GREMLIN Database
YJAH - Uncharacterized protein YjaH
UniProt: P32681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11917
Length: 231 (212)
Sequences: 111 (70)
Seq/√Len: 4.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_V207_A3.9290.88
161_R181_L3.5550.82
215_L218_N3.1240.72
77_T192_R3.1200.72
67_A206_E2.5760.57
182_D209_E2.5050.54
192_R218_N2.4430.52
68_V224_W2.4300.52
91_L105_R2.2120.45
108_F136_Y2.2000.45
163_H199_D2.1820.44
173_E225_Q2.1490.43
120_E125_K2.0430.40
57_K85_Q2.0320.39
77_T218_N1.9990.38
121_S126_Q1.9610.37
111_R124_E1.9460.37
117_M153_G1.8790.35
25_A161_R1.8740.35
21_M29_T1.8660.35
70_S192_R1.8410.34
103_N128_L1.8150.33
181_L189_I1.7760.32
58_D215_L1.7490.31
128_L221_F1.7420.31
58_D151_R1.6610.29
217_A221_F1.6540.29
192_R224_W1.6450.28
65_L144_R1.6290.28
19_S23_A1.6290.28
84_W91_L1.6210.28
66_L128_L1.6160.28
72_W83_R1.6150.28
64_H114_L1.5890.27
70_S217_A1.5570.26
80_R121_S1.5450.26
151_R161_R1.5420.26
155_V167_Q1.5420.26
183_S202_V1.5350.26
72_W84_W1.5320.26
132_Q173_E1.5190.25
189_I200_V1.4980.25
49_Q138_Y1.4780.24
76_D166_E1.4690.24
27_L193_Q1.4620.24
163_H170_T1.4440.24
32_S128_L1.4320.23
79_T200_V1.4110.23
45_F52_V1.4040.23
25_A181_L1.4010.23
70_S224_W1.3720.22
56_R162_W1.3720.22
221_F224_W1.3590.22
45_F219_S1.3590.22
192_R217_A1.3290.21
62_N146_I1.3270.21
43_S116_F1.3270.21
216_V220_D1.3180.21
122_D125_K1.3120.21
120_E126_Q1.3070.21
146_I208_P1.3060.21
202_V223_R1.2840.20
76_D202_V1.2820.20
45_F112_G1.2680.20
47_E143_I1.2510.19
30_A169_V1.2410.19
38_P116_F1.2360.19
87_D95_N1.2350.19
58_D201_S1.2340.19
46_A49_Q1.2320.19
85_Q115_S1.2300.19
43_S150_L1.2250.19
137_R229_K1.1960.18
40_F150_L1.1910.18
49_Q136_Y1.1890.18
54_I207_A1.1880.18
22_L166_E1.1860.18
114_L123_G1.1820.18
43_S89_L1.1810.18
121_S144_R1.1810.18
80_R126_Q1.1760.18
68_V175_Q1.1670.18
92_I143_I1.1650.18
117_M142_Q1.1620.18
77_T215_L1.1600.18
47_E144_R1.1520.17
30_A59_S1.1440.17
111_R187_A1.1430.17
37_L54_I1.1420.17
36_S58_D1.1390.17
77_T221_F1.1380.17
113_D146_I1.1350.17
149_A185_A1.1350.17
180_D229_K1.1320.17
30_A70_S1.1280.17
41_T58_D1.1230.17
137_R141_D1.1110.17
74_S144_R1.1080.17
51_A114_L1.1080.17
138_Y142_Q1.1060.17
217_A224_W1.0990.17
169_V189_I1.0980.17
58_D134_D1.0960.16
45_F143_I1.0880.16
194_S228_E1.0800.16
173_E219_S1.0640.16
209_E212_Q1.0610.16
33_H73_R1.0570.16
49_Q139_R1.0560.16
41_T189_I1.0450.16
195_R198_V1.0440.16
19_S229_K1.0410.16
207_A219_S1.0380.15
127_Q138_Y1.0360.15
88_N220_D1.0300.15
135_L178_K1.0290.15
57_K154_R1.0280.15
28_L150_L1.0230.15
70_S221_F1.0220.15
84_W93_N1.0200.15
46_A139_R1.0180.15
16_W47_E1.0140.15
48_D210_G1.0050.15
45_F168_T1.0020.15
129_S148_D0.9980.15
60_G202_V0.9960.15
54_I147_S0.9900.15
70_S218_N0.9830.15
34_N59_S0.9810.15
163_H198_V0.9700.14
85_Q189_I0.9660.14
67_A108_F0.9610.14
91_L229_K0.9510.14
43_S148_D0.9480.14
46_A97_Y0.9400.14
203_A224_W0.9400.14
121_S125_K0.9400.14
168_T183_S0.9370.14
52_V193_Q0.9290.14
87_D106_A0.9170.14
25_A227_N0.9160.14
58_D70_S0.9150.14
30_A73_R0.9150.14
77_T224_W0.9100.13
58_D85_Q0.9090.13
130_N219_S0.9090.13
106_A200_V0.9040.13
76_D196_S0.9020.13
75_G219_S0.9010.13
106_A126_Q0.8990.13
186_I189_I0.8960.13
115_S179_P0.8840.13
137_R225_Q0.8830.13
50_G162_W0.8810.13
36_S209_E0.8710.13
84_W105_R0.8710.13
69_F72_W0.8700.13
126_Q139_R0.8690.13
57_K135_L0.8620.13
117_M133_I0.8540.13
95_N133_I0.8540.13
201_S215_L0.8510.13
38_P89_L0.8510.13
22_L37_L0.8440.13
175_Q212_Q0.8390.12
98_S143_I0.8350.12
