GREMLIN Database
YJCC - Putative cyclic-di-GMP phosphodiesterase YjcC
UniProt: P32701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11938
Length: 528 (444)
Sequences: 19369 (15281)
Seq/√Len: 725.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_A512_F3.9721.00
294_I498_C3.8031.00
95_E99_A3.4891.00
336_D375_R3.4311.00
377_N415_A3.2091.00
446_K450_E3.0111.00
335_T366_D2.9601.00
340_D382_Q2.8951.00
285_C309_P2.8771.00
413_R440_D2.8241.00
504_A507_M2.7981.00
267_N320_E2.7651.00
288_Y345_D2.7521.00
391_K441_I2.7101.00
293_D296_T2.6191.00
350_L389_Q2.5281.00
167_S170_P2.5121.00
489_W493_R2.5081.00
347_G351_A2.4631.00
470_H496_R2.4351.00
484_E488_N2.3711.00
274_K310_G2.3101.00
337_Y341_N2.2271.00
487_V503_F2.2161.00
111_A185_F2.1871.00
345_D509_P2.1631.00
463_E471_S2.1481.00
341_N344_R2.1071.00
420_A441_I2.0971.00
435_K458_S2.0751.00
481_V498_C2.0671.00
309_P315_I2.0311.00
277_R281_K2.0021.00
106_C110_I1.9821.00
130_S228_V1.9741.00
310_G314_Q1.9631.00
325_A334_I1.9231.00
115_G232_Y1.9141.00
343_F379_K1.9061.00
459_H489_W1.9041.00
306_L338_V1.9001.00
285_C315_I1.8881.00
268_Y327_K1.8871.00
341_N345_D1.8791.00
362_L372_L1.8641.00
463_E493_R1.8341.00
508_P511_V1.8161.00
287_Y508_P1.8141.00
483_T486_Q1.8021.00
291_I497_Y1.7861.00
386_R389_Q1.7861.00
487_V498_C1.7721.00
86_I90_Y1.7631.00
340_D379_K1.7601.00
132_Y200_I1.7541.00
282_H341_N1.7361.00
231_S234_R1.7231.00
132_Y224_I1.7161.00
357_Y418_E1.7111.00
346_L385_V1.7061.00
379_K383_Y1.7011.00
487_V491_R1.6961.00
409_I419_V1.6891.00
391_K420_A1.6891.00
110_I114_N1.6831.00
291_I441_I1.6621.00
441_I477_I1.6531.00
453_T459_H1.6531.00
292_I503_F1.6521.00
345_D349_Y1.6501.00
286_L338_V1.6411.00
463_E467_E1.6391.00
340_D383_Y1.6371.00
249_A255_L1.6281.00
418_E440_D1.6251.00
153_Y156_V1.6181.00
484_E502_F1.6051.00
442_L469_A1.5851.00
246_A255_L1.5841.00
287_Y315_I1.5731.00
487_V502_F1.5341.00
357_Y391_K1.5321.00
157_I211_G1.5201.00
212_Y217_V1.5181.00
453_T485_E1.5171.00
310_G313_G1.5141.00
466_I495_V1.5141.00
300_I497_Y1.5121.00
380_T417_Y1.5121.00
284_L306_L1.4981.00
475_K497_Y1.4971.00
466_I493_R1.4961.00
137_T223_P1.4911.00
475_K496_R1.4881.00
352_T513_M1.4761.00
100_R178_D1.4751.00
291_I391_K1.4581.00
143_Y151_G1.4441.00
306_L334_I1.4421.00
283_Q310_G1.4341.00
138_P251_I1.4301.00
349_Y509_P1.4271.00
226_A256_V1.4241.00
157_I160_L1.4231.00
154_V220_T1.4231.00
114_N177_Y1.4181.00
501_W506_A1.4181.00
114_N117_T1.4071.00
441_I475_K1.3951.00
95_E104_F1.3881.00
286_L337_Y1.3871.00
507_M515_W1.3831.00
362_L392_F1.3741.00
435_K451_T1.3721.00
421_I439_V1.3691.00
179_T185_F1.3631.00
350_L386_R1.3601.00
378_Q382_Q1.3581.00
344_R383_Y1.3421.00
94_N98_Y1.3411.00
92_Y96_L1.3371.00
453_T489_W1.3341.00
348_D352_T1.3301.00
160_L163_S1.3291.00
291_I301_G1.3281.00
130_S196_F1.3161.00
86_I89_G1.3141.00
