GREMLIN Database
YEII - Uncharacterized sugar kinase YeiI
UniProt: P33020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12028
Length: 362 (289)
Sequences: 18970 (13945)
Seq/√Len: 820.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_R317_Y3.0421.00
59_Y189_G2.9601.00
61_V188_A2.5911.00
126_L141_R2.5871.00
284_C329_A2.5431.00
111_H135_N2.5161.00
192_L215_F2.4361.00
324_S327_D2.4181.00
277_L283_Y2.3961.00
318_S323_Y2.3321.00
59_Y109_D2.2001.00
123_E141_R2.1711.00
282_V311_F2.1261.00
118_D143_H2.0841.00
352_A356_L2.0561.00
266_H285_S2.0171.00
207_T233_H2.0051.00
351_S354_N2.0001.00
103_L108_R1.9951.00
62_V100_A1.9881.00
105_L132_A1.9341.00
215_F316_V1.9211.00
115_V177_L1.8981.00
323_Y327_D1.8831.00
310_G335_C1.8661.00
241_L277_L1.8561.00
321_E352_A1.8511.00
238_K312_M1.8361.00
102_N313_A1.8171.00
292_F326_R1.7941.00
318_S331_F1.7731.00
235_H271_Q1.7571.00
206_F214_V1.7411.00
115_V142_L1.7381.00
342_S354_N1.7281.00
203_E207_T1.7071.00
190_V213_P1.7001.00
282_V333_V1.6901.00
130_R136_V1.6801.00
213_P235_H1.6791.00
262_V285_S1.6671.00
101_H132_A1.6591.00
236_T272_Q1.6511.00
283_Y293_L1.6491.00
209_A212_I1.6391.00
204_W207_T1.6301.00
60_C103_L1.6241.00
66_I114_S1.6161.00
190_V215_F1.5991.00
314_G335_C1.5981.00
128_E131_R1.5981.00
277_L293_L1.5941.00
326_R330_R1.5881.00
127_E131_R1.5851.00
182_R208_L1.5651.00
203_E229_H1.5601.00
264_A268_Q1.5581.00
126_L130_R1.5401.00
264_A267_Q1.5361.00
307_A340_R1.5341.00
336_A340_R1.5341.00
118_D123_E1.5311.00
315_L328_S1.5281.00
274_F315_L1.5081.00
245_E251_A1.5051.00
272_Q286_E1.4881.00
204_W208_L1.4831.00
259_N291_Q1.4701.00
196_N199_A1.4661.00
190_V316_V1.4601.00
145_Q172_Q1.4601.00
284_C325_F1.4591.00
284_C292_F1.4531.00
257_D260_T1.4311.00
118_D141_R1.4281.00
213_P236_T1.4121.00
59_Y111_H1.4041.00
294_L329_A1.3881.00
92_A125_L1.3791.00
123_E127_E1.3771.00
277_L280_E1.3691.00
175_P204_W1.3671.00
208_L211_E1.3671.00
314_G331_F1.3521.00
126_L139_C1.3471.00
250_Q264_A1.3411.00
303_D344_S1.3391.00
299_H341_A1.3341.00
68_M124_M1.3341.00
103_L317_Y1.3271.00
217_D276_Y1.3221.00
297_P334_A1.3031.00
263_N267_Q1.2841.00
218_T239_P1.2841.00
142_L145_Q1.2771.00
70_I88_I1.2651.00
97_R129_T1.2611.00
317_Y321_E1.2551.00
228_K268_Q1.2511.00
263_N285_S1.2491.00
294_L333_V1.2441.00
244_L275_V1.2441.00
90_C124_M1.2391.00
259_N263_N1.2301.00
193_A214_V1.2211.00
315_L332_A1.2051.00
92_A128_E1.2051.00
128_E132_A1.2031.00
207_T211_E1.1981.00
234_I237_L1.1981.00
122_G147_T1.1911.00
75_D156_R1.1801.00
318_S328_S1.1801.00
103_L110_V1.1791.00
353_D357_S1.1781.00
266_H287_K1.1761.00
301_T340_R1.1591.00
236_T315_L1.1581.00
282_V329_A1.1541.00
109_D135_N1.1531.00
272_Q325_F1.1511.00
310_G349_T1.1491.00
236_T319_F1.1481.00
250_Q260_T1.1411.00
174_T177_L1.1291.00
106_L314_G1.1271.00
104_A134_V1.1261.00
315_L319_F1.1241.00
70_I90_C1.1211.00
338_I342_S1.1021.00
213_P271_Q1.0981.00
124_M127_E1.0981.00
272_Q319_F1.0981.00
123_E126_L1.0871.00
327_D330_R1.0851.00
210_D233_H1.0841.00
108_R320_L1.0841.00
338_I341_A1.0781.00
241_L280_E1.0711.00
272_Q315_L1.0631.00
314_G332_A1.0631.00
210_D235_H1.0631.00
66_I125_L1.0621.00
72_G151_L1.0611.00
191_V209_A1.0611.00
