GREMLIN Database
ALSE - D-allulose-6-phosphate 3-epimerase
UniProt: P32719 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11957
Length: 231 (210)
Sequences: 4360 (2676)
Seq/√Len: 184.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_K17_E3.4051.00
161_R168_Y3.4041.00
181_Y192_F2.7591.00
169_E190_D2.6101.00
176_C184_L2.3931.00
158_K162_E2.3201.00
84_I107_M2.2841.00
37_H67_T2.2591.00
62_C81_A2.2271.00
74_A101_E2.1521.00
120_E123_K2.1511.00
132_I157_L2.1421.00
148_P183_K2.1351.00
146_F151_L2.1301.00
202_H209_A2.0621.00
68_R71_D2.0501.00
85_T112_I2.0451.00
96_F128_K1.9721.00
110_G131_K1.9421.00
31_I49_V1.9241.00
182_E186_A1.9071.00
123_K156_E1.8781.00
77_A107_M1.8071.00
134_V150_M1.8001.00
59_P83_F1.7741.00
116_E138_D1.7701.00
88_P121_A1.7691.00
159_A163_R1.7651.00
70_Q91_I1.7561.00
152_D155_A1.7461.00
86_L95_A1.7461.00
74_A78_R1.7191.00
74_A105_H1.6981.00
27_D214_T1.6941.00
136_T150_M1.6691.00
101_E104_R1.6681.00
185_M192_F1.6551.00
89_E117_T1.6481.00
85_T131_K1.6461.00
119_V157_L1.6121.00
158_K161_R1.5981.00
204_E208_E1.5981.00
103_R109_V1.5941.00
28_Y191_V1.5711.00
177_N180_T1.5081.00
70_Q98_L1.5081.00
114_N138_D1.4801.00
169_E191_V1.4651.00
67_T92_N1.4641.00
123_K160_W1.4601.00
31_I60_L1.4551.00
180_T184_L1.4451.00
134_V157_L1.4411.00
50_S78_R1.3911.00
13_L16_K1.3891.00
94_Q97_R1.3781.00
53_K82_D1.3711.00
178_Q197_S1.3631.00
49_V60_L1.3571.00
4_S191_V1.3531.00
151_L183_K1.3501.00
53_K60_L1.3491.00
103_R130_D1.3491.00
161_R190_D1.3391.00
37_H68_R1.3291.00
23_D58_K1.3151.00
208_E212_I1.2941.00
100_D104_R1.2881.00
95_A125_Y1.2871.00
111_L129_A1.2841.00
28_Y169_E1.2841.00
83_F108_K1.2761.00
4_S28_Y1.2641.00
119_V124_Y1.2441.00
19_I52_V1.2361.00
171_E193_I1.2331.00
13_L55_L1.2321.00
120_E156_E1.2311.00
95_A111_L1.2221.00
206_I211_R1.2211.00
20_E23_D1.2001.00
109_V130_D1.1911.00
100_D128_K1.1661.00
211_R215_A1.1641.00
77_A105_H1.1581.00
73_I105_H1.1551.00
99_I129_A1.1351.00
183_K186_A1.1331.00
34_M39_V1.1311.00
86_L98_L1.1231.00
83_F131_K1.1231.00
38_F89_E1.1201.00
7_L29_F1.1191.00
28_Y83_F1.1161.00
160_W164_E1.1161.00
29_F58_K1.1061.00
101_E105_H1.1051.00
98_L101_E1.0941.00
102_I109_V1.0901.00
8_M142_A1.0871.00
178_Q212_I1.0551.00
95_A116_E1.0521.00
44_L48_F1.0501.00
88_P95_A1.0501.00
124_Y156_E1.0471.00
61_D85_T1.0441.00
99_I128_K1.0421.00
78_R105_H1.0391.00
161_R166_L1.0281.00
11_D14_K1.0261.00
136_T146_F1.0161.00
70_Q101_E1.0070.99
7_L31_I0.9980.99
99_I103_R0.9960.99
46_P75_Q0.9910.99
194_V197_S0.9770.99
202_H205_N0.9760.99
56_A60_L0.9740.99
155_A159_A0.9740.99
126_I166_L0.9730.99
99_I125_Y0.9700.99
75_Q78_R0.9680.99
194_V199_L0.9660.99
129_A132_I0.9660.99
99_I109_V0.9650.99
27_D59_P0.9600.99
155_A186_A0.9590.99
22_I58_K0.9570.99
161_R170_I0.9570.99
111_L125_Y0.9550.99
31_I44_L0.9520.99
13_L51_Q0.9470.99
208_E211_R0.9450.99
53_K56_A0.9440.99
108_K169_E0.9410.99
19_I29_F0.9400.99
17_E20_E0.9370.99
38_F117_T0.9210.99
85_T110_G0.9210.99
127_H164_E0.9190.99
47_F50_S0.9190.99
209_A212_I0.9180.99
184_L192_F0.9180.99
159_A162_E0.9150.99
151_L187_A0.9140.99
86_L99_I0.9120.99
3_I210_W0.9090.99
171_E191_V0.9040.99
172_V189_A0.9030.99
47_F51_Q0.9020.99
119_V160_W0.9010.99
189_A192_F0.8990.99
94_Q138_D0.8940.99
15_F48_F0.8930.99
96_F149_E0.8880.99
21_F205_N0.8840.99
88_P122_M0.8840.99
154_L172_V0.8740.98
52_V60_L0.8710.98
77_A84_I0.8670.98
9_C43_T0.8660.98
119_V134_V0.8640.98
22_I29_F0.8620.98
88_P119_V0.8600.98
66_V72_Y0.8590.98
