GREMLIN Database
YEEA - Inner membrane protein YeeA
UniProt: P33011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11891
Length: 352 (293)
Sequences: 5877 (4701)
Seq/√Len: 274.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T154_L2.8171.00
118_Y126_T2.6151.00
75_G79_G2.5791.00
21_V162_W2.5571.00
29_A158_F2.4741.00
44_E47_W2.4691.00
29_A52_M2.4661.00
122_L125_V2.3791.00
304_A307_E2.2361.00
300_K303_D2.1651.00
120_G126_T2.1201.00
126_T130_V2.1131.00
122_L131_V2.1101.00
72_R144_R2.0681.00
124_G128_A2.0641.00
30_F53_V2.0461.00
25_R159_T2.0461.00
33_T52_M1.9831.00
298_T302_N1.9651.00
51_T55_I1.9461.00
32_L154_L1.9281.00
121_L125_V1.9201.00
302_N306_E1.8851.00
303_D306_E1.8751.00
186_Q280_L1.8671.00
117_P121_L1.8231.00
182_N276_Q1.8021.00
297_N300_K1.7981.00
36_I40_F1.7631.00
47_W76_T1.7631.00
99_V103_A1.7591.00
142_L146_G1.7221.00
121_L124_G1.7081.00
305_V308_L1.6991.00
95_P99_V1.6991.00
21_V25_R1.6891.00
300_K304_A1.6891.00
275_M279_L1.6881.00
117_P130_V1.6841.00
301_L305_V1.6781.00
123_I126_T1.6761.00
72_R75_G1.6601.00
157_L160_G1.6601.00
61_F64_N1.6531.00
76_T144_R1.6321.00
36_I154_L1.5951.00
297_N304_A1.5901.00
198_R202_H1.5841.00
305_V309_R1.5701.00
238_N242_V1.5541.00
32_L158_F1.5411.00
180_E205_K1.5291.00
125_V128_A1.5271.00
124_G130_V1.5261.00
149_I153_L1.5201.00
34_F49_L1.5091.00
122_L129_I1.5001.00
301_L304_A1.4961.00
124_G131_V1.4931.00
123_I131_V1.4861.00
23_G27_A1.4841.00
214_R218_A1.4561.00
303_D307_E1.4501.00
29_A154_L1.4431.00
48_P51_T1.4351.00
120_G124_G1.4331.00
203_L207_L1.4311.00
266_Q270_D1.4131.00
105_M109_G1.3811.00
25_R158_F1.3801.00
76_T148_V1.3781.00
117_P122_L1.3771.00
214_R239_R1.3741.00
124_G127_L1.3711.00
47_W51_T1.3701.00
159_T164_Q1.3691.00
106_F110_W1.3661.00
123_I130_V1.3641.00
175_A182_N1.3571.00
284_H288_E1.3541.00
179_T287_Y1.3511.00
51_T72_R1.3501.00
68_R72_R1.3451.00
277_Q281_S1.3401.00
182_N283_V1.3381.00
53_V58_P1.3301.00
180_E209_D1.3221.00
265_A269_R1.3201.00
120_G125_V1.3141.00
238_N241_L1.3001.00
273_H277_Q1.3001.00
139_D143_W1.3001.00
251_A254_A1.2951.00
104_A108_C1.2841.00
243_C246_E1.2781.00
296_A301_L1.2761.00
270_D274_M1.2701.00
143_W146_G1.2641.00
280_L283_V1.2611.00
117_P125_V1.2511.00
166_A219_P1.2511.00
33_T48_P1.2421.00
300_K306_E1.2361.00
264_N267_K1.2351.00
210_A213_M1.2291.00
78_L81_I1.2181.00
122_L127_L1.2151.00
47_W144_R1.2111.00
243_C247_L1.2111.00
117_P120_G1.2031.00
299_E307_E1.1971.00
122_L126_T1.1931.00
280_L284_H1.1921.00
50_V53_V1.1911.00
275_M288_E1.1911.00
295_F298_T1.1881.00
232_E236_T1.1831.00
297_N301_L1.1811.00
271_T275_M1.1801.00
295_F299_E1.1781.00
23_G47_W1.1781.00
189_F192_N1.1781.00
123_I129_I1.1751.00
47_W72_R1.1701.00
56_M155_A1.1701.00
206_L209_D1.1621.00
186_Q276_Q1.1611.00
298_T308_L1.1561.00
182_N280_L1.1541.00
289_G292_Q1.1491.00
51_T148_V1.1411.00
119_Q130_V1.1381.00
30_F34_F1.1361.00
25_R161_I1.1341.00
297_N302_N1.1291.00
28_L158_F1.1251.00
141_A144_R1.1131.00
53_V57_G1.1051.00
27_A31_L1.1031.00
275_M278_I1.1011.00
300_K308_L1.1001.00
259_H263_L1.0981.00
51_T58_P1.0971.00
210_A214_R1.0961.00
45_S50_V1.0941.00
297_N307_E1.0831.00
144_R147_D1.0811.00