166_M176_V1.3141.00
153_Y214_Y1.3051.00
114_N175_G1.2931.00
299_C515_W1.2911.00
342_V358_V1.2861.00
116_Y232_Y1.2821.00
380_T387_P1.2791.00
158_N207_V1.2781.00
245_F248_P1.2751.00
406_T410_L1.2671.00
446_K480_G1.2661.00
332_E369_T1.2641.00
511_V514_Q1.2551.00
111_A177_Y1.2521.00
375_R379_K1.2511.00
469_A476_T1.2441.00
188_S199_L1.2341.00
283_Q308_W1.2271.00
267_N313_G1.2261.00
488_N491_R1.2261.00
197_S256_V1.2241.00
346_L358_V1.2241.00
377_N411_A1.2211.00
345_D348_D1.2201.00
478_A495_V1.2191.00
452_L489_W1.2031.00
274_K313_G1.2021.00
234_R238_H1.1981.00
498_C503_F1.1971.00
238_H262_L1.1881.00
293_D300_I1.1851.00
157_I161_F1.1821.00
377_N381_E1.1791.00
306_L337_Y1.1761.00
105_L159_P1.1751.00
313_G320_E1.1741.00
79_H82_R1.1741.00
406_T436_S1.1671.00
78_A82_R1.1661.00
504_A515_W1.1651.00
277_R283_Q1.1651.00
293_D298_K1.1651.00
245_F255_L1.1641.00
138_P141_S1.1571.00
134_Y222_R1.1561.00
373_I377_N1.1491.00
294_I487_V1.1491.00
355_D389_Q1.1481.00
488_N492_K1.1451.00
391_K418_E1.1421.00
245_F249_A1.1411.00
196_F200_I1.1381.00
467_E471_S1.1361.00
192_S195_T1.1351.00
246_A253_G1.1331.00
133_Y185_F1.1311.00
410_L414_Q1.1261.00
297_E491_R1.1251.00
206_T209_R1.1241.00
349_Y513_M1.1091.00
87_I90_Y1.1081.00
207_V222_R1.1031.00
359_S391_K1.1001.00
197_S201_H1.1001.00
439_V474_L1.0931.00
270_S274_K1.0901.00
507_M511_V1.0891.00
484_E487_V1.0841.00
453_T483_T1.0841.00
200_I226_A1.0821.00
291_I359_S1.0741.00
376_I412_F1.0721.00
373_I411_A1.0701.00
452_L462_A1.0701.00
204_D254_S1.0691.00
441_I497_Y1.0641.00
136_D158_N1.0641.00
153_Y157_I1.0631.00
75_C78_A1.0581.00
271_P324_L1.0581.00
455_H458_S1.0561.00
201_H205_L1.0561.00
347_G350_L1.0531.00
489_W492_K1.0511.00
227_I238_H1.0501.00
376_I392_F1.0471.00
340_D344_R1.0461.00
347_G383_Y1.0451.00
77_P80_Q1.0431.00
285_C508_P1.0401.00
464_H471_S1.0371.00
141_S272_K1.0371.00
301_G357_Y1.0341.00
364_A397_H1.0331.00
346_L350_L1.0291.00
118_I189_K1.0291.00
72_G82_R1.0281.00
460_L471_S1.0261.00
204_D224_I1.0221.00
404_K408_I1.0211.00
99_A110_I1.0181.00
284_L337_Y1.0151.00
318_P321_F1.0141.00
392_F417_Y1.0091.00
328_E332_E1.0061.00
343_F390_I1.0061.00
110_I113_V1.0051.00
342_V360_I1.0041.00
121_A189_K1.0021.00
133_Y243_L1.0001.00
509_P513_M1.0001.00
291_I357_Y0.9981.00
165_V206_T0.9931.00
98_Y109_L0.9851.00
373_I408_I0.9831.00
274_K312_Q0.9801.00
76_T79_H0.9781.00
402_V437_L0.9711.00
291_I477_I0.9701.00
275_L325_A0.9681.00
379_K382_Q0.9681.00
82_R86_I0.9621.00
319_A446_K0.9621.00
150_R153_Y0.9621.00
98_Y113_V0.9621.00
466_I476_T0.9571.00
135_R247_L0.9551.00
347_G384_A0.9541.00
286_L342_V0.9541.00
200_I254_S0.9521.00
283_Q311_E0.9521.00
344_R348_D0.9501.00
197_S254_S0.9501.00
262_L266_Q0.9491.00
372_L376_I0.9491.00
92_Y95_E0.9461.00
165_V202_L0.9461.00
208_Q252_L0.9441.00
292_I515_W0.9431.00
118_I129_V0.9381.00
75_C80_Q0.9371.00
