ALSC - ECOLI - GREMLIN Contacts

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ALSC - D-allose transport system permease protein AlsC

UniProt:	P32720	Sequences: MGFTTRVKSEASEKKPFNFALFWDKYGTFFILAIIVAIFGSLSPEYFLTTNNITQIFVQSSVTVLIGMGEFFAILVAGIDLSVGAILALSGMVTAKLMLAGVDPFLAAMIGGVLVGGALGAINGCLVNWTGLHPFIITLGTNAIFRGITLVISDANSVYGFSFDFVNFFAASVIGIPVPVIFSLIVALILWFLTTRMRLGRNIYALGGNKNSAFYSGIDVKFHILVVFIISGVCAGLAGVVSTARLGAAEPLAGMGFETYAIASAIIGGTSFFGGKGRIFSVVIGGLIIGTINNGLNILQVQTYYQLVVMGGLIIAAVALDRLISK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11958
Length:	326 (266)
Sequences:	31422 (19625)
Seq/√Len:	1203.3

ECOLI - ALSC XYLH YPHD ARAH RBSC MGLC YTFT LSRC LSRD YJFF LIVM LIVH
BACSU - RBSC YUFP YUFQ
HALSA - Q9HR22 Q9HR23
SULSO - Q97UZ9 Q97UZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_V	233_V	3.857	1.00
117_G	229_I	3.497	1.00
117_G	233_V	3.060	1.00
93_V	115_V	2.914	1.00
121_A	229_I	2.872	1.00
210_K	224_I	2.735	1.00
97_L	111_G	2.644	1.00
71_F	282_V	2.506	1.00
203_I	227_V	2.472	1.00
64_V	183_S	2.464	1.00
219_D	222_F	2.433	1.00
129_W	221_K	2.387	1.00
222_F	226_V	2.314	1.00
116_G	236_G	2.277	1.00
191_W	195_T	2.266	1.00
193_L	199_L	2.258	1.00
120_G	232_G	2.219	1.00
192_F	196_R	2.210	1.00
121_A	225_L	2.180	1.00
123_N	141_T	2.180	1.00
202_N	223_H	2.131	1.00
260_Y	293_N	2.111	1.00
125_C	129_W	2.100	1.00
189_I	193_L	2.060	1.00
199_L	226_V	2.049	1.00
104_P	107_A	1.999	1.00
88_A	149_T	1.959	1.00
66_I	261_A	1.929	1.00
94_T	112_G	1.919	1.00
113_V	237_L	1.891	1.00
106_L	110_I	1.849	1.00
188_L	192_F	1.827	1.00
116_G	232_G	1.786	1.00
109_M	240_V	1.755	1.00
94_T	240_V	1.737	1.00
67_G	282_V	1.725	1.00
97_L	101_G	1.719	1.00
60_S	290_G	1.700	1.00
206_L	223_H	1.685	1.00
73_A	231_S	1.670	1.00
143_A	146_R	1.660	1.00
124_G	225_L	1.653	1.00
72_F	190_L	1.653	1.00
205_A	213_A	1.652	1.00
198_R	202_N	1.601	1.00
60_S	287_L	1.579	1.00
96_K	100_A	1.573	1.00
64_V	286_G	1.532	1.00
98_M	108_A	1.513	1.00
156_N	159_Y	1.496	1.00
75_L	204_Y	1.487	1.00
119_L	145_F	1.477	1.00
199_L	203_I	1.453	1.00
129_W	225_L	1.445	1.00
260_Y	310_M	1.443	1.00
211_N	214_F	1.443	1.00
226_V	229_I	1.440	1.00
89_L	119_L	1.436	1.00
113_V	240_V	1.428	1.00
167_N	170_A	1.425	1.00
87_L	242_S	1.423	1.00
210_K	214_F	1.420	1.00
85_A	146_R	1.405	1.00
66_I	87_L	1.391	1.00
141_T	145_F	1.388	1.00
187_A	283_V	1.375	1.00
268_G	281_S	1.350	1.00
96_K	152_I	1.348	1.00
202_N	218_I	1.347	1.00
278_R	281_S	1.340	1.00
202_N	213_A	1.331	1.00
107_A	110_I	1.317	1.00
171_A	174_I	1.312	1.00
76_V	227_V	1.305	1.00
65_L	238_A	1.302	1.00
69_G	234_C	1.297	1.00
125_C	225_L	1.295	1.00
161_F	165_F	1.270	1.00
