_F402_N0.6850.47
297_I301_V0.6840.47
170_R383_R0.6830.47
147_V150_I0.6830.47
43_G313_W0.6830.47
45_I296_S0.6830.47
322_L334_A0.6800.47
311_V356_I0.6800.47
34_A162_K0.6720.46
385_P389_Q0.6710.46
178_C301_V0.6710.46
203_L207_L0.6710.46
202_L218_R0.6690.46
36_L408_I0.6690.46
142_E175_T0.6680.46
7_V411_F0.6660.45
145_V213_G0.6660.45
145_V176_A0.6650.45
112_I323_I0.6650.45
178_C362_G0.6650.45
243_S292_A0.6640.45
77_I266_V0.6600.45
288_G328_A0.6580.45
352_T356_I0.6570.44
330_N333_V0.6570.44
95_F100_R0.6560.44
10_M292_A0.6560.44
317_N320_G0.6560.44
331_E334_A0.6550.44
71_D75_A0.6550.44
185_A325_Q0.6540.44
299_G320_G0.6540.44
375_A387_I0.6520.44
364_A368_S0.6520.44
330_N334_A0.6520.44
149_T179_S0.6510.44
26_S358_F0.6490.44
35_A147_V0.6480.44
311_V352_T0.6480.44
149_T210_I0.6430.43
14_L215_L0.6400.43
282_G286_W0.6390.43
8_V308_I0.6390.43
14_L36_L0.6370.43
72_A277_N0.6360.42
259_A262_V0.6350.42
141_I144_F0.6340.42
62_G114_L0.6330.42
154_Q320_G0.6320.42
256_L263_A0.6320.42
267_M282_G0.6290.42
52_G142_E0.6280.42
53_K200_D0.6280.42
111_L272_I0.6280.42
370_G391_G0.6260.41
203_L355_I0.6240.41
123_L406_A0.6240.41
54_W58_Q0.6230.41
18_F22_V0.6230.41
330_N365_N0.6210.41
168_M409_A0.6200.41
277_N293_S0.6200.41
82_V99_F0.6190.41
51_P54_W0.6190.41
25_K134_K0.6180.41
119_G265_V0.6170.41
372_V376_F0.6170.41
221_S314_S0.6170.41
181_M394_A0.6170.41
263_A266_V0.6160.41
165_I279_I0.6150.40
58_Q61_L0.6150.40
370_G402_N0.6140.40
399_T402_N0.6120.40
65_K278_G0.6120.40
14_L379_I0.6110.40
146_A330_N0.6100.40
119_G123_L0.6080.40
8_V12_V0.6080.40
355_I399_T0.6050.39
82_V95_F0.6040.39
279_I318_L0.6030.39
201_Y405_S0.6030.39
121_M209_A0.6030.39
191_G199_I0.6020.39
101_V191_G0.6020.39
367_G389_Q0.6000.39
65_K120_V0.5980.39
30_R137_N0.5980.39
38_L136_L0.5960.39
13_L106_I0.5950.39
19_L260_A0.5950.39
149_T157_I0.5940.38
40_I44_G0.5940.38
221_S390_L0.5940.38
138_I171_N0.5930.38
109_T183_S0.5930.38
81_L94_G0.5910.38
148_T209_A0.5900.38
101_V332_F0.5870.38
139_S172_E0.5860.38
107_F142_E0.5860.38
62_G66_V0.5840.37
143_S153_G0.5840.37
165_I280_I0.5830.37
272_I342_L0.5830.37
312_D318_L0.5820.37
108_V159_A0.5810.37
305_L308_I0.5790.37
403_L406_A0.5790.37
318_L347_T0.5770.37
45_I355_I0.5760.37
70_S100_R0.5750.37
172_E294_L0.5740.37
77_I108_V0.5740.37
129_G168_M0.5730.36
60_A270_V0.5720.36
144_F160_I0.5690.36
41_A45_I0.5690.36
261_G374_G0.5670.36
177_I372_V0.5670.36
187_S369_I0.5660.36
352_T357_S0.5650.36
29_L33_G0.5650.36
276_I289_F0.5640.36
102_L259_A0.5630.36
368_S371_V0.5630.36
162_K311_V0.5620.35
159_A258_I0.5620.35
165_I340_P0.5610.35
29_L152_L0.5590.35
56_V129_G0.5580.35
247_A324_G0.5580.35
326_K365_N0.5570.35
