MDTN - ECOLI - GREMLIN Contacts

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MDTN - Multidrug resistance protein MdtN

UniProt:	P32716	Sequences: MESTPKKAPRSKFPALLVVALALVALVFVIWRVDSAPSTNDAYASADTIDVVPEVSGRIVELAVTDNQAVKQGDLLFRIDPRPYEANLAKAEASLAALDKQIMLTQRSVDAQQFGADSVNATVEKARAAAKQATDTLRRTEPLLKEGFVSAEDVDRARTAQRAAEADLNAVLLQAQSAASAVSGVDALVAQRAAVEADIALTKLHLEMATVRAPFDGRVISLKTSVGQFASAMRPIFTLIDTRHWYVIANFRETDLKNIRSGTPATIRLMSDSGKTFEGKVDSIGYGVLPDDGGLVLGGLPKVSRSINWVRVAQRFPVKIMVDKPDPEMFRIGASAVANLEPQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11954
Length:	343 (272)
Sequences:	25401 (19725)
Seq/√Len:	1196.0

ECOLI - MDTN YHII EMRK EMRA YBHG YIBH YIAV YDHJ MACA AAEA ACRA ACRE MDTE MDTA CUSB
BACSU - YVRP YKNX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_E	78_R	3.155	1.00
71_K	216_D	2.848	1.00
75_L	210_T	2.800	1.00
63_A	78_R	2.391	1.00
140_T	157_A	2.386	1.00
78_R	210_T	2.370	1.00
134_T	138_R	2.357	1.00
158_R	162_R	2.343	1.00
92_E	203_K	2.330	1.00
140_T	149_V	2.317	1.00
264_P	278_E	2.307	1.00
81_P	85_E	2.223	1.00
161_Q	165_E	2.175	1.00
54_E	208_M	2.174	1.00
71_K	74_D	2.136	1.00
69_A	218_R	2.082	1.00
141_E	158_R	2.052	1.00
63_A	75_L	2.030	1.00
141_E	145_K	2.007	1.00
266_T	278_E	2.005	1.00
99_D	196_E	1.976	1.00
75_L	212_R	1.968	1.00
144_L	151_A	1.965	1.00
134_T	165_E	1.951	1.00
130_A	161_Q	1.926	1.00
72_Q	216_D	1.921	1.00
134_T	161_Q	1.920	1.00
88_L	199_I	1.907	1.00
266_T	276_T	1.897	1.00
132_Q	136_T	1.891	1.00
151_A	155_D	1.874	1.00
153_D	156_R	1.868	1.00
95_L	199_I	1.858	1.00
88_L	203_K	1.857	1.00
137_L	154_V	1.824	1.00
28_F	31_W	1.820	1.00
220_I	240_I	1.818	1.00
137_L	161_Q	1.763	1.00
137_L	141_E	1.760	1.00
144_L	154_V	1.752	1.00
88_L	92_E	1.671	1.00
89_A	92_E	1.652	1.00
95_L	99_D	1.648	1.00
130_A	165_E	1.636	1.00
85_E	89_A	1.628	1.00
130_A	134_T	1.588	1.00
130_A	168_L	1.585	1.00
137_L	158_R	1.582	1.00
65_T	68_Q	1.570	1.00
44_A	247_V	1.563	1.00
90_K	198_D	1.556	1.00
162_R	165_E	1.544	1.00
249_A	318_V	1.543	1.00
92_E	199_I	1.542	1.00
96_A	99_D	1.541	1.00
87_N	90_K	1.540	1.00
87_N	201_L	1.528	1.00
282_D	300_L	1.524	1.00
95_L	196_E	1.523	1.00
85_E	206_L	1.519	1.00
154_V	158_R	1.519	1.00
264_P	280_K	1.503	1.00
136_T	156_R	1.496	1.00
165_E	169_N	1.490	1.00
131_K	135_D	1.484	1.00
27_V	31_W	1.478	1.00
156_R	160_A	1.477	1.00
60_V	80_D	1.460	1.00
50_D	235_P	1.460	1.00
201_L	205_H	1.453	1.00
200_A	203_K	1.449	1.00
59_I	77_F	1.441	1.00
69_A	242_T	1.440	1.00
59_I	224_T	1.424	1.00
199_I	203_K	1.384	1.00
247_V	316_F	1.371	1.00
193_A	196_E	1.367	1.00
84_Y	209_A	1.342	1.00
87_N	205_H	1.340	1.00
75_L	78_R	1.339	1.00
141_E	154_V	1.335	1.00
139_R	155_D	1.328	1.00
