GREMLIN Database
ALSA - D-allose import ATP-binding protein AlsA
UniProt: P32721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11959
Length: 510 (476)
Sequences: 9217 (6118)
Seq/√Len: 280.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T68_S3.5131.00
22_K222_S3.4111.00
32_E214_R3.3111.00
267_E285_S3.2551.00
123_R140_D3.1811.00
34_H216_T3.1481.00
393_R403_V3.1361.00
323_N429_E3.1201.00
319_E326_D3.1181.00
15_F55_H3.0341.00
65_N165_K2.9651.00
307_N313_D2.9371.00
269_R319_E2.9251.00
270_N281_D2.9101.00
10_G23_S2.8711.00
267_E321_R2.8711.00
35_A212_C2.8181.00
121_E125_R2.7621.00
127_A131_L2.6601.00
225_C240_L2.6091.00
264_T267_E2.5711.00
141_E145_N2.5631.00
7_S63_T2.5101.00
306_M465_V2.5051.00
7_S27_T2.4861.00
189_N210_R2.4861.00
14_S19_H2.4861.00
263_E288_R2.4451.00
9_A61_T2.4061.00
393_R400_C2.3481.00
228_I231_D2.2941.00
8_M11_I2.2671.00
264_T285_S2.2601.00
125_R128_M2.2301.00
212_C229_V2.2271.00
391_N395_L2.2051.00
71_K80_L2.1831.00
305_L482_F2.1711.00
132_R194_E2.1671.00
33_I188_M2.1631.00
353_F364_I2.1491.00
19_H22_K2.1431.00
268_V271_V2.1151.00
454_Q458_D2.1001.00
480_A490_I2.1001.00
12_G19_H2.0671.00
269_R321_R2.0361.00
464_M475_V2.0311.00
182_D210_R2.0011.00
72_L76_L1.9911.00
280_R486_R1.9851.00
239_R245_E1.9791.00
118_D121_E1.9781.00
292_L480_A1.9381.00
233_S236_D1.9071.00
392_Q421_S1.9061.00
48_M201_I1.8921.00
264_T287_C1.8841.00
10_G25_N1.8691.00
429_E460_K1.8341.00
325_K338_K1.8001.00
48_M84_I1.7861.00
9_A63_T1.7861.00
265_V461_V1.7851.00
286_V461_V1.7771.00
268_V284_F1.7631.00
295_A472_I1.7421.00
92_I103_I1.7201.00
12_G23_S1.7151.00
390_E394_E1.7141.00
433_F452_M1.7071.00
91_V143_V1.6851.00
293_G476_C1.6711.00
322_L327_I1.6651.00
291_I452_M1.6651.00
189_N192_R1.6641.00
63_T68_S1.6631.00
85_I169_M1.6631.00
359_A404_N1.6521.00
306_M432_I1.6491.00
363_A385_E1.6361.00
5_Y197_A1.6351.00
358_I400_C1.6081.00
390_E403_V1.5971.00
440_I448_I1.5961.00
227_G240_L1.5911.00
381_H384_D1.5881.00
64_I166_V1.5861.00
14_S59_K1.5851.00
124_V128_M1.5641.00
11_I50_V1.5631.00
492_T495_D1.5621.00
216_T223_S1.5461.00
98_L123_R1.5411.00
272_T281_D1.5351.00
407_I418_V1.5301.00
190_Q194_E1.5271.00
307_N350_N1.5111.00
286_V463_L1.5111.00
8_M51_L1.5041.00
142_K145_N1.5031.00
165_K196_T1.5021.00
128_M132_R1.5001.00
265_V323_N1.5001.00
400_C405_Q1.4841.00
132_R190_Q1.4831.00
121_E124_V1.4771.00
99_E119_W1.4741.00
405_Q409_E1.4681.00
264_T288_R1.4641.00
227_G232_V1.4571.00
94_E144_A1.4561.00
321_R326_D1.4541.00
67_I80_L1.4501.00
