ALSK - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ALSK - D-allose kinase

UniProt:	P32718	Sequences: MQKQHNVVAGVDMGATHIRFCLRTAEGETLHCEKKRTAEVIAPGLVSGIGEMIDEQLRRFNARCHGLVMGFPALVSKDKRTIISTPNLPLTAADLYDLADKLENTLNCPVEFSRDVNLQLSWDVVENRLTQQLVLAAYLGTGMGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCACGNPGCLETNCSGMALRRWYEQQPRNYPLRDLFVHAENAPFVQSLLENAARAIATSINLFDPDAVILGGGVMDMPAFPRETLVAMTQKYLRRPLPHQVVRFIAASSSDFNGAQGAAILAHQRFLPQFCAKAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11956
Length:	309 (287)
Sequences:	13348 (10086)
Seq/√Len:	595.3

ECOLI - ALSK MLC YPHH NAGC NANK NAGK MAK
BACSU - XYLR GLK SCRK
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_D	100_D	3.338	1.00
113_S	155_T	3.134	1.00
50_G	105_T	3.032	1.00
32_C	286_F	2.866	1.00
24_T	28_E	2.850	1.00
241_A	279_I	2.619	1.00
224_E	262_M	2.618	1.00
131_Q	241_A	2.570	1.00
23_R	293_A	2.513	1.00
21_C	289_A	2.458	1.00
184_L	229_A	2.359	1.00
220_Q	258_T	2.240	1.00
120_L	146_A	2.232	1.00
158_H	238_D	2.223	1.00
76_S	79_K	2.218	1.00
129_L	134_V	2.215	1.00
136_A	245_G	2.174	1.00
135_L	233_S	2.169	1.00
119_Q	136_A	2.165	1.00
99_A	103_E	2.159	1.00
33_E	55_E	2.112	1.00
20_F	52_M	2.097	1.00
66_G	296_A	2.097	1.00
178_C	183_C	1.975	1.00
113_S	118_L	1.954	1.00
113_S	117_N	1.931	1.00
9_A	53_I	1.888	1.00
120_L	148_W	1.883	1.00
126_E	294_I	1.862	1.00
157_A	240_D	1.862	1.00
167_I	232_T	1.858	1.00
133_L	240_D	1.845	1.00
96_Y	101_K	1.844	1.00
100_D	104_N	1.844	1.00
149_M	154_W	1.840	1.00
47_S	105_T	1.834	1.00
196_W	221_S	1.825	1.00
256_R	260_V	1.814	1.00
262_M	265_K	1.806	1.00
230_I	242_V	1.781	1.00
263_T	278_F	1.744	1.00
54_D	105_T	1.740	1.00
175_H	181_P	1.738	1.00
101_K	104_N	1.687	1.00
227_A	262_M	1.685	1.00
33_E	59_R	1.673	1.00
122_W	283_S	1.668	1.00
31_H	59_R	1.665	1.00
176_C	183_C	1.664	1.00
67_L	106_L	1.656	1.00
223_L	258_T	1.647	1.00
139_L	226_A	1.643	1.00
70_G	118_L	1.637	1.00
241_A	277_R	1.634	1.00
137_A	230_I	1.608	1.00
20_F	56_Q	1.589	1.00
132_Q	240_D	1.569	1.00
252_P	256_R	1.567	1.00
132_Q	150_N	1.542	1.00
131_Q	240_D	1.542	1.00
124_V	134_V	1.537	1.00
212_H	216_A	1.517	1.00
260_V	264_Q	1.512	1.00
38_A	48_G	1.491	1.00
69_M	102_L	1.481	1.00
258_T	261_A	1.475	1.00
223_L	259_L	1.461	1.00
256_R	280_A	1.454	1.00
168_P	232_T	1.450	1.00
67_L	108_C	1.441	1.00
17_H	34_K	1.437	1.00
228_R	232_T	1.423	1.00
223_L	227_A	1.420	1.00
134_V	148_W	1.402	1.00
10_G	289_A	1.396	1.00
234_I	263_T	1.374	1.00
193_L	222_L	1.370	1.00
124_V	148_W	1.366	1.00
196_W	199_Q	1.360	1.00
113_S	295_L	1.358	1.00
125_V	298_Q	1.355	1.00
41_I	44_G	1.352	1.00
262_M	266_Y	1.348	1.00
176_C	179_G	1.345	1.00
211_V	214_E	1.341	1.00
50_G	54_D	1.339	1.00
101_K	105_T	1.332	1.00
33_E	52_M	1.324	1.00
166_H	178_C	1.320	1.00
21_C	29_T	1.312	1.00
