GREMLIN Database
NRFG - Formate-dependent nitrite reductase complex subunit NrfG
UniProt: P32712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11950
Length: 198 (151)
Sequences: 18384 (16396)
Seq/√Len: 1334.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_N162_Q3.0181.00
88_D91_N2.8801.00
122_S128_Q2.8491.00
147_L166_L2.8181.00
54_T57_A2.7951.00
110_Y132_M2.5781.00
46_L62_L2.4991.00
76_W95_A2.4491.00
80_G96_Y2.4121.00
150_L166_L2.4001.00
114_A133_I2.3481.00
151_A167_W2.3121.00
62_L78_L2.2741.00
42_Q61_A2.1821.00
79_L95_A2.1761.00
134_D150_L2.0531.00
63_Q79_L2.0501.00
83_Y91_N1.9591.00
154_A166_L1.9231.00
97_R113_L1.9101.00
117_L132_M1.8881.00
154_A162_Q1.8781.00
96_Y112_A1.8681.00
133_I149_L1.8671.00
113_L132_M1.8331.00
49_F57_A1.7811.00
117_L128_Q1.7761.00
49_F61_A1.7741.00
45_P61_A1.7521.00
83_Y95_A1.7261.00
93_L97_R1.5341.00
130_R134_D1.4931.00
121_A126_T1.4621.00
164_I168_Q1.4551.00
59_L63_Q1.4181.00
66_I76_W1.4121.00
130_R157_Q1.3951.00
130_R154_A1.3841.00
93_L120_Q1.3611.00
49_F54_T1.3371.00
83_Y88_D1.2851.00
150_L154_A1.2821.00
110_Y135_K1.2701.00
167_W183_L1.2611.00
65_K75_Q1.2581.00
59_L83_Y1.2581.00
93_L113_L1.2461.00
100_L110_Y1.2391.00
79_L83_Y1.2381.00
147_L169_K1.2291.00
47_H78_L1.2261.00
48_Q52_Q1.2171.00
113_L117_L1.2071.00
137_L147_L1.2031.00
66_I75_Q1.1981.00
140_D143_E1.1891.00
72_N75_Q1.1881.00
136_A146_A1.1691.00
154_A159_N1.1621.00
59_L86_Q1.1551.00
137_L146_A1.1311.00
177_R180_R1.1311.00
45_P49_F1.1271.00
103_R106_N1.1221.00
117_L122_S1.1181.00
111_A149_L1.1031.00
76_W98_Q1.0971.00
99_A109_L1.0951.00
100_L109_L1.0941.00
174_N177_R1.0851.00
39_Y65_K1.0381.00
93_L117_L1.0321.00
127_A157_Q1.0291.00
144_I174_N1.0281.00
56_E86_Q1.0181.00
115_T149_L0.9851.00
81_E112_A0.9851.00
69_N72_N0.9841.00
50_A78_L0.9781.00
162_Q165_E0.9691.00
130_R150_L0.9661.00
57_A60_Q0.9661.00
42_Q64_D0.9641.00
116_V120_Q0.9541.00
128_Q131_A0.9541.00
59_L82_Y0.9321.00
98_Q102_L0.9281.00
130_R153_D0.9261.00
46_L65_K0.9211.00
77_A112_A0.9201.00
90_S120_Q0.9171.00
43_R78_L0.9161.00
42_Q65_K0.9091.00
73_S99_A0.9081.00
50_A62_L0.9031.00
43_R47_H0.8951.00
144_I170_V0.8841.00
64_D68_A0.8841.00
59_L79_L0.8661.00
169_K173_L0.8611.00
135_K139_L0.8591.00
148_M152_S0.8591.00
107_A136_A0.8551.00
152_S155_F0.8531.00
153_D157_Q0.8521.00
143_E146_A0.8491.00
132_M135_K0.8411.00
106_N109_L0.8401.00
98_Q101_Q0.8321.00
147_L170_V0.8301.00
42_Q68_A0.8301.00
77_A81_E0.8291.00
47_H51_S0.8181.00
73_S103_R0.8141.00
111_A115_T0.8041.00
89_Y119_Y0.8021.00
118_Y156_M0.8001.00
66_I79_L0.7891.00
93_L116_V0.7871.00
151_A170_V0.7861.00
