GREMLIN Database
MDTP - Multidrug resistance outer membrane protein MdtP
UniProt: P32714 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11952
Length: 488 (403)
Sequences: 18224 (13829)
Seq/√Len: 688.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_T190_V3.0631.00
318_V380_S2.7211.00
75_R269_A2.7181.00
222_Q226_A2.5941.00
222_Q239_R2.5761.00
215_D246_D2.5671.00
208_E253_K2.4411.00
208_E249_I2.4151.00
423_R454_E2.2911.00
92_K379_A2.2661.00
88_L378_A2.2211.00
85_E386_R2.2201.00
439_S442_Q2.1651.00
89_R382_M2.1611.00
430_E434_Q2.1371.00
96_Q375_G2.1341.00
201_Y256_I2.1341.00
82_T389_Q2.1201.00
97_A172_H2.1171.00
424_F427_R2.0791.00
178_E306_A2.0631.00
232_Q424_F2.0581.00
204_L253_K2.0431.00
95_S371_A2.0261.00
229_L437_L2.0171.00
167_A317_Q1.9881.00
211_H249_I1.9711.00
243_L246_D1.9501.00
225_V235_F1.9481.00
223_S431_A1.9241.00
203_M455_M1.9181.00
202_Q205_D1.9151.00
325_F373_L1.9041.00
216_Y219_K1.9031.00
74_Q78_S1.8781.00
416_A457_L1.8481.00
215_D242_I1.8431.00
170_G309_W1.8221.00
211_H242_I1.8191.00
177_A305_Q1.8091.00
197_M256_I1.8081.00
409_N464_R1.7851.00
315_L380_S1.7611.00
211_H246_D1.7591.00
204_L256_I1.7561.00
457_L461_D1.7461.00
68_Q71_A1.7421.00
379_A382_M1.7291.00
200_S259_T1.7151.00
204_L249_I1.7031.00
423_R427_R1.6911.00
308_R387_Y1.6771.00
84_A385_E1.6511.00
90_E179_T1.6471.00
243_L417_E1.6461.00
116_R143_T1.6421.00
199_A462_S1.6381.00
332_K356_I1.6301.00
215_D219_K1.6301.00
174_A310_Y1.6121.00
171_A313_A1.6061.00
218_V239_R1.5801.00
329_F359_L1.5781.00
192_Q466_I1.5741.00
200_S252_V1.5651.00
171_A317_Q1.5651.00
365_D369_L1.5511.00
163_S166_A1.5411.00
73_I187_A1.5401.00
389_Q393_N1.5211.00
256_I260_R1.5131.00
199_A458_L1.5101.00
408_L460_L1.5071.00
160_V328_S1.5011.00
309_W312_Q1.4961.00
225_V232_Q1.4961.00
396_R400_V1.4901.00
218_V222_Q1.4851.00
99_L375_G1.4821.00
236_H424_F1.4821.00
311_V387_Y1.4801.00
218_V242_I1.4801.00
71_A74_Q1.4751.00
173_N176_L1.4731.00
387_Y391_V1.4591.00
209_Q454_E1.4551.00
318_V373_L1.4531.00
450_V454_E1.4451.00
250_V410_D1.4421.00
72_L190_V1.4411.00
192_Q470_Q1.4361.00
164_A320_S1.4301.00
177_A180_A1.4291.00
311_V384_I1.4281.00
312_Q315_L1.4211.00
97_A169_I1.4161.00
88_L385_E1.4151.00
212_D216_Y1.4141.00
92_K382_M1.4071.00
104_S165_V1.4061.00
204_L208_E1.4061.00
88_L381_N1.4041.00
209_Q212_D1.3991.00
380_S384_I1.3981.00
191_A469_I1.3891.00
381_N384_I1.3831.00
203_M459_M1.3741.00
67_P72_L1.3711.00
91_E94_Q1.3701.00
89_R92_K1.3671.00
249_I253_K1.3641.00
408_L467_Q1.3581.00
75_R267_I1.3451.00
431_A434_Q1.3411.00
306_A310_Y1.3391.00
412_R457_L1.3351.00
