YEEA - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YEEA - Inner membrane protein YeeA

UniProt:	P33011	Sequences: MRADKSLSPFEIRVYRHYRIVHGTRVALAFLLTFLIIRLFTIPESTWPLVTMVVIMGPISFWGNVVPRAFERIGGTVLGSILGLIALQLELISLPLMLVWCAAAMFLCGWLALGKKPYQGLLIGVTLAIVVGSPTGEIDTALWRSGDVILGSLLAMLFTGIWPQRAFIHWRIQLAKSLTEYNRVYQSAFSPNLLERPRLESHLQKLLTDAVKMRGLIAPASKETRIPKSIYEGIQTINRNLVCMLELQINAYWATRPSHFVLLNAQKLRDTQHMMQQILLSLVHALYEGNPQPVFANTEKLNDAVEELRQLLNNHHDLKVVETPIYGYVWLNMETAHQLELLSNLICRALRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11891
Length:	352 (293)
Sequences:	5877 (4701)
Seq/√Len:	274.6

ECOLI - YEEA YCCS YHFK YDHK MDTO AAEB
BACSU - YGAE YVAC YQJA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_T	154_L	2.817	1.00
118_Y	126_T	2.615	1.00
75_G	79_G	2.579	1.00
21_V	162_W	2.557	1.00
29_A	158_F	2.474	1.00
44_E	47_W	2.469	1.00
29_A	52_M	2.466	1.00
122_L	125_V	2.379	1.00
304_A	307_E	2.236	1.00
300_K	303_D	2.165	1.00
120_G	126_T	2.120	1.00
126_T	130_V	2.113	1.00
122_L	131_V	2.110	1.00
72_R	144_R	2.068	1.00
124_G	128_A	2.064	1.00
30_F	53_V	2.046	1.00
25_R	159_T	2.046	1.00
33_T	52_M	1.983	1.00
298_T	302_N	1.965	1.00
51_T	55_I	1.946	1.00
32_L	154_L	1.928	1.00
121_L	125_V	1.920	1.00
302_N	306_E	1.885	1.00
303_D	306_E	1.875	1.00
186_Q	280_L	1.867	1.00
117_P	121_L	1.823	1.00
182_N	276_Q	1.802	1.00
297_N	300_K	1.798	1.00
36_I	40_F	1.763	1.00
47_W	76_T	1.763	1.00
99_V	103_A	1.759	1.00
142_L	146_G	1.722	1.00
121_L	124_G	1.708	1.00
305_V	308_L	1.699	1.00
95_P	99_V	1.699	1.00
21_V	25_R	1.689	1.00
300_K	304_A	1.689	1.00
275_M	279_L	1.688	1.00
117_P	130_V	1.684	1.00
301_L	305_V	1.678	1.00
123_I	126_T	1.676	1.00
72_R	75_G	1.660	1.00
157_L	160_G	1.660	1.00
61_F	64_N	1.653	1.00
76_T	144_R	1.632	1.00
36_I	154_L	1.595	1.00
297_N	304_A	1.590	1.00
198_R	202_H	1.584	1.00
305_V	309_R	1.570	1.00
238_N	242_V	1.554	1.00
32_L	158_F	1.541	1.00
180_E	205_K	1.529	1.00
125_V	128_A	1.527	1.00
124_G	130_V	1.526	1.00
149_I	153_L	1.520	1.00
34_F	49_L	1.509	1.00
122_L	129_I	1.500	1.00
301_L	304_A	1.496	1.00
124_G	131_V	1.493	1.00
123_I	131_V	1.486	1.00
23_G	27_A	1.484	1.00
214_R	218_A	1.456	1.00
303_D	307_E	1.450	1.00
29_A	154_L	1.443	1.00
48_P	51_T	1.435	1.00
120_G	124_G	1.433	1.00
203_L	207_L	1.431	1.00