73_D76_L1.4491.00
322_L430_V1.4491.00
380_F385_E1.4471.00
209_R237_I1.4451.00
308_C315_R1.4401.00
346_S349_D1.4401.00
480_A487_L1.4321.00
286_V292_L1.4321.00
192_R213_D1.4311.00
362_M398_L1.4291.00
393_R398_L1.4271.00
395_L454_Q1.4271.00
355_N408_T1.4261.00
286_V430_V1.4241.00
54_I86_Y1.4241.00
293_G472_I1.4161.00
352_F407_I1.4141.00
30_P197_A1.4121.00
330_R334_D1.3881.00
185_F211_I1.3821.00
272_T317_G1.3771.00
10_G59_K1.3761.00
384_D387_R1.3681.00
93_D151_K1.3621.00
101_L126_A1.3541.00
232_V236_D1.3411.00
387_R391_N1.3351.00
28_V166_V1.3311.00
261_A287_C1.3291.00
25_N223_S1.3291.00
16_G19_H1.3281.00
76_L79_Q1.3281.00
127_A139_L1.3261.00
183_Y186_L1.3231.00
71_K76_L1.3221.00
250_F474_T1.3201.00
147_S150_H1.3181.00
97_V137_V1.3151.00
14_S58_T1.3131.00
12_G59_K1.3111.00
116_I379_L1.2961.00
236_D239_R1.2811.00
96_T99_E1.2751.00
129_M161_M1.2731.00
270_N283_S1.2641.00
288_R429_E1.2631.00
284_F294_F1.2611.00
227_G231_D1.2611.00
52_S84_I1.2541.00
279_V308_C1.2511.00
138_D141_E1.2471.00
290_E478_R1.2471.00
333_L337_K1.2431.00
356_F360_Q1.2421.00
391_N394_E1.2411.00
269_R285_S1.2401.00
190_Q193_K1.2321.00
284_F480_A1.2251.00
401_H405_Q1.2201.00
454_Q457_D1.2161.00
478_R490_I1.2041.00
288_R461_V1.2021.00
386_Q404_N1.1991.00
215_Y229_V1.1881.00
406_N409_E1.1801.00
223_S226_S1.1761.00
214_R228_I1.1731.00
445_K468_E1.1701.00
427_C458_D1.1671.00
294_F480_A1.1601.00
277_K280_R1.1581.00
451_V454_Q1.1541.00
331_S334_D1.1401.00
188_M198_I1.1391.00
206_A234_N1.1361.00
27_T214_R1.1361.00
370_D388_T1.1321.00
227_G236_D1.1321.00
472_I476_C1.1311.00
419_L422_K1.1311.00
16_G20_A1.1221.00
131_L136_K1.1211.00
34_H226_S1.1191.00
109_K118_D1.1171.00
343_I433_F1.1081.00
358_I418_V1.1071.00
402_S405_Q1.1051.00
279_V282_I1.0981.00
292_L490_I1.0961.00
217_V240_L1.0941.00
30_P165_K1.0931.00
24_V218_M1.0891.00
169_M198_I1.0861.00
303_T345_E1.0851.00
216_T226_S1.0841.00
98_L139_L1.0801.00
133_V157_A1.0731.00
388_T425_C1.0711.00
271_V308_C1.0711.00
101_L161_M1.0701.00
188_M211_I1.0701.00
275_D316_A1.0661.00
37_L205_L1.0571.00
209_R233_S1.0541.00
284_F292_L1.0531.00
397_A447_E1.0521.00
189_N193_K1.0511.00
29_Y32_E1.0501.00
270_N317_G1.0481.00
466_S472_I1.0481.00
209_R234_N1.0481.00
5_Y166_V1.0451.00
281_D486_R1.0441.00
237_I243_G1.0421.00
362_M389_A1.0421.00
472_I479_I1.0381.00
5_Y65_N1.0341.00
344_T350_N1.0321.00
292_L463_L1.0321.00
392_Q398_L1.0291.00
107_L122_M1.0241.00
452_M464_M1.0231.00
123_R127_A1.0221.00
357_S360_Q1.0211.00
359_A386_Q1.0191.00
