GREMLIN Database
RIHB - Pyrimidine-specific ribonucleoside hydrolase RihB
UniProt: P33022 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12030
Length: 313 (302)
Sequences: 4007 (2889)
Seq/√Len: 166.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_T110_D3.9081.00
106_K136_M3.7091.00
175_R179_T3.2771.00
254_K292_T2.9931.00
135_R176_V2.9831.00
5_K30_D2.9141.00
167_I273_T2.6191.00
67_M132_V2.5821.00
33_G107_Y2.5781.00
113_M137_Q2.4881.00
194_Q292_T2.4541.00
257_E288_K2.3481.00
175_R261_E2.3091.00
36_I47_L2.2781.00
249_N297_W2.2401.00
110_D114_A2.2211.00
134_M141_L2.2191.00
122_V244_I2.1791.00
113_M143_K2.1761.00
8_L124_V2.1411.00
4_R146_E2.1251.00
20_I34_I2.1181.00
113_M139_A2.1151.00
23_A244_I2.0921.00
35_T104_A2.0731.00
5_K32_L2.0291.00
118_D145_R2.0071.00
167_I174_A1.9841.00
109_I137_Q1.9451.00
12_P50_G1.9441.00
51_L63_V1.9431.00
162_S272_R1.9411.00
123_P130_I1.9391.00
255_T290_G1.9231.00
192_T239_H1.8491.00
294_D297_W1.8281.00
123_P149_L1.8051.00
112_L119_I1.7861.00
64_Y100_E1.7431.00
32_L119_I1.7421.00
64_Y107_Y1.7281.00
21_M57_L1.7001.00
73_R270_Y1.6741.00
48_I52_N1.6701.00
7_I35_T1.6651.00
146_E185_V1.6591.00
133_A137_Q1.6491.00
24_A31_L1.6401.00
43_L65_A1.6341.00
238_V241_A1.6241.00
6_I122_V1.6181.00
263_D269_C1.6111.00
9_D129_N1.6081.00
107_Y111_T1.6081.00
109_I140_I1.5911.00
206_E217_S1.5871.00
4_R145_R1.5621.00
26_H305_C1.5541.00
10_C124_V1.5361.00
109_I133_A1.5331.00
120_T148_V1.5311.00
127_L177_V1.5161.00
103_H106_K1.5131.00
123_P127_L1.5091.00
300_G304_E1.4941.00
51_L98_Q1.4931.00
149_L186_M1.4821.00
187_M290_G1.4751.00
149_L167_I1.4701.00
214_E218_D1.4651.00
246_Y253_I1.4511.00
149_L178_F1.4481.00
133_A140_I1.4411.00
137_Q140_I1.4271.00
111_T114_A1.4231.00
252_G297_W1.4021.00
296_D300_G1.3761.00
112_L143_K1.3671.00
44_D65_A1.3611.00
172_E270_Y1.3561.00
112_L133_A1.3551.00
185_V288_K1.3531.00
130_I147_I1.3461.00
43_L47_L1.3361.00
103_H136_M1.3311.00
167_I178_F1.3251.00
5_K115_S1.3241.00
204_R300_G1.3231.00
120_T146_E1.3161.00
22_M301_L1.2981.00
83_G86_G1.2951.00
106_K110_D1.2831.00
8_L31_L1.2801.00
4_R120_T1.2651.00
108_I133_A1.2631.00
263_D267_G1.2611.00
47_L65_A1.2571.00
266_S269_C1.2511.00
48_I94_P1.2501.00
115_S118_D1.2491.00
54_C61_V1.2421.00
245_G298_F1.2381.00
245_G301_L1.2361.00
255_T288_K1.2341.00
127_L149_L1.2341.00
263_D266_S1.2281.00
111_T119_I1.2241.00
204_R303_E1.2091.00
10_C50_G1.2001.00
24_A61_V1.1951.00
