GREMLIN Database
ALSK - D-allose kinase
UniProt: P32718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11956
Length: 309 (287)
Sequences: 13348 (10086)
Seq/√Len: 595.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_D100_D3.3381.00
113_S155_T3.1341.00
50_G105_T3.0321.00
32_C286_F2.8661.00
24_T28_E2.8501.00
241_A279_I2.6191.00
224_E262_M2.6181.00
131_Q241_A2.5701.00
23_R293_A2.5131.00
21_C289_A2.4581.00
184_L229_A2.3591.00
220_Q258_T2.2401.00
120_L146_A2.2321.00
158_H238_D2.2231.00
76_S79_K2.2181.00
129_L134_V2.2151.00
136_A245_G2.1741.00
135_L233_S2.1691.00
119_Q136_A2.1651.00
99_A103_E2.1591.00
33_E55_E2.1121.00
20_F52_M2.0971.00
66_G296_A2.0971.00
178_C183_C1.9751.00
113_S118_L1.9541.00
113_S117_N1.9311.00
9_A53_I1.8881.00
120_L148_W1.8831.00
126_E294_I1.8621.00
157_A240_D1.8621.00
167_I232_T1.8581.00
133_L240_D1.8451.00
96_Y101_K1.8441.00
100_D104_N1.8441.00
149_M154_W1.8401.00
47_S105_T1.8341.00
196_W221_S1.8251.00
256_R260_V1.8141.00
262_M265_K1.8061.00
230_I242_V1.7811.00
263_T278_F1.7441.00
54_D105_T1.7401.00
175_H181_P1.7381.00
101_K104_N1.6871.00
227_A262_M1.6851.00
33_E59_R1.6731.00
122_W283_S1.6681.00
31_H59_R1.6651.00
176_C183_C1.6641.00
67_L106_L1.6561.00
223_L258_T1.6471.00
139_L226_A1.6431.00
70_G118_L1.6371.00
241_A277_R1.6341.00
137_A230_I1.6081.00
20_F56_Q1.5891.00
132_Q240_D1.5691.00
252_P256_R1.5671.00
132_Q150_N1.5421.00
131_Q240_D1.5421.00
124_V134_V1.5371.00
212_H216_A1.5171.00
260_V264_Q1.5121.00
38_A48_G1.4911.00
69_M102_L1.4811.00
258_T261_A1.4751.00
223_L259_L1.4611.00
256_R280_A1.4541.00
168_P232_T1.4501.00
67_L108_C1.4411.00
17_H34_K1.4371.00
228_R232_T1.4231.00
223_L227_A1.4201.00
134_V148_W1.4021.00
10_G289_A1.3961.00
234_I263_T1.3741.00
193_L222_L1.3701.00
124_V148_W1.3661.00
196_W199_Q1.3601.00
113_S295_L1.3581.00
125_V298_Q1.3551.00
41_I44_G1.3521.00
262_M266_Y1.3481.00
176_C179_G1.3451.00
211_V214_E1.3411.00
50_G54_D1.3391.00
101_K105_T1.3321.00
33_E52_M1.3241.00
166_H178_C1.3201.00
21_C29_T1.3121.00
196_W200_Q1.3111.00
50_G106_L1.3091.00
8_V297_H1.3081.00
120_L134_V1.3071.00
131_Q134_V1.3061.00
125_V294_I1.3021.00
174_Q195_R1.3021.00
11_V20_F1.3011.00
234_I242_V1.3001.00
197_Y201_P1.2961.00
207_R211_V1.2881.00
220_Q262_M1.2731.00
46_V101_K1.2661.00
47_S51_E1.2611.00
35_K52_M1.2551.00
31_H56_Q1.2531.00
253_A257_E1.2511.00
133_L149_M1.2211.00
171_D228_R1.2141.00
143_M188_C1.2111.00
170_G228_R1.2001.00
52_M55_E1.1851.00
54_D106_L1.1741.00
135_L145_F1.1741.00
10_G292_A1.1741.00
258_T262_M1.1701.00
7_V30_L1.1611.00
97_D101_K1.1541.00
11_V49_I1.1491.00
197_Y218_F1.1481.00
35_K48_G1.1481.00
70_G288_G1.1431.00
166_H176_C1.1401.00
23_R29_T1.1361.00
196_W218_F1.1341.00
35_K55_E1.1301.00
117_N153_P1.1281.00
55_E59_R1.1261.00
233_S236_L1.1161.00
133_L154_W1.1101.00
230_I244_L1.1031.00
208_D211_V1.0971.00
118_L292_A1.0951.00
134_V243_I1.0871.00
213_A219_V1.0731.00
9_A64_C1.0721.00
48_G51_E1.0671.00
64_C108_C1.0671.00
145_F164_L1.0641.00
11_V53_I1.0621.00
120_L136_A1.0511.00
35_K51_E1.0441.00
81_T97_D1.0401.00
135_L147_V1.0361.00