76_L80_L1.0131.00
57_P70_N1.0121.00
427_C460_K1.0111.00
263_E323_N1.0111.00
164_A167_I1.0041.00
30_P65_N1.0041.00
453_R457_D1.0021.00
21_L50_V0.9961.00
186_L190_Q0.9941.00
28_V197_A0.9911.00
265_V288_R0.9871.00
329_P334_D0.9831.00
120_R124_V0.9831.00
359_A403_V0.9821.00
483_C488_T0.9811.00
435_E467_S0.9811.00
6_I64_I0.9801.00
268_V309_L0.9791.00
353_F356_F0.9771.00
88_E438_R0.9731.00
49_K55_H0.9731.00
97_V146_L0.9691.00
128_M131_L0.9661.00
271_V315_R0.9651.00
12_G22_K0.9631.00
5_Y64_I0.9631.00
253_M457_D0.9601.00
107_L125_R0.9591.00
139_L142_K0.9581.00
302_R434_D0.9581.00
209_R229_V0.9551.00
269_R283_S0.9531.00
294_F463_L0.9521.00
431_I460_K0.9501.00
359_A385_E0.9501.00
432_I465_V0.9481.00
167_I198_I0.9461.00
88_E348_R0.9441.00
29_Y214_R0.9421.00
362_M418_V0.9391.00
262_H288_R0.9351.00
450_K454_Q0.9351.00
329_P335_A0.9331.00
75_K79_Q0.9331.00
268_V320_I0.9321.00
452_M475_V0.9301.00
251_N474_T0.9291.00
275_D278_K0.9291.00
83_G164_A0.9291.00
182_D186_L0.9221.00
9_A25_N0.9221.00
339_G429_E0.9201.00
69_Y80_L0.9141.00
97_V141_E0.9111.00
389_A403_V0.9101.00
401_H409_E0.9101.00
83_G159_T0.9101.00
452_M462_I0.9051.00
56_E70_N0.9021.00
130_L157_A0.9011.00
125_R163_D0.9001.00
310_F423_W0.8981.00
341_A423_W0.8961.00
288_R323_N0.8951.00
23_S59_K0.8931.00
294_F305_L0.8931.00
335_A340_M0.8911.00
455_L460_K0.8901.00
279_V305_L0.8891.00
348_R354_P0.8891.00
363_A367_S0.8881.00
383_V387_R0.8861.00
78_A162_L0.8851.00
340_M430_V0.8831.00
124_V127_A0.8831.00
329_P340_M0.8771.00
6_I51_L0.8751.00
208_I229_V0.8731.00
188_M200_Y0.8701.00
27_T226_S0.8641.00
51_L62_I0.8631.00
303_T434_D0.8611.00
310_F432_I0.8601.00
386_Q403_V0.8601.00
388_T391_N0.8591.00
107_L117_I0.8581.00
336_V423_W0.8581.00
332_P335_A0.8551.00
108_T118_D0.8541.00
344_T419_L0.8531.00
214_R226_S0.8501.00
432_I463_L0.8481.00
354_P407_I0.8481.00
102_Y125_R0.8461.00
98_L122_M0.8451.00
343_I419_L0.8431.00
476_C493_N0.8431.00
23_S222_S0.8381.00
358_I410_L0.8341.00
341_A431_I0.8301.00
50_V57_P0.8291.00
365_S423_W0.8281.00
359_A389_A0.8271.00
237_I241_M0.8251.00
390_E393_R0.8251.00
108_T115_N0.8231.00
102_Y122_M0.8211.00
52_S86_Y0.8200.99
71_K77_A0.8150.99
13_K58_T0.8140.99
105_R162_L0.8140.99
129_M157_A0.8120.99
33_I189_N0.8120.99
34_H214_R0.8090.99
392_Q425_C0.8080.99
446_A450_K0.8070.99
62_I71_K0.8070.99
47_L218_M0.8050.99
126_A139_L0.8040.99
236_D240_L0.8040.99
50_V55_H0.8030.99
341_A428_P0.8030.99
33_I192_R0.8000.99
8_M26_L0.7980.99
135_L153_M0.7970.99
105_R161_M0.7960.99
