GREMLIN Database
ACTP - Cation/acetate symporter ActP
UniProt: P32705 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11942
Length: 549 (471)
Sequences: 11508 (7266)
Seq/√Len: 334.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
467_L510_G6.1891.00
397_T400_E4.3011.00
290_D293_E3.9801.00
456_L511_I3.9351.00
393_K400_E3.6981.00
48_G52_W3.5681.00
224_F228_K3.3851.00
467_L506_V3.3121.00
193_M413_G3.2921.00
512_W516_A3.2841.00
236_N239_S3.2101.00
388_Y396_A3.2021.00
463_M514_F3.1831.00
510_G514_F3.1631.00
226_V318_G3.1321.00
514_F518_D3.0941.00
457_T518_D3.0331.00
464_G511_I3.0321.00
471_T506_V2.9511.00
459_R518_D2.9441.00
403_R407_I2.8791.00
399_R403_R2.8241.00
460_G515_S2.7771.00
180_N183_I2.7571.00
449_L511_I2.7411.00
138_S147_R2.6701.00
189_G417_I2.6121.00
319_A343_A2.4041.00
407_I411_I2.3781.00
61_S68_G2.3761.00
201_M287_T2.3621.00
70_I205_T2.3461.00
289_S293_E2.2881.00
127_N291_A2.2741.00
41_I45_F2.2381.00
145_P462_M2.2341.00
236_N240_E2.1551.00
459_R463_M2.1451.00
62_D67_G2.1401.00
396_A400_E2.1291.00
463_M510_G2.1051.00
457_T460_G2.1021.00
453_W456_L2.0831.00
446_I461_A2.0821.00
239_S243_A2.0731.00
186_V190_V2.0551.00
44_V48_G2.0351.00
94_A341_N2.0251.00
141_L456_L2.0111.00
136_V450_S1.9881.00
393_K396_A1.9641.00
457_T515_S1.9571.00
86_A168_G1.9511.00
218_G363_V1.9451.00
455_K516_A1.9431.00
460_G514_F1.9261.00
470_I474_V1.9121.00
385_H389_A1.8981.00
414_V418_I1.8981.00
293_E296_K1.8791.00
130_R139_Y1.8751.00
292_R296_K1.8511.00
346_H350_A1.8461.00
388_Y404_V1.8401.00
509_L513_F1.8381.00
220_S224_F1.8291.00
65_T68_G1.8201.00
142_K145_P1.8101.00
239_S242_M1.8061.00
389_A401_E1.8001.00
248_G252_M1.7981.00
449_L508_F1.7981.00
199_G203_A1.7951.00
323_V350_A1.7831.00
42_F46_T1.7781.00
292_R295_R1.7751.00
403_R406_K1.7741.00
453_W516_A1.7611.00
192_M372_V1.7591.00
49_I210_I1.7551.00
74_Q209_I1.7521.00
235_N239_S1.7361.00
460_G464_G1.7151.00
400_E403_R1.6961.00
383_V387_L1.6641.00
463_M467_L1.6621.00
383_V408_T1.6521.00
467_L471_T1.6441.00
453_W512_W1.6381.00
72_G293_E1.6331.00
250_D253_K1.6321.00
182_H421_V1.6191.00
240_E243_A1.6021.00
388_Y393_K1.6001.00
358_G362_A1.5721.00
455_K519_N1.5631.00
190_V194_M1.5341.00
55_K58_R1.5341.00
77_L209_I1.5321.00
376_T413_G1.5171.00
171_K339_G1.5171.00
505_T509_L1.5081.00
388_Y400_E1.4871.00
142_K458_T1.4721.00
36_I40_L1.4711.00
121_I448_L1.4551.00
135_D386_D1.4261.00
267_L270_G1.4151.00
170_G185_V1.4111.00
75_N288_V1.3991.00
379_G412_L1.3961.00
153_G469_L1.3931.00