57_G	79_I	1.323	1.00
213_A	239_L	1.312	1.00
142_P	146_E	1.309	1.00
204_L	208_M	1.304	1.00
77_F	211_V	1.299	1.00
160_A	163_A	1.292	1.00
133_A	164_A	1.282	1.00
219_V	237_F	1.277	1.00
203_K	207_E	1.271	1.00
241_D	244_H	1.264	1.00
60_V	78_R	1.263	1.00
152_E	156_R	1.262	1.00
231_S	234_R	1.256	1.00
138_R	142_P	1.255	1.00
64_V	74_D	1.246	1.00
275_K	309_W	1.245	1.00
279_G	299_G	1.242	1.00
48_T	238_T	1.237	1.00
196_E	200_A	1.226	1.00
89_A	200_A	1.222	1.00
61_E	226_V	1.219	1.00
252_R	255_D	1.212	1.00
88_L	206_L	1.202	1.00
266_T	321_M	1.201	1.00
47_D	241_D	1.196	1.00
138_R	141_E	1.191	1.00
92_E	96_A	1.186	1.00
95_L	192_R	1.179	1.00
39_T	319_K	1.179	1.00
56_S	232_A	1.166	1.00
50_D	238_T	1.163	1.00
97_A	101_Q	1.162	1.00
248_I	298_G	1.157	1.00
248_I	296_V	1.147	1.00
246_Y	298_G	1.135	1.00
90_K	94_S	1.132	1.00
268_R	276_T	1.120	1.00
136_T	152_E	1.117	1.00
142_P	145_K	1.116	1.00
76_L	237_F	1.114	1.00
249_A	299_G	1.110	1.00
131_K	162_R	1.110	1.00
99_D	192_R	1.109	1.00
131_K	134_T	1.109	1.00
94_S	97_A	1.103	1.00
135_D	155_D	1.102	1.00
289_L	292_D	1.101	1.00
155_D	158_R	1.087	1.00
221_S	238_T	1.086	1.00
158_R	161_Q	1.084	1.00
34_D	37_P	1.080	1.00
280_K	302_K	1.079	1.00
132_Q	159_T	1.078	1.00
222_L	225_S	1.070	1.00
268_R	319_K	1.066	1.00
81_P	209_A	1.062	1.00
54_E	58_R	1.061	1.00
53_P	211_V	1.055	1.00
140_T	153_D	1.048	1.00
81_P	210_T	1.048	1.00
160_A	164_A	1.046	1.00
98_L	101_Q	1.045	1.00
25_A	29_V	1.040	1.00
167_D	170_A	1.033	1.00
94_S	198_D	1.030	1.00
217_G	239_L	1.011	1.00
62_L	226_V	1.011	1.00
49_I	215_F	1.008	1.00
66_D	221_S	1.008	1.00
28_F	32_R	1.006	1.00
250_N	296_V	1.004	1.00
251_F	259_I	1.002	1.00
44_A	245_W	1.001	1.00
230_A	236_I	0.998	1.00
136_T	140_T	0.994	1.00
163_A	167_D	0.992	1.00
266_T	319_K	0.991	1.00
82_R	204_L	0.987	1.00
26_L	30_I	0.985	1.00
68_Q	74_D	0.985	1.00
93_A	197_A	0.982	1.00
132_Q	156_R	0.979	1.00
260_R	263_T	0.966	1.00
247_V	267_I	0.965	1.00
64_V	237_F	0.964	1.00
269_L	316_F	0.962	1.00
65_T	222_L	0.958	1.00
39_T	317_P	0.952	1.00
77_F	236_I	0.951	1.00
272_D	277_F	0.949	1.00
94_S	98_L	0.949	1.00
69_A	216_D	0.947	1.00
58_R	229_F	0.946	1.00
77_F	237_F	0.945	1.00
86_A	204_L	0.941	1.00
213_A	216_D	0.941	1.00
27_V	30_I	0.940	1.00
94_S	194_A	0.939	1.00
59_I	230_A	0.937	1.00
204_L	207_E	0.933	1.00
12_K	16_L	0.929	1.00
265_A	299_G	0.919	1.00
267_I	279_G	0.919	1.00
56_S	231_S	0.912	1.00
24_V	28_F	0.909	1.00
86_A	197_A	0.905	1.00
29_V	33_V	0.901	1.00
62_L	77_F	0.892	1.00
288_V	295_L	0.892	1.00
157_A	160_A	0.890	1.00
135_D	138_R	0.889	1.00
283_S	298_G	0.886	1.00
91_A	94_S	0.885	1.00
91_A	195_V	0.882	1.00
167_D	171_V	0.877	1.00
78_R	81_P	0.874	1.00