72_F	227_V	1.270	1.00
64_V	283_V	1.264	1.00
213_A	218_I	1.258	1.00
268_G	285_G	1.250	1.00
56_I	290_G	1.233	1.00
225_L	229_I	1.216	1.00
68_M	190_L	1.216	1.00
218_I	223_H	1.216	1.00
206_L	220_V	1.215	1.00
110_I	114_L	1.213	1.00
65_L	241_V	1.208	1.00
128_N	221_K	1.207	1.00
108_A	112_G	1.194	1.00
112_G	116_G	1.194	1.00
78_G	224_I	1.193	1.00
83_V	235_A	1.189	1.00
206_L	213_A	1.187	1.00
52_N	294_N	1.185	1.00
56_I	291_T	1.185	1.00
172_S	175_G	1.175	1.00
78_G	134_P	1.167	1.00
70_E	265_A	1.166	1.00
96_K	153_S	1.164	1.00
93_V	97_L	1.159	1.00
70_E	261_A	1.150	1.00
114_L	117_G	1.139	1.00
67_G	264_S	1.133	1.00
195_T	204_Y	1.128	1.00
229_I	233_V	1.124	1.00
294_N	297_N	1.119	1.00
186_V	234_C	1.111	1.00
78_G	228_F	1.106	1.00
161_F	164_D	1.105	1.00
191_W	196_R	1.105	1.00
232_G	236_G	1.096	1.00
60_S	286_G	1.086	1.00
214_F	221_K	1.085	1.00
169_F	172_S	1.077	1.00
160_G	164_D	1.075	1.00
94_T	244_A	1.070	1.00
67_G	265_A	1.069	1.00
69_G	83_V	1.068	1.00
181_I	185_I	1.067	1.00
85_A	145_F	1.056	1.00
86_I	119_L	1.052	1.00
188_L	191_W	1.048	1.00
126_L	137_I	1.045	1.00
226_V	230_I	1.041	1.00
92_M	149_T	1.041	1.00
252_L	255_M	1.040	1.00
170_A	173_V	1.035	1.00
223_H	226_V	1.035	1.00
257_F	260_Y	1.033	1.00
118_A	121_A	1.026	1.00
214_F	220_V	1.023	1.00
305_Y	308_V	1.010	1.00
187_A	234_C	1.010	1.00
293_N	310_M	1.009	1.00
203_I	223_H	1.009	1.00
125_C	130_T	1.004	1.00
54_T	58_V	1.001	1.00
185_I	189_I	0.997	1.00
95_A	99_L	0.995	1.00
190_L	230_I	0.994	1.00
75_L	277_G	0.987	1.00
112_G	240_V	0.987	1.00
117_G	236_G	0.986	1.00
146_R	150_L	0.986	1.00
264_S	286_G	0.985	1.00
92_M	251_P	0.984	1.00
264_S	285_G	0.983	1.00
97_L	100_A	0.982	1.00
160_G	163_F	0.981	1.00
128_N	138_T	0.981	1.00
71_F	265_A	0.974	1.00
123_N	137_I	0.973	1.00
89_L	93_V	0.971	1.00
61_S	180_V	0.968	1.00
178_V	181_I	0.962	1.00
142_N	146_R	0.952	1.00
230_I	234_C	0.950	1.00
110_I	113_V	0.949	1.00
239_G	243_T	0.941	1.00
66_I	238_A	0.941	1.00
307_L	310_M	0.939	1.00
174_I	181_I	0.933	1.00
199_L	223_H	0.929	1.00
74_I	265_A	0.928	1.00
92_M	153_S	0.925	1.00
231_S	235_A	0.925	1.00
126_L	130_T	0.921	1.00
222_F	225_L	0.917	1.00
84_G	258_E	0.914	1.00
103_D	107_A	0.909	1.00
280_F	284_I	0.909	1.00
191_W	280_F	0.907	1.00
80_D	83_V	0.900	1.00
131_G	210_K	0.894	1.00
295_G	299_L	0.894	1.00
85_A	142_N	0.890	1.00
87_L	254_G	0.888	1.00
97_L	108_A	0.887	1.00
296_L	309_V	0.884	1.00
70_E	83_V	0.883	1.00
162_S	165_F	0.882	1.00
169_F	173_V	0.881	1.00
256_G	260_Y	0.879	1.00
59_Q	63_T	0.879	1.00
90_S	116_G	0.878	1.00
67_G	286_G	0.871	1.00
76_V	203_I	0.870	1.00
71_F	277_G	0.869	1.00
103_D	111_G	0.869	1.00
62_V	238_A	0.868	1.00
86_I	235_A	0.868	1.00
