GREMLIN Database
NUPX - Nucleoside permease NupX
UniProt: P33021 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12029
Length: 416 (399)
Sequences: 1657 (930)
Seq/√Len: 46.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_Y278_G5.0231.00
315_D349_D4.5311.00
313_W316_A4.2271.00
277_N295_E3.8351.00
383_R386_E3.8271.00
295_E337_N3.7691.00
23_N26_K3.6781.00
105_I262_V3.6371.00
337_N340_P3.4821.00
175_T214_I3.2831.00
319_A356_I3.2461.00
22_V393_R3.1941.00
170_R389_Q2.9871.00
284_G292_A2.9411.00
161_V168_L2.9241.00
319_A352_T2.8971.00
10_M404_M2.7391.00
12_V308_V2.7241.00
20_L396_A2.7241.00
256_L260_A2.6091.00
77_I267_M2.5861.00
309_M403_L2.5811.00
123_I127_I2.5381.00
392_L396_A2.5281.00
212_G401_S2.4911.00
165_I380_A2.4791.00
114_I244_I2.4771.00
35_A215_L2.4431.00
18_F24_K2.4091.00
22_V221_S2.3621.00
57_E61_F2.3401.00
166_D382_H2.3151.00
325_Q337_N2.2961.00
252_A268_A2.2711.00
17_A219_L2.2491.00
366_F392_L2.1991.00
117_Y241_P2.1221.00
22_V170_R2.0871.00
338_F351_K2.0410.99
66_V111_L2.0400.99
114_I248_A2.0160.99
253_M261_G1.9870.99
118_I244_I1.9710.99
201_Y358_F1.9330.99
72_A75_A1.9120.99
17_A216_F1.9110.99
303_A320_G1.9070.99
309_M407_T1.9060.99
148_T160_I1.8800.99
248_A272_I1.8670.99
7_V11_V1.8620.99
71_D100_R1.8400.99
51_P55_V1.8150.99
209_A405_S1.8010.99
258_I261_G1.7910.99
220_L397_A1.7700.98
170_R386_E1.7580.98
358_F405_S1.7500.98
364_A402_N1.7490.98
142_E218_R1.7390.98
138_I143_S1.7260.98
257_K260_A1.7220.98
327_L399_T1.7160.98
220_L396_A1.7160.98
44_G412_F1.7060.98
131_I135_A1.6960.98
296_S300_Y1.6810.98
169_N223_A1.6640.98
32_V215_L1.6630.98
171_N223_A1.6590.98
45_I49_L1.6220.97
127_I130_G1.6060.97
155_N258_I1.6040.97
5_R307_W1.5950.97
294_L298_L1.5630.97
113_S117_Y1.5590.97
283_V287_F1.5520.97
209_A212_G1.5440.96
20_L220_L1.5430.96
154_Q372_V1.5340.96
8_L307_W1.5200.96
108_V152_L1.5190.96
154_Q368_S1.5080.96
173_L386_E1.5080.96
292_A297_I1.5070.96
33_G37_V1.5060.96
129_G140_K1.4970.96
102_L263_A1.4970.96
307_W313_W1.4860.96
119_G122_G1.4860.96
17_A400_L1.4850.96
93_A96_I1.4480.95
364_A399_T1.4420.95
123_I126_R1.4340.95
271_A367_G1.4150.94
4_M8_L1.4150.94
18_F27_I1.4050.94
23_N224_T1.3960.94
70_S74_S1.3900.94
244_I248_A1.3850.93
64_H68_A1.3840.93
181_M372_V1.3730.93
174_F397_A1.3700.93
261_G265_V1.3680.93
259_A263_A1.3660.93
328_A366_F1.3570.93
55_V58_K1.3530.93
154_Q367_G1.3510.93
275_L279_I1.3500.93
157_I179_S1.3490.93
303_A313_W1.3440.92
193_A199_V1.3420.92
155_N261_G1.3200.92
70_S271_A1.3150.92
354_A413_I1.3120.91
