GREMLIN Database
MDTN - Multidrug resistance protein MdtN
UniProt: P32716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11954
Length: 343 (272)
Sequences: 25401 (19725)
Seq/√Len: 1196.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_E78_R3.1551.00
71_K216_D2.8481.00
75_L210_T2.8001.00
63_A78_R2.3911.00
140_T157_A2.3861.00
78_R210_T2.3701.00
134_T138_R2.3571.00
158_R162_R2.3431.00
92_E203_K2.3301.00
140_T149_V2.3171.00
264_P278_E2.3071.00
81_P85_E2.2231.00
161_Q165_E2.1751.00
54_E208_M2.1741.00
71_K74_D2.1361.00
69_A218_R2.0821.00
141_E158_R2.0521.00
63_A75_L2.0301.00
141_E145_K2.0071.00
266_T278_E2.0051.00
99_D196_E1.9761.00
75_L212_R1.9681.00
144_L151_A1.9651.00
134_T165_E1.9511.00
130_A161_Q1.9261.00
72_Q216_D1.9211.00
134_T161_Q1.9201.00
88_L199_I1.9071.00
266_T276_T1.8971.00
132_Q136_T1.8911.00
151_A155_D1.8741.00
153_D156_R1.8681.00
95_L199_I1.8581.00
88_L203_K1.8571.00
137_L154_V1.8241.00
28_F31_W1.8201.00
220_I240_I1.8181.00
137_L161_Q1.7631.00
137_L141_E1.7601.00
144_L154_V1.7521.00
88_L92_E1.6711.00
89_A92_E1.6521.00
95_L99_D1.6481.00
130_A165_E1.6361.00
85_E89_A1.6281.00
130_A134_T1.5881.00
130_A168_L1.5851.00
137_L158_R1.5821.00
65_T68_Q1.5701.00
44_A247_V1.5631.00
90_K198_D1.5561.00
162_R165_E1.5441.00
249_A318_V1.5431.00
92_E199_I1.5421.00
96_A99_D1.5411.00
87_N90_K1.5401.00
87_N201_L1.5281.00
282_D300_L1.5241.00
95_L196_E1.5231.00
85_E206_L1.5191.00
154_V158_R1.5191.00
264_P280_K1.5031.00
136_T156_R1.4961.00
165_E169_N1.4901.00
131_K135_D1.4841.00
27_V31_W1.4781.00
156_R160_A1.4771.00
60_V80_D1.4601.00
50_D235_P1.4601.00
201_L205_H1.4531.00
200_A203_K1.4491.00
59_I77_F1.4411.00
69_A242_T1.4401.00
59_I224_T1.4241.00
199_I203_K1.3841.00
247_V316_F1.3711.00
193_A196_E1.3671.00
84_Y209_A1.3421.00
87_N205_H1.3401.00
75_L78_R1.3391.00
141_E154_V1.3351.00
139_R155_D1.3281.00
57_G79_I1.3231.00
213_A239_L1.3121.00
142_P146_E1.3091.00
204_L208_M1.3041.00
77_F211_V1.2991.00
160_A163_A1.2921.00
133_A164_A1.2821.00
219_V237_F1.2771.00
203_K207_E1.2711.00
241_D244_H1.2641.00
60_V78_R1.2631.00
152_E156_R1.2621.00
231_S234_R1.2561.00
138_R142_P1.2551.00
64_V74_D1.2461.00
275_K309_W1.2451.00
279_G299_G1.2421.00
48_T238_T1.2371.00
196_E200_A1.2261.00
89_A200_A1.2221.00
61_E226_V1.2191.00
252_R255_D1.2121.00
88_L206_L1.2021.00
266_T321_M1.2011.00
47_D241_D1.1961.00
138_R141_E1.1911.00
92_E96_A1.1861.00
95_L192_R1.1791.00
39_T319_K1.1791.00
56_S232_A1.1661.00
50_D238_T1.1631.00
97_A101_Q1.1621.00
248_I298_G1.1571.00
248_I296_V1.1471.00
246_Y298_G1.1351.00
90_K94_S1.1321.00
268_R276_T1.1201.00
136_T152_E1.1171.00
142_P145_K1.1161.00
76_L237_F1.1141.00
249_A299_G1.1101.00
131_K162_R1.1101.00
99_D192_R1.1091.00
131_K134_T1.1091.00
94_S97_A1.1031.00
135_D155_D1.1021.00
289_L292_D1.1011.00
155_D158_R1.0871.00
221_S238_T1.0861.00
158_R161_Q1.0841.00
34_D37_P1.0801.00
280_K302_K1.0791.00
132_Q159_T1.0781.00
222_L225_S1.0701.00
