GREMLIN Database
PTFB3 - Fructose-like phosphotransferase enzyme IIB component 3
UniProt: P32676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11912
Length: 113 (99)
Sequences: 2099 (1198)
Seq/√Len: 120.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_S53_D3.4441.00
51_D55_R3.1661.00
90_E93_R2.8621.00
31_E96_S2.7341.00
52_E56_R2.5351.00
45_T48_R2.4731.00
5_V60_A2.4541.00
31_E92_Q2.2871.00
3_Y34_G2.2251.00
30_L92_Q2.1721.00
6_A37_I2.0561.00
3_Y56_R1.9851.00
71_A81_Q1.9301.00
86_A90_E1.8981.00
69_A72_E1.8851.00
59_V98_V1.8771.00
21_A25_E1.8051.00
27_L30_L1.7301.00
25_E29_L1.7231.00
92_Q96_S1.7181.00
24_L35_V1.7171.00
28_C35_V1.7001.00
60_A77_C1.5821.00
27_L31_E1.5611.00
96_S100_K1.5221.00
5_V49_L1.4541.00
38_E73_R1.4391.00
50_A53_D1.4251.00
27_L91_P1.3471.00
22_E25_E1.3391.00
36_S47_N1.2550.99
49_L54_I1.2550.99
65_D84_I1.2340.99
9_A66_I1.1660.99
17_T39_T1.1440.99
84_I87_F1.1290.99
85_Y89_R1.1170.99
7_V40_Q1.1130.99
39_T47_N1.1130.99
64_T68_L1.0870.98
40_Q73_R1.0780.98
78_R101_V1.0620.98
52_E55_R1.0510.98
27_L92_Q1.0410.98
43_L46_E1.0240.98
93_R97_A1.0240.98
86_A97_A1.0030.97
34_G56_R0.9940.97
4_L59_V0.9920.97
80_V94_V0.9770.97
6_A35_V0.9770.97
82_C94_V0.9700.97
26_K29_L0.9300.96
3_Y58_D0.9190.96
33_W95_M0.9170.96
18_Y39_T0.9070.95
72_E75_E0.9060.95
22_E26_K0.8950.95
33_W99_R0.8940.95
54_I77_C0.8890.95
97_A102_L0.8780.95
64_T81_Q0.8730.94
31_E99_R0.8610.94
4_L33_W0.8480.93
9_A40_Q0.8450.93
62_L71_A0.8360.93
78_R102_L0.8260.93
19_M23_R0.8100.92
36_S50_A0.8100.92
60_A76_H0.8060.92
62_L69_A0.8000.91
10_C13_G0.7970.91
18_Y46_E0.7960.91
82_C86_A0.7940.91
87_F90_E0.7810.90
21_A47_N0.7800.90
59_V101_V0.7780.90
24_L28_C0.7610.89
9_A64_T0.7610.89
40_Q67_E0.7580.89
97_A101_V0.7560.89
27_L95_M0.7510.88
65_D83_S0.7480.88
91_P95_M0.7460.88
61_L98_V0.7320.87
62_L79_Y0.7270.87
59_V80_V0.7060.85
93_R96_S0.6970.84
63_I82_C0.6800.83
90_E97_A0.6770.83
66_I101_V0.6700.82
12_S43_L0.6640.81
4_L99_R0.6630.81
13_G17_T0.6620.81
53_D56_R0.6600.81
5_V57_A0.6480.80
40_Q69_A0.6380.79
55_R58_D0.6250.77
19_M43_L0.6230.77
40_Q62_L0.6230.77
23_R26_K0.6230.77
23_R27_L0.6210.77
7_V74_F0.6190.77
10_C17_T0.6160.76
98_V102_L0.6140.76
80_V86_A0.6120.76
20_A88_L0.6080.76
83_S89_R0.5990.74
11_V66_I0.5980.74
83_S86_A0.5970.74
54_I57_A0.5940.74
42_A46_E0.5940.74
38_E74_F0.5860.73
4_L28_C0.5850.73
40_Q71_A0.5810.72
87_F91_P0.5810.72
97_A100_K0.5800.72
18_Y41_G0.5760.72
87_F94_V0.5750.71
4_L95_M0.5750.71
26_K30_L0.5750.71
11_V83_S0.5740.71
59_V99_R0.5710.71
34_G58_D0.5700.71
11_V21_A0.5670.70
6_A16_H0.5660.70
8_T13_G0.5560.69
62_L68_L0.5550.69
40_Q49_L0.5520.68
29_L81_Q0.5510.68
58_D77_C0.5490.68
40_Q66_I0.5420.67
23_R88_L0.5410.67
64_T67_E0.5350.66
10_C14_V0.5350.66
25_E47_N0.5300.65
25_E35_V0.5300.65
80_V98_V0.5250.65
80_V101_V0.5230.64
8_T84_I0.5230.64
71_A75_E0.5220.64
39_T44_G0.5180.63
84_I91_P0.5160.63
29_L32_K0.5160.63
21_A42_A0.5110.62
49_L77_C0.5060.62
31_E95_M0.5050.62
60_A79_Y0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r48A 1 0.9292 100 0.139 Contact Map
2kyrA 1 0.9469 100 0.302 Contact Map
2r4qA 1 0.9027 99.9 0.312 Contact Map
4tn5A 2 1 99.9 0.33 Contact Map
2m1zA 1 0.9292 99.9 0.341 Contact Map
4mgeA 3 0.885 99.4 0.606 Contact Map
1e2bA 1 0.885 99.4 0.613 Contact Map
2l2qA 1 0.8673 99.2 0.648 Contact Map
3czcA 1 0.7965 98.4 0.74 Contact Map
1tvmA 1 0.823 98.1 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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