408_I411_A0.9371.00
333_Q336_D0.9361.00
411_A414_Q0.9351.00
161_F211_G0.9351.00
85_N88_R0.9311.00
313_G316_M0.9301.00
310_G316_M0.9281.00
477_I497_Y0.9251.00
110_I175_G0.9231.00
136_D222_R0.9231.00
277_R280_E0.9211.00
293_D496_R0.9211.00
282_H337_Y0.9201.00
322_I331_I0.9201.00
116_Y120_P0.9181.00
272_K276_Q0.9171.00
295_K496_R0.9151.00
166_M170_P0.9141.00
156_V160_L0.9131.00
143_Y181_T0.9131.00
132_Y188_S0.9131.00
101_D109_L0.9051.00
162_W176_V0.9051.00
371_R375_R0.9041.00
221_K252_L0.9011.00
345_D513_M0.9011.00
304_A358_V0.8991.00
326_E331_I0.8991.00
400_L433_N0.8991.00
280_E333_Q0.8991.00
330_M333_Q0.8991.00
339_I379_K0.8941.00
234_R237_T0.8931.00
401_D404_K0.8931.00
98_Y110_I0.8921.00
78_A84_L0.8881.00
112_P233_Q0.8871.00
114_N118_I0.8821.00
129_V187_L0.8821.00
135_R182_K0.8801.00
369_T375_R0.8791.00
154_V211_G0.8791.00
134_Y186_S0.8741.00
228_V256_V0.8731.00
90_Y94_N0.8721.00
275_L284_L0.8711.00
212_Y215_A0.8671.00
288_Y302_A0.8661.00
286_L306_L0.8651.00
466_I470_H0.8621.00
150_R216_T0.8581.00
241_N261_W0.8581.00
193_A197_S0.8551.00
259_L263_R0.8551.00
213_L218_Y0.8551.00
76_T80_Q0.8541.00
83_M86_I0.8541.00
336_D379_K0.8531.00
303_E361_N0.8501.00
407_P411_A0.8501.00
453_T486_Q0.8491.00
149_Q233_Q0.8481.00
205_L208_Q0.8471.00
164_E206_T0.8431.00
276_Q330_M0.8431.00
88_R92_Y0.8411.00
286_L304_A0.8411.00
89_G92_Y0.8401.00
278_A284_L0.8391.00
375_R378_Q0.8391.00
311_E314_Q0.8371.00
339_I376_I0.8361.00
199_L202_L0.8361.00
357_Y389_Q0.8361.00
295_K491_R0.8351.00
282_H340_D0.8351.00
348_D509_P0.8341.00
278_A283_Q0.8321.00
207_V211_G0.8261.00
72_G75_C0.8241.00
166_M186_S0.8221.00
374_A411_A0.8221.00
217_V277_R0.8221.00
302_A356_R0.8201.00
339_I360_I0.8181.00
272_K328_E0.8151.00
336_D340_D0.8101.00
200_I204_D0.8091.00
374_A378_Q0.8081.00
115_G187_L0.8071.00
385_V390_I0.8061.00
83_M87_I0.8041.00
112_P116_Y0.8041.00
73_Q76_T0.8031.00
78_A81_K0.8011.00
71_Q75_C0.8011.00
143_Y152_N0.8001.00
297_E487_V0.7981.00
75_C82_R0.7971.00
76_T82_R0.7961.00
343_F385_V0.7951.00
142_G151_G0.7941.00
113_V117_T0.7931.00
288_Y304_A0.7921.00
450_E486_Q0.7891.00
276_Q333_Q0.7891.00
470_H476_T0.7881.00
249_A253_G0.7871.00
191_A195_T0.7861.00
227_I235_L0.7831.00
460_L463_E0.7831.00
332_E366_D0.7821.00
348_D351_A0.7821.00
106_C175_G0.7801.00
75_C81_K0.7791.00
370_S404_K0.7761.00
481_V487_V0.7761.00
292_I299_C0.7751.00
137_T251_I0.7731.00
72_G76_T0.7711.00
140_F144_K0.7701.00
133_Y239_F0.7671.00
245_F264_I0.7651.00
102_N156_V0.7631.00
360_I390_I0.7621.00
467_E470_H0.7611.00
410_L438_N0.7591.00
435_K461_I0.7591.00
343_F383_Y0.7561.00
87_I91_L0.7561.00
288_Y509_P0.7551.00
226_A254_S0.7541.00
481_V490_L0.7541.00
196_F228_V0.7531.00
138_P272_K0.7511.00
418_E475_K0.7491.00
304_A342_V0.7481.00
75_C79_H0.7481.00
200_I224_I0.7471.00
77_P82_R0.7471.00
449_V452_L0.7461.00
