GREMLIN Database
DACD - D-alanyl-D-alanine carboxypeptidase DacD
UniProt: P33013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11893
Length: 388 (364)
Sequences: 4218 (3357)
Seq/√Len: 176.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_H182_Y3.7701.00
52_A55_E3.7411.00
118_V137_L3.0371.00
142_A151_M2.9591.00
91_G139_D2.8991.00
87_I115_R2.8871.00
73_V137_L2.8181.00
350_E362_H2.7451.00
41_L278_G2.6741.00
54_N57_Q2.6211.00
229_D253_R2.5471.00
188_S231_L2.5291.00
92_R112_E2.4851.00
161_L187_L2.4811.00
254_L278_G2.4771.00
86_D140_Y2.4621.00
347_R364_P2.4171.00
123_R204_E2.4001.00
155_Y158_K2.3931.00
125_L137_L2.3781.00
227_N249_D2.3771.00
58_Q178_H2.3491.00
75_R155_Y2.3381.00
71_Y190_A2.3261.00
229_D246_S2.2621.00
67_L244_I2.2061.00
117_S120_D2.1721.00
56_H163_D2.1631.00
124_G130_G2.1611.00
248_V251_Q2.1141.00
125_L134_C2.0961.00
342_I367_T2.0801.00
68_M164_T2.0371.00
39_W51_T2.0331.00
145_Q169_V1.9911.00
44_Y255_I1.9781.00
147_Q150_E1.9741.00
304_K369_E1.9621.00
182_Y186_V1.9581.00
286_Q289_H1.9561.00
89_T115_R1.9421.00
83_T86_D1.9371.00
256_A271_A1.9121.00
144_G147_Q1.8661.00
310_G368_L1.8511.00
68_M156_A1.8121.00
58_Q163_D1.8111.00
354_Y359_Q1.8001.00
338_L348_V1.7941.00
188_S244_I1.7461.00
82_I118_V1.7441.00
270_E273_K1.7411.00
247_A279_Q1.7331.00
150_E154_N1.7281.00
159_L190_A1.6901.00
87_I117_S1.6861.00
88_V140_Y1.6841.00
142_A147_Q1.6681.00
92_R96_A1.6481.00
347_R350_E1.6441.00
38_S59_R1.6401.00
41_L254_L1.6331.00
197_E200_H1.6301.00
90_V136_A1.6281.00
93_D139_D1.6221.00
88_V136_A1.6201.00
70_G126_I1.6121.00
38_S181_A1.6121.00
346_Q367_T1.6101.00
64_L244_I1.5941.00
330_K354_Y1.5931.00
91_G94_A1.5841.00
64_L184_L1.5831.00
85_D119_R1.5771.00
161_L186_V1.5621.00
359_Q362_H1.5621.00
190_A193_H1.5431.00
70_G125_L1.5421.00
312_E364_P1.5381.00
43_D252_R1.5361.00
164_T179_S1.5311.00
348_V367_T1.5291.00
82_I140_Y1.5151.00
236_T239_A1.5041.00
296_T306_N1.5041.00
69_T134_C1.5041.00
165_H178_H1.5021.00
154_N158_K1.4931.00
189_R255_I1.4931.00
73_V118_V1.4731.00
127_V204_E1.4701.00
37_G260_G1.4611.00
225_T276_R1.4371.00
352_E362_H1.4341.00
181_A259_M1.4281.00
173_D238_G1.4271.00
119_R123_R1.4251.00
76_A81_R1.4111.00
119_R200_H1.4061.00
167_E176_G1.4021.00
343_S370_S1.3981.00
332_T352_E1.3961.00
206_S213_T1.3941.00
307_I367_T1.3761.00
70_G122_S1.3701.00
343_S346_Q1.3551.00
344_A370_S1.3551.00
61_P179_S1.3521.00
119_R201_M1.3521.00
40_V55_E1.3511.00
352_E359_Q1.3391.00
65_T177_Q1.3311.00
40_V182_Y1.3201.00
90_V110_L1.3191.00
123_R207_L1.3161.00
124_G133_A1.3111.00
84_P122_S1.2971.00
190_A194_G1.2951.00
184_L244_I1.2911.00
167_E174_A1.2851.00
286_Q316_W1.2771.00
228_V245_A1.2651.00
60_N173_D1.2641.00
156_A161_L1.2431.00
208_T213_T1.2411.00
330_K352_E1.2371.00
64_L259_M1.2301.00
245_A271_A1.2291.00
84_P119_R1.2281.00
123_R127_V1.2211.00
151_M154_N1.2211.00
94_A139_D1.2151.00
189_R193_H1.2151.00
