GREMLIN Database
PTFC2 - Fructose-like permease IIC component 2
UniProt: P32672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11908
Length: 359 (334)
Sequences: 1747 (905)
Seq/√Len: 49.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_G327_T5.5991.00
233_A241_F4.2621.00
92_G109_A4.1201.00
14_H79_S4.0311.00
73_A109_A3.9821.00
190_F196_V3.6371.00
81_A85_A3.5971.00
235_L253_L3.5811.00
234_T249_G3.5111.00
296_Q311_E3.4921.00
69_V106_A3.4041.00
116_V145_I3.3721.00
281_V330_C3.2791.00
221_V320_V3.2761.00
186_L280_M3.2281.00
25_F90_A2.9201.00
190_F280_M2.8311.00
237_G332_N2.7471.00
271_D274_R2.7051.00
289_T293_V2.4691.00
315_G318_A2.4581.00
189_A283_S2.4311.00
64_G91_I2.3881.00
67_L94_W2.3841.00
241_F332_N2.3431.00
285_C326_V2.2691.00
278_S330_C2.1741.00
141_V145_I2.0961.00
228_L324_A2.0761.00
21_H86_L2.0361.00
17_T78_Y2.0231.00
55_K59_D2.0001.00
230_M331_V1.9850.99
117_V142_G1.9300.99
161_L164_S1.9260.99
202_A205_L1.8910.99
221_V286_G1.8760.99
36_S58_F1.8550.99
247_E250_K1.8210.99
231_G253_L1.8180.99
322_V326_V1.8080.99
204_M219_A1.7950.99
318_A322_V1.7860.99
239_K337_L1.7740.99
41_G44_A1.7710.99
184_M219_A1.7330.99
231_G235_L1.7150.98
87_A143_T1.6580.98
56_K152_W1.6340.98
163_N167_Q1.6330.98
223_I259_G1.6220.98
328_A332_N1.6210.98
271_D335_K1.6110.98
28_S143_T1.5990.98
240_N337_L1.5780.97
92_G146_T1.5690.97
213_Y298_Y1.5460.97
33_L65_L1.5440.97
118_H122_K1.5180.97
243_A246_R1.5170.97
288_V292_L1.5150.97
21_H75_Y1.5020.96
66_T94_W1.4980.96
295_A315_G1.4910.96
71_F90_A1.4900.96
58_F62_V1.4870.96
119_Y123_I1.4680.96
281_V322_V1.4630.96
17_T21_H1.4570.96
258_V305_I1.4560.96
75_Y86_L1.4520.96
89_C113_G1.4490.96
278_S334_L1.4450.96
75_Y78_Y1.4340.95
77_G113_G1.4270.95
31_I140_I1.4260.95
237_G240_N1.4260.95
233_A332_N1.4210.95
307_L313_K1.4160.95
289_T322_V1.4130.95
159_G163_N1.4070.95
289_T319_A1.3810.94
293_V315_G1.3810.94
189_A261_T1.3750.94
60_I147_A1.3710.94
238_R246_R1.3690.94
108_I112_I1.3610.94
80_I111_I1.3540.94
192_M261_T1.3490.94
74_A90_A1.3460.94
232_L324_A1.3420.93
120_L123_I1.3300.93
117_V138_I1.3250.93
77_G89_C1.3090.93
330_C334_L1.2960.92
275_V331_V1.2930.92
160_A164_S1.2900.92
104_F108_I1.2750.92
130_R133_M1.2580.91
12_R16_M1.2530.91
312_G315_G1.2410.90
240_N336_S1.2340.90
121_K261_T1.2270.90
119_Y122_K1.2240.90
112_I116_V1.2190.90
295_A311_E1.2100.89
220_A223_I1.2100.89
188_L223_I1.2060.89
133_M137_I1.2030.89
186_L190_F1.2000.89
276_I280_M1.1990.89
329_V333_V1.1980.89
