GREMLIN Database
SFGH2 - S-formylglutathione hydrolase YeiG
UniProt: P33018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12026
Length: 278 (227)
Sequences: 8474 (6184)
Seq/√Len: 410.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_A165_V3.9891.00
130_Q139_C3.3931.00
20_D27_P3.2721.00
236_A240_R2.8631.00
167_A170_P2.7271.00
128_L132_Q2.6691.00
130_Q135_V2.5031.00
119_D123_D2.4421.00
221_D252_P2.4421.00
168_F268_H2.3161.00
105_N119_D2.2961.00
118_Y158_N2.2741.00
249_R267_D2.2481.00
75_V135_V2.2271.00
238_A242_K2.2241.00
37_P73_G2.1951.00
18_R27_P2.1851.00
233_A250_I2.1421.00
236_A246_M2.1341.00
46_L74_I2.0731.00
43_P75_V2.0261.00
46_L142_S2.0181.00
45_V77_V2.0091.00
118_Y154_M1.9961.00
47_Y139_C1.9961.00
20_D25_N1.9491.00
38_R134_N1.9241.00
218_D264_F1.9071.00
77_V129_V1.8121.00
166_S268_H1.8011.00
38_R43_P1.7881.00
140_A164_S1.7541.00
48_W142_S1.7411.00
32_I77_V1.7051.00
126_P139_C1.6911.00
16_R29_T1.6591.00
19_H120_Y1.6451.00
18_R29_T1.6071.00
67_R71_E1.5891.00
122_R158_N1.5571.00
266_E270_R1.5351.00
47_Y130_Q1.5331.00
66_Q70_A1.5291.00
17_W30_F1.5281.00
120_Y125_L1.5221.00
118_Y157_K1.5151.00
34_L75_V1.5131.00
237_E241_Q1.4971.00
165_V215_T1.4881.00
41_T73_G1.4771.00
47_Y126_P1.4711.00
170_P232_P1.4681.00
234_V237_E1.4501.00
196_L202_A1.4011.00
99_G102_F1.3911.00
233_A237_E1.3881.00
193_N196_L1.3841.00
164_S214_P1.3821.00
237_E240_R1.3791.00
30_F125_L1.3651.00
129_V135_V1.3351.00
21_S124_E1.3241.00
153_I198_W1.3041.00
153_I157_K1.2961.00
152_L172_V1.2841.00
144_H261_I1.2831.00
99_G103_Y1.2741.00
221_D250_I1.2741.00
64_G67_R1.2631.00
123_D127_A1.2621.00
173_N234_V1.2601.00
216_L249_R1.2561.00
141_I151_A1.2491.00
126_P161_K1.2471.00
236_A250_I1.2441.00
151_A165_V1.2441.00
126_P130_Q1.2411.00
15_Q133_F1.2341.00
123_D158_N1.2091.00
236_A248_L1.2061.00
72_L269_L1.2041.00
23_T123_D1.1941.00
23_T124_E1.1931.00
238_A241_Q1.1881.00
48_W59_F1.1811.00
60_T78_M1.1801.00
16_R31_S1.1771.00
49_L150_G1.1631.00
49_L117_M1.1611.00
169_A261_I1.1521.00
199_D202_A1.1451.00
99_G105_N1.1411.00
23_T119_D1.1361.00
55_N58_N1.1281.00
122_R161_K1.1251.00
68_V266_E1.1201.00
232_P248_L1.1181.00
122_R154_M1.1181.00
45_V135_V1.1171.00
72_L270_R1.1061.00
46_L76_L1.1011.00
15_Q34_L1.1001.00
142_S166_S1.0841.00
100_A103_Y1.0731.00
203_L206_A1.0641.00
152_L167_A1.0581.00
139_C161_K1.0561.00
42_P134_N1.0531.00
202_A205_Y1.0521.00
30_F120_Y1.0521.00
68_V71_E1.0501.00
30_F128_L1.0491.00
168_F261_I1.0441.00
158_N161_K1.0391.00