382_M386_R1.3271.00
174_A313_A1.3201.00
242_I246_D1.3061.00
70_D74_Q1.3031.00
227_H435_R1.2991.00
173_N309_W1.2951.00
95_S374_E1.2941.00
219_K223_S1.2941.00
197_M260_R1.2921.00
429_A438_T1.2831.00
166_A316_D1.2821.00
307_M383_M1.2821.00
77_L187_A1.2771.00
180_A183_E1.2691.00
214_I245_V1.2671.00
175_A178_E1.2651.00
167_A320_S1.2641.00
223_S226_A1.2631.00
388_N391_V1.2611.00
419_V457_L1.2581.00
316_D319_D1.2531.00
201_Y260_R1.2511.00
85_E385_E1.2471.00
205_D209_Q1.2441.00
239_R417_E1.2431.00
430_E447_R1.2391.00
318_V377_R1.2371.00
452_A456_S1.2371.00
90_E176_L1.2351.00
375_G379_A1.2301.00
181_A185_S1.2301.00
88_L91_E1.2271.00
417_E420_E1.2221.00
211_H215_D1.2211.00
426_Q430_E1.2201.00
205_D208_E1.2201.00
265_A396_R1.2171.00
416_A420_E1.2161.00
372_N375_G1.2151.00
170_G312_Q1.2131.00
405_L464_R1.2091.00
73_I77_L1.2051.00
96_Q99_L1.2001.00
258_E404_R1.2001.00
196_S466_I1.1961.00
426_Q450_V1.1951.00
419_V454_E1.1941.00
177_A309_W1.1901.00
261_E400_V1.1861.00
413_E417_E1.1841.00
99_L372_N1.1831.00
87_K179_T1.1801.00
75_R79_G1.1701.00
459_M463_R1.1651.00
207_L245_V1.1641.00
416_A461_D1.1631.00
427_R431_A1.1631.00
97_A101_D1.1601.00
190_V263_L1.1601.00
236_H239_R1.1581.00
423_R450_V1.1561.00
199_A459_M1.1561.00
208_E212_D1.1531.00
73_I191_A1.1501.00
250_V253_K1.1481.00
419_V450_V1.1471.00
432_A438_T1.1461.00
322_R373_L1.1451.00
212_D215_D1.1411.00
95_S378_A1.1401.00
445_E448_L1.1381.00
232_Q236_H1.1351.00
219_K222_Q1.1331.00
240_A422_T1.1311.00
98_D371_A1.1301.00
156_D159_G1.1231.00
374_E377_R1.1181.00
433_Y440_R1.1091.00
368_R372_N1.1071.00
94_Q172_H1.1061.00
114_L145_A1.1051.00
222_Q235_F1.1031.00
188_T473_K1.1011.00
218_V235_F1.0971.00
170_G173_N1.0961.00
189_G192_Q1.0901.00
84_A87_K1.0901.00
258_E403_T1.0881.00
364_F367_G1.0851.00
77_L183_E1.0821.00
376_T379_A1.0811.00
301_R474_S1.0791.00
179_T183_E1.0771.00
161_H165_V1.0721.00
163_S316_D1.0711.00
332_K358_G1.0681.00
91_E381_N1.0671.00
69_L191_A1.0671.00
369_L373_L1.0661.00
241_Q244_A1.0621.00
334_F354_N1.0591.00
311_V380_S1.0591.00
181_A303_D1.0591.00
170_G316_D1.0581.00
185_S189_G1.0551.00
90_E172_H1.0541.00
102_A368_R1.0521.00
76_T186_L1.0461.00
87_K91_E1.0421.00
206_L458_L1.0411.00
178_E310_Y1.0411.00
310_Y386_R1.0391.00
81_H385_E1.0221.00
71_A75_R1.0201.00
464_R468_S1.0191.00
86_A182_V1.0171.00
308_R312_Q1.0081.00
72_L267_I1.0071.00
468_S472_M1.0061.00
325_F369_L1.0051.00
154_D157_L1.0031.00
193_L259_T1.0021.00
221_H230_E1.0011.00
243_L421_A0.9981.00
411_E463_R0.9921.00
204_L252_V0.9911.00
239_R243_L0.9901.00
83_L186_L0.9861.00
202_Q461_D0.9861.00
