GREMLIN Database
DUSA - tRNA-dihydrouridine synthase A
UniProt: P32695 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11932
Length: 345 (297)
Sequences: 6475 (3880)
Seq/√Len: 225.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L281_A4.7681.00
215_K243_D4.3481.00
231_S234_E3.2791.00
101_E147_S3.2281.00
230_K234_E2.9861.00
143_R181_E2.8841.00
237_A241_H2.7641.00
79_H106_D2.5801.00
175_S220_H2.5701.00
139_V180_C2.4731.00
212_Y216_R2.4391.00
209_P241_H2.3341.00
140_K144_D2.3321.00
93_L110_L2.2671.00
225_I238_H2.2181.00
236_K240_Q2.1701.00
130_G158_I2.1491.00
41_C45_L2.1111.00
97_A146_V2.0801.00
156_I210_R2.0241.00
213_Q216_R2.0241.00
236_K264_E2.0141.00
175_S221_L1.9351.00
136_A177_K1.9311.00
95_Q98_K1.9271.00
112_V135_V1.9041.00
229_I238_H1.8711.00
146_V150_V1.8631.00
211_V225_I1.8201.00
325_H328_G1.8111.00
91_A95_Q1.8091.00
237_A240_Q1.8051.00
230_K250_E1.7951.00
280_R330_D1.7891.00
212_Y241_H1.7871.00
131_N134_L1.7831.00
207_D210_R1.7811.00
82_A107_E1.7751.00
133_Q137_D1.7691.00
136_A173_T1.7491.00
234_E237_A1.7271.00
318_R322_E1.7221.00
284_P330_D1.7181.00
83_L100_A1.7121.00
98_K145_V1.7061.00
263_R267_G1.7001.00
135_V170_F1.6961.00
123_M131_N1.6731.00
235_A245_V1.6631.00
53_L82_A1.6621.00
93_L142_M1.6621.00
168_C217_D1.6231.00
200_N207_D1.6191.00
52_T262_D1.6161.00
136_A176_G1.6061.00
136_A140_K1.5971.00
169_D172_N1.5961.00
172_N217_D1.5931.00
154_T185_I1.5861.00
133_Q173_T1.5841.00
29_S224_S1.5791.00
89_D92_A1.5631.00
224_S246_M1.5571.00
225_I229_I1.5531.00
167_L214_L1.5521.00
282_M306_L1.5521.00
159_D162_D1.5511.00
212_Y238_H1.5471.00
263_R271_T1.5291.00
206_L228_G1.5221.00
182_M224_S1.5101.00
94_A145_V1.5051.00
224_S244_G1.5021.00
210_R213_Q1.4901.00
137_D140_K1.4601.00
134_L137_D1.4571.00
90_P94_A1.4421.00
87_G93_L1.4401.00
259_A274_D1.4391.00
110_L142_M1.4371.00
101_E148_I1.4281.00
233_E237_A1.4231.00
101_E146_V1.4221.00
152_V174_V1.4091.00
100_A108_I1.4041.00
328_G331_I1.3931.00
280_R334_L1.3851.00
26_G52_T1.3671.00
315_Q318_R1.3661.00
254_N260_A1.3471.00
215_K223_M1.3241.00
172_N175_S1.2971.00
225_I242_M1.2941.00
28_F245_V1.2751.00
140_K177_K1.2741.00
187_A211_V1.2621.00
163_S166_F1.2511.00
62_G92_A1.2321.00
28_F261_V1.2281.00
126_A190_A1.2181.00
276_V280_R1.2181.00
31_A248_G1.2171.00
323_N332_N1.2161.00
172_N176_G1.2101.00
160_D200_N1.2001.00
284_P288_R1.1911.00
175_S219_P1.1771.00
247_V261_V1.1731.00
