GREMLIN Database
YEEE - UPF0394 inner membrane protein YeeE
UniProt: P33015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11895
Length: 352 (316)
Sequences: 1178 (863)
Seq/√Len: 48.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_T286_G5.2031.00
78_V324_F5.0751.00
22_G203_T5.0021.00
55_G212_L4.8071.00
119_M290_V4.6981.00
18_V206_L3.9461.00
82_Y331_T3.6701.00
205_V209_L3.0921.00
111_I282_T2.9611.00
48_A308_L2.8951.00
86_L332_A2.8621.00
81_G324_F2.8381.00
13_A264_I2.7881.00
9_L257_G2.4711.00
230_T233_T2.4371.00
34_Y330_W2.4081.00
53_S158_A2.3751.00
20_Q104_E2.3231.00
231_S234_A2.2631.00
49_I322_L2.2301.00
30_F326_I2.2241.00
92_G101_R2.1611.00
18_V22_G2.0631.00
33_M39_N2.0391.00
89_V93_G2.0291.00
86_L335_L2.0161.00
263_F267_K2.0070.99
82_Y328_G1.9560.99
18_V210_I1.9400.99
115_T289_G1.9090.99
17_F21_R1.8980.99
228_G233_T1.8870.99
81_G325_M1.8860.99
51_V208_G1.8660.99
330_W334_W1.8640.99
87_G288_G1.8060.99
274_V283_L1.8050.99
131_L134_T1.8020.99
11_C210_I1.7530.99
267_K272_F1.7510.99
230_T296_A1.7410.99
115_T119_M1.7410.99
327_L331_T1.7400.99
17_F265_A1.7090.98
146_A149_F1.7080.98
123_M297_S1.6950.98
87_G295_G1.6650.98
130_G134_T1.6420.98
10_I14_L1.6390.98
83_I291_L1.6190.98
168_V335_L1.6120.98
267_K270_R1.6020.97
35_I333_S1.5750.97
264_I272_F1.5700.97
131_L135_L1.5530.97
127_H131_L1.5460.97
305_G309_V1.5360.97
307_G322_L1.5280.97
88_I329_V1.5250.97
89_V332_A1.5210.97
264_I331_T1.5120.96
11_C213_L1.5060.96
26_L29_G1.4950.96
154_W158_A1.4880.96
128_A131_L1.4680.96
52_Q312_A1.4600.96
23_R271_E1.4490.95
126_P132_N1.4380.95
157_V161_L1.4370.95
162_V205_V1.4080.95
93_G98_T1.4060.95
115_T290_V1.3970.94
25_C101_R1.3900.94
306_N318_G1.3830.94
311_T319_W1.3760.94
161_L164_T1.3720.94
91_A302_C1.3690.94
77_T317_Q1.3590.94
163_I323_V1.3580.94
58_A62_A1.3560.93
87_G291_L1.3550.93
14_L210_I1.3520.93
236_I240_L1.3500.93
163_I209_L1.3410.93
20_Q271_E1.3330.93
324_F327_L1.3320.93
80_G261_G1.3180.92
21_R269_S1.3110.92
129_S132_N1.3080.92
202_V206_L1.3060.92
114_F118_V1.3030.92
164_T167_V1.3020.92
119_M289_G1.3010.92
31_R89_V1.2960.92
158_A162_V1.2910.92
91_A112_A1.2890.92
12_G16_G1.2820.91
49_I59_L1.2760.91
49_I311_T1.2750.91
169_M172_L1.2590.91
164_T172_L1.2510.90
76_G204_A1.2460.90
37_K172_L1.2390.90
197_R200_P1.2380.90
107_I274_V1.2320.90
151_L155_P1.2210.89
126_P129_S1.2200.89
214_A218_S1.2130.89
278_D281_T1.2120.89
88_I302_C1.2090.89
42_F322_L1.2090.89
229_I258_I1.2000.88
148_T316_W1.1860.88
171_E175_P1.1750.87
77_T320_I1.1680.87
149_F327_L1.1660.87