91_A	202_T	0.873	1.00
147_G	151_A	0.871	1.00
29_V	32_R	0.867	1.00
30_I	33_V	0.857	1.00
223_K	235_P	0.846	1.00
77_F	222_L	0.846	1.00
87_N	202_T	0.846	1.00
60_V	63_A	0.844	1.00
88_L	202_T	0.837	1.00
64_V	219_V	0.836	1.00
198_D	201_L	0.836	1.00
223_K	238_T	0.836	1.00
246_Y	300_L	0.832	1.00
60_V	81_P	0.825	1.00
54_E	83_P	0.819	1.00
153_D	157_A	0.817	1.00
272_D	275_K	0.816	1.00
64_V	222_L	0.814	1.00
44_A	310_V	0.812	1.00
70_V	76_L	0.810	1.00
149_V	153_D	0.810	1.00
87_N	91_A	0.805	1.00
269_L	272_D	0.804	1.00
192_R	196_E	0.797	1.00
26_L	29_V	0.795	1.00
246_Y	282_D	0.795	1.00
215_F	239_L	0.794	1.00
268_R	274_G	0.792	1.00
247_V	318_V	0.790	1.00
202_T	205_H	0.787	1.00
164_A	168_L	0.786	1.00
331_R	335_S	0.784	1.00
267_I	301_P	0.784	1.00
194_A	198_D	0.782	1.00
72_Q	214_P	0.774	1.00
197_A	200_A	0.773	1.00
297_L	302_K	0.773	1.00
164_A	167_D	0.773	1.00
83_P	87_N	0.772	1.00
16_L	20_A	0.771	1.00
13_F	16_L	0.771	1.00
84_Y	202_T	0.770	1.00
280_K	300_L	0.766	1.00
311_R	314_Q	0.765	1.00
51_V	214_P	0.764	1.00
133_A	160_A	0.755	1.00
222_L	237_F	0.754	1.00
13_F	17_L	0.754	1.00
83_P	205_H	0.754	1.00
244_H	300_L	0.752	1.00
132_Q	135_D	0.747	1.00
140_T	152_E	0.746	1.00
207_E	212_R	0.741	1.00
259_I	281_V	0.736	1.00
91_A	95_L	0.730	1.00
53_P	77_F	0.729	1.00
144_L	149_V	0.726	1.00
96_A	193_A	0.722	1.00
90_K	201_L	0.717	1.00
321_M	324_K	0.715	1.00
53_P	230_A	0.715	1.00
136_T	157_A	0.714	1.00
92_E	95_L	0.714	1.00
58_R	80_D	0.714	1.00
56_S	229_F	0.711	1.00
265_A	279_G	0.710	1.00
151_A	154_V	0.706	1.00
281_V	299_G	0.706	1.00
235_P	238_T	0.706	1.00
46_A	244_H	0.703	1.00
207_E	210_T	0.703	1.00
218_R	242_T	0.703	1.00
297_L	303_V	0.698	1.00
42_A	316_F	0.698	1.00
85_E	88_L	0.698	1.00
53_P	236_I	0.696	1.00
37_P	319_K	0.690	1.00
81_P	206_L	0.687	1.00
151_A	158_R	0.687	1.00
64_V	68_Q	0.687	1.00
20_A	24_V	0.686	1.00
44_A	316_F	0.686	1.00
47_D	225_S	0.682	1.00
40_N	249_A	0.679	1.00
144_L	147_G	0.679	1.00
46_A	246_Y	0.678	1.00
132_Q	160_A	0.672	1.00
159_T	163_A	0.668	1.00
136_T	160_A	0.666	1.00
325_P	328_E	0.666	1.00
225_S	228_Q	0.665	1.00
66_D	222_L	0.663	1.00
303_V	308_N	0.663	1.00
268_R	317_P	0.663	1.00
196_E	199_I	0.662	1.00
86_A	89_A	0.662	1.00
55_V	84_Y	0.659	1.00
249_A	320_I	0.658	1.00
138_R	161_Q	0.656	1.00
91_A	199_I	0.654	1.00
141_E	144_L	0.652	1.00
97_A	167_D	0.649	1.00
51_V	237_F	0.646	1.00
133_A	157_A	0.645	1.00
139_R	152_E	0.641	1.00
34_D	38_S	0.641	1.00
84_Y	205_H	0.640	1.00
205_H	208_M	0.639	1.00
53_P	56_S	0.638	1.00
261_S	284_I	0.637	1.00
55_V	208_M	0.636	1.00
245_W	312_V	0.635	1.00
14_P	18_V	0.634	1.00
50_D	228_Q	0.633	1.00
255_D	258_N	0.631	1.00
166_A	169_N	0.629	1.00