43_Y47_L1.1671.00
190_A199_E1.1641.00
55_Y184_I1.1611.00
151_T182_M1.1551.00
156_I207_D1.1521.00
238_H242_M1.1511.00
171_I214_L1.1491.00
48_L278_V1.1481.00
129_M154_T1.1481.00
219_P223_M1.1461.00
281_A285_Y1.1441.00
53_L107_E1.1431.00
323_N328_G1.1401.00
213_Q217_D1.1401.00
90_P134_L1.1401.00
43_Y285_Y1.1361.00
169_D173_T1.1271.00
208_Y238_H1.1261.00
185_I214_L1.1261.00
330_D334_L1.1251.00
289_E294_T1.1211.00
64_I99_L1.1181.00
46_R78_E1.1151.00
324_A328_G1.1121.00
168_C213_Q1.1101.00
55_Y82_A1.1101.00
43_Y77_E1.1021.00
129_M166_F1.1001.00
232_L260_A1.0981.00
235_A261_V1.0971.00
143_R150_V1.0921.00
327_A331_I1.0821.00
139_V177_K1.0781.00
152_V180_C1.0721.00
29_S53_L1.0701.00
156_I163_S1.0681.00
128_L138_C1.0561.00
167_L210_R1.0541.00
279_V303_M1.0531.00
156_I187_A1.0501.00
40_H289_E1.0501.00
297_G300_T1.0471.00
98_K102_A1.0441.00
139_V174_V1.0421.00
170_F174_V1.0371.00
173_T177_K1.0351.00
233_E270_D1.0311.00
62_G66_H1.0311.00
39_R43_Y1.0301.00
282_M303_M1.0261.00
289_E292_Q1.0171.00
129_M170_F1.0161.00
293_G297_G1.0141.00
170_F173_T1.0111.00
274_D277_A1.0101.00
30_V45_L1.0081.00
30_V251_A0.9911.00
315_Q319_Y0.9851.00
264_E267_G0.9801.00
154_T170_F0.9801.00
256_G275_P0.9761.00
139_V152_V0.9721.00
135_V174_V0.9711.00
264_E268_S0.9671.00
323_N329_A0.9641.00
93_L138_C0.9601.00
262_D266_F0.9591.00
251_A257_I0.9541.00
61_T96_C0.9531.00
43_Y75_S0.9531.00
282_M286_I0.9521.00
94_A98_K0.9511.00
263_R269_S0.9461.00
132_A169_D0.9441.00
91_A141_A0.9381.00
40_H285_Y0.9331.00
229_I235_A0.9301.00
46_R80_P0.9160.99
287_E291_S0.9060.99
251_A258_L0.9050.99
263_R268_S0.9040.99
48_L259_A0.9020.99
250_E254_N0.9010.99
133_Q136_A0.8990.99
280_R284_P0.8900.99
319_Y323_N0.8880.99
177_K180_C0.8870.99
307_F313_A0.8820.99
180_C183_F0.8700.99
277_A281_A0.8690.99
174_V180_C0.8670.99
98_K101_E0.8670.99
82_A151_T0.8620.99
229_I245_V0.8610.99
285_Y288_R0.8610.99
282_M299_I0.8580.99
99_L102_A0.8580.99
116_S119_V0.8570.99
97_A142_M0.8550.99
290_L298_H0.8540.99
291_S295_Y0.8520.99
90_P137_D0.8510.99
171_I183_F0.8480.99
73_A103_R0.8450.99
200_N204_P0.8440.99
140_K176_G0.8400.99
233_E264_E0.8390.99
73_A76_E0.8380.99
184_I246_M0.8270.99
29_S55_Y0.8260.99
141_A144_D0.8250.99
232_L264_E0.8250.99
120_Q127_C0.8230.99
135_V139_V0.8230.99
301_R305_G0.8200.99
64_I69_G0.8180.99
168_C214_L0.8120.99
65_I95_Q0.8120.99
182_M222_T0.8080.99
30_V37_T0.8080.99
95_Q99_L0.8070.99