82_Y327_L1.1600.87
321_G325_M1.1540.86
31_R97_G1.1500.86
252_V256_L1.1460.86
317_Q321_G1.1450.86
29_G95_A1.1430.86
222_G318_G1.1420.86
265_A269_S1.1410.86
302_C305_G1.1380.86
111_I286_G1.1320.85
165_L169_M1.1300.85
101_R106_L1.1220.85
33_M42_F1.1090.84
204_A208_G1.1040.84
24_F98_T1.0940.83
323_V327_L1.0920.83
55_G208_G1.0860.83
20_Q265_A1.0800.82
27_T306_N1.0770.82
50_S54_V1.0730.82
10_I298_I1.0730.82
50_S117_M1.0690.82
327_L335_L1.0660.82
115_T118_V1.0600.81
69_A73_P1.0430.80
122_V268_A1.0350.80
242_A246_K1.0320.79
28_G32_D1.0300.79
239_F242_A1.0280.79
29_G45_L1.0250.79
151_L264_I1.0240.79
131_L206_L1.0200.79
118_V206_L1.0140.78
99_W259_F1.0060.78
70_G73_P1.0030.77
80_G295_G0.9950.77
167_V171_E0.9940.77
294_F315_T0.9850.76
12_G302_C0.9830.76
227_L234_A0.9790.76
103_G262_S0.9780.76
164_T168_V0.9750.75
48_A204_A0.9710.75
26_L96_T0.9550.74
155_P169_M0.9540.74
12_G92_G0.9520.74
58_A205_V0.9500.73
18_V207_I0.9480.73
59_L212_L0.9480.73
285_S306_N0.9480.73
125_S129_S0.9460.73
38_N112_A0.9370.72
163_I174_K0.9370.72
27_T304_I0.9350.72
31_R281_T0.9310.72
143_N316_W0.9250.71
165_L173_K0.9240.71
91_A102_A0.9200.71
123_M298_I0.9190.71
72_F320_I0.9180.71
228_G231_S0.9130.70
25_C255_V0.9120.70
167_V170_K0.9120.70
244_D269_S0.9110.70
94_C302_C0.9110.70
295_G305_G0.9050.70
157_V331_T0.9040.70
310_M318_G0.9020.70
11_C217_L0.8990.69
121_A234_A0.8970.69
211_A308_L0.8950.69
144_S147_E0.8880.68
221_T303_S0.8870.68
284_R335_L0.8840.68
166_W170_K0.8820.68
168_V172_L0.8800.68
5_I11_C0.8800.68
228_G238_Q0.8790.68
76_G142_H0.8760.67
54_V155_P0.8750.67
62_A118_V0.8740.67
101_R108_G0.8730.67
201_F204_A0.8670.66
157_V169_M0.8660.66
48_A309_V0.8650.66
23_R32_D0.8650.66
54_V159_V0.8630.66
115_T278_D0.8610.66
39_N42_F0.8600.66
304_I320_I0.8560.65
84_F293_G0.8560.65
198_W203_T0.8550.65
92_G109_S0.8550.65
214_A221_T0.8540.65
83_I298_I0.8540.65
26_L303_S0.8510.65
221_T226_G0.8470.65
25_C32_D0.8450.64
78_V258_I0.8440.64
236_I239_F0.8400.64
193_L198_W0.8400.64
107_I276_A0.8380.64
295_G301_G0.8380.64
104_E275_R0.8360.64
231_S235_N0.8330.63
219_E224_M0.8310.63
101_R109_S0.8310.63
102_A110_W0.8270.63
160_L171_E0.8260.63
168_V173_K0.8260.63
109_S112_A0.8240.62
20_Q23_R0.8230.62
278_D283_L0.8230.62
265_A270_R0.8170.62
102_A113_L0.8120.61
108_G281_T0.8080.61
117_M121_A0.8050.61
133_Q287_L0.8040.61
148_T172_L0.8030.60
103_G259_F0.7990.60
128_A138_Y0.7960.60
306_N311_T0.7930.60
30_F304_I0.7860.59
87_G292_M0.7860.59
46_L291_L0.7850.59
62_A149_F0.7830.59
119_M122_V0.7830.59