268_R319_K1.0661.00
81_P209_A1.0621.00
54_E58_R1.0611.00
53_P211_V1.0551.00
140_T153_D1.0481.00
81_P210_T1.0481.00
160_A164_A1.0461.00
98_L101_Q1.0451.00
25_A29_V1.0401.00
167_D170_A1.0331.00
94_S198_D1.0301.00
217_G239_L1.0111.00
62_L226_V1.0111.00
49_I215_F1.0081.00
66_D221_S1.0081.00
28_F32_R1.0061.00
250_N296_V1.0041.00
251_F259_I1.0021.00
44_A245_W1.0011.00
230_A236_I0.9981.00
136_T140_T0.9941.00
163_A167_D0.9921.00
266_T319_K0.9911.00
82_R204_L0.9871.00
26_L30_I0.9851.00
68_Q74_D0.9851.00
93_A197_A0.9821.00
132_Q156_R0.9791.00
260_R263_T0.9661.00
247_V267_I0.9651.00
64_V237_F0.9641.00
269_L316_F0.9621.00
65_T222_L0.9581.00
39_T317_P0.9521.00
77_F236_I0.9511.00
272_D277_F0.9491.00
94_S98_L0.9491.00
69_A216_D0.9471.00
58_R229_F0.9461.00
77_F237_F0.9451.00
86_A204_L0.9411.00
213_A216_D0.9411.00
27_V30_I0.9401.00
94_S194_A0.9391.00
59_I230_A0.9371.00
204_L207_E0.9331.00
12_K16_L0.9291.00
265_A299_G0.9191.00
267_I279_G0.9191.00
56_S231_S0.9121.00
24_V28_F0.9091.00
86_A197_A0.9051.00
29_V33_V0.9011.00
62_L77_F0.8921.00
288_V295_L0.8921.00
157_A160_A0.8901.00
135_D138_R0.8891.00
283_S298_G0.8861.00
91_A94_S0.8851.00
91_A195_V0.8821.00
167_D171_V0.8771.00
78_R81_P0.8741.00
91_A202_T0.8731.00
147_G151_A0.8711.00
29_V32_R0.8671.00
30_I33_V0.8571.00
223_K235_P0.8461.00
77_F222_L0.8461.00
87_N202_T0.8461.00
60_V63_A0.8441.00
88_L202_T0.8371.00
64_V219_V0.8361.00
198_D201_L0.8361.00
223_K238_T0.8361.00
246_Y300_L0.8321.00
60_V81_P0.8251.00
54_E83_P0.8191.00
153_D157_A0.8171.00
272_D275_K0.8161.00
64_V222_L0.8141.00
44_A310_V0.8121.00
70_V76_L0.8101.00
149_V153_D0.8101.00
87_N91_A0.8051.00
269_L272_D0.8041.00
192_R196_E0.7971.00
26_L29_V0.7951.00
246_Y282_D0.7951.00
215_F239_L0.7941.00
268_R274_G0.7921.00
247_V318_V0.7901.00
202_T205_H0.7871.00
164_A168_L0.7861.00
331_R335_S0.7841.00
267_I301_P0.7841.00
194_A198_D0.7821.00
72_Q214_P0.7741.00
197_A200_A0.7731.00
297_L302_K0.7731.00
164_A167_D0.7731.00
83_P87_N0.7721.00
16_L20_A0.7711.00
13_F16_L0.7711.00
84_Y202_T0.7701.00
280_K300_L0.7661.00
311_R314_Q0.7651.00
51_V214_P0.7641.00
133_A160_A0.7551.00
222_L237_F0.7541.00
13_F17_L0.7541.00
83_P205_H0.7541.00
244_H300_L0.7521.00
132_Q135_D0.7471.00
140_T152_E0.7461.00
207_E212_R0.7411.00
259_I281_V0.7361.00
91_A95_L0.7301.00
53_P77_F0.7291.00
144_L149_V0.7261.00
96_A193_A0.7221.00
90_K201_L0.7171.00
321_M324_K0.7151.00
53_P230_A0.7151.00
136_T157_A0.7141.00
92_E95_L0.7141.00
58_R80_D0.7141.00
56_S229_F0.7111.00
265_A279_G0.7101.00
151_A154_V0.7061.00
281_V299_G0.7061.00
235_P238_T0.7061.00
46_A244_H0.7031.00
207_E210_T0.7031.00
218_R242_T0.7031.00
297_L303_V0.6981.00
42_A316_F0.6981.00
85_E88_L0.6981.00
53_P236_I0.6961.00
37_P319_K0.6901.00
81_P206_L0.6871.00
151_A158_R0.6871.00
64_V68_Q0.6871.00
20_A24_V0.6861.00
44_A316_F0.6861.00
47_D225_S0.6821.00
40_N249_A0.6791.00
144_L147_G0.6791.00
46_A246_Y0.6781.00
132_Q160_A0.6721.00