148_M240_Y0.7451.00
159_P176_V0.7431.00
129_V229_A0.7421.00
272_K324_L0.7421.00
91_L94_N0.7411.00
407_P410_L0.7391.00
73_Q77_P0.7341.00
258_L261_W0.7331.00
404_K407_P0.7311.00
111_A187_L0.7311.00
490_L495_V0.7311.00
451_T454_T0.7301.00
436_S457_T0.7291.00
225_A239_F0.7261.00
279_L337_Y0.7241.00
76_T81_K0.7241.00
290_P504_A0.7221.00
112_P232_Y0.7221.00
223_P251_I0.7201.00
240_Y244_I0.7201.00
325_A331_I0.7171.00
110_I177_Y0.7171.00
478_A490_L0.7161.00
306_L321_F0.7161.00
142_G154_V0.7161.00
111_A115_G0.7151.00
195_T198_P0.7151.00
393_E443_K0.7151.00
451_T458_S0.7141.00
229_A235_L0.7131.00
71_Q74_V0.7111.00
89_G93_I0.7111.00
406_T438_N0.7111.00
93_I96_L0.7091.00
456_K459_H0.7061.00
395_T423_D0.7061.00
350_L353_H0.7051.00
225_A242_H0.7031.00
146_T218_Y0.7001.00
317_N320_E0.7001.00
146_T216_T0.6971.00
193_A256_V0.6971.00
74_V78_A0.6961.00
501_W505_K0.6961.00
227_I239_F0.6961.00
135_R244_I0.6961.00
71_Q82_R0.6951.00
167_S202_L0.6941.00
132_Y186_S0.6931.00
194_A197_S0.6921.00
73_Q80_Q0.6911.00
423_D479_E0.6911.00
328_E331_I0.6891.00
250_G253_G0.6881.00
459_H463_E0.6861.00
82_R87_I0.6861.00
139_F155_A0.6851.00
424_F465_I0.6851.00
134_Y224_I0.6851.00
257_L261_W0.6841.00
350_L355_D0.6841.00
290_P507_M0.6841.00
367_F408_I0.6831.00
185_F236_I0.6821.00
290_P299_C0.6801.00
132_Y226_A0.6791.00
138_P327_K0.6781.00
201_H204_D0.6771.00
99_A106_C0.6751.00
137_T221_K0.6741.00
150_R218_Y0.6721.00
95_E98_Y0.6701.00
238_H257_L0.6681.00
294_I491_R0.6671.00
108_S112_P0.6641.00
180_V183_T0.6641.00
466_I490_L0.6641.00
150_R213_L0.6631.00
181_T244_I0.6621.00
287_Y309_P0.6581.00
133_Y179_T0.6571.00
319_A323_P0.6571.00
183_T240_Y0.6561.00
85_N89_G0.6561.00
275_L330_M0.6551.00
158_N162_W0.6541.00
98_Y106_C0.6531.00
374_A377_N0.6531.00
198_P202_L0.6531.00
449_V478_A0.6511.00
449_V462_A0.6511.00
346_L389_Q0.6481.00
70_Y73_Q0.6471.00
331_I365_S0.6471.00
402_V406_T0.6451.00
459_H493_R0.6441.00
390_I417_Y0.6411.00
270_S313_G0.6401.00
458_S486_Q0.6401.00
158_N211_G0.6391.00
167_S199_L0.6381.00
512_F515_W0.6361.00
186_S203_K0.6351.00
260_L263_R0.6311.00
367_F398_A0.6291.00
182_K247_L0.6281.00
302_A358_V0.6281.00
140_F244_I0.6251.00
418_E441_I0.6251.00
275_L278_A0.6241.00
223_P246_A0.6241.00
127_P189_K0.6241.00
380_T385_V0.6241.00
109_L112_P0.6231.00
476_T496_R0.6231.00
373_I415_A0.6231.00
348_D513_M0.6221.00
129_V235_L0.6211.00
292_I297_E0.6201.00
219_S276_Q0.6201.00
112_P236_I0.6201.00
444_I495_V0.6191.00
336_D378_Q0.6171.00
210_N217_V0.6161.00
139_F151_G0.6151.00
507_M512_F0.6141.00
349_Y512_F0.6141.00
309_P314_Q0.6141.00
340_D375_R0.6141.00
411_A415_A0.6121.00
163_S176_V0.6111.00
274_K308_W0.6091.00
402_V405_M0.6071.00
263_R267_N0.6061.00
160_L164_E0.6061.00
204_D252_L0.6051.00
188_S196_F0.6041.00
490_L498_C0.6041.00
102_N152_N0.6031.00
297_E484_E0.6021.00
482_E501_W0.6021.00