161_L326_I0.7830.59
160_L205_V0.7820.58
303_S307_G0.7810.58
203_T290_V0.7810.58
307_G321_G0.7810.58
24_F45_L0.7780.58
142_H161_L0.7780.58
168_V217_L0.7760.58
77_T321_G0.7750.58
20_Q101_R0.7740.58
170_K174_K0.7740.58
119_M123_M0.7720.57
161_L172_L0.7700.57
20_Q25_C0.7670.57
143_N147_E0.7660.57
30_F34_Y0.7650.57
10_I264_I0.7620.56
207_I298_I0.7620.56
37_K43_Y0.7610.56
118_V204_A0.7600.56
116_Y293_G0.7570.56
263_F272_F0.7570.56
131_L157_V0.7550.56
218_S250_W0.7540.56
209_L213_L0.7530.56
7_S217_L0.7530.56
311_T322_L0.7530.56
27_T96_T0.7500.55
155_P162_V0.7490.55
80_G299_A0.7480.55
310_M313_M0.7460.55
240_L243_G0.7440.55
148_T163_I0.7430.55
21_R265_A0.7420.54
15_L19_M0.7420.54
58_A284_R0.7390.54
120_S204_A0.7350.54
157_V164_T0.7350.54
113_L289_G0.7340.54
32_D101_R0.7340.54
302_C309_V0.7330.54
14_L308_L0.7320.53
168_V174_K0.7280.53
129_S264_I0.7280.53
19_M289_G0.7270.53
120_S251_G0.7260.53
8_G250_W0.7260.53
159_V331_T0.7250.53
299_A302_C0.7200.52
225_F297_S0.7190.52
294_F298_I0.7180.52
288_G295_G0.7160.52
319_W322_L0.7080.51
168_V171_E0.7050.51
208_G215_W0.7040.51
30_F314_M0.7010.50
143_N146_A0.7010.50
39_N43_Y0.7010.50
27_T98_T0.7000.50
97_G101_R0.6970.50
13_A260_V0.6960.50
5_I205_V0.6950.50
76_G300_G0.6930.50
82_Y205_V0.6880.49
157_V160_L0.6870.49
27_T97_G0.6850.49
98_T113_L0.6810.48
90_L288_G0.6800.48
162_V165_L0.6790.48
78_V320_I0.6760.48
38_N310_M0.6750.48
27_T303_S0.6720.47
307_G325_M0.6700.47
33_M49_I0.6690.47
87_G108_G0.6680.47
168_V263_F0.6670.47
95_A306_N0.6670.47
34_Y326_I0.6630.47
97_G293_G0.6620.46
159_V314_M0.6590.46
163_I166_W0.6560.46
78_V174_K0.6560.46
26_L41_M0.6550.46
253_F256_L0.6490.45
159_V166_W0.6470.45
326_I330_W0.6440.45
211_A326_I0.6390.44
145_I316_W0.6380.44
156_L168_V0.6340.44
29_G41_M0.6320.43
255_V309_V0.6310.43
130_G133_Q0.6310.43
147_E320_I0.6300.43
116_Y252_V0.6270.43
92_G97_G0.6260.43
207_I216_P0.6240.43
155_P158_A0.6230.43
228_G258_I0.6230.43
230_T234_A0.6230.43
141_E262_S0.6220.42
12_G23_R0.6210.42
51_V239_F0.6200.42
106_L109_S0.6190.42
37_K332_A0.6180.42
204_A302_C0.6170.42
260_V322_L0.6160.42
215_W218_S0.6160.42
25_C293_G0.6150.42
207_I210_I0.6150.42
194_F291_L0.6130.42
17_F203_T0.6110.41
15_L97_G0.6110.41
229_I233_T0.6100.41
12_G214_A0.6090.41
45_L307_G0.6070.41
152_S161_L0.6060.41
91_A304_I0.6030.41
53_S165_L0.6030.41
96_T306_N0.6020.40
79_I298_I0.6010.40
90_L287_L0.6010.40
160_L289_G0.6000.40
140_T143_N0.6000.40
167_V331_T0.6000.40
115_T282_T0.5980.40
152_S263_F0.5970.40
95_A116_Y0.5930.40
118_V196_K0.5930.40