261_V265_I0.8060.99
162_D166_F0.8010.99
65_I92_A0.7970.99
263_R270_D0.7940.99
92_A95_Q0.7930.99
185_I223_M0.7930.99
232_L236_K0.7920.99
39_R73_A0.7900.98
123_M127_C0.7900.98
27_R52_T0.7890.98
154_T167_L0.7880.98
275_P310_I0.7870.98
239_L245_V0.7870.98
99_L103_R0.7850.98
94_A141_A0.7830.98
307_F316_W0.7780.98
100_A105_Y0.7770.98
28_F258_L0.7770.98
233_E236_K0.7740.98
113_G226_N0.7730.98
212_Y242_M0.7670.98
239_L242_M0.7640.98
45_L251_A0.7640.98
56_T81_V0.7590.98
228_G249_R0.7580.98
117_D121_N0.7570.98
36_W305_G0.7570.98
74_Y81_V0.7500.98
142_M150_V0.7490.98
314_R318_R0.7490.98
209_P213_Q0.7480.98
127_C130_G0.7480.98
225_I241_H0.7480.98
112_V152_V0.7450.98
27_R244_G0.7440.98
159_D189_K0.7370.98
326_K330_D0.7350.98
283_Y326_K0.7300.97
90_P138_C0.7290.97
284_P287_E0.7280.97
141_A145_V0.7270.97
252_Y305_G0.7260.97
31_A246_M0.7230.97
294_T298_H0.7210.97
107_E151_T0.7210.97
45_L50_R0.7190.97
331_I334_L0.7170.97
74_Y78_E0.7160.97
143_R180_C0.7160.97
283_Y287_E0.7110.97
234_E238_H0.7090.97
109_N184_I0.7080.97
260_A273_A0.7070.97
60_T86_G0.7070.97
168_C172_N0.7030.97
281_A284_P0.7020.97
47_L77_E0.7020.97
53_L182_M0.7010.97
175_S183_F0.7010.97
327_A330_D0.7000.97
230_K248_G0.6910.97
94_A146_V0.6900.96
154_T171_I0.6900.96
211_V223_M0.6890.96
166_F170_F0.6850.96
46_R54_L0.6840.96
45_L258_L0.6840.96
293_G324_A0.6820.96
313_A317_R0.6780.96
317_R321_S0.6780.96
117_D120_Q0.6780.96
223_M242_M0.6780.96
72_L78_E0.6770.96
328_G332_N0.6770.96
200_N206_L0.6740.96
72_L75_S0.6720.96
28_F235_A0.6700.96
275_P279_V0.6680.96
34_L58_M0.6620.96
104_G148_I0.6600.95
85_L93_L0.6590.95
159_D199_E0.6570.95
264_E270_D0.6570.95
120_Q158_I0.6520.95
183_F221_L0.6510.95
108_I146_V0.6500.95
163_S210_R0.6490.95
267_G271_T0.6460.95
61_T93_L0.6430.95
47_L285_Y0.6430.95
110_L139_V0.6410.95
212_Y229_I0.6370.95
61_T92_A0.6360.94
182_M244_G0.6340.94
154_T183_F0.6290.94
171_I185_I0.6290.94
88_S123_M0.6280.94
163_S168_C0.6270.94
36_W252_Y0.6270.94
45_L48_L0.6260.94
40_H43_Y0.6260.94
268_S271_T0.6250.94
184_I224_S0.6240.94
112_V174_V0.6230.94
161_Q166_F0.6210.94
44_F285_Y0.6200.94
270_D273_A0.6200.94
214_L217_D0.6180.94
88_S124_F0.6160.94
232_L261_V0.6160.94
296_L300_T0.6150.93
247_V251_A0.6150.93
74_Y79_H0.6130.93
80_P106_D0.6120.93
279_V282_M0.6100.93
160_D199_E0.6080.93
180_C221_L0.6070.93
130_G159_D0.6070.93
202_E228_G0.6070.93
132_A173_T0.6070.93
295_Y298_H0.6040.93