299_H340_R1.0581.00
238_K276_Y1.0541.00
263_N291_Q1.0491.00
315_L325_F1.0451.00
318_S321_E1.0431.00
216_V234_I1.0281.00
244_L261_A1.0271.00
248_W261_A1.0251.00
120_F123_E1.0211.00
127_E130_R1.0211.00
192_L316_V1.0181.00
73_M87_T1.0181.00
103_L313_A1.0181.00
66_I97_R1.0131.00
277_L281_S1.0121.00
188_A212_I1.0071.00
100_A110_V1.0071.00
272_Q284_C1.0051.00
101_H105_L1.0041.00
118_D144_G1.0031.00
179_N204_W0.9961.00
71_R91_S0.9941.00
201_A205_V0.9901.00
191_V212_I0.9881.00
276_Y311_F0.9861.00
111_H184_L0.9831.00
260_T263_N0.9811.00
192_L312_M0.9731.00
70_I121_Y0.9661.00
111_H138_G0.9611.00
136_V139_C0.9581.00
286_E290_E0.9551.00
63_V191_V0.9511.00
182_R211_E0.9431.00
297_P330_R0.9421.00
70_I149_T0.9411.00
111_H188_A0.9401.00
183_D186_R0.9381.00
104_A133_G0.9351.00
62_V96_G0.9341.00
61_V113_L0.9301.00
108_R321_E0.9261.00
102_N310_G0.9251.00
262_V275_V0.9231.00
99_I192_L0.9221.00
317_Y352_A0.9201.00
117_G147_T0.9191.00
328_S332_A0.9181.00
301_T304_S0.9171.00
116_I122_G0.9141.00
80_Q159_Q0.9101.00
67_N148_S0.9081.00
116_I126_L0.9061.00
185_L212_I0.9041.00
300_T341_A0.9011.00
285_S291_Q0.9001.00
66_I112_L0.8971.00
106_L335_C0.8941.00
297_P333_V0.8931.00
116_I141_R0.8901.00
142_L172_Q0.8871.00
319_F328_S0.8861.00
185_L188_A0.8841.00
59_Y187_H0.8821.00
310_G339_S0.8811.00
238_K315_L0.8691.00
239_P244_L0.8661.00
280_E293_L0.8651.00
140_V177_L0.8631.00
333_V336_A0.8621.00
232_A269_G0.8621.00
86_G163_A0.8601.00
193_A206_F0.8591.00
296_A333_V0.8581.00
92_A124_M0.8581.00
73_M89_H0.8531.00
290_E326_R0.8511.00
161_V164_I0.8491.00
126_L136_V0.8491.00
317_Y331_F0.8461.00
330_R334_A0.8441.00
323_Y331_F0.8431.00
193_A202_L0.8411.00
97_R346_N0.8401.00
353_D356_L0.8391.00
241_L245_E0.8321.00
271_Q287_K0.8281.00
281_S296_A0.8281.00
297_P337_A0.8251.00
124_M128_E0.8211.00
260_T264_A0.8201.00
314_G318_S0.8191.00
115_V140_V0.8171.00
161_V165_N0.8161.00
324_S328_S0.8151.00
63_V205_V0.8111.00
179_N182_R0.8071.00
104_A109_D0.8061.00
231_L234_I0.8061.00
99_I312_M0.8051.00
119_D147_T0.8041.00
217_D238_K0.7991.00
175_P200_E0.7981.00
153_I163_A0.7961.00
206_F209_A0.7951.00
126_L140_V0.7931.00
302_V343_G0.7921.00
244_L265_L0.7911.00
195_C199_A0.7891.00
163_A167_T0.7881.00
217_D239_P0.7871.00
191_V205_V0.7871.00
200_E203_E0.7871.00
200_E204_W0.7851.00
195_C216_V0.7821.00
162_L166_D0.7811.00
68_M121_Y0.7791.00
60_C320_L0.7781.00
61_V111_H0.7701.00
229_H232_A0.7681.00
215_F238_K0.7661.00
311_F333_V0.7631.00
336_A339_S0.7621.00
60_C190_V0.7601.00
160_T164_I0.7571.00
76_I82_A0.7561.00
184_L188_A0.7531.00
106_L355_A0.7511.00
331_F352_A0.7501.00
182_R186_R0.7451.00
69_D93_G0.7431.00
294_L326_R0.7411.00
106_L317_Y0.7381.00
125_L147_T0.7381.00
100_A112_L0.7371.00
170_L173_L0.7341.00
106_L331_F0.7341.00
163_A166_D0.7321.00
310_G314_G0.7311.00
301_T341_A0.7301.00
274_F284_C0.7301.00
159_Q165_N0.7291.00
259_N293_L0.7291.00
61_V184_L0.7241.00
138_G184_L0.7241.00
354_N357_S0.7231.00
162_L165_N0.7211.00
266_H286_E0.7211.00
331_F355_A0.7201.00
232_A268_Q0.7181.00
263_N266_H0.7161.00
203_E233_H0.7131.00
190_V320_L0.7131.00
240_T243_E0.7131.00
306_G349_T0.7111.00
310_G336_A0.7071.00
68_M90_C0.7061.00