72_A274_A1.3110.91
110_A248_A1.3010.91
256_L264_T1.2950.91
392_L395_L1.2910.91
27_I219_L1.2810.90
169_N225_E1.2680.90
127_I131_I1.2660.90
28_S31_T1.2630.90
65_K68_A1.2590.90
74_S99_F1.2560.90
155_N375_A1.2520.89
15_T19_L1.2480.89
258_I262_V1.2400.89
78_F98_G1.2400.89
300_Y317_N1.2380.89
198_P342_L1.2250.88
246_E384_A1.2250.88
165_I379_V1.2240.88
97_F367_G1.2240.88
65_K69_Y1.2100.88
351_K355_I1.2050.88
169_N172_E1.2000.87
294_L328_A1.1960.87
322_L341_Y1.1900.87
306_A323_I1.1860.87
49_L52_G1.1860.87
175_T179_S1.1830.87
145_V157_I1.1820.86
246_E250_T1.1790.86
81_L96_I1.1690.86
315_D348_L1.1630.86
247_A251_G1.1600.85
314_S318_L1.1450.85
402_N405_S1.1380.84
148_T152_L1.1350.84
279_I282_G1.1330.84
303_A317_N1.1310.84
104_A187_S1.1200.83
110_A252_A1.1140.83
409_A412_F1.1040.82
268_A370_G1.1040.82
38_L135_A1.1020.82
187_S258_I1.0990.82
80_S96_I1.0940.82
158_P180_G1.0930.82
191_G332_F1.0930.82
395_L399_T1.0790.81
292_A296_S1.0750.81
295_E325_Q1.0730.81
45_I51_P1.0700.80
338_F356_I1.0690.80
80_S93_A1.0680.80
284_G293_S1.0570.80
128_L150_I1.0550.79
154_Q371_V1.0550.79
276_I294_L1.0530.79
273_I329_I1.0530.79
14_L32_V1.0500.79
19_L24_K1.0480.79
329_I333_V1.0420.79
61_F64_H1.0420.79
125_I164_F1.0370.78
43_G352_T1.0370.78
342_L353_V1.0330.78
401_S405_S1.0320.78
395_L398_A1.0310.78
42_I212_G1.0290.78
209_A358_F1.0280.78
154_Q327_L1.0250.77
335_Y361_C1.0250.77
366_F395_L1.0220.77
16_I305_L1.0210.77
369_I372_V1.0190.77
16_I379_V1.0190.77
40_V408_I1.0080.76
311_V319_A1.0060.76
145_V179_S1.0050.76
261_G375_A0.9990.76
216_F397_A0.9940.75
313_W320_G0.9940.75
175_T217_A0.9910.75
80_S84_P0.9900.75
341_Y347_T0.9890.75
21_S219_L0.9860.75
330_N367_G0.9810.74
118_I121_M0.9800.74
384_A398_A0.9720.74
376_F387_I0.9710.74
44_G48_W0.9710.74
293_S296_S0.9680.73
62_G65_K0.9660.73
74_S271_A0.9610.73
18_F219_L0.9600.73
160_I262_V0.9580.73
67_M190_I0.9500.72
43_G320_G0.9490.72
59_V62_G0.9470.72
149_T183_S0.9400.71
106_I255_G0.9370.71
5_R8_L0.9360.71
35_A136_L0.9290.70
321_S325_Q0.9270.70
188_T367_G0.9250.70
55_V59_V0.9250.70
40_V412_F0.9230.70
179_S210_I0.9230.70
283_V286_W0.9210.69
14_L219_L0.9190.69
152_L160_I0.9140.69
6_S351_K0.9130.69
132_F136_L0.9120.69
114_I272_I0.9060.68
369_I391_G0.9030.68
83_G96_I0.9010.68
30_R34_A0.9000.68
13_L216_F0.8990.68
138_I214_I0.8970.67
189_M202_L0.8970.67
314_S349_D0.8900.67
284_G291_H0.8900.67
170_R390_L0.8900.67
120_V350_A0.8890.67
13_L404_M0.8890.67
42_I112_V0.8890.67
195_L336_L0.8870.67
195_L369_I0.8850.66
167_R228_Q0.8840.66
326_K332_F0.8830.66