169_M188_M0.7950.99
127_A140_D0.7930.99
159_T167_I0.7910.99
369_K427_C0.7900.99
284_F305_L0.7880.99
127_A138_D0.7860.99
241_M244_R0.7800.99
215_Y237_I0.7790.99
348_R415_Q0.7770.99
215_Y227_G0.7760.99
282_I305_L0.7760.99
163_D194_E0.7750.99
282_I487_L0.7740.99
64_I69_Y0.7740.99
302_R345_E0.7740.99
291_I453_R0.7730.99
266_F286_V0.7710.99
360_Q385_E0.7700.99
91_V151_K0.7660.99
362_M421_S0.7640.99
285_S490_I0.7640.99
175_S298_V0.7580.99
298_V467_S0.7580.99
49_K86_Y0.7570.99
366_R369_K0.7570.99
89_L148_I0.7540.99
109_K116_I0.7520.99
28_V199_V0.7500.99
29_Y228_I0.7500.99
366_R425_C0.7480.99
123_R139_L0.7480.99
357_S404_N0.7470.99
276_R316_A0.7470.99
14_S20_A0.7460.99
134_G190_Q0.7440.99
265_V430_V0.7430.99
155_E158_K0.7430.99
351_G419_L0.7420.99
400_C410_L0.7400.99
130_L139_L0.7400.99
143_V154_L0.7370.99
238_V243_G0.7370.99
386_Q390_E0.7370.99
361_N364_I0.7360.99
487_L490_I0.7340.99
94_E142_K0.7310.99
473_I479_I0.7290.99
272_T279_V0.7280.99
8_M62_I0.7280.99
294_F306_M0.7270.99
376_A381_H0.7260.99
394_E397_A0.7230.99
264_T269_R0.7210.99
275_D279_V0.7190.99
167_I196_T0.7180.99
99_E106_H0.7170.99
98_L107_L0.7160.99
9_A27_T0.7160.99
322_L340_M0.7140.99
449_Y474_T0.7140.99
266_F430_V0.7130.99
49_K54_I0.7120.99
334_D337_K0.7070.99
354_P408_T0.7070.99
259_N262_H0.7060.98
243_G246_L0.7060.98
83_G162_L0.7050.98
24_V223_S0.7050.98
109_K115_N0.7040.98
228_I232_V0.7000.98
384_D388_T0.6990.98
473_I493_N0.6990.98
16_G401_H0.6980.98
420_I448_I0.6970.98
96_T142_K0.6960.98
242_V246_L0.6950.98
101_L154_L0.6940.98
35_A229_V0.6920.98
262_H287_C0.6900.98
26_L34_H0.6880.98
74_H77_A0.6870.98
132_R163_D0.6860.98
308_C313_D0.6840.98
91_V154_L0.6840.98
329_P338_K0.6820.98
240_L243_G0.6800.98
146_L154_L0.6800.98
206_A210_R0.6790.98
320_I329_P0.6790.98
334_D338_K0.6780.98
371_G378_G0.6770.98
271_V320_I0.6760.98
127_A136_K0.6750.98
6_I166_V0.6750.98
400_C403_V0.6730.98
253_M477_D0.6730.98
327_I338_K0.6730.98
387_R390_E0.6690.98
341_A426_C0.6680.98
428_P431_I0.6680.98
315_R328_S0.6670.98
134_G186_L0.6650.98
267_E324_G0.6630.98
352_F415_Q0.6610.98
263_E287_C0.6590.98
189_N211_I0.6590.98
106_H122_M0.6540.98
184_L188_M0.6540.98
119_W123_R0.6530.98
365_S426_C0.6530.98
453_R477_D0.6510.97
209_R232_V0.6500.97
265_V286_V0.6500.97
16_G22_K0.6490.97
37_L208_I0.6470.97
102_Y126_A0.6470.97
86_Y90_S0.6470.97
48_M168_I0.6470.97
36_L199_V0.6470.97
129_M132_R0.6460.97
252_A453_R0.6460.97
456_A462_I0.6440.97
305_L309_L0.6430.97
430_V463_L0.6420.97
420_I440_I0.6420.97