259_N285_S0.7031.00
286_E325_F0.7031.00
206_F210_D0.7001.00
120_F124_M0.6991.00
215_F236_T0.6991.00
294_L330_R0.6981.00
101_H346_N0.6931.00
152_A162_L0.6931.00
116_I139_C0.6911.00
283_Y291_Q0.6911.00
202_L209_A0.6881.00
153_I161_V0.6821.00
338_I354_N0.6821.00
159_Q162_L0.6821.00
111_H137_S0.6801.00
311_F332_A0.6801.00
73_M156_R0.6791.00
104_A110_V0.6731.00
128_E346_N0.6731.00
89_H343_G0.6721.00
331_F356_L0.6711.00
173_L177_L0.6701.00
76_I79_P0.6691.00
202_L205_V0.6681.00
244_L258_R0.6641.00
202_L206_F0.6611.00
299_H337_A0.6561.00
73_M343_G0.6551.00
334_A338_I0.6541.00
204_W209_A0.6541.00
114_S139_C0.6541.00
215_F312_M0.6531.00
190_V319_F0.6521.00
259_N283_Y0.6521.00
205_V208_L0.6511.00
207_T229_H0.6481.00
237_L273_L0.6461.00
100_A134_V0.6441.00
311_F336_A0.6441.00
258_R277_L0.6381.00
203_E206_F0.6361.00
206_F233_H0.6351.00
228_K232_A0.6351.00
279_D298_A0.6341.00
323_Y328_S0.6331.00
79_P82_A0.6321.00
80_Q155_N0.6271.00
262_V273_L0.6231.00
175_P201_A0.6211.00
242_P246_I0.6181.00
292_F329_A0.6181.00
132_A351_S0.6091.00
286_E292_F0.6041.00
152_A305_F0.6021.00
333_V337_A0.6011.00
189_G212_I0.5971.00
338_I355_A0.5961.00
170_L174_T0.5921.00
137_S184_L0.5911.00
121_Y149_T0.5901.00
103_L316_V0.5891.00
66_I129_T0.5881.00
184_L187_H0.5871.00
190_V236_T0.5831.00
322_G328_S0.5821.00
201_A209_A0.5821.00
258_R261_A0.5821.00
274_F311_F0.5811.00
93_G98_N0.5791.00
311_F329_A0.5781.00
266_H270_V0.5761.00
72_G86_G0.5761.00
120_F127_E0.5761.00
205_V209_A0.5721.00
220_S223_K0.5721.00
145_Q169_L0.5691.00
176_Q179_N0.5691.00
83_S86_G0.5681.00
119_D122_G0.5671.00
192_L195_C0.5641.00
91_S347_N0.5641.00
182_R204_W0.5641.00
97_R112_L0.5641.00
99_I194_D0.5611.00
169_L177_L0.5601.00
273_L285_S0.5601.00
244_L285_S0.5581.00
123_E130_R0.5561.00
101_H134_V0.5561.00
62_V103_L0.5551.00
235_H272_Q0.5551.00
155_N159_Q0.5521.00
73_M154_A0.5511.00
138_G141_R0.5471.00
99_I313_A0.5441.00
201_A204_W0.5421.00
92_A346_N0.5411.00
150_Y164_I0.5381.00
279_D301_T0.5381.00
305_F345_L0.5381.00
60_C108_R0.5371.00
106_L313_A0.5361.00
250_Q257_D0.5351.00
274_F282_V0.5311.00
318_S352_A0.5301.00
160_T165_N0.5301.00
109_D320_L0.5291.00
62_V110_V0.5291.00
161_V167_T0.5281.00
72_G88_I0.5261.00
281_S293_L0.5251.00
262_V266_H0.5241.00
196_N200_E0.5221.00
329_A333_V0.5211.00
337_A341_A0.5201.00
59_Y188_A0.5201.00
164_I167_T0.5191.00
335_C355_A0.5171.00
95_V219_V0.5161.00
175_P179_N0.5161.00
77_R161_V0.5151.00
162_L167_T0.5151.00
270_V273_L0.5121.00
70_I151_L0.5111.00
203_E227_I0.5111.00
129_T134_V0.5111.00
217_D309_D0.5071.00
195_C198_T0.5051.00
221_E224_A0.5021.00
148_S170_L0.5011.00
68_M125_L0.5011.00
286_E291_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fv7A 2 0.8343 100 0.341 Contact Map
3kzhA 2 0.8453 100 0.341 Contact Map
1vm7A 2 0.8204 100 0.341 Contact Map
2rbcA 2 0.8204 100 0.345 Contact Map
2nwhA 2 0.8204 100 0.346 Contact Map
1rkdA 2 0.8343 100 0.352 Contact Map
3ry7A 2 0.8232 100 0.355 Contact Map
4xdaA 2 0.8343 100 0.358 Contact Map
3ljsA 2 0.8066 100 0.372 Contact Map
3iq0A 2 0.8122 100 0.372 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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