318_L341_Y0.8800.66
369_I395_L0.8800.66
169_N224_T0.8790.66
165_I176_A0.8770.66
280_I292_A0.8760.66
266_V270_V0.8730.65
28_S137_N0.8670.65
125_I184_I0.8670.65
348_L353_V0.8620.64
369_I387_I0.8620.64
295_E340_P0.8620.64
170_R221_S0.8620.64
28_S33_G0.8610.64
206_S209_A0.8590.64
215_L402_N0.8580.64
219_L308_V0.8550.64
16_I396_A0.8550.64
70_S104_A0.8530.64
14_L411_F0.8520.63
146_A214_I0.8460.63
54_W57_E0.8440.63
181_M398_A0.8440.63
309_M355_I0.8360.62
10_M405_S0.8340.62
249_A253_M0.8330.62
120_V301_L0.8270.61
49_L53_R0.8260.61
101_V259_A0.8240.61
76_F97_F0.8230.61
265_V366_F0.8210.61
116_Y163_P0.8180.60
6_S203_L0.8180.60
68_A71_D0.8180.60
37_V308_V0.8170.60
149_T189_M0.8150.60
35_A48_W0.8110.60
41_V44_G0.8100.59
155_N188_T0.8100.59
136_L176_A0.8090.59
112_V152_L0.8080.59
75_A80_S0.8060.59
121_M163_P0.8050.59
189_M193_A0.8040.59
259_A320_G0.7990.58
8_L162_K0.7980.58
34_A136_L0.7960.58
273_I321_S0.7930.58
209_A402_N0.7910.58
59_V203_L0.7890.57
80_S83_G0.7880.57
39_Q212_G0.7880.57
27_I59_V0.7870.57
129_G143_S0.7870.57
299_G321_S0.7810.57
99_F103_P0.7800.57
173_L383_R0.7780.56
129_G132_F0.7750.56
350_A353_V0.7740.56
34_A37_V0.7730.56
355_I393_R0.7730.56
327_L364_A0.7700.56
147_V191_G0.7680.55
318_L348_L0.7680.55
98_G263_A0.7660.55
154_Q259_A0.7600.55
254_T257_K0.7600.55
38_L253_M0.7590.55
185_A188_T0.7590.55
112_V183_S0.7570.54
297_I301_L0.7560.54
365_N368_S0.7550.54
168_L176_A0.7550.54
13_L309_M0.7530.54
112_V121_M0.7530.54
350_A354_A0.7530.54
171_N218_R0.7500.54
358_F409_A0.7460.53
12_V15_T0.7440.53
69_Y275_L0.7440.53
167_R295_E0.7420.53
352_T356_I0.7420.53
8_L12_V0.7370.52
274_A278_G0.7360.52
212_G405_S0.7350.52
43_G341_Y0.7330.52
10_M292_A0.7310.52
53_R57_E0.7300.52
189_M206_S0.7280.51
154_Q249_A0.7270.51
121_M125_I0.7260.51
145_V176_A0.7260.51
28_S136_L0.7230.51
141_I157_I0.7230.51
78_F103_P0.7220.51
184_I188_T0.7210.51
355_I404_M0.7180.50
7_V385_P0.7170.50
358_F402_N0.7160.50
242_K389_Q0.7140.50
216_F370_G0.7130.50
10_M212_G0.7120.50
58_K62_G0.7100.50
171_N210_I0.7100.50
108_V269_F0.7090.50
113_S241_P0.7080.50
371_V374_G0.7070.49
203_L207_L0.7010.49
15_T18_F0.7000.49
84_P220_L0.6990.49
184_I302_L0.6990.49
145_V213_G0.6990.49
36_L408_I0.6980.49
265_V371_V0.6950.48
179_S351_K0.6930.48
202_L218_R0.6910.48
141_I168_L0.6900.48
72_A277_N0.6900.48
71_D75_A0.6880.48
149_T179_S0.6860.47
142_E175_T0.6850.47
95_F100_R0.6840.47
305_L403_L0.6830.47
299_G320_G0.6830.47
18_F22_V0.6810.47
282_G286_W0.6800.47
178_C362_G0.6790.47
147_V150_I0.6720.46