148_G167_A1.0381.00
28_M120_Y1.0301.00
17_W132_Q1.0151.00
21_S24_L1.0041.00
214_P271_F1.0001.00
239_A246_M0.9991.00
57_E61_T0.9961.00
22_S124_E0.9951.00
59_F63_A0.9911.00
43_P134_N0.9881.00
207_S211_D0.9881.00
240_R246_M0.9841.00
48_W78_M0.9831.00
118_Y122_R0.9821.00
226_L233_A0.9761.00
17_W128_L0.9741.00
128_L131_S0.9651.00
120_Y124_E0.9601.00
126_P162_Y0.9561.00
217_I236_A0.9511.00
47_Y77_V0.9511.00
173_N176_S0.9441.00
75_V133_F0.9401.00
69_A76_L0.9381.00
153_I200_S0.9351.00
37_P43_P0.9301.00
122_R162_Y0.9271.00
251_Q264_F0.9181.00
202_A206_A0.9091.00
221_D251_Q0.9061.00
141_I154_M0.9031.00
63_A258_Y0.8981.00
16_R56_D0.8951.00
217_I232_P0.8941.00
29_T80_D0.8851.00
47_Y129_V0.8821.00
45_V139_C0.8821.00
29_T56_D0.8821.00
194_A197_E0.8801.00
149_H153_I0.8801.00
214_P245_P0.8801.00
138_R163_T0.8771.00
151_A167_A0.8751.00
64_G68_V0.8731.00
44_P74_I0.8701.00
42_P136_S0.8681.00
45_V75_V0.8601.00
239_A244_W0.8561.00
47_Y162_Y0.8541.00
31_S56_D0.8521.00
264_F267_D0.8521.00
121_L154_M0.8471.00
65_A76_L0.8441.00
116_R119_D0.8411.00
172_V235_L0.8391.00
126_P129_V0.8391.00
16_R57_E0.8391.00
217_I235_L0.8321.00
102_F105_N0.8231.00
49_L79_P0.8221.00
166_S272_H0.8201.00
267_D270_R0.8131.00
39_D42_P0.8121.00
205_Y241_Q0.8121.00
77_V125_L0.8091.00
247_T271_F0.8081.00
235_L239_A0.8081.00
49_L141_I0.8071.00
145_S256_H0.8011.00
251_Q260_F0.7951.00
60_T63_A0.7941.00
66_Q69_A0.7931.00
155_A213_I0.7901.00
43_P73_G0.7861.00
102_F106_A0.7811.00
122_R127_A0.7811.00
97_G101_G0.7801.00
222_N253_G0.7791.00
205_Y208_N0.7781.00
195_W199_D0.7761.00
204_M207_S0.7681.00
217_I246_M0.7671.00
193_N197_E0.7541.00
98_Q102_F0.7511.00
31_S80_D0.7481.00
34_L43_P0.7451.00
22_S25_N0.7441.00
201_C205_Y0.7441.00
24_L28_M0.7431.00
105_N116_R0.7391.00
17_W133_F0.7351.00
204_M242_K0.7311.00
218_D251_Q0.7291.00
34_L38_R0.7281.00
260_F264_F0.7261.00
104_L153_I0.7251.00
127_A162_Y0.7231.00
221_D253_G0.7201.00
142_S168_F0.7181.00
167_A217_I0.7151.00
65_A69_A0.7151.00
54_C58_N0.7151.00
157_K197_E0.7111.00
52_L100_A0.7041.00
144_H258_Y0.7031.00
127_A161_K0.7031.00
50_S58_N0.7001.00
212_A244_W0.6991.00
139_C163_T0.6981.00
49_L151_A0.6921.00
50_S54_C0.6911.00
142_S265_I0.6901.00
44_P138_R0.6851.00
141_I165_V0.6841.00
149_H200_S0.6841.00
130_Q161_K0.6831.00
79_P121_L0.6761.00
38_R42_P0.6750.99
45_V130_Q0.6750.99
196_L206_A0.6740.99
14_Q60_T0.6730.99
231_Q234_V0.6710.99
122_R126_P0.6700.99
67_R70_A0.6670.99
33_F70_A0.6630.99
152_L170_P0.6610.99