419_V423_R0.9841.00
385_E388_N0.9841.00
373_L377_R0.9811.00
412_R464_R0.9721.00
248_Q251_A0.9671.00
257_T403_T0.9641.00
335_F351_R0.9611.00
304_L394_A0.9611.00
188_T469_I0.9601.00
307_M390_S0.9591.00
305_Q308_R0.9591.00
95_S98_D0.9581.00
410_D413_E0.9531.00
251_A255_Q0.9521.00
114_L143_T0.9501.00
325_F370_N0.9471.00
438_T442_Q0.9451.00
195_Y469_I0.9451.00
409_N413_E0.9441.00
431_A435_R0.9421.00
254_G404_R0.9391.00
383_M386_R0.9381.00
207_L252_V0.9371.00
172_H176_L0.9351.00
321_A324_L0.9331.00
420_E423_R0.9321.00
111_L148_G0.9311.00
314_S376_T0.9281.00
224_K230_E0.9261.00
462_S466_I0.9251.00
461_D465_V0.9221.00
254_G407_T0.9191.00
233_V429_A0.9141.00
253_K410_D0.9131.00
406_Q410_D0.9121.00
180_A305_Q0.9071.00
163_S319_D0.9061.00
99_L371_A0.9051.00
168_A171_A0.9041.00
301_R397_D0.9031.00
308_R391_V0.9011.00
225_V230_E0.9011.00
250_V414_M0.8981.00
196_S262_S0.8971.00
317_Q321_A0.8961.00
254_G258_E0.8951.00
415_Q460_L0.8891.00
88_L382_M0.8881.00
412_R416_A0.8881.00
235_F239_R0.8871.00
470_Q473_K0.8821.00
167_A171_A0.8811.00
101_D165_V0.8801.00
265_A389_Q0.8781.00
162_R166_A0.8781.00
202_Q458_L0.8751.00
251_A411_E0.8741.00
301_R394_A0.8731.00
197_M201_Y0.8721.00
393_N397_D0.8721.00
91_E378_A0.8701.00
200_S203_M0.8701.00
241_Q448_L0.8701.00
184_L302_P0.8671.00
104_S162_R0.8661.00
317_Q320_S0.8631.00
185_S473_K0.8631.00
239_R421_A0.8621.00
314_S317_Q0.8571.00
422_T453_E0.8541.00
307_M310_Y0.8521.00
260_R264_R0.8511.00
377_R381_N0.8511.00
223_S227_H0.8491.00
237_G445_E0.8471.00
324_L372_N0.8461.00
104_S161_H0.8461.00
87_K183_E0.8441.00
165_V169_I0.8441.00
402_G406_Q0.8411.00
100_L168_A0.8401.00
97_A165_V0.8381.00
230_E234_P0.8351.00
420_E424_F0.8311.00
412_R460_L0.8311.00
257_T260_R0.8271.00
246_D414_M0.8261.00
211_H245_V0.8261.00
109_A365_D0.8251.00
398_V471_L0.8241.00
412_R461_D0.8211.00
401_N467_Q0.8201.00
221_H238_A0.8201.00
207_L249_I0.8201.00
81_H392_L0.8171.00
321_A376_T0.8161.00
296_E299_A0.8091.00
247_K411_E0.8081.00
362_P365_D0.8071.00
163_S320_S0.8051.00
386_R390_S0.8021.00
72_L263_L0.8021.00
303_D394_A0.8011.00
197_M259_T0.7981.00
318_V322_R0.7971.00
186_L190_V0.7961.00
193_L266_L0.7951.00
105_Q366_G0.7951.00
445_E449_P0.7941.00
244_A418_R0.7931.00
214_I238_A0.7911.00
203_M207_L0.7901.00
298_L395_V0.7901.00
411_E415_Q0.7891.00
236_H421_A0.7881.00
108_V151_A0.7871.00
105_Q364_F0.7821.00
255_Q259_T0.7811.00
102_A366_G0.7811.00
195_Y462_S0.7771.00
395_V399_A0.7761.00
93_A175_A0.7741.00
413_E416_A0.7731.00
297_L398_V0.7721.00
188_T470_Q0.7681.00
231_A234_P0.7671.00
319_D322_R0.7671.00