261_A264_T0.6410.97
428_P460_K0.6410.97
192_R198_I0.6410.97
310_F342_Y0.6410.97
89_L155_E0.6410.97
90_S155_E0.6390.97
358_I393_R0.6380.97
187_I190_Q0.6360.97
125_R129_M0.6360.97
98_L140_D0.6360.97
5_Y30_P0.6360.97
71_K82_I0.6350.97
21_L218_M0.6300.97
177_T181_V0.6300.97
200_Y204_K0.6290.97
306_M342_Y0.6280.97
107_L121_E0.6270.97
29_Y197_A0.6270.97
294_F482_F0.6260.97
146_L150_H0.6260.97
28_V34_H0.6260.97
284_F463_L0.6250.97
8_M168_I0.6240.97
395_L451_V0.6240.97
202_S208_I0.6240.97
130_L135_L0.6240.97
322_L338_K0.6230.97
398_L421_S0.6230.97
268_V315_R0.6210.97
371_G379_L0.6190.97
217_V237_I0.6190.97
89_L174_S0.6180.97
244_R250_F0.6180.97
205_L208_I0.6180.97
366_R370_D0.6180.97
98_L126_A0.6160.96
235_D245_E0.6130.96
405_Q408_T0.6120.96
69_Y72_L0.6120.96
166_V197_A0.6100.96
357_S406_N0.6090.96
7_S66_N0.6080.96
107_L118_D0.6080.96
455_L458_D0.6060.96
108_T116_I0.6060.96
388_T392_Q0.6040.96
26_L199_V0.6040.96
481_V488_T0.6040.96
259_N457_D0.6040.96
101_L129_M0.6030.96
420_I424_L0.6030.96
282_I482_F0.6020.96
399_K405_Q0.5990.96
20_A401_H0.5990.96
306_M434_D0.5990.96
239_R243_G0.5980.96
134_G183_Y0.5980.96
178_N182_D0.5970.96
272_T280_R0.5970.96
229_V232_V0.5970.96
298_V302_R0.5960.96
89_L175_S0.5960.96
218_M223_S0.5950.96
26_L36_L0.5950.96
174_S438_R0.5950.96
129_M133_V0.5940.96
219_K224_V0.5940.96
407_I422_K0.5940.96
428_P433_F0.5940.96
34_H199_V0.5930.96
271_V279_V0.5930.96
248_N251_N0.5920.96
310_F336_V0.5910.96
124_V131_L0.5890.95
123_R126_A0.5890.95
382_E385_E0.5880.95
64_I80_L0.5870.95
264_T268_V0.5860.95
200_Y211_I0.5860.95
238_V241_M0.5860.95
141_E150_H0.5850.95
185_F192_R0.5850.95
148_I151_K0.5830.95
181_V204_K0.5830.95
18_V401_H0.5830.95
392_Q395_L0.5830.95
358_I407_I0.5820.95
8_M25_N0.5810.95
148_I174_S0.5810.95
220_D399_K0.5790.95
343_I420_I0.5780.95
396_L424_L0.5780.95
389_A393_R0.5780.95
358_I409_E0.5780.95
148_I438_R0.5770.95
39_E244_R0.5760.95
186_L210_R0.5760.95
179_K182_D0.5750.95
181_V211_I0.5750.95
93_D144_A0.5740.95
420_I433_F0.5730.95
354_P422_K0.5720.95
464_M476_C0.5710.95
363_A388_T0.5710.95
97_V139_L0.5710.95
366_R426_C0.5710.95
307_N312_V0.5680.94
177_T180_E0.5680.94
310_F332_P0.5670.94
75_K78_A0.5670.94
14_S22_K0.5670.94
144_A151_K0.5660.94
481_V491_L0.5660.94
295_A469_L0.5660.94
234_N237_I0.5650.94
306_M463_L0.5640.94
270_N319_E0.5640.94
97_V154_L0.5640.94
133_V153_M0.5630.94
241_M245_E0.5610.94
407_I419_L0.5590.94
200_Y208_I0.5580.94
363_A370_D0.5580.94
482_F487_L0.5550.94
