GREMLIN Database
YJAG - Uncharacterized protein YjaG
UniProt: P32680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11916
Length: 196 (190)
Sequences: 251 (159)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_F85_F3.4170.98
23_A55_I3.2990.97
9_R165_A2.7560.92
140_S143_E2.6970.91
49_R53_D2.6680.91
27_E49_R2.6320.90
29_M99_A2.5680.89
23_A119_V2.5450.89
127_V153_E2.4890.88
127_V189_N2.4750.87
16_W170_R2.4570.87
123_S189_N2.3810.85
123_S127_V2.3150.84
142_E194_F2.2330.81
50_R194_F2.2180.81
42_F85_F2.2160.81
36_F92_P2.1920.80
123_S153_E2.1720.79
55_I104_V2.1530.79
33_Y43_G2.1260.78
6_I164_L2.0970.77
36_F81_S2.0090.73
130_L149_A1.9520.71
21_F157_Q1.9010.69
26_C103_L1.8830.68
88_Y92_P1.8690.68
33_Y41_G1.8590.67
176_K179_R1.8530.67
20_T59_L1.8390.66
98_V122_T1.8180.66
38_Q173_E1.7910.64
13_L119_V1.7760.64
25_L189_N1.6640.58
37_C71_Q1.6510.58
13_L194_F1.6400.57
98_V117_V1.6350.57
134_Q173_E1.6310.57
153_E189_N1.6280.57
32_N188_S1.5920.55
120_S157_Q1.5780.54
78_A190_I1.5750.54
130_L134_Q1.5660.54
77_E192_I1.5170.51
10_L192_I1.4890.50
57_E61_V1.4600.48
124_I154_W1.4570.48
25_L120_S1.4450.48
36_F86_D1.4450.48
65_K90_V1.4420.48
84_D194_F1.4350.47
36_F42_F1.3820.45
16_W27_E1.3790.44
131_E147_N1.3200.42
14_E194_F1.3050.41
9_R74_K1.3030.41
156_I184_E1.2960.40
35_M186_G1.2920.40
47_I78_A1.2840.40
36_F90_V1.2840.40
67_N90_V1.2770.40
77_E179_R1.2730.39
130_L140_S1.2660.39
94_I159_E1.2430.38
35_M132_M1.2350.38
28_R31_P1.2250.37
28_R32_N1.2220.37
27_E94_I1.2120.37
53_D175_I1.2080.36
75_F181_D1.1900.36
42_F78_A1.1900.36
73_E84_D1.1850.35
156_I190_I1.1830.35
28_R153_E1.1810.35
33_Y44_D1.1600.34
82_A90_V1.1500.34
71_Q74_K1.1490.34
101_S130_L1.1460.34
16_W72_L1.1440.33
100_L161_F1.1310.33
72_L188_S1.1220.33
116_A135_A1.0940.31
67_N92_P1.0900.31
18_H113_L1.0900.31
38_Q125_T1.0710.30
128_A132_M1.0670.30
50_R57_E1.0610.30
41_G50_R1.0460.29
31_P52_L1.0400.29
37_C43_G1.0390.29
36_F87_L1.0280.29
164_L171_D1.0240.28
166_E177_G1.0230.28
130_L167_C1.0200.28
156_I181_D1.0060.28
13_L140_S0.9890.27
23_A71_Q0.9880.27
69_D95_D0.9820.27
71_Q157_Q0.9790.27
38_Q146_E0.9780.27
29_M119_V0.9720.26
117_V193_I0.9640.26
31_P76_E0.9580.26
22_M160_I0.9470.25
48_Y97_C0.9430.25
150_V178_L0.9430.25
15_S116_A0.9420.25
39_Q179_R0.9380.25
35_M89_G0.9370.25
172_I190_I0.9340.25
54_L57_E0.9260.25
89_G192_I0.9240.25
64_A68_F0.9170.24
40_T87_L0.9160.24
50_R108_L0.9150.24
12_R30_Y0.9060.24
31_P80_P0.9050.24
147_N150_V0.8980.24
155_D183_R0.8900.23
92_P95_D0.8850.23
21_F120_S0.8850.23
83_D193_I0.8800.23
38_Q103_L0.8790.23
27_E59_L0.8710.23
35_M115_H0.8630.22
99_A119_V0.8630.22
43_G139_M0.8590.22
35_M160_I0.8470.22
67_N123_S0.8430.22
80_P92_P0.8390.22
88_Y130_L0.8380.22
28_R96_A0.8290.21
6_I157_Q0.8250.21
42_F128_A0.8200.21
23_A59_L0.8190.21
10_L114_E0.8180.21
26_C178_L0.8180.21
25_L75_F0.8110.21
90_V163_L0.8110.21
10_L21_F0.8100.21
96_A108_L0.8100.21
13_L148_P0.8030.20
61_V64_A0.8000.20
11_E124_I0.7970.20
157_Q161_F0.7970.20
88_Y91_Y0.7950.20
41_G45_G0.7940.20
33_Y40_T0.7920.20
31_P49_R0.7920.20
66_V180_A0.7920.20
144_L192_I0.7870.20
86_D146_E0.7860.20