149_P181_E0.6030.93
232_L235_A0.6020.93
56_T83_L0.6010.93
129_M135_V0.5980.93
167_L185_I0.5980.93
247_V257_I0.5920.92
247_V258_L0.5910.92
254_N257_I0.5910.92
71_Y74_Y0.5910.92
97_A150_V0.5900.92
208_Y225_I0.5900.92
97_A108_I0.5890.92
236_K239_L0.5850.92
62_G89_D0.5850.92
168_C171_I0.5840.92
116_S201_R0.5790.91
173_T176_G0.5780.91
304_L321_S0.5770.91
29_S182_M0.5760.91
208_Y241_H0.5740.91
119_V124_F0.5730.91
316_W319_Y0.5730.91
276_V333_V0.5730.91
238_H241_H0.5720.91
171_I219_P0.5710.91
123_M134_L0.5710.91
29_S184_I0.5700.91
60_T63_A0.5680.90
113_G246_M0.5610.90
44_F282_M0.5610.90
211_V242_M0.5600.90
307_F317_R0.5600.90
236_K265_I0.5570.90
65_I96_C0.5570.90
70_D103_R0.5550.89
33_M36_W0.5550.89
64_I103_R0.5550.89
37_T45_L0.5550.89
94_A142_M0.5520.89
175_S222_T0.5520.89
290_L294_T0.5520.89
64_I68_K0.5520.89
131_N137_D0.5510.89
287_E326_K0.5510.89
50_R54_L0.5490.89
39_R74_Y0.5480.89
259_A263_R0.5460.89
28_F262_D0.5460.89
235_A239_L0.5450.89
158_I190_A0.5440.89
286_I299_I0.5430.88
136_A174_V0.5400.88
168_C210_R0.5400.88
211_V238_H0.5390.88
290_L295_Y0.5390.88
285_Y289_E0.5390.88
239_L265_I0.5380.88
171_I223_M0.5370.88
269_S272_D0.5360.88
44_F48_L0.5360.88
72_L76_E0.5350.88
142_M146_V0.5330.88
260_A264_E0.5320.87
229_I247_V0.5300.87
126_A129_M0.5270.87
83_L105_Y0.5260.87
187_A206_L0.5260.87
286_I290_L0.5260.87
232_L270_D0.5260.87
85_L142_M0.5260.87
287_E330_D0.5250.87
294_T299_I0.5250.87
117_D201_R0.5250.87
28_F52_T0.5250.87
174_V183_F0.5250.87
256_G259_A0.5200.86
91_A94_A0.5160.86
97_A101_E0.5160.86
44_F281_A0.5140.86
261_V264_E0.5130.85
257_I261_V0.5130.85
94_A144_D0.5120.85
216_R241_H0.5100.85
284_P326_K0.5090.85
162_D189_K0.5080.85
98_K146_V0.5070.85
55_Y107_E0.5060.85
73_A289_E0.5050.85
55_Y151_T0.5050.85
82_A182_M0.5050.85
209_P212_Y0.5030.84
64_I67_G0.5030.84
298_H301_R0.5030.84
143_R177_K0.5030.84
98_K144_D0.5020.84
138_C141_A0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b0pA 1 0.8754 100 0.372 Contact Map
1vhnA 1 0.8609 100 0.398 Contact Map
4bfaA 1 0.8783 100 0.407 Contact Map
4xp7A 1 0.8319 100 0.45 Contact Map
1gteA 4 0.9507 100 0.625 Contact Map
3l5aA 1 0.8261 100 0.638 Contact Map
3tjlA 2 0.8435 100 0.645 Contact Map
1o94A 2 0.9536 100 0.652 Contact Map
4gbuA 2 0.8203 100 0.652 Contact Map
4jicA 1 0.7739 100 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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