60_N238_G1.2091.00
248_V253_R1.2081.00
41_L256_A1.2081.00
199_Y246_S1.2071.00
246_S253_R1.2071.00
332_T350_E1.2031.00
71_Y155_Y1.1961.00
147_Q151_M1.1741.00
78_D197_E1.1741.00
331_Y365_L1.1731.00
73_V125_L1.1651.00
108_M124_G1.1651.00
205_K222_W1.1631.00
38_S54_N1.1521.00
367_T370_S1.1491.00
71_Y194_G1.1371.00
308_D368_L1.1371.00
76_A151_M1.1301.00
283_T321_K1.1281.00
374_G378_S1.1271.00
129_S232_K1.1271.00
55_E182_Y1.1231.00
42_M185_A1.1201.00
40_V49_I1.1171.00
67_L231_L1.1161.00
82_I137_L1.1061.00
155_Y190_A1.0971.00
323_E326_H1.0941.00
103_V135_V1.0901.00
72_V76_A1.0901.00
263_S266_G1.0891.00
239_A242_N1.0891.00
67_L188_S1.0861.00
303_D372_G1.0811.00
77_I198_F1.0781.00
39_W53_G1.0651.00
296_T308_D1.0651.00
261_A270_E1.0631.00
302_G340_A1.0621.00
56_H180_S1.0581.00
289_H314_E1.0561.00
258_V271_A1.0551.00
225_T228_V1.0471.00
47_G189_R1.0431.00
202_Y231_L1.0411.00
286_Q314_E1.0390.99
167_E177_Q1.0380.99
149_V169_V1.0300.99
309_L348_V1.0290.99
247_A275_L1.0280.99
272_R276_R1.0280.99
73_V82_I1.0200.99
149_V153_N1.0150.99
156_A187_L1.0090.99
36_A261_A1.0080.99
90_V116_V1.0060.99
192_I199_Y1.0030.99
312_E366_V0.9970.99
289_H292_K0.9920.99
375_S378_S0.9920.99
134_C169_V0.9910.99
290_R314_E0.9910.99
328_K354_Y0.9900.99
77_I82_I0.9890.99
199_Y253_R0.9850.99
58_Q180_S0.9840.99
249_D279_Q0.9830.99
93_D146_R0.9790.99
228_V275_L0.9760.99
245_A275_L0.9720.99
72_V155_Y0.9640.99
95_W112_E0.9640.99
129_S233_T0.9640.99
13_V16_L0.9560.99
185_A257_V0.9540.99
163_D180_S0.9500.99
85_D117_S0.9460.99
354_Y357_D0.9460.99
72_V141_I0.9370.99
76_A141_I0.9340.99
43_D284_T0.9340.99
249_D276_R0.9280.99
37_G59_R0.9270.99
225_T247_A0.9260.99
307_I371_V0.9230.99
45_T284_T0.9230.99
141_I151_M0.9230.99
61_P259_M0.9210.99
297_E309_L0.9190.99
74_D198_F0.9180.99
288_L311_T0.9170.99
299_I302_G0.9160.99
374_G382_D0.9140.99
244_I257_V0.9090.99
165_H176_G0.9060.99
299_I340_A0.9050.99
277_W282_F0.9020.99
162_K182_Y0.8970.99
308_D369_E0.8960.98
93_D145_Q0.8920.98
373_E379_R0.8810.98
231_L246_S0.8760.98
184_L259_M0.8740.98
135_V145_Q0.8720.98
88_V118_V0.8710.98
73_V141_I0.8660.98
45_T316_W0.8650.98
35_H270_E0.8650.98
200_H203_S0.8650.98
130_G133_A0.8610.98
110_L136_A0.8610.98
284_T318_V0.8590.98
111_K114_D0.8570.98
67_L191_I0.8570.98
40_V52_A0.8560.98
225_T272_R0.8550.98
126_I202_Y0.8490.98
63_S232_K0.8480.98
307_I342_I0.8480.98
179_S184_L0.8450.98
45_T253_R0.8450.98
90_V121_L0.8440.98
43_D318_V0.8410.98
10_S16_L0.8400.98
14_F17_S0.8400.98
77_I84_P0.8350.98
40_V257_V0.8330.98
191_I231_L0.8310.98
75_R194_G0.8290.98
315_F361_A0.8290.98
62_A239_A0.8280.97
68_M152_M0.8260.97
173_D236_T0.8250.97
277_W281_N0.8220.97
33_E53_G0.8220.97
248_V279_Q0.8220.97
153_N165_H0.8190.97
342_I348_V0.8190.97
284_T316_W0.8180.97
346_Q370_S0.8170.97
186_V189_R0.8160.97
154_N157_E0.8140.97
209_W214_Q0.8120.97
285_V324_I0.8100.97
199_Y202_Y0.8070.97
329_A353_L0.8060.97