266_Q	270_D	1.413	1.00
105_M	109_G	1.381	1.00
25_R	158_F	1.380	1.00
76_T	148_V	1.378	1.00
117_P	122_L	1.377	1.00
214_R	239_R	1.374	1.00
124_G	127_L	1.371	1.00
47_W	51_T	1.370	1.00
159_T	164_Q	1.369	1.00
106_F	110_W	1.366	1.00
123_I	130_V	1.364	1.00
175_A	182_N	1.357	1.00
284_H	288_E	1.354	1.00
179_T	287_Y	1.351	1.00
51_T	72_R	1.350	1.00
68_R	72_R	1.345	1.00
277_Q	281_S	1.340	1.00
182_N	283_V	1.338	1.00
53_V	58_P	1.330	1.00
180_E	209_D	1.322	1.00
265_A	269_R	1.320	1.00
120_G	125_V	1.314	1.00
238_N	241_L	1.300	1.00
273_H	277_Q	1.300	1.00
139_D	143_W	1.300	1.00
251_A	254_A	1.295	1.00
104_A	108_C	1.284	1.00
243_C	246_E	1.278	1.00
296_A	301_L	1.276	1.00
270_D	274_M	1.270	1.00
143_W	146_G	1.264	1.00
280_L	283_V	1.261	1.00
117_P	125_V	1.251	1.00
166_A	219_P	1.251	1.00
33_T	48_P	1.242	1.00
300_K	306_E	1.236	1.00
264_N	267_K	1.235	1.00
210_A	213_M	1.229	1.00
78_L	81_I	1.218	1.00
122_L	127_L	1.215	1.00
47_W	144_R	1.211	1.00
243_C	247_L	1.211	1.00
117_P	120_G	1.203	1.00
299_E	307_E	1.197	1.00
122_L	126_T	1.193	1.00
280_L	284_H	1.192	1.00
50_V	53_V	1.191	1.00
275_M	288_E	1.191	1.00
295_F	298_T	1.188	1.00
232_E	236_T	1.183	1.00
297_N	301_L	1.181	1.00
271_T	275_M	1.180	1.00
295_F	299_E	1.178	1.00
23_G	47_W	1.178	1.00
189_F	192_N	1.178	1.00
123_I	129_I	1.175	1.00
47_W	72_R	1.170	1.00
56_M	155_A	1.170	1.00
206_L	209_D	1.162	1.00
186_Q	276_Q	1.161	1.00
298_T	308_L	1.156	1.00
182_N	280_L	1.154	1.00
289_G	292_Q	1.149	1.00
51_T	148_V	1.141	1.00
119_Q	130_V	1.138	1.00
30_F	34_F	1.136	1.00
25_R	161_I	1.134	1.00
297_N	302_N	1.129	1.00
28_L	158_F	1.125	1.00
141_A	144_R	1.113	1.00
53_V	57_G	1.105	1.00
27_A	31_L	1.103	1.00
275_M	278_I	1.101	1.00
300_K	308_L	1.100	1.00
259_H	263_L	1.098	1.00
51_T	58_P	1.097	1.00
210_A	214_R	1.096	1.00
45_S	50_V	1.094	1.00
297_N	307_E	1.083	1.00
144_R	147_D	1.081	1.00
141_A	145_S	1.079	1.00
120_G	123_I	1.066	1.00
238_N	247_L	1.064	1.00
276_Q	280_L	1.062	1.00
79_G	144_R	1.058	1.00
46_T	49_L	1.057	1.00
118_Y	121_L	1.048	1.00
207_L	210_A	1.048	1.00
81_I	85_I	1.047	1.00
118_Y	125_V	1.046	1.00
122_L	128_A	1.037	1.00
299_E	303_D	1.033	1.00
242_V	246_E	1.024	1.00
125_V	130_V	1.020	1.00
72_R	76_T	1.019	1.00
119_Q	124_G	1.018	1.00
235_Q	244_M	1.018	1.00
213_M	217_I	1.014	1.00