73_R172_E1.1911.00
256_Q291_I1.1891.00
178_F186_M1.1871.00
122_V247_L1.1831.00
26_H248_I1.1781.00
55_Q97_R1.1711.00
242_T253_I1.1681.00
242_T293_I1.1671.00
116_D143_K1.1661.00
121_L144_I1.1651.00
185_V255_T1.1401.00
8_L23_A1.1371.00
112_L144_I1.1351.00
105_V136_M1.1331.00
56_K215_L1.1331.00
36_I50_G1.1321.00
201_V299_W1.1271.00
28_A305_C1.1211.00
71_I131_A1.1211.00
7_I33_G1.1191.00
175_R264_V1.1081.00
31_L124_V1.0981.00
69_Q135_R1.0971.00
105_V133_A1.0941.00
258_M289_V1.0821.00
258_M275_C1.0821.00
112_L140_I1.0791.00
196_V235_G1.0761.00
260_V287_T1.0751.00
108_I112_L1.0710.99
185_V246_Y1.0610.99
54_C58_E1.0590.99
108_I140_I1.0580.99
263_D268_P1.0560.99
160_T163_A1.0530.99
148_V246_Y1.0460.99
54_C63_V1.0450.99
209_G214_E1.0440.99
142_P145_R1.0420.99
269_C274_V1.0340.99
42_T45_K1.0320.99
203_A207_R1.0310.99
22_M305_C1.0290.99
32_L111_T1.0270.99
84_E89_G1.0240.99
85_T88_D1.0230.99
195_T293_I1.0210.99
151_G167_I1.0190.99
147_I182_V1.0190.99
72_M172_E1.0190.99
41_Q45_K1.0180.99
82_H86_G1.0170.99
148_V247_L1.0030.99
225_K229_E0.9950.99
8_L20_I0.9950.99
199_P203_A0.9840.99
123_P147_I0.9810.99
24_A58_E0.9790.99
85_T91_V0.9780.99
121_L130_I0.9770.99
122_V243_C0.9760.99
109_I113_M0.9750.99
7_I108_I0.9680.99
154_Y188_G0.9670.99
261_E268_P0.9660.99
178_F184_L0.9640.99
34_I54_C0.9620.99
132_V135_R0.9610.99
24_A54_C0.9570.99
81_I226_T0.9570.99
147_I184_L0.9560.99
146_E183_P0.9550.99
144_I182_V0.9460.99
108_I130_I0.9460.99
58_E61_V0.9450.99
269_C272_R0.9440.99
251_D297_W0.9420.99
18_I302_V0.9400.99
139_A142_P0.9390.99
134_M180_S0.9390.99
47_L99_A0.9360.99
210_G213_G0.9340.99
55_Q95_L0.9330.99
201_V303_E0.9310.99
249_N301_L0.9230.99
246_Y255_T0.9230.99
187_M246_Y0.9220.98
14_H223_T0.9180.98
38_A169_A0.9130.98
198_T201_V0.9130.98
112_L115_S0.9110.98
163_A168_F0.9090.98
17_A53_V0.9050.98
109_I136_M0.9030.98
23_A122_V0.8990.98
179_T261_E0.8970.98
6_I29_I0.8970.98
150_M192_T0.8930.98
35_T108_I0.8930.98
23_A29_I0.8890.98
55_Q96_T0.8850.98
67_M128_S0.8840.98
259_Y283_K0.8840.98
7_I107_Y0.8830.98
126_P169_A0.8830.98
80_N159_F0.8820.98
206_E221_N0.8820.98
5_K118_D0.8820.98
64_Y102_T0.8820.98
243_C247_L0.8800.98
71_I132_V0.8730.98
208_A213_G0.8730.98
44_D68_P0.8720.98
35_T129_N0.8710.98
300_G303_E0.8600.98
149_L184_L0.8570.98
171_P270_Y0.8550.98
183_P288_K0.8550.98
7_I119_I0.8540.98
33_G111_T0.8540.98
262_V273_T0.8500.97
41_Q46_T0.8470.97
195_T298_F0.8400.97