335_F353_F0.7651.00
244_A456_S0.7641.00
85_E389_Q0.7631.00
311_V315_L0.7631.00
216_Y430_E0.7631.00
85_E382_M0.7631.00
378_A381_N0.7621.00
85_E89_R0.7621.00
207_L248_Q0.7561.00
304_L387_Y0.7561.00
261_E399_A0.7531.00
404_R470_Q0.7521.00
264_R269_A0.7491.00
408_L411_E0.7491.00
192_Q196_S0.7481.00
324_L369_L0.7451.00
379_A383_M0.7431.00
315_L319_D0.7411.00
163_S323_A0.7401.00
110_A361_L0.7391.00
84_A388_N0.7381.00
253_K257_T0.7371.00
426_Q447_R0.7351.00
154_D330_D0.7351.00
191_A472_M0.7351.00
405_L468_S0.7351.00
313_A317_Q0.7351.00
92_K96_Q0.7331.00
243_L414_M0.7311.00
406_Q409_N0.7301.00
237_G442_Q0.7261.00
401_N474_S0.7261.00
62_K70_D0.7221.00
152_G330_D0.7211.00
177_A302_P0.7201.00
258_E400_V0.7201.00
224_K229_L0.7181.00
304_L391_V0.7171.00
98_D374_E0.7141.00
388_N392_L0.7141.00
169_I173_N0.7131.00
200_S256_I0.7131.00
210_T214_I0.7131.00
262_S396_R0.7111.00
305_Q309_W0.7091.00
200_S255_Q0.7091.00
386_R389_Q0.7081.00
405_L409_N0.7071.00
465_V468_S0.7061.00
181_A306_A0.7061.00
456_S459_M0.7041.00
216_Y220_A0.7041.00
92_K378_A0.7021.00
269_A273_D0.7011.00
203_M255_Q0.7011.00
76_T267_I0.7001.00
166_A169_I0.6981.00
167_A313_A0.6951.00
405_L471_L0.6931.00
61_W70_D0.6921.00
81_H388_N0.6901.00
247_K415_Q0.6901.00
427_R430_E0.6901.00
418_R422_T0.6891.00
160_V164_A0.6861.00
295_Y299_A0.6851.00
390_S393_N0.6851.00
160_V323_A0.6841.00
330_D358_G0.6831.00
94_Q176_L0.6791.00
314_S383_M0.6791.00
171_A174_A0.6791.00
206_L455_M0.6741.00
189_G193_L0.6721.00
196_S259_T0.6721.00
244_A248_Q0.6711.00
370_N374_E0.6701.00
157_L161_H0.6701.00
196_S200_S0.6691.00
113_M146_T0.6691.00
154_D161_H0.6671.00
176_L180_A0.6661.00
174_A178_E0.6651.00
83_L183_E0.6631.00
75_R78_S0.6611.00
404_R467_Q0.6601.00
236_H428_A0.6591.00
148_G334_F0.6581.00
112_G147_V0.6551.00
296_E300_R0.6541.00
82_T85_E0.6541.00
261_E403_T0.6541.00
208_E211_H0.6541.00
384_I388_N0.6521.00
199_A203_M0.6511.00
207_L455_M0.6501.00
328_S360_K0.6501.00
407_T410_D0.6481.00
217_A440_R0.6471.00
110_A149_L0.6461.00
156_D326_Y0.6431.00
259_T262_S0.6391.00
408_L463_R0.6391.00
73_I190_V0.6371.00
225_V231_A0.6371.00
246_D417_E0.6341.00
315_L384_I0.6321.00
377_R380_S0.6311.00
333_A355_F0.6271.00
365_D368_R0.6251.00
432_A437_L0.6251.00
317_Q379_A0.6241.00
80_S266_L0.6241.00
214_I241_Q0.6241.00
298_L391_V0.6221.00
90_E94_Q0.6201.00
441_L445_E0.6201.00
442_Q445_E0.6191.00
369_L372_N0.6181.00
233_V428_A0.6161.00
237_G241_Q0.6161.00
253_K407_T0.6141.00
101_D105_Q0.6101.00
116_R141_Y0.6091.00
157_L330_D0.6081.00
367_G371_A0.6081.00
463_R467_Q0.6071.00
183_E187_A0.6031.00
92_K375_G0.6021.00