297_N	305_V	1.007	1.00
52_M	55_I	1.007	1.00
218_A	221_S	1.005	1.00
202_H	205_K	1.003	1.00
47_W	50_V	1.003	1.00
120_G	130_V	1.000	1.00
49_L	52_M	0.999	1.00
122_L	130_V	0.995	1.00
299_E	302_N	0.993	1.00
66_V	69_A	0.988	1.00
226_I	231_Y	0.986	1.00
93_S	96_L	0.986	1.00
271_T	278_I	0.984	1.00
274_M	277_Q	0.981	1.00
123_I	127_L	0.980	1.00
220_A	223_E	0.976	1.00
297_N	309_R	0.974	1.00
295_F	309_R	0.973	1.00
199_L	203_L	0.973	1.00
302_N	305_V	0.972	1.00
126_T	129_I	0.970	1.00
240_N	244_M	0.969	1.00
37_I	45_S	0.968	1.00
35_L	39_L	0.967	1.00
298_T	307_E	0.963	1.00
119_Q	122_L	0.962	1.00
75_G	144_R	0.958	1.00
55_I	58_P	0.954	1.00
158_F	161_I	0.954	1.00
177_S	206_L	0.953	1.00
301_L	309_R	0.952	1.00
117_P	124_G	0.950	1.00
220_A	224_T	0.948	1.00
121_L	127_L	0.948	1.00
268_L	271_T	0.948	1.00
144_R	151_G	0.947	1.00
252_Y	258_S	0.938	1.00
118_Y	129_I	0.935	1.00
166_A	220_A	0.931	1.00
51_T	54_V	0.929	1.00
244_M	248_Q	0.928	1.00
83_G	87_L	0.927	1.00
239_R	243_C	0.923	1.00
241_L	246_E	0.919	1.00
117_P	131_V	0.917	1.00
52_M	58_P	0.917	1.00
183_R	187_S	0.912	1.00
298_T	303_D	0.910	1.00
241_L	244_M	0.910	1.00
219_P	223_E	0.909	1.00
77_V	81_I	0.908	1.00
88_Q	91_L	0.908	1.00
146_G	150_L	0.898	1.00
274_M	279_L	0.898	1.00
119_Q	131_V	0.898	1.00
128_A	131_V	0.895	1.00
105_M	110_W	0.894	1.00
29_A	33_T	0.894	1.00
151_G	155_A	0.892	1.00
84_L	88_Q	0.890	1.00
50_V	55_I	0.889	1.00
180_E	183_R	0.887	1.00
208_T	212_K	0.886	1.00
226_I	235_Q	0.881	1.00
273_H	276_Q	0.881	1.00
72_R	148_V	0.876	1.00
120_G	131_V	0.874	1.00
183_R	186_Q	0.858	1.00
269_R	277_Q	0.857	1.00
64_N	72_R	0.854	1.00
301_L	307_E	0.853	1.00
73_I	152_S	0.851	1.00
277_Q	287_Y	0.848	1.00
54_V	58_P	0.843	1.00
120_G	129_I	0.840	1.00
227_P	231_Y	0.839	1.00
149_I	152_S	0.833	1.00
144_R	148_V	0.829	0.99
296_A	302_N	0.827	0.99
20_I	23_G	0.823	0.99
267_K	271_T	0.820	0.99
298_T	306_E	0.820	0.99
306_E	309_R	0.819	0.99
69_A	72_R	0.819	0.99
103_A	107_L	0.817	0.99
260_F	263_L	0.817	0.99
283_V	306_E	0.809	0.99
282_L	286_L	0.805	0.99
48_P	150_L	0.803	0.99
55_I	69_A	0.801	0.99
281_S	290_N	0.798	0.99
210_A	218_A	0.797	0.99
119_Q	126_T	0.797	0.99
166_A	216_L	0.796	0.99
217_I	231_Y	0.790	0.99
296_A	300_K	0.788	0.99
243_C	250_N	0.787	0.99
46_T	50_V	0.786	0.99
82_L	104_A	0.786	0.99