84_P201_M0.8050.97
42_M189_R0.8040.97
121_L133_A0.8040.97
120_D123_R0.8030.97
227_N276_R0.7990.97
116_V121_L0.7980.97
351_I363_W0.7960.97
198_F202_Y0.7890.97
116_V120_D0.7890.97
40_V185_A0.7890.97
341_P371_V0.7880.97
184_L188_S0.7870.97
67_L126_I0.7830.96
157_E162_K0.7810.96
243_L271_A0.7800.96
256_A275_L0.7780.96
338_L342_I0.7750.96
258_V261_A0.7740.96
206_S215_Q0.7730.96
262_D266_G0.7730.96
82_I88_V0.7720.96
89_T140_Y0.7700.96
315_F363_W0.7690.96
38_S259_M0.7670.96
78_D194_G0.7660.96
75_R79_S0.7660.96
72_V75_R0.7640.96
76_A82_I0.7640.96
207_L214_Q0.7630.96
120_D210_N0.7570.96
50_L282_F0.7560.96
188_S230_G0.7540.96
116_V209_W0.7530.96
214_Q217_R0.7530.96
152_M156_A0.7530.96
106_S130_G0.7510.96
235_H241_F0.7510.96
166_F184_L0.7490.95
156_A166_F0.7490.95
82_I86_D0.7470.95
219_G268_E0.7400.95
153_N166_F0.7400.95
236_T242_N0.7400.95
146_R150_E0.7390.95
156_A159_L0.7380.95
192_I229_D0.7360.95
68_M72_V0.7350.95
103_V107_L0.7340.95
114_D212_I0.7320.95
91_G136_A0.7310.95
302_G371_V0.7300.95
218_N245_A0.7250.95
122_S201_M0.7230.95
326_H356_R0.7220.94
218_N243_L0.7220.94
37_G57_Q0.7210.94
63_S234_G0.7190.94
107_L110_L0.7170.94
84_P87_I0.7160.94
74_D122_S0.7160.94
68_M166_F0.7160.94
256_A274_L0.7140.94
311_T365_L0.7120.94
302_G341_P0.7100.94
123_R201_M0.7080.94
18_S23_E0.7040.94
20_F23_E0.7020.94
68_M161_L0.7020.94
128_D217_R0.7020.94
70_G74_D0.6980.93
48_Q318_V0.6980.93
192_I253_R0.6940.93
376_M380_L0.6900.93
191_I198_F0.6880.93
355_D358_K0.6870.93
159_L187_L0.6830.93
345_H367_T0.6810.93
60_N174_A0.6770.92
63_S129_S0.6740.92
80_H83_T0.6720.92
64_L242_N0.6720.92
108_M128_D0.6710.92
18_S22_A0.6710.92
72_V152_M0.6690.92
252_R284_T0.6680.92
63_S66_K0.6680.92
88_V121_L0.6680.92
225_T275_L0.6670.92
293_K308_D0.6660.92
327_I355_D0.6650.92
108_M116_V0.6630.92
128_D214_Q0.6590.91
70_G202_Y0.6580.91
329_A351_I0.6580.91
151_M155_Y0.6570.91
273_K276_R0.6560.91
252_R282_F0.6550.91
105_S109_F0.6540.91
21_A25_I0.6520.91
104_G107_L0.6520.91
309_L365_L0.6510.91
76_A79_S0.6510.91
202_Y230_G0.6510.91
266_G270_E0.6490.91
320_P323_E0.6470.91
59_R259_M0.6470.91
208_T211_G0.6440.90
68_M187_L0.6430.90
75_R158_K0.6420.90
355_D360_V0.6410.90
227_N247_A0.6360.90
67_L187_L0.6340.90
327_I360_V0.6340.90
245_A256_A0.6330.90
105_S132_D0.6330.90
163_D183_D0.6310.90
42_M255_I0.6290.89
261_A266_G0.6280.89
120_D207_L0.6280.89
126_I198_F0.6250.89
21_A24_N0.6240.89
184_L242_N0.6230.89
202_Y246_S0.6150.88
162_K186_V0.6140.88
121_L137_L0.6140.88
198_F231_L0.6130.88
217_R235_H0.6130.88
52_A182_Y0.6100.88
165_H177_Q0.6100.88
311_T315_F0.6100.88
164_T183_D0.6100.88
32_P277_W0.6090.88
161_L183_D0.6080.88
149_V164_T0.6070.88
18_S21_A0.6060.88
334_D337_E0.6060.88
63_S233_T0.6050.87
378_S381_S0.6030.87
127_V207_L0.6030.87
155_Y159_L0.6020.87
44_Y253_R0.6010.87
81_R151_M0.5990.87
20_F24_N0.5960.87
62_A233_T0.5960.87
12_F16_L0.5940.87
72_V151_M0.5940.87
