GREMLIN Database
ALSC - D-allose transport system permease protein AlsC
UniProt: P32720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11958
Length: 326 (266)
Sequences: 31422 (19625)
Seq/√Len: 1203.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_V233_V3.8571.00
117_G229_I3.4971.00
117_G233_V3.0601.00
93_V115_V2.9141.00
121_A229_I2.8721.00
210_K224_I2.7351.00
97_L111_G2.6441.00
71_F282_V2.5061.00
203_I227_V2.4721.00
64_V183_S2.4641.00
219_D222_F2.4331.00
129_W221_K2.3871.00
222_F226_V2.3141.00
116_G236_G2.2771.00
191_W195_T2.2661.00
193_L199_L2.2581.00
120_G232_G2.2191.00
192_F196_R2.2101.00
121_A225_L2.1801.00
123_N141_T2.1801.00
202_N223_H2.1311.00
260_Y293_N2.1111.00
125_C129_W2.1001.00
189_I193_L2.0601.00
199_L226_V2.0491.00
104_P107_A1.9991.00
88_A149_T1.9591.00
66_I261_A1.9291.00
94_T112_G1.9191.00
113_V237_L1.8911.00
106_L110_I1.8491.00
188_L192_F1.8271.00
116_G232_G1.7861.00
109_M240_V1.7551.00
94_T240_V1.7371.00
67_G282_V1.7251.00
97_L101_G1.7191.00
60_S290_G1.7001.00
206_L223_H1.6851.00
73_A231_S1.6701.00
143_A146_R1.6601.00
124_G225_L1.6531.00
72_F190_L1.6531.00
205_A213_A1.6521.00
198_R202_N1.6011.00
60_S287_L1.5791.00
96_K100_A1.5731.00
64_V286_G1.5321.00
98_M108_A1.5131.00
156_N159_Y1.4961.00
75_L204_Y1.4871.00
119_L145_F1.4771.00
199_L203_I1.4531.00
129_W225_L1.4451.00
260_Y310_M1.4431.00
211_N214_F1.4431.00
226_V229_I1.4401.00
89_L119_L1.4361.00
113_V240_V1.4281.00
167_N170_A1.4251.00
87_L242_S1.4231.00
210_K214_F1.4201.00
85_A146_R1.4051.00
66_I87_L1.3911.00
141_T145_F1.3881.00
187_A283_V1.3751.00
268_G281_S1.3501.00
96_K152_I1.3481.00
202_N218_I1.3471.00
278_R281_S1.3401.00
202_N213_A1.3311.00
107_A110_I1.3171.00
171_A174_I1.3121.00
76_V227_V1.3051.00
65_L238_A1.3021.00
69_G234_C1.2971.00
125_C225_L1.2951.00
161_F165_F1.2701.00
72_F227_V1.2701.00
64_V283_V1.2641.00
213_A218_I1.2581.00
268_G285_G1.2501.00
56_I290_G1.2331.00
225_L229_I1.2161.00
68_M190_L1.2161.00
218_I223_H1.2161.00
206_L220_V1.2151.00
110_I114_L1.2131.00
65_L241_V1.2081.00
128_N221_K1.2071.00
108_A112_G1.1941.00
112_G116_G1.1941.00
78_G224_I1.1931.00
83_V235_A1.1891.00
206_L213_A1.1871.00
52_N294_N1.1851.00
56_I291_T1.1851.00
172_S175_G1.1751.00
78_G134_P1.1671.00
70_E265_A1.1661.00
96_K153_S1.1641.00
93_V97_L1.1591.00
70_E261_A1.1501.00
114_L117_G1.1391.00
67_G264_S1.1331.00
195_T204_Y1.1281.00
229_I233_V1.1241.00
294_N297_N1.1191.00
186_V234_C1.1111.00
78_G228_F1.1061.00
161_F164_D1.1051.00
191_W196_R1.1051.00
232_G236_G1.0961.00
60_S286_G1.0861.00
214_F221_K1.0851.00
169_F172_S1.0771.00
160_G164_D1.0751.00
94_T244_A1.0701.00
67_G265_A1.0691.00
69_G83_V1.0681.00
181_I185_I1.0671.00
85_A145_F1.0561.00
86_I119_L1.0521.00
188_L191_W1.0481.00
126_L137_I1.0451.00
226_V230_I1.0411.00
92_M149_T1.0411.00
252_L255_M1.0401.00
170_A173_V1.0351.00
223_H226_V1.0351.00
257_F260_Y1.0331.00
118_A121_A1.0261.00