21_M65_L0.8340.12
38_P160_G0.8310.12
39_P67_A0.8300.12
135_L173_E0.8270.12
62_N227_N0.8250.12
215_L219_S0.8240.12
149_A192_R0.8230.12
183_S194_S0.8210.12
88_N148_D0.8200.12
218_N224_W0.8150.12
100_P104_I0.8140.12
64_H84_W0.8110.12
91_L137_R0.8090.12
120_E124_E0.8090.12
26_L70_S0.8080.12
29_T229_K0.8040.12
135_L182_D0.7990.12
89_L226_P0.7990.12
120_E147_S0.7940.12
148_D180_D0.7910.12
69_F125_K0.7890.12
68_V78_T0.7870.12
17_R115_S0.7830.12
145_Q195_R0.7800.12
35_S61_D0.7780.12
41_T79_T0.7770.12
68_V203_A0.7710.12
109_D170_T0.7660.11
169_V202_V0.7590.11
22_L64_H0.7590.11
54_I114_L0.7570.11
62_N225_Q0.7540.11
137_R145_Q0.7490.11
128_L215_L0.7490.11
45_F228_E0.7420.11
21_M89_L0.7400.11
174_G179_P0.7380.11
181_L190_E0.7330.11
116_F181_L0.7330.11
134_D189_I0.7310.11
131_D174_G0.7250.11
142_Q169_V0.7230.11
196_S218_N0.7230.11
40_F207_A0.7180.11
45_F98_S0.7180.11
156_V206_E0.7100.11
57_K189_I0.7050.11
203_A215_L0.7040.11
118_Q131_D0.7020.11
108_F135_L0.7020.11
183_S197_S0.7010.11
176_T181_L0.7010.11
148_D216_V0.7000.11
118_Q142_Q0.7000.11
23_A64_H0.6990.11
79_T93_N0.6950.11
181_L198_V0.6930.11
179_P201_S0.6910.11
106_A121_S0.6900.11
16_W183_S0.6820.10
105_R139_R0.6810.10
17_R161_R0.6730.10
104_I189_I0.6710.10
60_G184_Q0.6660.10
181_L191_R0.6660.10
202_V219_S0.6650.10
32_S220_D0.6610.10
168_T200_V0.6560.10
94_I125_K0.6550.10
54_I126_Q0.6520.10
94_I116_F0.6500.10
18_R137_R0.6470.10
94_I126_Q0.6450.10
22_L154_R0.6430.10
42_A48_D0.6390.10
83_R186_I0.6380.10
64_H72_W0.6370.10
85_Q151_R0.6370.10
61_D115_S0.6360.10
103_N200_V0.6360.10
153_G210_G0.6330.10
174_G216_V0.6270.10
192_R215_L0.6250.10
30_A185_A0.6240.10
61_D125_K0.6220.10
36_S227_N0.6200.10
65_L202_V0.6170.10
64_H91_L0.6060.10
79_T186_I0.6020.10
148_D179_P0.6010.09
118_Q153_G0.5980.09
137_R173_E0.5980.09
21_M223_R0.5950.09
146_I212_Q0.5950.09
19_S176_T0.5930.09
33_H142_Q0.5930.09
93_N206_E0.5900.09
189_I201_S0.5900.09
59_S228_E0.5880.09
40_F146_I0.5870.09
78_T143_I0.5850.09
155_V161_R0.5840.09
17_R181_L0.5830.09
46_A142_Q0.5820.09
220_D225_Q0.5810.09
63_V84_W0.5810.09
135_L175_Q0.5780.09
81_E84_W0.5740.09
106_A120_E0.5720.09
135_L211_S0.5710.09
135_L179_P0.5670.09
173_E220_D0.5640.09
79_T154_R0.5560.09
22_L34_N0.5470.09
28_L43_S0.5460.09
121_S199_D0.5460.09
140_A209_E0.5450.09
30_A206_E0.5410.09
40_F149_A0.5410.09
35_S181_L0.5400.09
64_H140_A0.5400.09
54_I186_I0.5390.09
41_T84_W0.5360.09
58_D179_P0.5340.09
16_W132_Q0.5330.09
54_I188_H0.5320.09
118_Q125_K0.5310.09
98_S105_R0.5310.09
36_S122_D0.5300.09
93_N227_N0.5290.09
40_F56_R0.5290.09
84_W188_H0.5280.09
182_D194_S0.5260.09
88_N144_R0.5250.09
40_F123_G0.5240.09
100_P196_S0.5230.09
23_A124_E0.5210.09
45_F151_R0.5200.09
98_S158_R0.5200.09
51_A167_Q0.5140.09
45_F104_I0.5120.09
38_P43_S0.5100.09
47_E223_R0.5070.09
65_L178_K0.5060.09
194_S227_N0.5060.09
77_T217_A0.5040.08
117_M131_D0.5030.08
125_K136_Y0.5030.08
63_V185_A0.5030.08
43_S169_V0.5030.08
65_L123_G0.5020.08
23_A30_A0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ecfA 2 0.7532 89.7 0.954 Contact Map
3o4hA 2 0.8052 83.6 0.958 Contact Map
1sq9A 1 0.8658 74.4 0.962 Contact Map
1yr2A 1 0.619 67.8 0.964 Contact Map
2xyiA 1 0.8961 66.3 0.964 Contact Map
1jofA 4 0.671 65.3 0.964 Contact Map
3vgzA 1 0.7619 61.6 0.965 Contact Map
4uerb 1 0.8528 59.4 0.966 Contact Map
3zbiC 1 0.1126 59.2 0.966 Contact Map
1ri6A 1 0.6623 55.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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