184_L	188_L	0.866	1.00
289_I	310_M	0.866	1.00
151_V	305_Y	0.865	1.00
90_S	112_G	0.864	1.00
201_R	204_Y	0.863	1.00
64_V	187_A	0.863	1.00
75_L	195_T	0.861	1.00
183_S	187_A	0.861	1.00
212_S	216_S	0.856	1.00
93_V	96_K	0.855	1.00
167_N	172_S	0.851	1.00
170_A	174_I	0.851	1.00
51_N	54_T	0.851	1.00
87_L	257_F	0.846	1.00
114_L	118_A	0.845	1.00
65_L	183_S	0.845	1.00
127_V	137_I	0.833	1.00
242_S	246_L	0.833	1.00
174_I	177_P	0.831	1.00
91_G	243_T	0.830	1.00
220_V	224_I	0.828	1.00
84_G	256_G	0.828	1.00
235_A	239_G	0.823	1.00
121_A	125_C	0.822	1.00
73_A	80_D	0.821	1.00
53_I	295_G	0.821	1.00
206_L	227_V	0.819	1.00
194_T	203_I	0.814	1.00
221_K	224_I	0.809	1.00
122_I	126_L	0.808	1.00
179_P	241_V	0.807	1.00
72_F	230_I	0.807	1.00
209_N	212_S	0.806	1.00
94_T	98_M	0.804	1.00
113_V	236_G	0.803	1.00
107_A	111_G	0.800	1.00
68_M	186_V	0.800	1.00
68_M	282_V	0.800	1.00
168_F	171_A	0.798	1.00
193_L	196_R	0.790	1.00
147_G	150_L	0.789	1.00
124_G	128_N	0.787	1.00
90_S	239_G	0.784	1.00
118_A	122_I	0.782	1.00
294_N	298_I	0.780	1.00
276_K	280_F	0.780	1.00
316_A	320_L	0.776	1.00
278_R	282_V	0.776	1.00
178_V	182_F	0.774	1.00
221_K	225_L	0.771	1.00
72_F	194_T	0.771	1.00
66_I	83_V	0.763	1.00
189_I	192_F	0.757	1.00
167_N	171_A	0.757	1.00
206_L	224_I	0.755	1.00
91_G	249_A	0.755	1.00
86_I	116_G	0.755	1.00
95_A	249_A	0.751	1.00
66_I	69_G	0.749	1.00
180_V	184_L	0.747	1.00
210_K	220_V	0.745	1.00
113_V	117_G	0.740	1.00
89_L	116_G	0.732	1.00
91_G	253_A	0.732	1.00
233_V	236_G	0.730	1.00
124_G	129_W	0.728	1.00
94_T	108_A	0.723	1.00
233_V	237_L	0.719	1.00
282_V	286_G	0.716	1.00
166_V	169_F	0.714	1.00
55_Q	59_Q	0.713	1.00
87_L	238_A	0.713	1.00
109_M	113_V	0.712	1.00
65_L	186_V	0.708	1.00
202_N	219_D	0.703	1.00
90_S	115_V	0.703	1.00
69_G	235_A	0.702	1.00
166_V	170_A	0.700	1.00
81_L	262_I	0.699	1.00
52_N	298_I	0.693	1.00
144_I	148_I	0.690	1.00
128_N	225_L	0.688	1.00
63_T	260_Y	0.685	1.00
287_L	291_T	0.683	1.00
97_L	103_D	0.672	1.00
98_M	244_A	0.672	1.00
78_G	210_K	0.667	1.00
73_A	228_F	0.665	1.00
263_A	314_I	0.663	1.00
286_G	290_G	0.663	1.00
312_G	316_A	0.662	1.00
89_L	145_F	0.659	1.00
56_I	294_N	0.659	1.00
71_F	75_L	0.658	1.00
192_F	195_T	0.658	1.00
304_Y	307_L	0.656	1.00
63_T	264_S	0.654	1.00
71_F	279_I	0.648	1.00
57_F	61_S	0.648	1.00
146_R	255_M	0.648	1.00
134_P	228_F	0.647	1.00
50_T	53_I	0.641	1.00
74_I	262_I	0.641	1.00
159_Y	162_S	0.639	1.00
60_S	64_V	0.639	1.00
116_G	120_G	0.635	1.00
187_A	191_W	0.634	1.00
86_I	123_N	0.633	1.00
56_I	60_S	0.632	1.00
86_I	90_S	0.632	1.00
267_I	285_G	0.623	1.00
86_I	232_G	0.621	1.00
193_L	226_V	0.618	1.00
230_I	233_V	0.618	1.00