214_F220_V1.0231.00
305_Y308_V1.0101.00
187_A234_C1.0101.00
293_N310_M1.0091.00
203_I223_H1.0091.00
125_C130_T1.0041.00
54_T58_V1.0011.00
185_I189_I0.9971.00
95_A99_L0.9951.00
190_L230_I0.9941.00
75_L277_G0.9871.00
112_G240_V0.9871.00
117_G236_G0.9861.00
146_R150_L0.9861.00
264_S286_G0.9851.00
92_M251_P0.9841.00
264_S285_G0.9831.00
97_L100_A0.9821.00
160_G163_F0.9811.00
128_N138_T0.9811.00
71_F265_A0.9741.00
123_N137_I0.9731.00
89_L93_V0.9711.00
61_S180_V0.9681.00
178_V181_I0.9621.00
142_N146_R0.9521.00
230_I234_C0.9501.00
110_I113_V0.9491.00
239_G243_T0.9411.00
66_I238_A0.9411.00
307_L310_M0.9391.00
174_I181_I0.9331.00
199_L223_H0.9291.00
74_I265_A0.9281.00
92_M153_S0.9251.00
231_S235_A0.9251.00
126_L130_T0.9211.00
222_F225_L0.9171.00
84_G258_E0.9141.00
103_D107_A0.9091.00
280_F284_I0.9091.00
191_W280_F0.9071.00
80_D83_V0.9001.00
131_G210_K0.8941.00
295_G299_L0.8941.00
85_A142_N0.8901.00
87_L254_G0.8881.00
97_L108_A0.8871.00
296_L309_V0.8841.00
70_E83_V0.8831.00
162_S165_F0.8821.00
169_F173_V0.8811.00
256_G260_Y0.8791.00
59_Q63_T0.8791.00
90_S116_G0.8781.00
67_G286_G0.8711.00
76_V203_I0.8701.00
71_F277_G0.8691.00
103_D111_G0.8691.00
62_V238_A0.8681.00
86_I235_A0.8681.00
184_L188_L0.8661.00
289_I310_M0.8661.00
151_V305_Y0.8651.00
90_S112_G0.8641.00
201_R204_Y0.8631.00
64_V187_A0.8631.00
75_L195_T0.8611.00
183_S187_A0.8611.00
212_S216_S0.8561.00
93_V96_K0.8551.00
167_N172_S0.8511.00
170_A174_I0.8511.00
51_N54_T0.8511.00
87_L257_F0.8461.00
114_L118_A0.8451.00
65_L183_S0.8451.00
127_V137_I0.8331.00
242_S246_L0.8331.00
174_I177_P0.8311.00
91_G243_T0.8301.00
220_V224_I0.8281.00
84_G256_G0.8281.00
235_A239_G0.8231.00
121_A125_C0.8221.00
73_A80_D0.8211.00
53_I295_G0.8211.00
206_L227_V0.8191.00
194_T203_I0.8141.00
221_K224_I0.8091.00
122_I126_L0.8081.00
179_P241_V0.8071.00
72_F230_I0.8071.00
209_N212_S0.8061.00
94_T98_M0.8041.00
113_V236_G0.8031.00
107_A111_G0.8001.00
68_M186_V0.8001.00
68_M282_V0.8001.00
168_F171_A0.7981.00
193_L196_R0.7901.00
147_G150_L0.7891.00
124_G128_N0.7871.00
90_S239_G0.7841.00
118_A122_I0.7821.00
294_N298_I0.7801.00
276_K280_F0.7801.00
316_A320_L0.7761.00
278_R282_V0.7761.00
178_V182_F0.7741.00
221_K225_L0.7711.00
72_F194_T0.7711.00
66_I83_V0.7631.00
189_I192_F0.7571.00
167_N171_A0.7571.00
206_L224_I0.7551.00
91_G249_A0.7551.00
86_I116_G0.7551.00
95_A249_A0.7511.00
66_I69_G0.7491.00
180_V184_L0.7471.00
210_K220_V0.7451.00
113_V117_G0.7401.00
89_L116_G0.7321.00
91_G253_A0.7321.00
233_V236_G0.7301.00
124_G129_W0.7281.00
94_T108_A0.7231.00
233_V237_L0.7191.00
282_V286_G0.7161.00
166_V169_F0.7141.00
55_Q59_Q0.7131.00
87_L238_A0.7131.00
109_M113_V0.7121.00
65_L186_V0.7081.00
202_N219_D0.7031.00
90_S115_V0.7031.00
69_G235_A0.7021.00
166_V170_A0.7001.00
81_L262_I0.6991.00
52_N298_I0.6931.00
144_I148_I0.6901.00
128_N225_L0.6881.00
63_T260_Y0.6851.00
287_L291_T0.6831.00
97_L103_D0.6721.00