200_E	204_Q	0.786	0.99
298_T	301_L	0.780	0.99
121_L	130_V	0.779	0.99
67_P	71_E	0.772	0.99
269_R	273_H	0.766	0.99
218_A	222_K	0.764	0.99
274_M	280_L	0.763	0.99
235_Q	246_E	0.762	0.99
17_H	20_I	0.761	0.99
211_V	214_R	0.759	0.99
68_R	144_R	0.757	0.99
267_K	270_D	0.756	0.99
252_Y	255_T	0.755	0.99
117_P	126_T	0.753	0.99
257_P	260_F	0.753	0.99
45_S	48_P	0.751	0.99
45_S	52_M	0.750	0.99
154_L	158_F	0.749	0.99
217_I	222_K	0.747	0.99
297_N	308_L	0.746	0.99
79_G	83_G	0.746	0.99
207_L	214_R	0.742	0.99
213_M	223_E	0.740	0.99
299_E	304_A	0.740	0.99
233_G	237_I	0.736	0.99
119_Q	123_I	0.733	0.99
296_A	304_A	0.732	0.99
302_N	307_E	0.732	0.99
198_R	201_S	0.731	0.99
211_V	215_G	0.729	0.99
206_L	222_K	0.726	0.99
73_I	149_I	0.723	0.99
62_W	163_P	0.722	0.99
248_Q	252_Y	0.722	0.99
276_Q	285_A	0.721	0.99
104_A	127_L	0.718	0.99
247_L	255_T	0.717	0.99
34_F	38_R	0.717	0.99
165_R	168_I	0.715	0.99
296_A	305_V	0.710	0.98
295_F	304_A	0.709	0.98
172_I	176_K	0.706	0.98
70_F	74_G	0.705	0.98
85_I	89_L	0.704	0.98
234_I	237_I	0.703	0.98
298_T	309_R	0.703	0.98
121_L	128_A	0.700	0.98
188_A	245_L	0.699	0.98
62_W	65_V	0.695	0.98
264_N	268_L	0.695	0.98
118_Y	124_G	0.694	0.98
205_K	209_D	0.692	0.98
274_M	286_L	0.687	0.98
78_L	123_I	0.685	0.98
290_N	293_P	0.685	0.98
130_V	141_A	0.683	0.98
187_S	202_H	0.682	0.98
200_E	203_L	0.680	0.98
283_V	287_Y	0.675	0.98
47_W	79_G	0.675	0.98
301_L	308_L	0.673	0.98
48_P	147_D	0.672	0.98
208_T	218_A	0.671	0.98
226_I	234_I	0.671	0.98
190_S	195_E	0.669	0.98
130_V	137_E	0.669	0.98
236_T	239_R	0.667	0.98
142_L	145_S	0.664	0.98
86_A	90_E	0.663	0.98
72_R	151_G	0.662	0.98
57_G	61_F	0.661	0.98
126_T	148_V	0.659	0.97
235_Q	240_N	0.656	0.97
36_I	150_L	0.656	0.97
179_T	283_V	0.656	0.97
69_A	156_M	0.648	0.97
69_A	152_S	0.645	0.97
290_N	294_V	0.643	0.97
259_H	262_L	0.641	0.97
179_T	280_L	0.640	0.97
19_R	26_V	0.640	0.97
120_G	128_A	0.640	0.97
89_L	92_I	0.639	0.97
255_T	258_S	0.634	0.97
299_E	306_E	0.629	0.97
64_N	68_R	0.628	0.97
278_I	288_E	0.623	0.96
177_S	209_D	0.623	0.96
101_C	115_K	0.622	0.96
253_W	258_S	0.620	0.96
51_T	63_G	0.618	0.96
102_A	109_G	0.616	0.96
119_Q	129_I	0.616	0.96
127_L	131_V	0.615	0.96
48_P	52_M	0.613	0.96
75_G	81_I	0.612	0.96
108_C	113_L	0.610	0.96
283_V	286_L	0.606	0.96