380_T383_Y0.6001.00
334_I338_V0.5951.00
274_K277_R0.5941.00
161_F210_N0.5941.00
376_I417_Y0.5941.00
257_L262_L0.5921.00
336_D366_D0.5901.00
275_L334_I0.5901.00
271_P274_K0.5901.00
266_Q270_S0.5891.00
170_P199_L0.5881.00
146_T150_R0.5871.00
426_I447_S0.5851.00
451_T455_H0.5841.00
260_L264_I0.5821.00
456_K460_L0.5811.00
325_A329_G0.5811.00
392_F419_V0.5811.00
364_A398_A0.5811.00
512_F516_M0.5791.00
270_S312_Q0.5761.00
135_R143_Y0.5761.00
204_D222_R0.5741.00
72_G78_A0.5731.00
230_T238_H0.5731.00
332_E336_D0.5731.00
426_I448_F0.5731.00
139_F143_Y0.5731.00
376_I379_K0.5711.00
264_I268_Y0.5701.00
465_I469_A0.5701.00
127_P190_E0.5691.00
421_I433_N0.5691.00
442_L474_L0.5681.00
285_C510_Q0.5671.00
358_V385_V0.5671.00
316_M323_P0.5661.00
165_V203_K0.5641.00
118_I121_A0.5631.00
350_L354_A0.5631.00
419_V440_D0.5631.00
336_D369_T0.5601.00
165_V199_L0.5591.00
71_Q79_H0.5561.00
84_L88_R0.5551.00
204_D208_Q0.5541.00
460_L464_H0.5541.00
284_L308_W0.5531.00
196_F226_A0.5531.00
432_H447_S0.5521.00
435_K455_H0.5491.00
287_Y506_A0.5481.00
285_C341_N0.5481.00
279_L334_I0.5481.00
120_P123_Y0.5471.00
346_L390_I0.5471.00
263_R266_Q0.5461.00
73_Q78_A0.5431.00
144_K244_I0.5421.00
105_L176_V0.5421.00
513_M516_M0.5391.00
71_Q78_A0.5391.00
78_A83_M0.5391.00
149_Q214_Y0.5381.00
149_Q153_Y0.5381.00
339_I343_F0.5381.00
400_L405_M0.5371.00
269_L273_R0.5361.00
137_T252_L0.5361.00
347_G385_V0.5341.00
485_E488_N0.5341.00
361_N422_D0.5341.00
77_P81_K0.5331.00
161_F206_T0.5321.00
365_S368_H0.5291.00
444_I465_I0.5291.00
114_N187_L0.5291.00
211_G220_T0.5291.00
388_Q418_E0.5281.00
282_H344_R0.5281.00
433_N436_S0.5281.00
329_G365_S0.5271.00
267_N271_P0.5251.00
106_C177_Y0.5231.00
80_Q84_L0.5231.00
385_V389_Q0.5231.00
201_H254_S0.5221.00
149_Q237_T0.5221.00
409_I438_N0.5221.00
378_Q381_E0.5211.00
462_A478_A0.5201.00
335_T338_V0.5191.00
305_L361_N0.5181.00
90_Y93_I0.5171.00
396_E425_G0.5151.00
119_A229_A0.5141.00
412_F417_Y0.5141.00
297_E503_F0.5141.00
118_I187_L0.5131.00
402_V436_S0.5131.00
342_V346_L0.5111.00
339_I362_L0.5101.00
433_N437_L0.5081.00
213_L216_T0.5081.00
461_I465_I0.5081.00
435_K457_T0.5071.00
286_L341_N0.5071.00
372_L375_R0.5050.99
205_L209_R0.5050.99
76_T83_M0.5040.99
265_R269_L0.5040.99
303_E443_K0.5040.99
301_G359_S0.5010.99
410_L413_R0.5000.99
159_P163_S0.5000.99
309_P313_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnhA 2 0.7803 100 0.198 Contact Map
4j40A 2 0.4735 100 0.21 Contact Map
3pjxA 1 0.786 100 0.224 Contact Map
3gfzA 2 0.7159 100 0.35 Contact Map
4hjfA 1 0.4905 100 0.392 Contact Map
4hu4A 1 0.464 100 0.459 Contact Map
2r6oA 2 0.483 100 0.464 Contact Map
4kieA 1 0.4905 100 0.465 Contact Map
4rniA 2 0.4773 100 0.468 Contact Map
3sy8A 6 0.7348 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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