GREMLIN Database
SBMC - DNA gyrase inhibitor
UniProt: P33012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11892
Length: 157 (147)
Sequences: 1157 (863)
Seq/√Len: 71.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_V147_E3.7781.00
12_T86_L3.4651.00
93_Q123_Y2.8881.00
53_D64_R2.7221.00
117_L121_S2.7151.00
10_K91_G2.5251.00
13_V68_V2.4261.00
133_V147_E2.3991.00
124_E153_Q2.3831.00
59_P62_K2.3821.00
16_F29_G2.3731.00
17_H66_D2.3401.00
123_Y152_V2.3001.00
36_W84_V2.0991.00
10_K88_E2.0141.00
15_G87_T1.9991.00
100_R145_D1.9501.00
136_N144_W1.9111.00
21_P60_A1.8551.00
51_Y65_C1.8161.00
49_A65_C1.7961.00
33_L37_V1.7741.00
46_E133_V1.7611.00
48_V133_V1.7561.00
110_W148_M1.7231.00
118_L121_S1.7131.00
137_N140_E1.6531.00
101_V146_I1.6460.99
135_L145_D1.6410.99
66_D87_T1.5770.99
46_E70_T1.5760.99
97_A113_F1.5720.99
90_T128_K1.5560.99
110_W132_E1.5520.99
52_Y87_T1.5220.99
22_W63_L1.4760.99
141_D144_W1.4650.99
13_V89_I1.4520.99
14_A84_V1.4440.99
51_Y132_E1.4040.98
131_F149_Y1.3780.98
98_V145_D1.3750.98
37_V69_V1.3520.98
30_F65_C1.3460.98
49_A67_T1.3440.98
15_G85_I1.3370.98
3_Y117_L1.3280.98
113_F150_V1.3240.98
16_F33_L1.2450.96
8_E131_F1.2430.96
52_Y66_D1.2420.96
99_A109_P1.2410.96
11_R46_E1.2240.96
51_Y63_L1.2200.96
32_Q83_G1.1970.96
126_L153_Q1.1890.95
29_G67_T1.1850.95
14_A71_V1.1740.95
26_V67_T1.1520.95
40_K81_S1.1470.94
49_A134_Y1.1210.94
97_A109_P1.1160.94
19_V62_K1.1070.93
30_F67_T1.0730.92
96_V147_E1.0600.92
6_K149_Y1.0580.92
101_V144_W1.0450.91
100_R143_Y1.0400.91
103_G144_W1.0310.91
30_F63_L1.0240.90
99_A105_D1.0080.90
8_E11_R1.0060.89
92_G126_L0.9910.89
7_Q93_Q0.9850.88
6_K147_E0.9820.88
26_V65_C0.9770.88
102_V146_I0.9720.88
6_K96_V0.9710.88
16_F32_Q0.9540.87
103_G146_I0.9450.86
109_P148_M0.9430.86
96_V149_Y0.9390.86
101_V106_F0.9390.86
30_F51_Y0.9260.85
17_H52_Y0.9250.85
53_D132_E0.9240.85
116_S120_D0.9130.84
95_A117_L0.9130.84
114_F118_L0.9110.84
110_W130_C0.9110.84
138_G144_W0.8990.83
77_L86_L0.8850.82
33_L69_V0.8810.82
53_D62_K0.8740.82
65_C106_F0.8720.81
133_V149_Y0.8570.80
30_F101_V0.8550.80
111_Y115_N0.8510.80
118_L125_M0.8500.80
126_L149_Y0.8490.80
24_Q28_K0.8390.79
26_V30_F0.8310.78
81_S84_V0.8170.77
54_N57_E0.8090.76
13_V87_T0.8090.76
15_G82_E0.8080.76
7_Q91_G0.7850.74
53_D58_T0.7840.74
19_V53_D0.7820.74
103_G134_Y0.7730.73
71_V75_F0.7690.73
119_Q122_A0.7570.71
27_K31_E0.7560.71
31_E35_M0.7390.70
106_F110_W0.7330.69
16_F84_V0.7300.69
33_L67_T0.7270.68