19_R34_K1.0361.00
261_A265_K1.0301.00
124_V151_G1.0281.00
17_H190_G1.0271.00
24_T30_L1.0261.00
147_V154_W1.0171.00
223_L262_M1.0141.00
220_Q261_A1.0131.00
174_Q187_N1.0101.00
22_L56_Q1.0101.00
257_E260_V1.0091.00
116_V138_Y1.0041.00
29_T32_C0.9881.00
43_P101_K0.9861.00
210_F219_V0.9841.00
243_I279_I0.9821.00
132_Q151_G0.9791.00
166_H183_C0.9701.00
205_P208_D0.9691.00
10_G68_V0.9671.00
111_E296_A0.9661.00
134_V241_A0.9651.00
257_E261_A0.9641.00
15_A141_T0.9631.00
253_A280_A0.9581.00
174_Q196_W0.9551.00
119_Q288_G0.9521.00
228_R266_Y0.9511.00
250_D285_D0.9461.00
244_L249_M0.9441.00
42_A101_K0.9431.00
51_E55_E0.9371.00
250_D280_A0.9351.00
126_E290_Q0.9301.00
81_T95_L0.9291.00
147_V162_G0.9261.00
264_Q275_V0.9251.00
114_R163_E0.9221.00
221_S225_N0.9201.00
10_G293_A0.9181.00
123_D127_N0.9121.00
174_Q186_T0.9111.00
227_A266_Y0.9071.00
103_E110_V0.9061.00
252_P280_A0.9011.00
213_A254_F0.9001.00
224_E228_R0.8961.00
20_F33_E0.8941.00
174_Q199_Q0.8921.00
8_V296_A0.8901.00
243_I281_A0.8861.00
42_A96_Y0.8851.00
135_L239_P0.8841.00
131_Q277_R0.8811.00
50_G101_K0.8751.00
91_T95_L0.8751.00
117_N163_E0.8691.00
133_L157_A0.8691.00
22_L60_F0.8681.00
76_S83_I0.8671.00
147_V237_F0.8651.00
102_L110_V0.8651.00
208_D212_H0.8631.00
18_I37_T0.8631.00
80_R99_A0.8601.00
133_L150_N0.8591.00
256_R259_L0.8421.00
169_L225_N0.8381.00
135_L242_V0.8361.00
103_E107_N0.8281.00
44_G47_S0.8261.00
103_E109_P0.8231.00
210_F251_M0.8231.00
57_L108_C0.8141.00
21_C32_C0.8091.00
23_R290_Q0.8061.00
13_M49_I0.8061.00
71_F82_I0.8041.00
234_I276_V0.8011.00
150_N154_W0.8011.00
231_A266_Y0.7981.00
19_R32_C0.7981.00
118_L295_L0.7971.00
230_I263_T0.7921.00
126_E283_S0.7891.00
194_R198_E0.7861.00
156_G161_A0.7851.00
7_V63_R0.7791.00
279_I282_S0.7791.00
170_G187_N0.7781.00
71_F75_V0.7761.00
156_G238_D0.7761.00
68_V296_A0.7691.00
44_G48_G0.7671.00
192_A195_R0.7591.00
187_N225_N0.7581.00
129_L243_I0.7571.00
85_T90_L0.7571.00
183_C186_T0.7561.00
80_R103_E0.7541.00
128_R279_I0.7541.00
13_M71_F0.7541.00
252_P257_E0.7531.00
224_E266_Y0.7481.00
231_A235_N0.7441.00
180_N266_Y0.7421.00
51_E54_D0.7381.00
121_S124_V0.7341.00
54_D57_L0.7341.00
235_N268_R0.7331.00
48_G52_M0.7331.00
127_N130_T0.7321.00
218_F222_L0.7301.00
156_G162_G0.7281.00
68_V118_L0.7271.00
74_L85_T0.7231.00
47_S50_G0.7211.00
196_W222_L0.7201.00
13_M18_I0.7191.00
201_P204_Y0.7141.00
99_A112_F0.7121.00
244_L278_F0.7081.00
227_A231_A0.7081.00
100_D103_E0.7021.00
46_V96_Y0.7021.00
136_A243_I0.7001.00
128_R282_S0.6981.00
87_N177_A0.6981.00
46_V105_T0.6961.00
85_T88_L0.6961.00
200_Q218_F0.6951.00
218_F221_S0.6941.00
167_I229_A0.6931.00
168_P228_R0.6911.00
7_V22_L0.6911.00
284_S287_N0.6891.00
137_A145_F0.6881.00
123_D281_A0.6871.00
54_D58_R0.6871.00
116_V146_A0.6851.00
31_H60_F0.6831.00
230_I259_L0.6821.00
111_E295_L0.6801.00
38_A44_G0.6771.00
283_S290_Q0.6751.00
194_R209_L0.6751.00
168_P171_D0.6721.00
169_L229_A0.6711.00
260_V277_R0.6691.00
104_N107_N0.6631.00
176_C180_N0.6611.00
197_Y209_L0.6611.00
142_G185_E0.6611.00
190_G194_R0.6601.00
56_Q60_F0.6591.00
261_A264_Q0.6571.00