49_L	58_P	0.603	0.96
265_A	277_Q	0.601	0.96
90_E	94_L	0.601	0.96
214_R	221_S	0.600	0.96
86_A	100_W	0.600	0.96
63_G	68_R	0.598	0.96
228_K	231_Y	0.597	0.96
68_R	79_G	0.597	0.96
26_V	51_T	0.596	0.95
202_H	206_L	0.596	0.95
287_Y	290_N	0.593	0.95
225_R	231_Y	0.593	0.95
276_Q	281_S	0.593	0.95
225_R	239_R	0.593	0.95
299_E	305_V	0.592	0.95
127_L	130_V	0.592	0.95
175_A	287_Y	0.592	0.95
232_E	235_Q	0.590	0.95
97_M	105_M	0.588	0.95
108_C	127_L	0.587	0.95
30_F	134_P	0.581	0.95
206_L	224_T	0.578	0.95
62_W	159_T	0.578	0.95
61_F	65_V	0.577	0.95
109_G	112_A	0.576	0.95
304_A	309_R	0.575	0.95
197_P	201_S	0.575	0.95
80_S	145_S	0.575	0.95
26_V	30_F	0.573	0.94
120_G	127_L	0.573	0.94
281_S	285_A	0.568	0.94
182_N	186_Q	0.567	0.94
210_A	221_S	0.566	0.94
277_Q	280_L	0.564	0.94
225_R	228_K	0.561	0.94
302_N	309_R	0.559	0.94
296_A	307_E	0.553	0.93
46_T	147_D	0.553	0.93
244_M	249_I	0.550	0.93
25_R	163_P	0.549	0.93
54_V	57_G	0.547	0.93
65_V	148_V	0.546	0.93
284_H	291_P	0.545	0.93
92_I	96_L	0.544	0.93
68_R	118_Y	0.542	0.93
300_K	307_E	0.541	0.93
253_W	256_R	0.540	0.93
304_A	308_L	0.540	0.93
303_D	309_R	0.539	0.92
165_R	224_T	0.537	0.92
134_P	138_I	0.535	0.92
200_E	209_D	0.534	0.92
276_Q	283_V	0.532	0.92
117_P	127_L	0.531	0.92
217_I	220_A	0.530	0.92
214_R	217_I	0.530	0.92
268_L	272_Q	0.527	0.92
111_L	120_G	0.525	0.91
46_T	53_V	0.525	0.91
227_P	230_I	0.524	0.91
77_V	145_S	0.522	0.91
121_L	126_T	0.522	0.91
302_N	308_L	0.520	0.91
246_E	249_I	0.517	0.91
299_E	309_R	0.517	0.91
197_P	205_K	0.515	0.91
298_T	305_V	0.514	0.91
196_R	200_E	0.514	0.91
240_N	247_L	0.514	0.91
140_T	144_R	0.514	0.91
104_A	111_L	0.511	0.90
256_R	263_L	0.509	0.90
134_P	137_E	0.509	0.90
94_L	98_L	0.508	0.90
51_T	56_M	0.507	0.90
40_F	43_P	0.502	0.90
101_C	109_G	0.500	0.89
145_S	148_V	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2oltA	5	0.5426	81.6	0.907	Contact Map
4q4gX	1	0	55	0.923	Contact Map
1t72A	5	0.5568	52.5	0.924	Contact Map
4jkvA	2	0.392	43.1	0.928	Contact Map
3l39A	3	0.5312	33	0.933	Contact Map
4cgkA	3	0.483	32.1	0.933	Contact Map
1sumB	2	0.5227	29.1	0.935	Contact Map
2i0mA	2	0.5085	27.3	0.935	Contact Map
2d1lA	2	0.392	26.3	0.936	Contact Map
4q25A	2	0.5455	25.9	0.936	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.