60_A270_V0.6720.46
243_S292_A0.6700.46
317_N320_G0.6700.46
221_S314_S0.6690.46
62_G114_I0.6690.46
164_F398_A0.6680.46
26_K358_F0.6660.45
43_G313_W0.6650.45
132_F395_L0.6630.45
267_M282_G0.6600.45
7_V411_F0.6590.45
399_T402_N0.6590.45
281_G313_W0.6590.45
111_L272_I0.6580.45
177_I186_G0.6580.45
322_L334_A0.6580.45
277_N293_S0.6570.44
165_I340_P0.6560.44
330_N334_A0.6540.44
178_C301_L0.6540.44
112_V323_I0.6540.44
352_T357_S0.6530.44
34_A162_K0.6520.44
45_I296_S0.6500.44
168_L409_A0.6490.44
259_A262_V0.6490.44
141_I144_F0.6470.44
14_L36_L0.6470.44
146_A330_N0.6460.43
35_A147_V0.6460.43
370_G391_G0.6450.43
8_L308_V0.6440.43
385_P389_Q0.6440.43
375_A387_I0.6440.43
330_N365_N0.6400.43
241_P250_T0.6390.43
331_E334_A0.6370.43
364_A368_S0.6370.43
14_L27_I0.6360.42
53_R200_E0.6360.42
40_V44_G0.6360.42
58_K61_F0.6360.42
272_I342_L0.6350.42
14_L215_L0.6350.42
82_V99_F0.6340.42
45_I55_V0.6340.42
165_I280_I0.6310.42
372_V376_F0.6300.42
101_V332_F0.6300.42
82_V95_F0.6290.42
288_G328_A0.6280.42
25_K134_K0.6280.42
350_A412_F0.6270.42
77_I266_V0.6270.42
154_Q320_G0.6260.41
149_T210_I0.6250.41
111_L264_T0.6240.41
170_R383_R0.6240.41
52_G142_E0.6210.41
263_A266_V0.6200.41
370_G402_N0.6200.41
65_K278_G0.6160.41
54_W106_I0.6130.40
119_G265_V0.6100.40
30_R137_N0.6100.40
297_I320_G0.6070.40
109_T183_S0.6070.40
123_I406_A0.6060.40
181_M394_A0.6050.39
148_T209_A0.6050.39
183_S198_P0.6040.39
70_S100_R0.6040.39
54_W58_K0.6020.39
65_K120_V0.6020.39
223_A227_S0.6020.39
311_V356_I0.6020.39
185_A325_Q0.6010.39
355_I399_T0.6000.39
292_A300_Y0.5990.39
187_S369_I0.5990.39
130_G135_A0.5970.39
305_L389_Q0.5970.39
101_V191_G0.5960.39
380_A386_E0.5920.38
138_I171_N0.5910.38
330_N333_V0.5890.38
119_G123_I0.5890.38
102_L259_A0.5890.38
29_L152_L0.5870.38
19_L260_A0.5860.38
149_T157_I0.5840.38
191_G199_V0.5830.37
51_P54_W0.5820.37
403_L406_A0.5820.37
116_Y122_G0.5810.37
19_L219_L0.5810.37
177_I372_V0.5800.37
201_Y405_S0.5790.37
45_I355_I0.5780.37
70_S216_F0.5770.37
107_F142_E0.5760.37
261_G374_G0.5750.37
368_S371_V0.5740.37
139_S172_E0.5740.37
62_G66_V0.5730.36
29_L33_G0.5720.36
121_M209_A0.5710.36
255_G259_A0.5700.36
367_G371_V0.5700.36
281_G293_S0.5690.36
226_S230_S0.5680.36
305_L308_V0.5680.36
191_G196_G0.5650.36
253_M260_A0.5650.36
159_A258_I0.5640.36
64_H366_F0.5630.36
81_L99_F0.5630.36
162_K311_V0.5630.36
129_G229_V0.5600.35
325_Q330_N0.5600.35
201_Y212_G0.5590.35
104_A210_I0.5580.35
84_P340_P0.5580.35
42_I45_I0.5580.35
407_T410_G0.5570.35
221_S390_L0.5570.35
43_G398_A0.5560.35