123_D161_K0.6550.99
103_Y106_A0.6540.99
147_G150_G0.6440.99
205_Y238_A0.6420.99
23_T116_R0.6420.99
32_I133_F0.6420.99
58_N258_Y0.6410.99
48_W265_I0.6410.99
33_F36_P0.6400.99
31_S57_E0.6350.99
65_A68_V0.6340.99
68_V72_L0.6340.99
130_Q136_S0.6340.99
97_G100_A0.6330.99
68_V270_R0.6270.99
39_D134_N0.6260.99
152_L215_T0.6250.99
129_V133_F0.6210.99
164_S272_H0.6190.99
164_S271_F0.6180.99
148_G170_P0.6180.99
227_A231_Q0.6150.99
219_Q232_P0.6140.99
215_T239_A0.6110.99
168_F218_D0.6110.99
98_Q186_S0.6100.99
72_L273_A0.6080.99
33_F76_L0.6080.99
144_H170_P0.6060.99
63_A262_A0.6040.99
201_C238_A0.6020.99
265_I269_L0.5990.99
251_Q267_D0.5990.99
208_N211_D0.5970.99
64_G262_A0.5950.99
44_P136_S0.5950.99
220_G253_G0.5940.99
34_L133_F0.5930.99
127_A131_S0.5930.99
251_Q263_S0.5930.99
98_Q103_Y0.5900.99
68_V269_L0.5890.99
64_G69_A0.5890.99
97_G102_F0.5880.99
59_F65_A0.5860.99
100_A105_N0.5820.99
19_H30_F0.5780.98
117_M150_G0.5770.98
218_D260_F0.5760.98
61_T66_Q0.5750.98
102_F146_M0.5740.98
118_Y153_I0.5720.98
57_E60_T0.5690.98
255_D260_F0.5640.98
114_H150_G0.5610.98
38_R75_V0.5610.98
213_I244_W0.5590.98
63_A66_Q0.5580.98
63_A68_V0.5580.98
232_P246_M0.5560.98
247_T267_D0.5550.98
142_S268_H0.5520.98
51_G145_S0.5480.98
204_M239_A0.5460.98
218_D249_R0.5450.98
59_F78_M0.5400.98
45_V76_L0.5370.98
45_V129_V0.5360.97
223_D226_L0.5360.97
118_Y198_W0.5360.97
44_P73_G0.5360.97
58_N61_T0.5350.97
50_S55_N0.5340.97
186_S189_G0.5340.97
101_G104_L0.5320.97
230_L234_V0.5320.97
103_Y150_G0.5300.97
59_F144_H0.5290.97
46_L140_A0.5240.97
58_N144_H0.5240.97
201_C204_M0.5240.97
155_A159_P0.5230.97
168_F264_F0.5230.97
40_H134_N0.5220.97
28_M125_L0.5220.97
24_L124_E0.5200.97
59_F261_I0.5180.97
60_T66_Q0.5170.97
55_N59_F0.5150.97
41_T134_N0.5140.97
68_V265_I0.5140.97
32_I75_V0.5120.97
127_A130_Q0.5120.97
227_A233_A0.5120.97
217_I239_A0.5090.97
100_A106_A0.5070.96
171_I174_P0.5060.96
263_S267_D0.5020.96
14_Q66_Q0.5010.96
233_A236_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ls2A 2 0.9964 100 0.348 Contact Map
3i6yA 1 0.9928 100 0.383 Contact Map
3e4dA 3 0.9892 100 0.394 Contact Map
4folA 2 0.9784 100 0.4 Contact Map
3fcxA 2 0.9964 100 0.42 Contact Map
4b6gA 1 0.9892 100 0.432 Contact Map
4rotA 4 0.8741 100 0.452 Contact Map
4w9rA 2 0.8094 100 0.46 Contact Map
2uz0A 4 0.8489 100 0.461 Contact Map
3gffA 2 0.8633 100 0.476 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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