402_L406_K1.3861.00
40_L44_V1.3791.00
183_I187_L1.3761.00
233_S236_N1.3671.00
135_D385_H1.3471.00
64_Y405_S1.3431.00
189_G413_G1.3381.00
208_Q284_R1.3261.00
396_A401_E1.3131.00
263_S267_L1.3111.00
185_V417_I1.3001.00
230_V237_L1.2991.00
35_A355_L1.2921.00
183_I186_V1.2861.00
138_S143_Q1.2851.00
234_F238_F1.2791.00
140_R450_S1.2751.00
186_V417_I1.2751.00
266_S269_L1.2651.00
45_F49_I1.2621.00
192_M369_L1.2581.00
59_S62_D1.2541.00
207_V373_A1.2531.00
46_T210_I1.2501.00
37_I40_L1.2471.00
37_I41_I1.2461.00
383_V388_Y1.2391.00
458_T462_M1.2331.00
132_T381_S1.2301.00
455_K520_S1.2281.00
152_C156_V1.2231.00
506_V510_G1.2191.00
76_G300_Y1.2191.00
457_T514_F1.2111.00
152_C387_L1.2021.00
457_T519_N1.1971.00
400_E404_V1.1951.00
248_G251_I1.1951.00
182_H186_V1.1951.00
471_T510_G1.1931.00
136_V140_R1.1881.00
82_D374_G1.1861.00
146_I462_M1.1791.00
149_L462_M1.1781.00
96_V103_G1.1771.00
169_A188_V1.1761.00
138_S390_N1.1751.00
505_T508_F1.1741.00
508_F512_W1.1721.00
240_E321_M1.1611.00
145_P149_L1.1551.00
174_E181_Y1.1531.00
66_A201_M1.1521.00
166_M189_G1.1491.00
474_V478_L1.1481.00
48_G51_Y1.1461.00
268_G271_L1.1411.00
78_A374_G1.1411.00
459_R514_F1.1401.00
52_W56_R1.1401.00
150_S465_G1.1341.00
404_V408_T1.1321.00
104_L108_L1.1311.00
446_I465_G1.1291.00
213_V217_F1.1271.00
217_F221_F1.1271.00
392_F396_A1.1251.00
464_G468_G1.1221.00
398_E401_E1.1211.00
47_L51_Y1.1191.00
225_M229_H1.1161.00
229_H322_L1.1141.00
186_V421_V1.1131.00
162_L416_A1.1041.00
384_S405_S1.0981.00
34_Q37_I1.0981.00
466_W470_I1.0961.00
456_L515_S1.0931.00
61_S129_G1.0911.00
396_A404_V1.0901.00
179_L184_A1.0821.00
221_F356_F1.0781.00
147_R386_D1.0731.00
249_V253_K1.0731.00
208_Q373_A1.0651.00
384_S404_V1.0651.00
345_V348_A1.0631.00
242_M245_H1.0601.00
80_A304_F1.0591.00
510_G513_F1.0591.00
502_F505_T1.0571.00
116_I120_L1.0561.00
66_A70_I1.0561.00
47_L50_T1.0531.00
431_M435_A1.0511.00
264_A267_L1.0501.00
238_F242_M1.0421.00
146_I461_A1.0421.00
500_A504_I1.0421.00
221_F225_M1.0401.00
235_N238_F1.0331.00
408_T411_I1.0311.00
153_G465_G1.0301.00
57_V62_D1.0291.00
459_R517_T1.0261.00
45_F210_I1.0251.00
72_G76_G1.0201.00
192_M373_A1.0201.00
346_H349_N1.0181.00
42_F369_L1.0171.00
211_K373_A1.0171.00
195_Y369_L1.0081.00
348_A360_I1.0071.00
34_Q38_M1.0061.00
464_G507_A1.0061.00
267_L271_L1.0051.00
163_I419_L1.0021.00
456_L460_G1.0021.00
195_Y373_A1.0001.00
122_A125_L0.9941.00
252_M255_G0.9921.00
442_C507_A0.9901.00
197_L410_L0.9891.00
45_F48_G0.9851.00