27_T45_L0.5930.40
104_E262_S0.5880.39
22_G97_G0.5830.39
154_W161_L0.5820.39
114_F117_M0.5800.38
5_I253_F0.5790.38
94_C289_G0.5790.38
141_E144_S0.5780.38
64_L320_I0.5770.38
59_L153_V0.5760.38
222_G305_G0.5740.38
46_L159_V0.5740.38
109_S302_C0.5730.38
159_V268_A0.5720.38
74_W78_V0.5720.38
266_A271_E0.5710.37
92_G121_A0.5690.37
122_V290_V0.5690.37
166_W264_I0.5680.37
150_N156_L0.5680.37
6_L10_I0.5680.37
29_G63_G0.5680.37
153_V157_V0.5670.37
51_V205_V0.5660.37
167_V268_A0.5630.37
37_K272_F0.5630.37
14_L209_L0.5630.37
322_L325_M0.5620.37
172_L176_K0.5620.37
47_I312_A0.5610.37
214_A254_L0.5610.37
29_G307_G0.5590.36
13_A242_A0.5590.36
152_S166_W0.5580.36
12_G257_G0.5580.36
175_P202_V0.5560.36
92_G265_A0.5560.36
286_G290_V0.5550.36
10_I169_M0.5550.36
52_Q308_L0.5540.36
77_T304_I0.5530.36
81_G314_M0.5520.36
21_R111_I0.5520.36
150_N154_W0.5510.36
10_I287_L0.5510.36
331_T334_W0.5500.36
30_F100_Y0.5470.35
152_S160_L0.5470.35
98_T221_T0.5460.35
309_V329_V0.5460.35
26_L88_I0.5450.35
41_M96_T0.5440.35
116_Y255_V0.5440.35
222_G225_F0.5430.35
144_S162_V0.5430.35
170_K323_V0.5420.35
125_S137_H0.5410.35
25_C84_F0.5390.35
264_I267_K0.5370.34
45_L325_M0.5370.34
230_T235_N0.5360.34
8_G218_S0.5350.34
74_W143_N0.5340.34
93_G303_S0.5330.34
222_G297_S0.5290.34
308_L334_W0.5290.34
130_G135_L0.5280.34
19_M26_L0.5270.33
129_S133_Q0.5260.33
6_L131_L0.5250.33
29_G33_M0.5250.33
63_G111_I0.5230.33
38_N314_M0.5220.33
28_G76_G0.5210.33
92_G102_A0.5210.33
306_N333_S0.5200.33
154_W160_L0.5200.33
54_V212_L0.5190.33
166_W326_I0.5190.33
71_A144_S0.5190.33
19_M210_I0.5170.33
79_I202_V0.5170.33
112_A253_F0.5160.32
51_V170_K0.5150.32
57_F296_A0.5150.32
157_V335_L0.5150.32
100_Y296_A0.5150.32
263_F266_A0.5140.32
88_I94_C0.5130.32
122_V127_H0.5090.32
310_M315_T0.5080.32
91_A207_I0.5070.32
164_T198_W0.5050.31
237_L243_G0.5050.31
19_M303_S0.5050.31
24_F302_C0.5050.31
33_M281_T0.5040.31
127_H130_G0.5030.31
95_A98_T0.5020.31
99_W102_A0.5010.31
163_I167_V0.5010.31
149_F164_T0.5000.31
133_Q138_Y0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.8409 60 0.952 Contact Map
2gfpA 2 0.7983 56.5 0.953 Contact Map
4m64A 1 0.8438 54.5 0.953 Contact Map
4xnjA 1 0.429 47.9 0.955 Contact Map
2cfqA 1 0.4233 45.4 0.956 Contact Map
4j05A 3 0.8097 40 0.957 Contact Map
4uvmA 1 0.483 40 0.957 Contact Map
4ikvA 1 0.4602 36.9 0.958 Contact Map
4q65A 1 0.3977 25.1 0.961 Contact Map
1pw4A 1 0.4347 23.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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