141_A145_S1.0791.00
120_G123_I1.0661.00
238_N247_L1.0641.00
276_Q280_L1.0621.00
79_G144_R1.0581.00
46_T49_L1.0571.00
118_Y121_L1.0481.00
207_L210_A1.0481.00
81_I85_I1.0471.00
118_Y125_V1.0461.00
122_L128_A1.0371.00
299_E303_D1.0331.00
242_V246_E1.0241.00
125_V130_V1.0201.00
72_R76_T1.0191.00
119_Q124_G1.0181.00
235_Q244_M1.0181.00
213_M217_I1.0141.00
297_N305_V1.0071.00
52_M55_I1.0071.00
218_A221_S1.0051.00
202_H205_K1.0031.00
47_W50_V1.0031.00
120_G130_V1.0001.00
49_L52_M0.9991.00
122_L130_V0.9951.00
299_E302_N0.9931.00
66_V69_A0.9881.00
226_I231_Y0.9861.00
93_S96_L0.9861.00
271_T278_I0.9841.00
274_M277_Q0.9811.00
123_I127_L0.9801.00
220_A223_E0.9761.00
297_N309_R0.9741.00
295_F309_R0.9731.00
199_L203_L0.9731.00
302_N305_V0.9721.00
126_T129_I0.9701.00
240_N244_M0.9691.00
37_I45_S0.9681.00
35_L39_L0.9671.00
298_T307_E0.9631.00
119_Q122_L0.9621.00
75_G144_R0.9581.00
55_I58_P0.9541.00
158_F161_I0.9541.00
177_S206_L0.9531.00
301_L309_R0.9521.00
117_P124_G0.9501.00
220_A224_T0.9481.00
121_L127_L0.9481.00
268_L271_T0.9481.00
144_R151_G0.9471.00
252_Y258_S0.9381.00
118_Y129_I0.9351.00
166_A220_A0.9311.00
51_T54_V0.9291.00
244_M248_Q0.9281.00
83_G87_L0.9271.00
239_R243_C0.9231.00
241_L246_E0.9191.00
117_P131_V0.9171.00
52_M58_P0.9171.00
183_R187_S0.9121.00
298_T303_D0.9101.00
241_L244_M0.9101.00
219_P223_E0.9091.00
77_V81_I0.9081.00
88_Q91_L0.9081.00
146_G150_L0.8981.00
274_M279_L0.8981.00
119_Q131_V0.8981.00
128_A131_V0.8951.00
105_M110_W0.8941.00
29_A33_T0.8941.00
151_G155_A0.8921.00
84_L88_Q0.8901.00
50_V55_I0.8891.00
180_E183_R0.8871.00
208_T212_K0.8861.00
226_I235_Q0.8811.00
273_H276_Q0.8811.00
72_R148_V0.8761.00
120_G131_V0.8741.00
183_R186_Q0.8581.00
269_R277_Q0.8571.00
64_N72_R0.8541.00
301_L307_E0.8531.00
73_I152_S0.8511.00
277_Q287_Y0.8481.00
54_V58_P0.8431.00
120_G129_I0.8401.00
227_P231_Y0.8391.00
149_I152_S0.8331.00
144_R148_V0.8290.99
296_A302_N0.8270.99
20_I23_G0.8230.99
267_K271_T0.8200.99
298_T306_E0.8200.99
306_E309_R0.8190.99
69_A72_R0.8190.99
103_A107_L0.8170.99
260_F263_L0.8170.99
283_V306_E0.8090.99
282_L286_L0.8050.99
48_P150_L0.8030.99
55_I69_A0.8010.99
281_S290_N0.7980.99
210_A218_A0.7970.99
119_Q126_T0.7970.99
166_A216_L0.7960.99
217_I231_Y0.7900.99
296_A300_K0.7880.99
243_C250_N0.7870.99
46_T50_V0.7860.99
82_L104_A0.7860.99
200_E204_Q0.7860.99
298_T301_L0.7800.99
121_L130_V0.7790.99
67_P71_E0.7720.99
269_R273_H0.7660.99
218_A222_K0.7640.99
274_M280_L0.7630.99
235_Q246_E0.7620.99
17_H20_I0.7610.99
211_V214_R0.7590.99
68_R144_R0.7570.99
267_K270_D0.7560.99
252_Y255_T0.7550.99
117_P126_T0.7530.99
257_P260_F0.7530.99
45_S48_P0.7510.99
45_S52_M0.7500.99
154_L158_F0.7490.99
217_I222_K0.7470.99
297_N308_L0.7460.99
79_G83_G0.7460.99
207_L214_R0.7420.99
213_M223_E0.7400.99
299_E304_A0.7400.99
233_G237_I0.7360.99
119_Q123_I0.7330.99
296_A304_A0.7320.99
302_N307_E0.7320.99
198_R201_S0.7310.99
211_V215_G0.7290.99
206_L222_K0.7260.99
73_I149_I0.7230.99
62_W163_P0.7220.99
248_Q252_Y0.7220.99
276_Q285_A0.7210.99
104_A127_L0.7180.99
247_L255_T0.7170.99
34_F38_R0.7170.99
165_R168_I0.7150.99
296_A305_V0.7100.98
295_F304_A0.7090.98