237_L318_G0.9851.00
260_D264_A0.9801.00
98_T340_N0.9801.00
339_G342_M0.9791.00
111_L306_G0.9751.00
449_L456_L0.9741.00
429_A433_G0.9621.00
468_G472_A0.9601.00
223_A311_L0.9601.00
166_M185_V0.9591.00
389_A394_K0.9581.00
145_P458_T0.9541.00
414_V417_I0.9491.00
455_K521_A0.9421.00
208_Q374_G0.9401.00
383_V412_L0.9351.00
434_L476_M0.9341.00
446_I507_A0.9341.00
427_N430_F0.9271.00
237_L241_A0.9261.00
137_A150_S0.9211.00
124_R127_N0.9191.00
380_A384_S0.9171.00
249_V252_M0.9131.00
392_F395_G0.9101.00
250_D254_P0.9091.00
82_D208_Q0.9081.00
521_A524_A0.9041.00
264_A271_L0.9021.00
78_A205_T0.9011.00
145_P148_I0.8931.00
227_M233_S0.8931.00
72_G296_K0.8891.00
95_L99_S0.8891.00
318_G322_L0.8881.00
64_Y381_S0.8871.00
123_E295_R0.8861.00
288_V294_A0.8861.00
337_I340_N0.8841.00
261_P264_A0.8801.00
348_A357_L0.8781.00
449_L512_W0.8771.00
39_F43_V0.8761.00
78_A81_G0.8721.00
43_V46_T0.8711.00
71_T293_E0.8711.00
140_R453_W0.8691.00
261_P266_S0.8681.00
388_Y394_K0.8681.00
405_S409_V0.8651.00
450_S461_A0.8641.00
370_A373_A0.8631.00
411_I415_I0.8621.00
261_P265_L0.8591.00
74_Q205_T0.8591.00
148_I391_V0.8561.00
460_G463_M0.8521.00
226_V229_H0.8511.00
428_I432_V0.8461.00
433_G437_A0.8461.00
240_E244_V0.8451.00
229_H351_V0.8451.00
141_L450_S0.8451.00
137_A146_I0.8441.00
263_S266_S0.8421.00
388_Y392_F0.8391.00
101_Y317_F0.8391.00
453_W460_G0.8361.00
507_A511_I0.8361.00
155_L383_V0.8361.00
149_L465_G0.8351.00
39_F365_F0.8341.00
247_K250_D0.8331.00
445_P508_F0.8331.00
179_L187_L0.8311.00
519_N522_E0.8301.00
54_S57_V0.8301.00
299_F303_G0.8301.00
453_W515_S0.8291.00
268_G272_M0.8281.00
228_K234_F0.8281.00
85_S161_Y0.8241.00
471_T474_V0.8221.00
260_D263_S0.8211.00
141_L511_I0.8201.00
513_F516_A0.8201.00
207_V211_K0.8171.00
225_M228_K0.8161.00
72_G300_Y0.8151.00
86_A368_I0.8141.00
211_K366_A0.8141.00
474_V477_I0.8141.00
42_F366_A0.8131.00
262_I266_S0.8101.00
248_G254_P0.8071.00
461_A468_G0.8041.00
377_L380_A0.8041.00
174_E178_G0.8031.00
319_A347_L0.8031.00
219_A312_T0.8021.00
471_T475_L0.8011.00
185_V420_G0.7991.00
96_V317_F0.7981.00
222_M226_V0.7981.00
52_W55_K0.7961.00
506_V509_L0.7961.00
204_T207_V0.7951.00
231_G236_N0.7941.00
249_V254_P0.7941.00
251_I255_G0.7931.00
81_G284_R0.7901.00
38_M355_L0.7901.00
512_W515_S0.7901.00
462_M466_W0.7901.00
315_I347_L0.7881.00
251_I254_P0.7861.00
237_L321_M0.7861.00
352_G356_F0.7841.00
52_W206_W0.7831.00
46_T50_T0.7821.00
134_A150_S0.7801.00
78_A82_D0.7781.00
237_L240_E0.7771.00
457_T520_S0.7771.00