196_W	200_Q	1.311	1.00
50_G	106_L	1.309	1.00
8_V	297_H	1.308	1.00
120_L	134_V	1.307	1.00
131_Q	134_V	1.306	1.00
125_V	294_I	1.302	1.00
174_Q	195_R	1.302	1.00
11_V	20_F	1.301	1.00
234_I	242_V	1.300	1.00
197_Y	201_P	1.296	1.00
207_R	211_V	1.288	1.00
220_Q	262_M	1.273	1.00
46_V	101_K	1.266	1.00
47_S	51_E	1.261	1.00
35_K	52_M	1.255	1.00
31_H	56_Q	1.253	1.00
253_A	257_E	1.251	1.00
133_L	149_M	1.221	1.00
171_D	228_R	1.214	1.00
143_M	188_C	1.211	1.00
170_G	228_R	1.200	1.00
52_M	55_E	1.185	1.00
54_D	106_L	1.174	1.00
135_L	145_F	1.174	1.00
10_G	292_A	1.174	1.00
258_T	262_M	1.170	1.00
7_V	30_L	1.161	1.00
97_D	101_K	1.154	1.00
11_V	49_I	1.149	1.00
197_Y	218_F	1.148	1.00
35_K	48_G	1.148	1.00
70_G	288_G	1.143	1.00
166_H	176_C	1.140	1.00
23_R	29_T	1.136	1.00
196_W	218_F	1.134	1.00
35_K	55_E	1.130	1.00
117_N	153_P	1.128	1.00
55_E	59_R	1.126	1.00
233_S	236_L	1.116	1.00
133_L	154_W	1.110	1.00
230_I	244_L	1.103	1.00
208_D	211_V	1.097	1.00
118_L	292_A	1.095	1.00
134_V	243_I	1.087	1.00
213_A	219_V	1.073	1.00
9_A	64_C	1.072	1.00
48_G	51_E	1.067	1.00
64_C	108_C	1.067	1.00
145_F	164_L	1.064	1.00
11_V	53_I	1.062	1.00
120_L	136_A	1.051	1.00
35_K	51_E	1.044	1.00
81_T	97_D	1.040	1.00
135_L	147_V	1.036	1.00
19_R	34_K	1.036	1.00
261_A	265_K	1.030	1.00
124_V	151_G	1.028	1.00
17_H	190_G	1.027	1.00
24_T	30_L	1.026	1.00
147_V	154_W	1.017	1.00
223_L	262_M	1.014	1.00
220_Q	261_A	1.013	1.00
174_Q	187_N	1.010	1.00
22_L	56_Q	1.010	1.00
257_E	260_V	1.009	1.00
116_V	138_Y	1.004	1.00
29_T	32_C	0.988	1.00
43_P	101_K	0.986	1.00
210_F	219_V	0.984	1.00
243_I	279_I	0.982	1.00
132_Q	151_G	0.979	1.00
166_H	183_C	0.970	1.00
205_P	208_D	0.969	1.00
10_G	68_V	0.967	1.00
111_E	296_A	0.966	1.00
134_V	241_A	0.965	1.00
257_E	261_A	0.964	1.00
15_A	141_T	0.963	1.00
253_A	280_A	0.958	1.00
174_Q	196_W	0.955	1.00
119_Q	288_G	0.952	1.00
228_R	266_Y	0.951	1.00
250_D	285_D	0.946	1.00
244_L	249_M	0.944	1.00
42_A	101_K	0.943	1.00
51_E	55_E	0.937	1.00
250_D	280_A	0.935	1.00
126_E	290_Q	0.930	1.00
81_T	95_L	0.929	1.00
147_V	162_G	0.926	1.00
264_Q	275_V	0.925	1.00
114_R	163_E	0.922	1.00
221_S	225_N	0.920	1.00
10_G	293_A	0.918	1.00
123_D	127_N	0.912	1.00
174_Q	186_T	0.911	1.00
227_A	266_Y	0.907	1.00
103_E	110_V	0.906	1.00
252_P	280_A	0.901	1.00
213_A	254_F	0.900	1.00
224_E	228_R	0.896	1.00
20_F	33_E	0.894	1.00
174_Q	199_Q	0.892	1.00
8_V	296_A	0.890	1.00
243_I	281_A	0.886	1.00
42_A	96_Y	0.885	1.00
135_L	239_P	0.884	1.00
131_Q	277_R	0.881	1.00
50_G	101_K	0.875	1.00
91_T	95_L	0.875	1.00
117_N	163_E	0.869	1.00
133_L	157_A	0.869	1.00
22_L	60_F	0.868	1.00
76_S	83_I	0.867	1.00
147_V	237_F	0.865	1.00
102_L	110_V	0.865	1.00
208_D	212_H	0.863	1.00
18_I	37_T	0.863	1.00
80_R	99_A	0.860	1.00
133_L	150_N	0.859	1.00