192_A196_W0.6571.00
123_D282_S0.6571.00
99_A110_V0.6561.00
137_A233_S0.6541.00
14_G141_T0.6541.00
184_L222_L0.6541.00
227_A263_T0.6541.00
198_E201_P0.6511.00
128_R243_I0.6511.00
224_E265_K0.6481.00
122_W294_I0.6471.00
11_V67_L0.6471.00
115_D144_G0.6441.00
226_A259_L0.6441.00
231_A263_T0.6421.00
138_Y288_G0.6421.00
169_L187_N0.6421.00
294_I298_Q0.6421.00
254_F258_T0.6411.00
16_T141_T0.6381.00
180_N183_C0.6381.00
283_S287_N0.6361.00
20_F35_K0.6341.00
52_M56_Q0.6321.00
193_L209_L0.6311.00
232_T235_N0.6301.00
127_N279_I0.6291.00
8_V25_A0.6271.00
125_V297_H0.6231.00
9_A57_L0.6221.00
43_P47_S0.6211.00
171_D224_E0.6181.00
66_G109_P0.6151.00
123_D283_S0.6141.00
176_C182_G0.6141.00
82_I86_P0.6141.00
195_R199_Q0.6121.00
140_G247_G0.6121.00
286_F290_Q0.6121.00
223_L255_P0.6101.00
170_G174_Q0.6101.00
193_L218_F0.6081.00
18_I49_I0.6081.00
19_R289_A0.6071.00
114_R142_G0.6061.00
188_C222_L0.6061.00
157_A239_P0.6001.00
213_A223_L0.5991.00
154_W237_F0.5961.00
8_V66_G0.5961.00
197_Y200_Q0.5951.00
170_G225_N0.5951.00
193_L248_V0.5941.00
18_I35_K0.5941.00
102_L106_L0.5931.00
13_M45_L0.5901.00
286_F289_A0.5881.00
77_K155_T0.5881.00
84_S91_T0.5871.00
255_P258_T0.5861.00
55_E58_R0.5841.00
137_A164_L0.5841.00
161_A238_D0.5821.00
206_L210_F0.5811.00
9_A22_L0.5801.00
152_A298_Q0.5791.00
198_E202_R0.5771.00
148_W153_P0.5741.00
245_G281_A0.5741.00
142_G163_E0.5731.00
66_G108_C0.5681.00
251_M254_F0.5651.00
50_G102_L0.5641.00
190_G248_V0.5631.00
57_L64_C0.5631.00
119_Q138_Y0.5621.00
196_W225_N0.5611.00
191_M195_R0.5611.00
179_G183_C0.5601.00
33_E56_Q0.5580.99
209_L213_A0.5580.99
12_D19_R0.5580.99
222_L255_P0.5580.99
75_V82_I0.5550.99
22_L64_C0.5550.99
172_M224_E0.5550.99
194_R206_L0.5550.99
146_A153_P0.5540.99
176_C186_T0.5530.99
14_G247_G0.5520.99
254_F257_E0.5470.99
119_Q245_G0.5460.99
219_V223_L0.5450.99
13_M69_M0.5450.99
83_I95_L0.5440.99
290_Q293_A0.5440.99
185_E189_S0.5410.99
66_G111_E0.5410.99
121_S295_L0.5400.99
224_E258_T0.5390.99
157_A238_D0.5380.99
239_P242_V0.5370.99
149_M152_A0.5370.99
294_I297_H0.5330.99
194_R197_Y0.5320.99
167_I233_S0.5310.99
142_G165_G0.5290.99
259_L263_T0.5280.99
57_L60_F0.5280.99
34_K285_D0.5270.99
210_F213_A0.5260.99
114_R117_N0.5250.99
168_P180_N0.5210.99
130_T151_G0.5170.99
8_V65_H0.5170.99
158_H275_V0.5160.99
253_A256_R0.5150.99
107_N110_V0.5130.99
227_A259_L0.5120.99
166_H179_G0.5110.99
252_P258_T0.5100.99
169_L184_L0.5100.99
167_I235_N0.5080.99
68_V295_L0.5070.99
14_G17_H0.5040.99
188_C226_A0.5030.99
80_R97_D0.5030.99
47_S101_K0.5020.99
144_G163_E0.5010.99
158_H240_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3htvA 2 0.9029 100 0.18 Contact Map
1z05A 2 0.9838 100 0.218 Contact Map
1z6rA 3 0.9871 100 0.222 Contact Map
2hoeA 2 0.9353 100 0.257 Contact Map
2ap1A 2 0.932 100 0.258 Contact Map
2qm1A 2 0.9644 100 0.259 Contact Map
3vovA 3 0.9385 100 0.261 Contact Map
4db3A 2 0.9417 100 0.266 Contact Map
3vglA 3 0.9288 100 0.266 Contact Map
2yhwA 2 0.9288 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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