159_T163_A0.6681.00
136_T160_A0.6661.00
325_P328_E0.6661.00
225_S228_Q0.6651.00
66_D222_L0.6631.00
303_V308_N0.6631.00
268_R317_P0.6631.00
196_E199_I0.6621.00
86_A89_A0.6621.00
55_V84_Y0.6591.00
249_A320_I0.6581.00
138_R161_Q0.6561.00
91_A199_I0.6541.00
141_E144_L0.6521.00
97_A167_D0.6491.00
51_V237_F0.6461.00
133_A157_A0.6451.00
139_R152_E0.6411.00
34_D38_S0.6411.00
84_Y205_H0.6401.00
205_H208_M0.6391.00
53_P56_S0.6381.00
261_S284_I0.6371.00
55_V208_M0.6361.00
245_W312_V0.6351.00
14_P18_V0.6341.00
50_D228_Q0.6331.00
255_D258_N0.6311.00
166_A169_N0.6291.00
195_V198_D0.6281.00
285_G296_V0.6271.00
162_R166_A0.6221.00
69_A308_N0.6221.00
150_S153_D0.6191.00
270_M317_P0.6181.00
200_A204_L0.6161.00
261_S282_D0.6121.00
55_V205_H0.6101.00
165_E168_L0.6101.00
288_V297_L0.6081.00
148_F152_E0.6031.00
91_A198_D0.6021.00
295_L298_G0.5991.00
88_L91_A0.5991.00
86_A201_L0.5991.00
262_G280_K0.5981.00
264_P321_M0.5971.00
130_A164_A0.5951.00
62_L222_L0.5951.00
48_T240_I0.5951.00
297_L301_P0.5931.00
82_R207_E0.5931.00
49_I239_L0.5901.00
89_A197_A0.5901.00
201_L204_L0.5881.00
256_L295_L0.5851.00
149_V154_V0.5851.00
53_P79_I0.5821.00
216_D243_R0.5811.00
63_A74_D0.5801.00
211_V236_I0.5791.00
195_V199_I0.5771.00
83_P204_L0.5751.00
26_L31_W0.5721.00
297_L300_L0.5711.00
40_N251_F0.5701.00
135_D159_T0.5681.00
279_G301_P0.5651.00
133_A136_T0.5651.00
98_L192_R0.5601.00
244_H302_K0.5591.00
52_V229_F0.5551.00
206_L209_A0.5541.00
49_I214_P0.5511.00
46_A241_D0.5501.00
25_A28_F0.5501.00
281_V297_L0.5491.00
25_A31_W0.5491.00
83_P208_M0.5481.00
98_L195_V0.5461.00
15_A19_V0.5441.00
23_L27_V0.5441.00
60_V226_V0.5421.00
155_D159_T0.5421.00
303_V307_I0.5381.00
152_E155_D0.5381.00
16_L19_V0.5361.00
140_T144_L0.5351.00
70_V213_A0.5351.00
136_T139_R0.5341.00
202_T206_L0.5311.00
18_V25_A0.5301.00
265_A320_I0.5291.00
295_L301_P0.5281.00
198_D202_T0.5271.00
304_S307_I0.5261.00
84_Y88_L0.5251.00
289_L294_G0.5231.00
221_S235_P0.5211.00
22_A25_A0.5201.00
27_V32_R0.5201.00
89_A93_A0.5191.00
93_A96_A0.5161.00
40_N320_I0.5141.00
86_A90_K0.5131.00
135_D151_A0.5121.00
220_I285_G0.5111.00
40_N255_D0.5111.00
59_I236_I0.5091.00
17_L21_L0.5081.00
298_G303_V0.5071.00
130_A133_A0.5061.00
318_V321_M0.5061.00
249_A265_A0.5061.00
143_L148_F0.5061.00
98_L171_V0.5051.00
293_G297_L0.5041.00
14_P17_L0.5031.00
134_T137_L0.5031.00
250_N289_L0.5021.00
52_V235_P0.5011.00
94_S195_V0.5011.00
143_L150_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tkoB 1 0.8338 100 0.312 Contact Map
3fppA 3 0.7668 100 0.364 Contact Map
4dk0A 5 0.8105 100 0.367 Contact Map
2f1mA 2 0.6764 100 0.387 Contact Map
3lnnA 6 0.8251 100 0.421 Contact Map
1vf7A 5 0.656 100 0.427 Contact Map
4l8jA 2 0.7522 100 0.442 Contact Map
3ne5B 3 0.6793 100 0.452 Contact Map
4kkuA 1 0.5743 100 0.521 Contact Map
2k32A 1 0.3353 99.8 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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