120_T145_R0.8400.97
118_D143_K0.8380.97
165_F169_A0.8310.97
12_P46_T0.8300.97
55_Q59_I0.8290.97
154_Y186_M0.8180.97
259_Y286_N0.8160.97
257_E286_N0.8120.97
245_G252_G0.8110.97
65_A99_A0.8080.97
160_T168_F0.8060.96
297_W301_L0.8020.96
186_M289_V0.7990.96
18_I216_F0.7940.96
209_G213_G0.7920.96
72_M176_V0.7890.96
127_L174_A0.7880.96
228_F234_A0.7880.96
67_M103_H0.7880.96
43_L46_T0.7880.96
260_V273_T0.7880.96
36_I46_T0.7850.96
116_D119_I0.7820.96
244_I247_L0.7790.96
24_A57_L0.7780.96
32_L115_S0.7770.96
189_L239_H0.7680.95
76_I168_F0.7670.95
105_V132_V0.7660.95
78_A81_I0.7660.95
34_I50_G0.7650.95
172_E264_V0.7620.95
178_F273_T0.7550.95
243_C246_Y0.7550.95
148_V243_C0.7540.95
13_G17_A0.7530.95
134_M144_I0.7500.95
164_E189_L0.7500.95
29_I248_I0.7470.95
21_M216_F0.7460.95
150_M240_D0.7450.95
115_S119_I0.7420.94
85_T89_G0.7420.94
112_L137_Q0.7420.94
157_G163_A0.7390.94
14_H88_D0.7390.94
22_M245_G0.7360.94
196_V237_P0.7360.94
47_L51_L0.7340.94
71_I173_A0.7330.94
45_K48_I0.7310.94
172_E266_S0.7310.94
121_L147_I0.7280.94
253_I290_G0.7260.94
127_L167_I0.7260.94
188_G191_L0.7220.94
7_I111_T0.7210.94
97_R100_E0.7150.93
9_D35_T0.7140.93
249_N252_G0.7110.93
57_L212_A0.7100.93
40_N49_N0.7080.93
105_V109_I0.7000.93
187_M243_C0.6990.92
77_V169_A0.6970.92
112_L141_L0.6960.92
295_T299_W0.6940.92
146_E246_Y0.6890.92
51_L99_A0.6850.92
20_I23_A0.6840.92
82_H88_D0.6790.91
16_D240_D0.6780.91
211_P214_E0.6780.91
21_M53_V0.6750.91
146_E288_K0.6740.91
215_L219_I0.6730.91
186_M273_T0.6730.91
31_L34_I0.6700.91
301_L305_C0.6690.91
51_L97_R0.6680.91
35_T107_Y0.6660.91
117_G145_R0.6640.90
71_I176_V0.6630.90
71_I135_R0.6620.90
242_T298_F0.6620.90
191_L293_I0.6620.90
158_N189_L0.6600.90
259_Y285_A0.6570.90
36_I129_N0.6550.90
252_G301_L0.6540.90
37_V125_G0.6510.90
54_C59_I0.6490.89
153_A190_D0.6480.89
153_A156_T0.6470.89
19_A244_I0.6460.89
53_V215_L0.6450.89
154_Y291_I0.6440.89
15_D240_D0.6390.89
148_V187_M0.6370.89
114_A117_G0.6350.88
120_T247_L0.6330.88
106_K109_I0.6320.88
107_Y110_D0.6220.87
141_L144_I0.6220.87
83_G88_D0.6190.87
254_K294_D0.6190.87
134_M182_V0.6180.87
146_E250_P0.6170.87
43_L68_P0.6170.87
140_I143_K0.6150.87
25_K305_C0.6140.87
112_L116_D0.6130.87
187_M255_T0.6130.87
104_A129_N0.6100.86
117_G143_K0.6090.86
301_L304_E0.6090.86
174_A177_V0.6070.86
158_N164_E0.6060.86
85_T90_P0.6050.86
102_T106_K0.6050.86
69_Q74_Q0.6020.86
115_S143_K0.6020.86
52_N56_K0.6010.86