118_Y149_L0.7841.00
155_F167_W0.7781.00
80_G99_A0.7771.00
166_L169_K0.7761.00
169_K172_D0.7681.00
81_E85_W0.7621.00
76_W102_L0.7591.00
149_L152_S0.7531.00
130_R159_N0.7531.00
126_T153_D0.7431.00
95_A98_Q0.7411.00
89_Y116_V0.7291.00
170_V180_R0.7221.00
80_G92_S0.7201.00
91_N94_L0.7151.00
147_L173_L0.7121.00
55_P82_Y0.7121.00
151_A163_A0.7051.00
118_Y126_T0.7021.00
61_A64_D0.6961.00
107_A140_D0.6951.00
126_T156_M0.6871.00
100_L113_L0.6851.00
118_Y153_D0.6811.00
135_K138_A0.6741.00
111_A143_E0.6741.00
38_E41_R0.6741.00
65_K68_A0.6721.00
84_L112_A0.6701.00
82_Y86_Q0.6671.00
84_L92_S0.6621.00
43_R72_N0.6581.00
114_A129_T0.6501.00
50_A55_P0.6491.00
148_M170_V0.6441.00
126_T157_Q0.6441.00
50_A85_W0.6401.00
134_D154_A0.6361.00
171_M180_R0.6341.00
152_S183_L0.6321.00
155_F160_Y0.6291.00
110_Y139_L0.6291.00
50_A82_Y0.6291.00
84_L89_Y0.6271.00
49_F52_Q0.6261.00
77_A106_N0.6241.00
84_L116_V0.6171.00
163_A167_W0.6151.00
60_Q64_D0.6141.00
152_S156_M0.6071.00
107_A143_E0.6061.00
92_S96_Y0.6061.00
76_W99_A0.6031.00
78_L81_E0.5961.00
77_A109_L0.5961.00
115_T118_Y0.5961.00
136_A139_L0.5961.00
148_M183_L0.5901.00
128_Q132_M0.5891.00
84_L96_Y0.5881.00
93_L122_S0.5871.00
40_Q44_D0.5831.00
58_Q62_L0.5831.00
129_T153_D0.5781.00
148_M177_R0.5781.00
64_D67_R0.5781.00
110_Y136_A0.5761.00
47_H50_A0.5741.00
170_V173_L0.5711.00
57_A61_A0.5701.00
45_P48_Q0.5691.00
114_A136_A0.5691.00
162_Q166_L0.5681.00
41_R48_Q0.5601.00
154_A157_Q0.5601.00
46_L58_Q0.5601.00
97_R132_M0.5501.00
152_S167_W0.5501.00
133_I153_D0.5501.00
91_N95_A0.5491.00
89_Y120_Q0.5471.00
84_L119_Y0.5461.00
95_A99_A0.5451.00
99_A102_L0.5441.00
77_A99_A0.5411.00
180_R183_L0.5411.00
155_F163_A0.5411.00
118_Y129_T0.5361.00
44_D48_Q0.5321.00
81_E84_L0.5321.00
89_Y93_L0.5301.00
168_Q172_D0.5261.00
127_A130_R0.5231.00
134_D138_A0.5221.00
115_T119_Y0.5171.00
171_M181_T0.5171.00
168_Q171_M0.5171.00
44_D47_H0.5151.00
160_Y164_I0.5141.00
131_A135_K0.5111.00
166_L170_V0.5071.00
83_Y86_Q0.5041.00
178_V181_T0.5041.00
118_Y133_I0.5031.00
97_R101_Q0.5021.00
43_R75_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gywA 2 0.8081 99.8 0.269 Contact Map
2pziA 1 0.9242 99.8 0.273 Contact Map
4l9pA 1 0.9747 99.8 0.288 Contact Map
3q7aA 1 0.9545 99.8 0.294 Contact Map
5aioA 1 0.7778 99.8 0.294 Contact Map
3dssA 1 0.9848 99.8 0.295 Contact Map
2e2eA 2 0.8081 99.8 0.304 Contact Map
2h6fA 1 0.9545 99.8 0.306 Contact Map
2vsyA 1 0.6313 99.8 0.309 Contact Map
3urzA 1 0.7828 99.8 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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