350_E364_P0.5920.86
228_V247_A0.5910.86
331_Y351_I0.5910.86
62_A65_T0.5910.86
82_I141_I0.5900.86
65_T179_S0.5900.86
34_I39_W0.5890.86
258_V274_L0.5890.86
127_V201_M0.5860.86
285_V319_L0.5850.86
74_D197_E0.5840.86
153_N157_E0.5820.85
42_M186_V0.5820.85
179_S183_D0.5810.85
300_W337_E0.5810.85
19_G22_A0.5810.85
141_I149_V0.5810.85
192_I231_L0.5790.85
275_L278_G0.5790.85
66_K131_N0.5790.85
303_D378_S0.5780.85
106_S233_T0.5770.85
19_G23_E0.5760.85
191_I202_Y0.5750.85
61_P177_Q0.5740.85
340_A371_V0.5720.84
218_N221_L0.5720.84
48_Q358_K0.5710.84
274_L278_G0.5710.84
138_A145_Q0.5690.84
64_L67_L0.5690.84
61_P65_T0.5680.84
243_L256_A0.5670.84
43_D46_T0.5650.84
291_G311_T0.5650.84
243_L258_V0.5640.84
52_A56_H0.5630.83
49_I55_E0.5630.83
72_V164_T0.5610.83
114_D210_N0.5610.83
62_A129_S0.5610.83
124_G209_W0.5610.83
293_K296_T0.5600.83
173_D239_A0.5600.83
25_I28_S0.5550.83
301_Y339_T0.5530.82
233_T267_R0.5520.82
136_A140_Y0.5520.82
12_F15_N0.5510.82
74_D201_M0.5510.82
229_D248_V0.5510.82
378_S382_D0.5490.82
170_H173_D0.5480.82
116_V124_G0.5480.82
75_R78_D0.5480.82
225_T249_D0.5470.82
36_A270_E0.5450.81
288_L351_I0.5450.81
108_M130_G0.5450.81
243_L268_E0.5450.81
225_T279_Q0.5450.81
44_Y189_R0.5450.81
288_L353_L0.5450.81
49_I52_A0.5440.81
235_H264_A0.5430.81
281_N320_P0.5410.81
241_F267_R0.5410.81
107_L132_D0.5410.81
16_L20_F0.5400.81
71_Y159_L0.5400.81
319_L327_I0.5390.81
10_S13_V0.5390.81
224_K272_R0.5380.81
203_S229_D0.5370.81
42_M49_I0.5360.80
58_Q179_S0.5360.80
103_V172_L0.5340.80
196_P199_Y0.5340.80
50_L254_L0.5340.80
11_L15_N0.5320.80
18_S24_N0.5320.80
184_L187_L0.5320.80
145_Q149_V0.5320.80
41_L274_L0.5290.80
93_D135_V0.5280.79
287_I317_M0.5260.79
62_A234_G0.5260.79
119_R197_E0.5250.79
51_T274_L0.5240.79
16_L19_G0.5230.79
90_V114_D0.5230.79
106_S232_K0.5220.79
20_F25_I0.5190.78
328_K357_D0.5190.78
254_L279_Q0.5170.78
74_D202_Y0.5170.78
108_M214_Q0.5160.78
359_Q363_W0.5160.78
199_Y229_D0.5140.78
199_Y203_S0.5120.77
377_F381_S0.5120.77
54_N59_R0.5110.77
42_M47_G0.5100.77
263_S267_R0.5100.77
186_V190_A0.5100.77
71_Y187_L0.5090.77
142_A145_Q0.5080.77
67_L74_D0.5080.77
110_L116_V0.5080.77
148_F152_M0.5070.77
124_G214_Q0.5070.77
34_I270_E0.5060.77
61_P184_L0.5060.77
177_Q242_N0.5050.76
219_G264_A0.5050.76
345_H366_V0.5030.76
287_I353_L0.5020.76
241_F268_E0.5010.76
92_R95_W0.5010.76
205_K215_Q0.5010.76
22_A26_P0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzfA 1 0.9046 100 0.228 Contact Map
4k91A 1 0.884 100 0.246 Contact Map
3itaA 1 0.8969 100 0.247 Contact Map
3a3jA 1 0.8789 100 0.261 Contact Map
1xp4A 3 0.8686 100 0.268 Contact Map
3mfdA 1 0.8222 100 0.279 Contact Map
3hunA 1 0.8222 100 0.365 Contact Map
1tvfA 1 0.8608 100 0.393 Contact Map
4pprA 1 0.7371 100 0.477 Contact Map
4ryeA 1 0.6572 100 0.486 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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