140_I144_I0.6000.85
246_Y290_G0.6000.85
268_P274_V0.5990.85
216_F219_I0.5980.85
258_M291_I0.5970.85
113_M140_I0.5920.85
65_A68_P0.5900.84
176_V179_T0.5900.84
111_T115_S0.5880.84
83_G89_G0.5880.84
124_V149_L0.5860.84
217_S221_N0.5850.84
91_V94_P0.5840.84
159_F168_F0.5840.84
13_G239_H0.5810.84
6_I23_A0.5790.83
200_D203_A0.5760.83
201_V204_R0.5760.83
57_L216_F0.5750.83
150_M239_H0.5750.83
49_N83_G0.5740.83
5_K117_G0.5740.83
141_L181_G0.5730.83
33_G64_Y0.5720.83
206_E214_E0.5690.82
276_D279_G0.5650.82
256_Q277_E0.5650.82
155_G190_D0.5640.82
20_I24_A0.5630.82
226_T230_N0.5610.81
189_L192_T0.5610.81
137_Q143_K0.5590.81
78_A82_H0.5570.81
282_G285_A0.5550.81
42_T77_V0.5540.81
86_G89_G0.5540.81
141_L182_V0.5530.81
38_A165_F0.5530.81
109_I112_L0.5520.80
259_Y281_L0.5510.80
124_V243_C0.5510.80
133_A136_M0.5510.80
72_M135_R0.5500.80
37_V129_N0.5500.80
154_Y275_C0.5480.80
202_I221_N0.5460.80
151_G174_A0.5450.80
130_I144_I0.5440.79
11_D15_D0.5420.79
71_I128_S0.5420.79
102_T114_A0.5390.79
260_V289_V0.5380.79
201_V205_M0.5380.79
26_H301_L0.5380.79
29_I247_L0.5380.79
22_M244_I0.5370.79
18_I220_M0.5370.79
36_I65_A0.5340.78
195_T242_T0.5330.78
49_N86_G0.5320.78
206_E218_D0.5320.78
127_L130_I0.5310.78
75_Q169_A0.5310.78
204_R207_R0.5300.78
154_Y260_V0.5290.78
221_N225_K0.5290.78
205_M213_G0.5280.77
154_Y190_D0.5270.77
103_H132_V0.5270.77
17_A49_N0.5270.77
4_R28_A0.5250.77
134_M140_I0.5240.77
174_A262_V0.5230.77
173_A177_V0.5220.77
80_N89_G0.5220.77
264_V270_Y0.5190.76
128_S170_D0.5190.76
186_M287_T0.5190.76
131_A176_V0.5170.76
148_V185_V0.5170.76
40_N82_H0.5160.76
52_N95_L0.5150.76
297_W300_G0.5150.76
92_F95_L0.5140.76
105_V112_L0.5120.75
8_L12_P0.5110.75
257_E284_P0.5110.75
39_G49_N0.5100.75
216_F306_V0.5100.75
9_D123_P0.5100.75
72_M175_R0.5060.74
102_T107_Y0.5060.74
150_M158_N0.5030.74
193_N239_H0.5030.74
266_S270_Y0.5020.74
161_P281_L0.5020.74
255_T291_I0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q8fA 4 0.984 100 0.041 Contact Map
4wr2A 4 0.9585 100 0.049 Contact Map
2masA 3 0.9904 100 0.063 Contact Map
4kpoA 2 0.9808 100 0.068 Contact Map
4kpnA 2 0.9808 100 0.069 Contact Map
3t8jA 3 0.9776 100 0.076 Contact Map
3fz0A 3 0.9681 100 0.092 Contact Map
3t8iA 3 0.9681 100 0.095 Contact Map
4i71A 2 0.9489 100 0.137 Contact Map
3epwA 2 0.9617 100 0.14 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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