256_R	259_L	0.842	1.00
169_L	225_N	0.838	1.00
135_L	242_V	0.836	1.00
103_E	107_N	0.828	1.00
44_G	47_S	0.826	1.00
103_E	109_P	0.823	1.00
210_F	251_M	0.823	1.00
57_L	108_C	0.814	1.00
21_C	32_C	0.809	1.00
23_R	290_Q	0.806	1.00
13_M	49_I	0.806	1.00
71_F	82_I	0.804	1.00
234_I	276_V	0.801	1.00
150_N	154_W	0.801	1.00
231_A	266_Y	0.798	1.00
19_R	32_C	0.798	1.00
118_L	295_L	0.797	1.00
230_I	263_T	0.792	1.00
126_E	283_S	0.789	1.00
194_R	198_E	0.786	1.00
156_G	161_A	0.785	1.00
7_V	63_R	0.779	1.00
279_I	282_S	0.779	1.00
170_G	187_N	0.778	1.00
71_F	75_V	0.776	1.00
156_G	238_D	0.776	1.00
68_V	296_A	0.769	1.00
44_G	48_G	0.767	1.00
192_A	195_R	0.759	1.00
187_N	225_N	0.758	1.00
129_L	243_I	0.757	1.00
85_T	90_L	0.757	1.00
183_C	186_T	0.756	1.00
80_R	103_E	0.754	1.00
128_R	279_I	0.754	1.00
13_M	71_F	0.754	1.00
252_P	257_E	0.753	1.00
224_E	266_Y	0.748	1.00
231_A	235_N	0.744	1.00
180_N	266_Y	0.742	1.00
51_E	54_D	0.738	1.00
121_S	124_V	0.734	1.00
54_D	57_L	0.734	1.00
235_N	268_R	0.733	1.00
48_G	52_M	0.733	1.00
127_N	130_T	0.732	1.00
218_F	222_L	0.730	1.00
156_G	162_G	0.728	1.00
68_V	118_L	0.727	1.00
74_L	85_T	0.723	1.00
47_S	50_G	0.721	1.00
196_W	222_L	0.720	1.00
13_M	18_I	0.719	1.00
201_P	204_Y	0.714	1.00
99_A	112_F	0.712	1.00
244_L	278_F	0.708	1.00
227_A	231_A	0.708	1.00
100_D	103_E	0.702	1.00
46_V	96_Y	0.702	1.00
136_A	243_I	0.700	1.00
128_R	282_S	0.698	1.00
87_N	177_A	0.698	1.00
46_V	105_T	0.696	1.00
85_T	88_L	0.696	1.00
200_Q	218_F	0.695	1.00
218_F	221_S	0.694	1.00
167_I	229_A	0.693	1.00
168_P	228_R	0.691	1.00
7_V	22_L	0.691	1.00
284_S	287_N	0.689	1.00
137_A	145_F	0.688	1.00
123_D	281_A	0.687	1.00
54_D	58_R	0.687	1.00
116_V	146_A	0.685	1.00
31_H	60_F	0.683	1.00
230_I	259_L	0.682	1.00
111_E	295_L	0.680	1.00
38_A	44_G	0.677	1.00
283_S	290_Q	0.675	1.00
194_R	209_L	0.675	1.00
168_P	171_D	0.672	1.00
169_L	229_A	0.671	1.00
260_V	277_R	0.669	1.00
104_N	107_N	0.663	1.00
176_C	180_N	0.661	1.00
197_Y	209_L	0.661	1.00
142_G	185_E	0.661	1.00
190_G	194_R	0.660	1.00
56_Q	60_F	0.659	1.00
261_A	264_Q	0.657	1.00
192_A	196_W	0.657	1.00
123_D	282_S	0.657	1.00
99_A	110_V	0.656	1.00
137_A	233_S	0.654	1.00
14_G	141_T	0.654	1.00
184_L	222_L	0.654	1.00
227_A	263_T	0.654	1.00
198_E	201_P	0.651	1.00
128_R	243_I	0.651	1.00
224_E	265_K	0.648	1.00
122_W	294_I	0.647	1.00
11_V	67_L	0.647	1.00
115_D	144_G	0.644	1.00
226_A	259_L	0.644	1.00
231_A	263_T	0.642	1.00
138_Y	288_G	0.642	1.00
169_L	187_N	0.642	1.00
294_I	298_Q	0.642	1.00
254_F	258_T	0.641	1.00
16_T	141_T	0.638	1.00
180_N	183_C	0.638	1.00
283_S	287_N	0.636	1.00
20_F	35_K	0.634	1.00
52_M	56_Q	0.632	1.00
193_L	209_L	0.631	1.00
232_T	235_N	0.630	1.00
127_N	279_I	0.629	1.00
8_V	25_A	0.627	1.00
125_V	297_H	0.623	1.00
9_A	57_L	0.622	1.00