4_M130_S0.5570.35
120_V123_L0.5560.35
265_V399_T0.5560.35
174_F178_C0.5550.35
6_S411_F0.5540.35
116_Y122_G0.5540.35
146_A209_A0.5510.34
136_L179_S0.5510.34
305_L389_Q0.5500.34
52_G197_V0.5500.34
147_V313_W0.5500.34
350_V412_F0.5490.34
341_Y346_G0.5490.34
407_T410_G0.5490.34
14_L29_L0.5470.34
69_Y274_A0.5460.34
298_F328_A0.5460.34
241_P250_S0.5460.34
173_L336_L0.5460.34
177_I186_G0.5450.34
227_S231_F0.5450.34
253_M260_A0.5450.34
131_I314_S0.5450.34
70_S216_F0.5420.34
130_S135_A0.5420.34
188_M371_V0.5420.34
104_A210_I0.5410.34
276_I374_G0.5400.34
19_L219_I0.5390.33
188_M332_F0.5390.33
380_S386_E0.5390.33
325_Q330_N0.5380.33
223_A227_S0.5380.33
262_V271_A0.5370.33
74_S407_T0.5370.33
255_G259_A0.5360.33
297_I320_G0.5360.33
5_R9_G0.5360.33
45_I55_A0.5350.33
35_A39_Q0.5340.33
163_P381_P0.5340.33
336_L339_S0.5330.33
49_F220_L0.5320.33
258_I375_A0.5310.33
181_M369_I0.5300.33
43_G354_A0.5300.33
280_I296_S0.5290.33
42_I45_I0.5280.32
196_G330_N0.5280.32
125_I412_F0.5280.32
74_S203_L0.5270.32
144_F149_T0.5260.32
188_M265_V0.5260.32
4_M224_T0.5250.32
114_L118_I0.5250.32
84_P340_P0.5250.32
37_L41_A0.5230.32
216_F373_V0.5230.32
226_P230_T0.5220.32
147_V179_S0.5220.32
149_T180_G0.5220.32
190_I194_G0.5210.32
6_S282_G0.5200.32
98_A267_M0.5200.32
160_I213_G0.5190.32
184_I314_S0.5190.32
62_G275_L0.5180.32
107_F320_G0.5180.32
18_F25_K0.5180.32
114_L264_T0.5170.32
161_V176_A0.5170.32
250_S384_A0.5170.32
292_A300_Y0.5160.31
97_F188_M0.5160.31
31_T207_L0.5150.31
109_T159_A0.5150.31
371_V375_A0.5140.31
215_L391_G0.5130.31
157_I375_A0.5130.31
247_A252_A0.5130.31
399_T403_L0.5130.31
105_I259_A0.5130.31
210_I223_A0.5120.31
129_G229_V0.5120.31
387_I395_L0.5120.31
183_S193_A0.5120.31
43_G398_A0.5120.31
149_T158_P0.5110.31
178_C401_S0.5110.31
201_Y212_G0.5090.31
74_S204_A0.5090.31
159_A178_C0.5090.31
166_D170_R0.5090.31
139_S335_Y0.5080.31
9_G409_A0.5080.31
325_Q328_A0.5070.31
373_V408_I0.5060.31
113_S246_E0.5050.31
150_I210_I0.5050.31
283_I408_I0.5050.31
245_I366_F0.5050.31
4_M248_A0.5040.30
79_G96_I0.5040.30
408_I411_F0.5030.30
41_A137_N0.5030.30
77_I263_A0.5020.30
23_N321_S0.5010.30
108_V327_L0.5000.30
377_S388_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9591 100 0.113 Contact Map
2cfqA 1 0.863 54.3 0.975 Contact Map
2mofA 1 0.0769 28.3 0.979 Contact Map
4ikvA 1 0.4159 12.1 0.982 Contact Map
4o6yA 2 0.4519 10.9 0.982 Contact Map
4j05A 3 0.3654 6.8 0.984 Contact Map
4oh3A 2 0.4183 5.6 0.985 Contact Map
4f35D 2 0.863 5.3 0.985 Contact Map
4fc4A 3 0.3918 5.3 0.985 Contact Map
4czbA 2 0.3245 3.4 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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