465_G468_G0.7721.00
181_Y185_V0.7711.00
238_F241_A0.7711.00
468_G507_A0.7691.00
418_I422_L0.7691.00
480_P483_W0.7671.00
453_W457_T0.7661.00
35_A38_M0.7661.00
459_R519_N0.7651.00
234_F237_L0.7651.00
342_M346_H0.7631.00
111_L302_T0.7631.00
467_L514_F0.7621.00
355_L359_F0.7611.00
53_A57_V0.7611.00
161_Y279_P0.7591.00
97_F337_I0.7581.00
468_G471_T0.7571.00
126_R291_A0.7571.00
66_A287_T0.7571.00
503_S507_A0.7571.00
78_A284_R0.7561.00
383_V404_V0.7561.00
119_F299_F0.7521.00
77_L212_A0.7521.00
155_L379_G0.7521.00
264_A268_G0.7511.00
97_F325_A0.7501.00
170_G181_Y0.7470.99
211_K369_L0.7470.99
195_Y211_K0.7450.99
109_G113_G0.7450.99
201_M205_T0.7430.99
499_P503_S0.7410.99
508_F511_I0.7390.99
35_A357_L0.7380.99
260_D267_L0.7380.99
513_F517_T0.7360.99
242_M246_P0.7360.99
41_I48_G0.7350.99
449_L453_W0.7350.99
501_L505_T0.7330.99
464_G467_L0.7320.99
115_P119_F0.7280.99
517_T520_S0.7250.99
51_Y54_S0.7250.99
206_W209_I0.7250.99
259_K263_S0.7250.99
135_D139_Y0.7220.99
51_Y198_F0.7220.99
204_T374_G0.7210.99
429_A432_V0.7200.99
143_Q458_T0.7190.99
171_K174_E0.7190.99
418_I421_V0.7170.99
216_L220_S0.7150.99
148_I152_C0.7150.99
88_S309_Y0.7130.99
409_V413_G0.7130.99
302_T306_G0.7130.99
520_S523_G0.7130.99
509_L512_W0.7130.99
122_A294_A0.7110.99
256_G259_K0.7100.99
142_K524_A0.7090.99
89_F219_A0.7090.99
195_Y203_A0.7080.99
142_K522_E0.7070.99
195_Y370_A0.7070.99
384_S401_E0.7060.99
244_V320_I0.7060.99
248_G253_K0.7050.99
57_V402_L0.7040.99
475_L502_F0.7030.99
157_V438_I0.7030.99
54_S198_F0.7020.99
184_A188_V0.7020.99
222_M344_A0.6990.99
257_L260_D0.6990.99
53_A206_W0.6960.99
211_K371_V0.6960.99
60_R64_Y0.6950.99
389_A398_E0.6950.99
106_Y109_G0.6930.99
169_A368_I0.6920.99
227_M231_G0.6920.99
518_D521_A0.6910.99
456_L464_G0.6900.99
50_T53_A0.6860.99
171_K341_N0.6840.99
38_M358_G0.6810.99
174_E180_N0.6760.99
51_Y55_K0.6740.99
70_I75_N0.6730.99
227_M314_I0.6730.99
380_A408_T0.6720.99
165_Q372_V0.6710.99
46_T51_Y0.6700.99
73_F209_I0.6690.99
121_I125_L0.6680.99
407_I410_L0.6670.99
132_T386_D0.6650.99
303_G307_Y0.6650.99
167_V171_K0.6640.99
196_V373_A0.6630.99
433_G436_F0.6620.99
504_I507_A0.6620.99
258_V261_P0.6620.99
149_L466_W0.6610.99
463_M466_W0.6600.99
320_I343_A0.6590.99
38_M362_A0.6580.99
478_L482_I0.6520.99
89_F360_I0.6500.99
288_V293_E0.6490.99
241_A317_F0.6490.99
42_F50_T0.6480.99
337_I346_H0.6470.99
63_Y409_V0.6470.99
245_H248_G0.6470.99
254_P257_L0.6460.99
401_E405_S0.6420.98
131_Y135_D0.6420.98
220_S223_A0.6420.98