158_K168_Y0.8530.98
181_Y185_M0.8520.98
41_N141_F0.8430.98
42_L76_L0.8430.98
10_M15_F0.8400.98
50_S54_K0.8350.98
64_L76_L0.8330.98
91_I98_L0.8250.98
205_N209_A0.8240.98
115_P137_V0.8220.98
157_L170_I0.8180.98
33_I76_L0.8160.98
156_E160_W0.8110.98
127_H149_E0.8110.98
71_D75_Q0.8040.97
33_I49_V0.7970.97
154_L170_I0.7920.97
160_W163_R0.7890.97
204_E209_A0.7870.97
155_A187_A0.7800.97
86_L91_I0.7770.97
14_K18_Q0.7770.97
37_H71_D0.7760.97
96_F100_D0.7720.97
181_Y213_M0.7650.97
43_T46_P0.7650.97
9_C196_T0.7580.96
119_V156_E0.7550.96
22_I57_T0.7530.96
197_S209_A0.7490.96
150_M153_K0.7470.96
18_Q205_N0.7460.96
152_D156_E0.7450.96
124_Y127_H0.7360.96
151_L184_L0.7330.96
95_A98_L0.7270.95
16_K20_E0.7260.95
88_P113_L0.7140.95
131_K191_V0.7090.95
51_Q54_K0.7080.95
117_T121_A0.7080.95
154_L189_A0.7060.95
178_Q209_A0.6970.94
5_P26_A0.6950.94
10_M18_Q0.6930.94
122_M132_I0.6900.94
75_Q79_A0.6890.94
111_L122_M0.6880.94
28_Y131_K0.6810.93
157_L161_R0.6790.93
123_K164_E0.6790.93
142_A175_S0.6780.93
142_A195_G0.6760.93
172_V176_C0.6720.93
148_P152_D0.6690.93
8_M175_S0.6670.93
102_I107_M0.6670.93
73_I98_L0.6550.92
147_I150_M0.6540.92
64_L84_I0.6500.92
145_P179_A0.6470.92
100_D103_R0.6440.91
129_A168_Y0.6360.91
65_M87_H0.6350.91
122_M125_Y0.6340.91
24_S205_N0.6340.91
165_G168_Y0.6260.90
25_H211_R0.6230.90
11_D18_Q0.6220.90
19_I58_K0.6190.90
161_R164_E0.6120.89
178_Q213_M0.6100.89
66_V76_L0.6040.89
94_Q125_Y0.6040.89
50_S75_Q0.6020.88
46_P79_A0.6010.88
86_L111_L0.5990.88
115_P139_P0.5990.88
94_Q116_E0.5970.88
156_E159_A0.5960.88
177_N197_S0.5950.88
59_P82_D0.5950.88
73_I77_A0.5950.88
43_T49_V0.5840.87
137_V144_Q0.5810.87
74_A104_R0.5750.86
164_E168_Y0.5740.86
4_S171_E0.5700.86
197_S212_I0.5700.86
197_S213_M0.5670.85
42_L45_S0.5670.85
126_I157_L0.5660.85
160_W166_L0.5660.85
29_F56_A0.5630.85
127_H166_L0.5620.85
126_I168_Y0.5610.85
128_K149_E0.5600.85
199_L210_W0.5590.85
42_L66_V0.5560.84
151_L180_T0.5550.84
136_T172_V0.5540.84
126_I161_R0.5530.84
82_D107_M0.5520.84
113_L134_V0.5480.83
44_L47_F0.5480.83
31_I62_C0.5470.83
145_P177_N0.5460.83
31_I52_V0.5450.83
157_L164_E0.5440.83
21_F29_F0.5390.82
132_I168_Y0.5380.82
68_R92_N0.5370.82
137_V142_A0.5340.82
96_F138_D0.5330.82
20_E205_N0.5320.82
141_F144_Q0.5320.82
163_R166_L0.5300.81
41_N144_Q0.5300.81
103_R128_K0.5300.81
3_I213_M0.5290.81
199_L205_N0.5280.81
9_C18_Q0.5250.81
36_G72_Y0.5240.81
170_I191_V0.5230.80
73_I101_E0.5230.80
120_E124_Y0.5220.80
112_I134_V0.5210.80
43_T47_F0.5210.80
121_A124_Y0.5200.80
97_R101_E0.5180.80
73_I102_I0.5180.80
176_C192_F0.5170.80
142_A194_V0.5170.80
180_T213_M0.5170.80
119_V153_K0.5150.79
12_L48_F0.5140.79
56_A59_P0.5140.79
5_P40_P0.5090.79
110_G129_A0.5090.79
146_F150_M0.5080.79
37_H46_P0.5080.79
36_G42_L0.5070.78
82_D108_K0.5060.78
100_D138_D0.5040.78
76_L81_A0.5040.78
83_F171_E0.5040.78
209_A213_M0.5020.78
18_Q204_E0.5020.78
172_V184_L0.5000.77
67_T71_D0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cu2A 2 0.9134 100 0.37 Contact Map
3ctlA 4 0.9394 100 0.421 Contact Map
4muzA 2 0.8874 100 0.476 Contact Map
3inpA 6 0.9307 100 0.484 Contact Map
1dbtA 2 0.9004 100 0.485 Contact Map
2yyuA 2 0.8831 100 0.487 Contact Map
4df0A 2 0.8398 100 0.487 Contact Map
3w07A 2 0.8918 100 0.488 Contact Map
1eixA 2 0.8788 100 0.492 Contact Map
1rpxA 4 0.9437 100 0.493 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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