28_K120_D0.7260.68
108_K112_Q0.7250.68
8_E149_Y0.7240.68
8_E94_Y0.7220.68
32_Q62_K0.7170.67
50_V151_A0.7170.67
45_K89_I0.7160.67
17_H21_P0.7150.67
98_V131_F0.7070.66
22_W55_P0.7020.66
10_K90_T0.7010.66
28_K31_E0.6990.65
136_N146_I0.6950.65
3_Y113_F0.6890.64
100_R135_L0.6890.64
15_G66_D0.6870.64
82_E85_I0.6860.64
35_M39_S0.6840.64
53_D110_W0.6800.63
51_Y105_D0.6750.63
114_F125_M0.6750.63
18_L26_V0.6750.63
105_D108_K0.6740.63
19_V64_R0.6720.62
94_Y131_F0.6720.62
135_L149_Y0.6710.62
28_K32_Q0.6690.62
36_W40_K0.6620.61
12_T74_Y0.6580.61
4_E96_V0.6540.60
10_K81_S0.6510.60
13_V48_V0.6500.60
14_A69_V0.6490.60
71_V74_Y0.6460.59
51_Y131_F0.6440.59
63_L67_T0.6410.59
49_A129_P0.6390.58
26_V34_M0.6370.58
11_R89_I0.6340.58
141_D146_I0.6300.57
91_G151_A0.6280.57
94_Y113_F0.6250.57
89_I108_K0.6240.57
106_F146_I0.6210.56
31_E96_V0.6210.56
17_H20_G0.6170.56
127_P153_Q0.6140.55
112_Q116_S0.6130.55
41_N90_T0.6100.55
29_G33_L0.6080.55
3_Y121_S0.6060.54
49_A150_V0.6020.54
8_E151_A0.5970.53
55_P64_R0.5970.53
30_F97_A0.5960.53
77_L82_E0.5930.53
42_I76_T0.5900.53
105_D142_G0.5890.52
12_T124_E0.5880.52
18_L29_G0.5860.52
94_Y128_K0.5840.52
50_V68_V0.5790.51
14_A36_W0.5780.51
106_F124_E0.5760.51
101_V110_W0.5750.51
32_Q121_S0.5750.51
66_D91_G0.5740.51
15_G68_V0.5720.50
15_G67_T0.5700.50
38_D43_V0.5700.50
37_V43_V0.5640.49
12_T72_P0.5640.49
137_N141_D0.5610.49
118_L150_V0.5600.49
12_T88_E0.5600.49
147_E151_A0.5590.49
52_Y58_T0.5590.49
73_G91_G0.5580.49
103_G106_F0.5560.48
65_C132_E0.5490.47
34_M50_V0.5470.47
108_K115_N0.5460.47
9_E12_T0.5460.47
90_T94_Y0.5440.47
12_T71_V0.5430.47
71_V77_L0.5420.47
106_F144_W0.5410.47
75_F89_I0.5400.46
72_P91_G0.5400.46
83_G152_V0.5390.46
76_T82_E0.5340.46
71_V86_L0.5330.46
3_Y97_A0.5290.45
48_V68_V0.5230.44
103_G142_G0.5170.44
64_R132_E0.5150.43
54_N58_T0.5080.43
54_N112_Q0.5050.42
5_I114_F0.5040.42
14_A34_M0.5030.42
60_A107_A0.5010.42
4_E43_V0.5000.42
95_A121_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jyhA 1 0.9873 100 0.303 Contact Map
3b49A 1 0.9682 100 0.369 Contact Map
3lurA 1 0.9299 100 0.421 Contact Map
3gk6A 1 0.879 100 0.437 Contact Map
3e0hA 1 0.9299 99.9 0.455 Contact Map
1r8eA 2 0.949 99.9 0.463 Contact Map
1d5yA 1 0.949 99.9 0.468 Contact Map
4b0yA 1 0.9299 98.7 0.774 Contact Map
2govA 1 0.949 97.4 0.836 Contact Map
3r8jA 1 0.9554 97.1 0.845 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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