417_I421_V0.6410.98
337_I342_M0.6400.98
137_A446_I0.6400.98
37_I44_V0.6390.98
107_S114_W0.6390.98
471_T503_S0.6390.98
326_N337_I0.6390.98
62_D202_L0.6390.98
141_L449_L0.6380.98
186_V414_V0.6380.98
426_Q430_F0.6380.98
459_R462_M0.6360.98
391_V394_K0.6350.98
211_K370_A0.6320.98
380_A409_V0.6320.98
461_A464_G0.6320.98
47_L194_M0.6300.98
241_A245_H0.6290.98
81_G211_K0.6290.98
371_V375_L0.6280.98
221_F224_F0.6280.98
71_T74_Q0.6270.98
193_M410_L0.6270.98
274_G279_P0.6250.98
336_L339_G0.6250.98
70_I287_T0.6240.98
146_I458_T0.6230.98
142_K146_I0.6210.98
375_L378_A0.6210.98
166_M203_A0.6210.98
233_S237_L0.6210.98
236_N321_M0.6200.98
323_V346_H0.6200.98
78_A208_Q0.6190.98
432_V436_F0.6180.98
223_A314_I0.6170.98
63_Y406_K0.6170.98
73_F77_L0.6170.98
106_Y110_F0.6140.98
261_P267_L0.6120.98
469_L473_V0.6110.98
74_Q206_W0.6090.98
514_F517_T0.6080.98
202_L206_W0.6080.98
228_K233_S0.6080.98
112_V269_L0.6060.98
83_Y436_F0.6060.98
456_L461_A0.6060.98
259_K262_I0.6050.98
165_Q371_V0.6050.98
296_K300_Y0.6040.98
267_L272_M0.6030.98
313_F317_F0.6020.98
134_A154_S0.6020.98
123_E291_A0.6020.98
173_I184_A0.6010.98
85_S89_F0.6000.98
171_K175_L0.5990.98
428_I431_M0.5990.98
241_A244_V0.5990.98
494_F502_F0.5980.98
444_F448_L0.5970.98
109_G118_L0.5960.98
322_L347_L0.5960.98
80_A308_F0.5960.98
95_L98_T0.5960.98
342_M345_V0.5950.97
467_L470_I0.5950.97
347_L351_V0.5920.97
280_H283_M0.5920.97
107_S110_F0.5900.97
159_A419_L0.5900.97
43_V47_L0.5900.97
83_Y110_F0.5890.97
445_P511_I0.5860.97
457_T461_A0.5840.97
305_M309_Y0.5830.97
455_K515_S0.5830.97
81_G212_A0.5830.97
114_W117_I0.5820.97
123_E127_N0.5820.97
219_A311_L0.5820.97
164_A435_A0.5810.97
120_L124_R0.5810.97
193_M197_L0.5810.97
354_N357_L0.5800.97
472_A503_S0.5770.97
265_L272_M0.5770.97
369_L373_A0.5740.97
388_Y391_V0.5740.97
455_K459_R0.5740.97
458_T461_A0.5730.97
35_A358_G0.5730.97
230_V236_N0.5710.97
60_R63_Y0.5700.97
80_A212_A0.5700.97
91_G161_Y0.5700.97
217_F220_S0.5690.97
384_S408_T0.5690.97
230_V321_M0.5690.97
148_I151_A0.5690.97
315_I344_A0.5680.97
227_M234_F0.5670.97
154_S382_A0.5660.97
498_Y502_F0.5650.97
296_K299_F0.5640.97
195_Y199_G0.5640.97
320_I324_G0.5630.96
46_T53_A0.5630.96
141_L461_A0.5630.96
60_R401_E0.5620.96
75_N78_A0.5620.96
113_G117_I0.5620.96
189_G420_G0.5610.96
175_L345_V0.5600.96
120_L123_E0.5600.96
227_M237_L0.5600.96
453_W517_T0.5590.96
161_Y375_L0.5590.96
157_V439_A0.5580.96
231_G234_F0.5580.96
61_S398_E0.5580.96
384_S388_Y0.5570.96
496_Y500_A0.5550.96