83_L179_T0.6021.00
255_Q258_E0.6021.00
86_A89_R0.6011.00
333_A353_F0.6001.00
422_T449_P0.5971.00
424_F428_A0.5971.00
182_V185_S0.5971.00
307_M387_Y0.5951.00
240_A425_T0.5931.00
178_E181_A0.5911.00
174_A306_A0.5911.00
160_V324_L0.5911.00
196_S199_A0.5901.00
81_H268_G0.5901.00
425_T446_A0.5861.00
467_Q470_Q0.5861.00
111_L150_F0.5841.00
294_S395_V0.5841.00
381_N385_E0.5831.00
188_T192_Q0.5831.00
252_V255_Q0.5811.00
314_S380_S0.5801.00
199_A463_R0.5801.00
81_H389_Q0.5801.00
164_A167_A0.5781.00
150_F334_F0.5761.00
262_S400_V0.5751.00
414_M417_E0.5741.00
321_A372_N0.5721.00
374_E378_A0.5711.00
371_A374_E0.5671.00
449_P452_A0.5661.00
429_A446_A0.5651.00
109_A362_P0.5641.00
226_A434_Q0.5641.00
317_Q376_T0.5631.00
393_N396_R0.5611.00
158_W326_Y0.5601.00
219_K427_R0.5591.00
198_Q201_Y0.5581.00
154_D160_V0.5581.00
166_A170_G0.5551.00
400_V404_R0.5551.00
155_L331_I0.5541.00
428_A432_A0.5531.00
310_Y314_S0.5501.00
207_L211_H0.5491.00
220_A224_K0.5491.00
206_L451_L0.5471.00
408_L464_R0.5441.00
98_D101_D0.5421.00
448_L452_A0.5421.00
250_V254_G0.5421.00
198_Q202_Q0.5401.00
415_Q456_S0.5401.00
426_Q443_A0.5371.00
463_R466_I0.5371.00
218_V238_A0.5371.00
341_H344_T0.5361.00
315_L318_V0.5361.00
157_L329_F0.5361.00
79_G268_G0.5361.00
93_A96_Q0.5351.00
89_R178_E0.5341.00
399_A403_T0.5331.00
297_L394_A0.5321.00
67_P75_R0.5311.00
430_E443_A0.5301.00
203_M252_V0.5291.00
390_S394_A0.5251.00
84_A88_L0.5251.00
190_V266_L0.5241.00
274_M277_I0.5241.00
103_G161_H0.5231.00
265_A393_N0.5231.00
329_F357_P0.5221.00
215_D218_V0.5211.00
91_E95_S0.5211.00
403_T407_T0.5211.00
233_V425_T0.5191.00
359_L362_P0.5180.99
182_V186_L0.5180.99
224_K234_P0.5180.99
193_L263_L0.5170.99
246_D410_D0.5170.99
397_D400_V0.5160.99
95_S375_G0.5160.99
264_R270_G0.5150.99
88_L92_K0.5140.99
293_L475_L0.5100.99
415_Q453_E0.5100.99
186_L266_L0.5100.99
247_K414_M0.5090.99
96_Q171_A0.5080.99
107_Q365_D0.5080.99
221_H225_V0.5060.99
158_W323_A0.5040.99
213_V447_R0.5030.99
296_E477_G0.5030.99
110_A363_L0.5030.99
148_G336_G0.5010.99
438_T443_A0.5010.99
419_V453_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt4A 3 0.9324 100 0.218 Contact Map
3d5kA 3 0.9201 100 0.23 Contact Map
4mt0A 3 0.9057 100 0.236 Contact Map
4k7rA 3 0.875 100 0.237 Contact Map
1yc9A 3 0.8402 100 0.239 Contact Map
1ek9A 3 0.832 100 0.296 Contact Map
4tkoB 1 0.3525 80 0.939 Contact Map
4dk0A 5 0.3197 46.6 0.952 Contact Map
3fppA 3 0.3053 39.6 0.954 Contact Map
2f1mA 2 0.2787 32.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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