172_I176_K0.7060.98
70_F74_G0.7050.98
85_I89_L0.7040.98
234_I237_I0.7030.98
298_T309_R0.7030.98
121_L128_A0.7000.98
188_A245_L0.6990.98
62_W65_V0.6950.98
264_N268_L0.6950.98
118_Y124_G0.6940.98
205_K209_D0.6920.98
274_M286_L0.6870.98
78_L123_I0.6850.98
290_N293_P0.6850.98
130_V141_A0.6830.98
187_S202_H0.6820.98
200_E203_L0.6800.98
283_V287_Y0.6750.98
47_W79_G0.6750.98
301_L308_L0.6730.98
48_P147_D0.6720.98
208_T218_A0.6710.98
226_I234_I0.6710.98
190_S195_E0.6690.98
130_V137_E0.6690.98
236_T239_R0.6670.98
142_L145_S0.6640.98
86_A90_E0.6630.98
72_R151_G0.6620.98
57_G61_F0.6610.98
126_T148_V0.6590.97
235_Q240_N0.6560.97
36_I150_L0.6560.97
179_T283_V0.6560.97
69_A156_M0.6480.97
69_A152_S0.6450.97
290_N294_V0.6430.97
259_H262_L0.6410.97
179_T280_L0.6400.97
19_R26_V0.6400.97
120_G128_A0.6400.97
89_L92_I0.6390.97
255_T258_S0.6340.97
299_E306_E0.6290.97
64_N68_R0.6280.97
278_I288_E0.6230.96
177_S209_D0.6230.96
101_C115_K0.6220.96
253_W258_S0.6200.96
51_T63_G0.6180.96
102_A109_G0.6160.96
119_Q129_I0.6160.96
127_L131_V0.6150.96
48_P52_M0.6130.96
75_G81_I0.6120.96
108_C113_L0.6100.96
283_V286_L0.6060.96
49_L58_P0.6030.96
265_A277_Q0.6010.96
90_E94_L0.6010.96
214_R221_S0.6000.96
86_A100_W0.6000.96
63_G68_R0.5980.96
228_K231_Y0.5970.96
68_R79_G0.5970.96
26_V51_T0.5960.95
202_H206_L0.5960.95
287_Y290_N0.5930.95
225_R231_Y0.5930.95
276_Q281_S0.5930.95
225_R239_R0.5930.95
299_E305_V0.5920.95
127_L130_V0.5920.95
175_A287_Y0.5920.95
232_E235_Q0.5900.95
97_M105_M0.5880.95
108_C127_L0.5870.95
30_F134_P0.5810.95
206_L224_T0.5780.95
62_W159_T0.5780.95
61_F65_V0.5770.95
109_G112_A0.5760.95
304_A309_R0.5750.95
197_P201_S0.5750.95
80_S145_S0.5750.95
26_V30_F0.5730.94
120_G127_L0.5730.94
281_S285_A0.5680.94
182_N186_Q0.5670.94
210_A221_S0.5660.94
277_Q280_L0.5640.94
225_R228_K0.5610.94
302_N309_R0.5590.94
296_A307_E0.5530.93
46_T147_D0.5530.93
244_M249_I0.5500.93
25_R163_P0.5490.93
54_V57_G0.5470.93
65_V148_V0.5460.93
284_H291_P0.5450.93
92_I96_L0.5440.93
68_R118_Y0.5420.93
300_K307_E0.5410.93
253_W256_R0.5400.93
304_A308_L0.5400.93
303_D309_R0.5390.92
165_R224_T0.5370.92
134_P138_I0.5350.92
200_E209_D0.5340.92
276_Q283_V0.5320.92
117_P127_L0.5310.92
217_I220_A0.5300.92
214_R217_I0.5300.92
268_L272_Q0.5270.92
111_L120_G0.5250.91
46_T53_V0.5250.91
227_P230_I0.5240.91
77_V145_S0.5220.91
121_L126_T0.5220.91
302_N308_L0.5200.91
246_E249_I0.5170.91
299_E309_R0.5170.91
197_P205_K0.5150.91
298_T305_V0.5140.91
196_R200_E0.5140.91
240_N247_L0.5140.91
140_T144_R0.5140.91
104_A111_L0.5110.90
256_R263_L0.5090.90
134_P137_E0.5090.90
94_L98_L0.5080.90
51_T56_M0.5070.90
40_F43_P0.5020.90
101_C109_G0.5000.89
145_S148_V0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oltA 5 0.5426 81.6 0.907 Contact Map
4q4gX 1 0 55 0.923 Contact Map
1t72A 5 0.5568 52.5 0.924 Contact Map
4jkvA 2 0.392 43.1 0.928 Contact Map
3l39A 3 0.5312 33 0.933 Contact Map
4cgkA 3 0.483 32.1 0.933 Contact Map
1sumB 2 0.5227 29.1 0.935 Contact Map
2i0mA 2 0.5085 27.3 0.935 Contact Map
2d1lA 2 0.392 26.3 0.936 Contact Map
4q25A 2 0.5455 25.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.