87_A436_F0.5550.96
322_L351_V0.5540.96
204_T284_R0.5530.96
175_L342_M0.5530.96
352_G360_I0.5520.96
76_G80_A0.5520.96
410_L413_G0.5510.96
245_H249_V0.5510.96
432_V435_A0.5500.96
208_Q370_A0.5490.96
325_A338_G0.5490.96
162_L372_V0.5490.96
479_G483_W0.5490.96
42_F211_K0.5480.96
476_M481_T0.5450.96
476_M499_P0.5440.96
415_I418_I0.5420.96
60_R398_E0.5420.96
42_F214_L0.5420.96
426_Q431_M0.5410.96
111_L114_W0.5410.96
180_N184_A0.5410.96
325_A337_I0.5400.96
241_A247_K0.5400.96
266_S501_L0.5390.96
92_I96_V0.5370.95
115_P298_V0.5360.95
380_A405_S0.5360.95
266_S271_L0.5350.95
504_I508_F0.5340.95
97_F343_A0.5340.95
56_R202_L0.5340.95
289_S292_R0.5320.95
83_Y305_M0.5310.95
82_D280_H0.5310.95
160_L435_A0.5300.95
428_I433_G0.5300.95
153_G442_C0.5300.95
264_A270_G0.5300.95
170_G184_A0.5280.95
113_G116_I0.5280.95
53_A56_R0.5270.95
460_G510_G0.5270.95
441_S445_P0.5260.95
401_E404_V0.5260.95
173_I177_F0.5260.95
185_V188_V0.5250.95
285_F298_V0.5250.95
470_I473_V0.5250.95
197_L403_R0.5240.95
460_G507_A0.5240.95
423_F426_Q0.5240.95
417_I420_G0.5230.95
204_T377_L0.5230.95
82_D284_R0.5220.95
393_K398_E0.5210.95
349_N357_L0.5210.95
186_V189_G0.5200.95
167_V181_Y0.5200.95
131_Y385_H0.5190.95
455_K458_T0.5180.94
166_M416_A0.5180.94
205_T208_Q0.5160.94
185_V189_G0.5160.94
475_L479_G0.5160.94
497_E501_L0.5140.94
228_K231_G0.5140.94
317_F321_M0.5140.94
376_T409_V0.5140.94
148_I387_L0.5140.94
83_Y432_V0.5130.94
263_S268_G0.5130.94
299_F302_T0.5130.94
34_Q354_N0.5130.94
179_L183_I0.5130.94
105_I109_G0.5120.94
89_F94_A0.5120.94
111_L115_P0.5110.94
353_G356_F0.5110.94
122_A291_A0.5110.94
222_M348_A0.5090.94
154_S443_N0.5090.94
496_Y499_P0.5080.94
220_S307_Y0.5070.94
269_L272_M0.5070.94
222_M360_I0.5060.94
321_M324_G0.5060.94
468_G510_G0.5060.94
428_I436_F0.5050.94
230_V233_S0.5050.94
109_G112_V0.5040.94
273_F444_F0.5040.94
291_A295_R0.5040.94
226_V351_V0.5030.94
165_Q375_L0.5010.93
56_R69_N0.5000.93
133_F447_I0.5000.93
473_V477_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.8725 100 0.309 Contact Map
3dh4A 3 0.8324 100 0.351 Contact Map
3l1lA 2 0.7432 99.4 0.87 Contact Map
3giaA 1 0.7705 99.3 0.873 Contact Map
4djkA 2 0.7577 99.1 0.888 Contact Map
2jlnA 1 0.7668 98.9 0.896 Contact Map
4wgvA 2 0.6794 98.8 0.898 Contact Map
4c7rA 3 0.8506 97.9 0.921 Contact Map
2wswA 3 0.7851 97.2 0.932 Contact Map
4xp4A 1 0.7978 94 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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