195_V	198_D	0.628	1.00
285_G	296_V	0.627	1.00
162_R	166_A	0.622	1.00
69_A	308_N	0.622	1.00
150_S	153_D	0.619	1.00
270_M	317_P	0.618	1.00
200_A	204_L	0.616	1.00
261_S	282_D	0.612	1.00
55_V	205_H	0.610	1.00
165_E	168_L	0.610	1.00
288_V	297_L	0.608	1.00
148_F	152_E	0.603	1.00
91_A	198_D	0.602	1.00
295_L	298_G	0.599	1.00
88_L	91_A	0.599	1.00
86_A	201_L	0.599	1.00
262_G	280_K	0.598	1.00
264_P	321_M	0.597	1.00
130_A	164_A	0.595	1.00
62_L	222_L	0.595	1.00
48_T	240_I	0.595	1.00
297_L	301_P	0.593	1.00
82_R	207_E	0.593	1.00
49_I	239_L	0.590	1.00
89_A	197_A	0.590	1.00
201_L	204_L	0.588	1.00
256_L	295_L	0.585	1.00
149_V	154_V	0.585	1.00
53_P	79_I	0.582	1.00
216_D	243_R	0.581	1.00
63_A	74_D	0.580	1.00
211_V	236_I	0.579	1.00
195_V	199_I	0.577	1.00
83_P	204_L	0.575	1.00
26_L	31_W	0.572	1.00
297_L	300_L	0.571	1.00
40_N	251_F	0.570	1.00
135_D	159_T	0.568	1.00
279_G	301_P	0.565	1.00
133_A	136_T	0.565	1.00
98_L	192_R	0.560	1.00
244_H	302_K	0.559	1.00
52_V	229_F	0.555	1.00
206_L	209_A	0.554	1.00
49_I	214_P	0.551	1.00
46_A	241_D	0.550	1.00
25_A	28_F	0.550	1.00
281_V	297_L	0.549	1.00
25_A	31_W	0.549	1.00
83_P	208_M	0.548	1.00
98_L	195_V	0.546	1.00
15_A	19_V	0.544	1.00
23_L	27_V	0.544	1.00
60_V	226_V	0.542	1.00
155_D	159_T	0.542	1.00
303_V	307_I	0.538	1.00
152_E	155_D	0.538	1.00
16_L	19_V	0.536	1.00
140_T	144_L	0.535	1.00
70_V	213_A	0.535	1.00
136_T	139_R	0.534	1.00
202_T	206_L	0.531	1.00
18_V	25_A	0.530	1.00
265_A	320_I	0.529	1.00
295_L	301_P	0.528	1.00
198_D	202_T	0.527	1.00
304_S	307_I	0.526	1.00
84_Y	88_L	0.525	1.00
289_L	294_G	0.523	1.00
221_S	235_P	0.521	1.00
22_A	25_A	0.520	1.00
27_V	32_R	0.520	1.00
89_A	93_A	0.519	1.00
93_A	96_A	0.516	1.00
40_N	320_I	0.514	1.00
86_A	90_K	0.513	1.00
135_D	151_A	0.512	1.00
220_I	285_G	0.511	1.00
40_N	255_D	0.511	1.00
59_I	236_I	0.509	1.00
17_L	21_L	0.508	1.00
298_G	303_V	0.507	1.00
130_A	133_A	0.506	1.00
318_V	321_M	0.506	1.00
249_A	265_A	0.506	1.00
143_L	148_F	0.506	1.00
98_L	171_V	0.505	1.00
293_G	297_L	0.504	1.00
14_P	17_L	0.503	1.00
134_T	137_L	0.503	1.00
250_N	289_L	0.502	1.00
52_V	235_P	0.501	1.00
94_S	195_V	0.501	1.00
143_L	150_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4tkoB	1	0.8338	100	0.312	Contact Map
3fppA	3	0.7668	100	0.364	Contact Map
4dk0A	5	0.8105	100	0.367	Contact Map
2f1mA	2	0.6764	100	0.387	Contact Map
3lnnA	6	0.8251	100	0.421	Contact Map
1vf7A	5	0.656	100	0.427	Contact Map
4l8jA	2	0.7522	100	0.442	Contact Map
3ne5B	3	0.6793	100	0.452	Contact Map
4kkuA	1	0.5743	100	0.521	Contact Map
2k32A	1	0.3353	99.8	0.669	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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