143_S153_G0.5550.35
144_F149_T0.5550.35
32_V165_I0.5520.35
108_V159_A0.5510.34
52_G197_V0.5510.34
129_G168_L0.5510.34
136_L179_S0.5500.34
43_G354_A0.5490.34
107_F320_G0.5490.34
69_Y274_A0.5480.34
203_L355_I0.5480.34
318_L347_T0.5470.34
149_T180_G0.5460.34
247_A324_G0.5460.34
146_A209_A0.5460.34
131_I314_S0.5450.34
4_M248_A0.5450.34
188_T332_F0.5430.34
114_I118_I0.5430.34
109_T159_A0.5420.34
399_T403_L0.5400.34
315_D352_T0.5390.33
147_V179_S0.5380.33
56_A129_G0.5380.33
81_L94_G0.5380.33
227_S267_M0.5370.33
387_I395_L0.5370.33
326_K365_N0.5360.33
49_L220_L0.5360.33
149_T158_P0.5360.33
74_S204_A0.5360.33
188_T371_V0.5360.33
6_S282_G0.5340.33
43_G402_N0.5330.33
77_I108_V0.5330.33
215_L391_G0.5330.33
317_N321_S0.5320.33
312_D318_L0.5310.33
38_L136_L0.5310.33
311_V352_T0.5310.33
197_V360_L0.5310.33
262_V271_A0.5310.33
120_V123_I0.5300.33
276_I374_G0.5300.33
105_I332_F0.5300.33
165_I279_I0.5290.33
74_S407_T0.5290.33
258_I375_A0.5280.32
172_E294_L0.5260.32
279_I318_L0.5250.32
157_I375_A0.5240.32
265_V399_T0.5240.32
77_I263_A0.5230.32
298_L328_A0.5220.32
14_L379_V0.5220.32
5_R9_G0.5220.32
216_F373_V0.5210.32
114_I264_T0.5200.32
174_F178_C0.5200.32
256_L263_A0.5190.32
113_S246_E0.5190.32
150_I210_I0.5180.32
74_S203_L0.5180.32
280_I296_S0.5180.32
408_I411_F0.5180.32
262_V388_A0.5180.32
154_Q271_A0.5170.32
9_G409_A0.5160.31
253_M375_A0.5150.31
163_P381_P0.5150.31
152_L157_I0.5150.31
184_I314_S0.5130.31
371_V375_A0.5130.31
6_S411_F0.5120.31
341_Y346_G0.5120.31
183_S193_A0.5120.31
31_T207_L0.5120.31
144_F160_I0.5120.31
17_A399_T0.5120.31
108_V327_L0.5110.31
250_T384_A0.5110.31
138_I218_R0.5090.31
23_N321_S0.5090.31
190_I194_A0.5080.31
139_S335_Y0.5070.31
41_V137_N0.5060.31
201_Y354_A0.5060.31
227_S231_F0.5060.31
147_V313_W0.5050.31
54_W301_L0.5040.30
336_L339_S0.5040.30
289_F300_Y0.5040.30
188_T265_V0.5030.30
97_F154_Q0.5020.30
274_A277_N0.5020.30
171_N224_T0.5010.30
4_M130_G0.5010.30
41_V45_I0.5010.30
248_A409_A0.5000.30
82_V100_R0.5000.30
34_A135_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd6A 3 0.9591 100 0.111 Contact Map
2cfqA 1 0.8606 54.5 0.975 Contact Map
2mofA 1 0.0769 32.8 0.978 Contact Map
4o6yA 2 0.4519 20.2 0.98 Contact Map
4ikvA 1 0.4159 11.9 0.982 Contact Map
4j05A 3 0.3654 7.3 0.984 Contact Map
4oh3A 2 0.4231 6.2 0.984 Contact Map
4fc4A 3 0.3918 5.7 0.984 Contact Map
4f35D 2 0.863 5.5 0.984 Contact Map
4u0qB 1 0 3 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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