158_V	161_F	0.616	1.00
220_V	223_H	0.616	1.00
63_T	286_G	0.613	1.00
163_F	166_V	0.613	1.00
236_G	240_V	0.612	1.00
186_V	237_L	0.612	1.00
146_R	258_E	0.610	1.00
55_Q	294_N	0.610	1.00
97_L	115_V	0.608	1.00
61_S	183_S	0.608	1.00
120_G	229_I	0.606	1.00
293_N	306_Q	0.605	1.00
88_A	254_G	0.604	1.00
57_F	60_S	0.600	1.00
86_I	145_F	0.597	1.00
310_M	314_I	0.595	1.00
58_V	245_R	0.591	1.00
190_L	234_C	0.591	1.00
58_V	180_V	0.591	1.00
90_S	235_A	0.590	1.00
190_L	194_T	0.590	1.00
127_V	134_P	0.588	1.00
76_V	224_I	0.588	1.00
199_L	230_I	0.586	1.00
303_T	306_Q	0.586	1.00
101_G	104_P	0.585	1.00
105_F	244_A	0.584	1.00
173_V	181_I	0.583	1.00
232_G	235_A	0.582	1.00
62_V	242_S	0.579	1.00
62_V	245_R	0.578	1.00
69_G	73_A	0.577	1.00
139_L	143_A	0.576	1.00
264_S	282_V	0.576	1.00
94_T	239_G	0.575	1.00
306_Q	310_M	0.574	1.00
296_L	301_V	0.572	1.00
242_S	257_F	0.571	1.00
72_F	193_L	0.569	1.00
224_I	227_V	0.567	1.00
185_I	188_L	0.565	1.00
76_V	206_L	0.562	1.00
63_T	257_F	0.562	1.00
93_V	111_G	0.561	1.00
51_N	55_Q	0.561	1.00
193_L	197_M	0.561	1.00
97_L	102_V	0.560	1.00
86_I	120_G	0.560	1.00
173_V	177_P	0.560	1.00
117_G	120_G	0.559	1.00
68_M	187_A	0.559	1.00
142_N	258_E	0.559	1.00
50_T	54_T	0.553	1.00
82_S	123_N	0.550	1.00
127_V	228_F	0.548	1.00
213_A	220_V	0.547	1.00
229_I	232_G	0.545	1.00
211_N	215_Y	0.544	1.00
143_A	147_G	0.544	1.00
131_G	221_K	0.544	1.00
113_V	116_G	0.542	1.00
265_A	282_V	0.541	1.00
260_Y	307_L	0.540	1.00
182_F	186_V	0.540	1.00
264_S	289_I	0.538	1.00
96_K	99_L	0.537	1.00
93_V	116_G	0.528	1.00
191_W	278_R	0.527	1.00
53_I	57_F	0.525	1.00
138_T	142_N	0.525	1.00
68_M	191_W	0.524	1.00
267_I	317_A	0.523	1.00
167_N	173_V	0.522	1.00
64_V	68_M	0.519	1.00
204_Y	207_G	0.519	1.00
105_F	109_M	0.517	1.00
204_Y	277_G	0.517	1.00
117_G	232_G	0.517	1.00
268_G	282_V	0.515	1.00
139_L	142_N	0.515	1.00
186_V	190_L	0.515	1.00
59_Q	294_N	0.514	1.00
77_A	210_K	0.514	1.00
93_V	112_G	0.513	1.00
301_V	305_Y	0.510	1.00
166_V	175_G	0.510	1.00
160_G	165_F	0.510	1.00
89_L	115_V	0.509	1.00
182_F	185_I	0.503	1.00
182_F	237_L	0.503	1.00
250_E	253_A	0.501	1.00
309_V	312_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g1uA	2	0.8067	97.5	0.869	Contact Map
2nq2A	2	0.8313	97.2	0.876	Contact Map
2qi9A	2	0.8742	96.9	0.882	Contact Map
3d31C	2	0.7147	24.3	0.949	Contact Map
2onkC	2	0.7147	23.6	0.949	Contact Map
2cfqA	1	0.6104	17.9	0.952	Contact Map
1u7gA	3	0.5859	17.8	0.952	Contact Map
4ytpC	1	0.3466	14.3	0.954	Contact Map
1zoyC	1	0.3466	10.8	0.957	Contact Map
3dh4A	3	0.1503	9.6	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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