252_A477_D0.5540.94
186_L189_N0.5540.94
191_L196_T0.5520.94
479_I493_N0.5520.94
254_K457_D0.5510.94
88_E155_E0.5510.94
291_I475_V0.5510.94
33_I213_D0.5500.94
396_L421_S0.5500.94
243_G247_Q0.5490.93
205_L237_I0.5480.93
238_V242_V0.5480.93
160_L191_L0.5480.93
186_L193_K0.5470.93
449_Y453_R0.5470.93
323_N326_D0.5460.93
50_V58_T0.5450.93
141_E146_L0.5450.93
455_L462_I0.5450.93
302_R467_S0.5440.93
292_L461_V0.5430.93
304_E313_D0.5420.93
119_W122_M0.5420.93
8_M50_V0.5420.93
246_L250_F0.5410.93
264_T321_R0.5410.93
272_T277_K0.5410.93
276_R280_R0.5400.93
294_F487_L0.5400.93
225_C232_V0.5400.93
396_L451_V0.5390.93
212_C215_Y0.5390.93
16_G405_Q0.5390.93
308_C314_K0.5380.93
137_V157_A0.5370.93
64_I82_I0.5350.93
293_G466_S0.5340.93
272_T316_A0.5330.92
392_Q396_L0.5330.92
235_D239_R0.5330.92
358_I405_Q0.5320.92
39_E241_M0.5310.92
10_G61_T0.5300.92
149_S298_V0.5300.92
440_I451_V0.5280.92
100_N143_V0.5280.92
26_L197_A0.5280.92
33_I211_I0.5270.92
206_A468_E0.5260.92
192_R211_I0.5240.92
36_L48_M0.5220.92
267_E319_E0.5220.92
173_T181_V0.5210.92
362_M392_Q0.5210.92
277_K316_A0.5210.92
453_R475_V0.5210.92
191_L198_I0.5210.92
449_Y475_V0.5200.92
172_P180_E0.5190.91
320_I327_I0.5190.91
322_L429_E0.5190.91
275_D313_D0.5190.91
342_Y350_N0.5190.91
310_F341_A0.5180.91
362_M393_R0.5160.91
344_T351_G0.5160.91
355_N406_N0.5160.91
252_A259_N0.5150.91
45_S49_K0.5150.91
351_G422_K0.5150.91
148_I349_D0.5150.91
400_C409_E0.5150.91
136_K150_H0.5150.91
174_S204_K0.5150.91
102_Y129_M0.5140.91
360_Q363_A0.5140.91
449_Y464_M0.5130.91
452_M456_A0.5120.91
453_R456_A0.5120.91
288_R292_L0.5110.91
137_V141_E0.5100.91
14_S17_P0.5100.91
177_T298_V0.5090.91
105_R125_R0.5090.91
329_P332_P0.5090.91
276_R308_C0.5080.91
86_Y89_L0.5080.91
13_K55_H0.5080.91
310_F335_A0.5070.90
12_G20_A0.5070.90
34_H197_A0.5060.90
32_E197_A0.5060.90
73_D77_A0.5050.90
295_A466_S0.5050.90
447_E450_K0.5040.90
17_P20_A0.5040.90
39_E443_G0.5040.90
456_A461_V0.5030.90
107_L115_N0.5010.90
336_V365_S0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.951 100 0.389 Contact Map
4finA 2 0.9098 100 0.397 Contact Map
4f4cA 1 0.9333 100 0.418 Contact Map
1yqtA 1 0.8922 100 0.434 Contact Map
3ux8A 2 0.8529 100 0.438 Contact Map
3bk7A 1 0.9078 100 0.447 Contact Map
3ozxA 1 0.8765 100 0.448 Contact Map
2iw3A 2 0.8961 100 0.451 Contact Map
3j16B 1 0.9078 100 0.461 Contact Map
2vf7A 2 0.9431 100 0.528 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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