35_M41_G0.7780.20
116_A156_I0.7740.20
127_V157_Q0.7740.20
72_L143_E0.7710.19
46_Q179_R0.7660.19
111_E129_M0.7630.19
7_H124_I0.7600.19
108_L136_G0.7570.19
67_N91_Y0.7540.19
31_P53_D0.7530.19
144_L167_C0.7520.19
42_F179_R0.7500.19
109_S164_L0.7460.19
45_G187_E0.7410.19
63_D175_I0.7400.18
78_A82_A0.7400.18
28_R127_V0.7390.18
152_Q175_I0.7310.18
46_Q50_R0.7270.18
77_E142_E0.7260.18
175_I190_I0.7190.18
84_D135_A0.7130.18
69_D148_P0.7050.17
21_F25_L0.7010.17
28_R178_L0.7000.17
124_I150_V0.6950.17
126_T190_I0.6910.17
140_S159_E0.6900.17
76_E153_E0.6890.17
111_E167_C0.6850.17
27_E185_A0.6830.17
65_K91_Y0.6800.17
173_E176_K0.6790.17
14_E169_E0.6770.17
125_T128_A0.6730.17
173_E185_A0.6730.17
76_E126_T0.6690.16
57_E71_Q0.6670.16
57_E66_V0.6660.16
140_S179_R0.6650.16
79_I175_I0.6620.16
49_R159_E0.6610.16
104_V109_S0.6570.16
24_C160_I0.6560.16
12_R77_E0.6540.16
7_H164_L0.6530.16
18_H115_H0.6520.16
41_G148_P0.6500.16
24_C98_V0.6460.16
17_Q128_A0.6450.16
51_I68_F0.6410.16
87_L152_Q0.6380.16
37_C78_A0.6360.16
131_E176_K0.6340.16
83_D179_R0.6320.15
81_S94_I0.6320.15
86_D130_L0.6300.15
165_A177_G0.6300.15
144_L170_R0.6290.15
177_G187_E0.6280.15
18_H167_C0.6270.15
89_G191_G0.6250.15
61_V68_F0.6250.15
63_D75_F0.6240.15
76_E79_I0.6200.15
113_L117_V0.6190.15
121_K190_I0.6170.15
41_G194_F0.6160.15
80_P93_A0.6150.15
150_V161_F0.6120.15
7_H121_K0.6090.15
122_T161_F0.6060.15
62_K66_V0.6050.15
75_F99_A0.6000.15
118_E186_G0.5960.15
66_V124_I0.5950.15
17_Q99_A0.5950.15
105_H175_I0.5910.14
20_T150_V0.5910.14
144_L174_L0.5890.14
106_S128_A0.5890.14
174_L179_R0.5870.14
10_L98_V0.5860.14
112_T130_L0.5830.14
6_I154_W0.5830.14
8_L11_E0.5770.14
112_T144_L0.5760.14
9_R22_M0.5750.14
116_A143_E0.5740.14
171_D183_R0.5730.14
40_T53_D0.5710.14
30_Y136_G0.5690.14
6_I124_I0.5610.14
86_D117_V0.5600.14
72_L145_K0.5570.14
119_V149_A0.5560.14
89_G144_L0.5550.14
37_C55_I0.5550.14
90_V160_I0.5540.14
62_K114_E0.5520.14
42_F127_V0.5460.13
81_S84_D0.5450.13
111_E115_H0.5450.13
11_E121_K0.5430.13
60_T173_E0.5420.13
108_L134_Q0.5400.13
139_M143_E0.5390.13
106_S122_T0.5370.13
33_Y39_Q0.5370.13
13_L149_A0.5350.13
114_E168_E0.5340.13
115_H118_E0.5320.13
9_R183_R0.5290.13
16_W76_E0.5280.13
57_E60_T0.5270.13
41_G122_T0.5250.13
29_M92_P0.5250.13
67_N70_S0.5250.13
33_Y47_I0.5230.13
77_E138_E0.5220.13
28_R188_S0.5210.13
20_T23_A0.5170.13
113_L127_V0.5160.13
163_L186_G0.5130.13
86_D106_S0.5130.13
68_F160_I0.5110.13
60_T170_R0.5070.13
7_H29_M0.5070.13
161_F179_R0.5060.13
39_Q79_I0.5060.13
36_F164_L0.5050.12
15_S30_Y0.5010.12
116_A144_L0.5000.12
103_L156_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f7cA 2 0.9898 100 0.041 Contact Map
2q9rA 2 0.9745 100 0.056 Contact Map
3ibvA 1 0.2296 17.9 0.961 Contact Map
2cwyA 1 0.3673 8.9 0.966 Contact Map
3fzeA 1 0.5051 7.7 0.967 Contact Map
3tosA 5 0.2755 7.3 0.967 Contact Map
4a1nA 2 0.3571 5.5 0.969 Contact Map
2vfrA 1 0.301 3.9 0.971 Contact Map
3sgvB 2 0.25 3.6 0.971 Contact Map
1y9bA 4 0.4082 3.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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