98_M244_A0.6721.00
78_G210_K0.6671.00
73_A228_F0.6651.00
263_A314_I0.6631.00
286_G290_G0.6631.00
312_G316_A0.6621.00
89_L145_F0.6591.00
56_I294_N0.6591.00
71_F75_L0.6581.00
192_F195_T0.6581.00
304_Y307_L0.6561.00
63_T264_S0.6541.00
71_F279_I0.6481.00
57_F61_S0.6481.00
146_R255_M0.6481.00
134_P228_F0.6471.00
50_T53_I0.6411.00
74_I262_I0.6411.00
159_Y162_S0.6391.00
60_S64_V0.6391.00
116_G120_G0.6351.00
187_A191_W0.6341.00
86_I123_N0.6331.00
56_I60_S0.6321.00
86_I90_S0.6321.00
267_I285_G0.6231.00
86_I232_G0.6211.00
193_L226_V0.6181.00
230_I233_V0.6181.00
158_V161_F0.6161.00
220_V223_H0.6161.00
63_T286_G0.6131.00
163_F166_V0.6131.00
236_G240_V0.6121.00
186_V237_L0.6121.00
146_R258_E0.6101.00
55_Q294_N0.6101.00
97_L115_V0.6081.00
61_S183_S0.6081.00
120_G229_I0.6061.00
293_N306_Q0.6051.00
88_A254_G0.6041.00
57_F60_S0.6001.00
86_I145_F0.5971.00
310_M314_I0.5951.00
58_V245_R0.5911.00
190_L234_C0.5911.00
58_V180_V0.5911.00
90_S235_A0.5901.00
190_L194_T0.5901.00
127_V134_P0.5881.00
76_V224_I0.5881.00
199_L230_I0.5861.00
303_T306_Q0.5861.00
101_G104_P0.5851.00
105_F244_A0.5841.00
173_V181_I0.5831.00
232_G235_A0.5821.00
62_V242_S0.5791.00
62_V245_R0.5781.00
69_G73_A0.5771.00
139_L143_A0.5761.00
264_S282_V0.5761.00
94_T239_G0.5751.00
306_Q310_M0.5741.00
296_L301_V0.5721.00
242_S257_F0.5711.00
72_F193_L0.5691.00
224_I227_V0.5671.00
185_I188_L0.5651.00
76_V206_L0.5621.00
63_T257_F0.5621.00
93_V111_G0.5611.00
51_N55_Q0.5611.00
193_L197_M0.5611.00
97_L102_V0.5601.00
86_I120_G0.5601.00
173_V177_P0.5601.00
117_G120_G0.5591.00
68_M187_A0.5591.00
142_N258_E0.5591.00
50_T54_T0.5531.00
82_S123_N0.5501.00
127_V228_F0.5481.00
213_A220_V0.5471.00
229_I232_G0.5451.00
211_N215_Y0.5441.00
143_A147_G0.5441.00
131_G221_K0.5441.00
113_V116_G0.5421.00
265_A282_V0.5411.00
260_Y307_L0.5401.00
182_F186_V0.5401.00
264_S289_I0.5381.00
96_K99_L0.5371.00
93_V116_G0.5281.00
191_W278_R0.5271.00
53_I57_F0.5251.00
138_T142_N0.5251.00
68_M191_W0.5241.00
267_I317_A0.5231.00
167_N173_V0.5221.00
64_V68_M0.5191.00
204_Y207_G0.5191.00
105_F109_M0.5171.00
204_Y277_G0.5171.00
117_G232_G0.5171.00
268_G282_V0.5151.00
139_L142_N0.5151.00
186_V190_L0.5151.00
59_Q294_N0.5141.00
77_A210_K0.5141.00
93_V112_G0.5131.00
301_V305_Y0.5101.00
166_V175_G0.5101.00
160_G165_F0.5101.00
89_L115_V0.5091.00
182_F185_I0.5031.00
182_F237_L0.5031.00
250_E253_A0.5011.00
309_V312_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.8067 97.5 0.869 Contact Map
2nq2A 2 0.8313 97.2 0.876 Contact Map
2qi9A 2 0.8742 96.9 0.882 Contact Map
3d31C 2 0.7147 24.3 0.949 Contact Map
2onkC 2 0.7147 23.6 0.949 Contact Map
2cfqA 1 0.6104 17.9 0.952 Contact Map
1u7gA 3 0.5859 17.8 0.952 Contact Map
4ytpC 1 0.3466 14.3 0.954 Contact Map
1zoyC 1 0.3466 10.8 0.957 Contact Map
3dh4A 3 0.1503 9.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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