43_P	47_S	0.621	1.00
171_D	224_E	0.618	1.00
66_G	109_P	0.615	1.00
123_D	283_S	0.614	1.00
176_C	182_G	0.614	1.00
82_I	86_P	0.614	1.00
195_R	199_Q	0.612	1.00
140_G	247_G	0.612	1.00
286_F	290_Q	0.612	1.00
223_L	255_P	0.610	1.00
170_G	174_Q	0.610	1.00
193_L	218_F	0.608	1.00
18_I	49_I	0.608	1.00
19_R	289_A	0.607	1.00
114_R	142_G	0.606	1.00
188_C	222_L	0.606	1.00
157_A	239_P	0.600	1.00
213_A	223_L	0.599	1.00
154_W	237_F	0.596	1.00
8_V	66_G	0.596	1.00
197_Y	200_Q	0.595	1.00
170_G	225_N	0.595	1.00
193_L	248_V	0.594	1.00
18_I	35_K	0.594	1.00
102_L	106_L	0.593	1.00
13_M	45_L	0.590	1.00
286_F	289_A	0.588	1.00
77_K	155_T	0.588	1.00
84_S	91_T	0.587	1.00
255_P	258_T	0.586	1.00
55_E	58_R	0.584	1.00
137_A	164_L	0.584	1.00
161_A	238_D	0.582	1.00
206_L	210_F	0.581	1.00
9_A	22_L	0.580	1.00
152_A	298_Q	0.579	1.00
198_E	202_R	0.577	1.00
148_W	153_P	0.574	1.00
245_G	281_A	0.574	1.00
142_G	163_E	0.573	1.00
66_G	108_C	0.568	1.00
251_M	254_F	0.565	1.00
50_G	102_L	0.564	1.00
190_G	248_V	0.563	1.00
57_L	64_C	0.563	1.00
119_Q	138_Y	0.562	1.00
196_W	225_N	0.561	1.00
191_M	195_R	0.561	1.00
179_G	183_C	0.560	1.00
33_E	56_Q	0.558	0.99
209_L	213_A	0.558	0.99
12_D	19_R	0.558	0.99
222_L	255_P	0.558	0.99
75_V	82_I	0.555	0.99
22_L	64_C	0.555	0.99
172_M	224_E	0.555	0.99
194_R	206_L	0.555	0.99
146_A	153_P	0.554	0.99
176_C	186_T	0.553	0.99
14_G	247_G	0.552	0.99
254_F	257_E	0.547	0.99
119_Q	245_G	0.546	0.99
219_V	223_L	0.545	0.99
13_M	69_M	0.545	0.99
83_I	95_L	0.544	0.99
290_Q	293_A	0.544	0.99
185_E	189_S	0.541	0.99
66_G	111_E	0.541	0.99
121_S	295_L	0.540	0.99
224_E	258_T	0.539	0.99
157_A	238_D	0.538	0.99
239_P	242_V	0.537	0.99
149_M	152_A	0.537	0.99
294_I	297_H	0.533	0.99
194_R	197_Y	0.532	0.99
167_I	233_S	0.531	0.99
142_G	165_G	0.529	0.99
259_L	263_T	0.528	0.99
57_L	60_F	0.528	0.99
34_K	285_D	0.527	0.99
210_F	213_A	0.526	0.99
114_R	117_N	0.525	0.99
168_P	180_N	0.521	0.99
130_T	151_G	0.517	0.99
8_V	65_H	0.517	0.99
158_H	275_V	0.516	0.99
253_A	256_R	0.515	0.99
107_N	110_V	0.513	0.99
227_A	259_L	0.512	0.99
166_H	179_G	0.511	0.99
252_P	258_T	0.510	0.99
169_L	184_L	0.510	0.99
167_I	235_N	0.508	0.99
68_V	295_L	0.507	0.99
14_G	17_H	0.504	0.99
188_C	226_A	0.503	0.99
80_R	97_D	0.503	0.99
47_S	101_K	0.502	0.99
144_G	163_E	0.501	0.99
158_H	240_D	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3htvA	2	0.9029	100	0.18	Contact Map
1z05A	2	0.9838	100	0.218	Contact Map
1z6rA	3	0.9871	100	0.222	Contact Map
2hoeA	2	0.9353	100	0.257	Contact Map
2ap1A	2	0.932	100	0.258	Contact Map
2qm1A	2	0.9644	100	0.259	Contact Map
3vovA	3	0.9385	100	0.261	Contact Map
4db3A	2	0.9417	100	0.266	Contact Map
3vglA	3	0.9288	100	0.266	Contact Map
2yhwA	2	0.9288	100	0.267	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.