164_S168_W1.1960.89
178_V292_L1.1920.89
212_V215_V1.1860.88
182_V288_V1.1860.88
149_I153_G1.1760.88
277_P280_M1.1740.88
189_A226_P1.1580.87
182_V284_V1.1470.87
232_L325_V1.1450.86
220_A259_G1.1380.86
162_T199_V1.1340.86
82_E121_K1.1300.86
232_L328_A1.1270.86
73_A106_A1.1160.85
240_N332_N1.1160.85
44_A54_L1.1140.85
285_C322_V1.1090.85
295_A312_G1.1020.84
40_Y54_L1.1020.84
319_A322_V1.1000.84
158_V199_V1.1000.84
125_V133_M1.0990.84
218_I291_A1.0980.84
14_H80_I1.0920.84
186_L284_V1.0890.84
289_T315_G1.0870.83
189_A279_I1.0830.83
73_A93_A1.0780.83
324_A328_A1.0770.83
201_Y216_V1.0760.83
224_C259_G1.0760.83
166_T170_Q1.0710.83
116_V146_T1.0690.82
192_M279_I1.0690.82
243_A247_E1.0660.82
7_I11_T1.0620.82
138_I142_G1.0600.82
186_L222_G1.0490.81
169_L203_F1.0460.81
73_A77_G1.0460.81
117_V120_L1.0430.81
188_L220_A1.0420.81
142_G146_T1.0400.81
144_L148_G1.0390.81
188_L259_G1.0320.80
293_V322_V1.0310.80
290_A295_A1.0260.80
27_V135_I1.0220.79
80_I115_I1.0210.79
88_P143_T1.0180.79
282_G327_T1.0160.79
225_I286_G1.0060.78
314_L318_A1.0060.78
289_T292_L1.0050.78
172_M183_I1.0040.78
242_S245_E1.0020.78
273_L277_P0.9990.78
178_V288_V0.9910.77
109_A150_M0.9890.77
56_K148_G0.9860.77
36_S41_G0.9800.77
268_A275_V0.9790.76
168_W171_G0.9790.76
89_C93_A0.9780.76
182_V186_L0.9760.76
184_M215_V0.9740.76
7_I10_N0.9720.76
172_M176_S0.9700.76
165_L168_W0.9680.76
120_L142_G0.9680.76
236_I324_A0.9620.75
43_G46_P0.9600.75
242_S270_A0.9560.75
95_V151_M0.9540.75
317_I321_A0.9470.74
90_A94_W0.9450.74
325_V329_V0.9440.74
230_M252_A0.9440.74
216_V219_A0.9350.73
17_T86_L0.9260.72
240_N338_A0.9240.72
325_V328_A0.9210.72
101_A105_G0.9190.72
225_I283_S0.9190.72
88_P142_G0.9120.71
176_S179_M0.9120.71
277_P334_L0.9110.71
284_V288_V0.9110.71
175_G178_V0.9100.71
232_L236_I0.9090.71
205_L209_A0.9090.71
41_G46_P0.9040.71
154_L158_V0.9030.70
261_T283_S0.9030.70
164_S167_Q0.8950.70
181_A287_A0.8930.70
201_Y208_V0.8900.69
217_A220_A0.8900.69
53_N144_L0.8880.69
230_M261_T0.8870.69
197_N200_A0.8840.69
221_V290_A0.8830.69
15_L111_I0.8820.69
205_L216_V0.8800.68
181_A185_G0.8790.68
77_G85_A0.8780.68
190_F279_I0.8760.68
220_A224_C0.8710.68
177_I294_G0.8700.68
201_Y205_L0.8620.67
73_A92_G0.8610.67
224_C305_I0.8590.67
265_I268_A0.8550.66
274_R335_K0.8510.66
10_N14_H0.8450.65
129_L258_V0.8350.64
107_L206_I0.8270.64
42_K46_P0.8200.63
257_C304_L0.8180.63
188_L218_I0.8170.63
275_V279_I0.8110.62
158_V161_L0.8100.62
15_L107_L0.8090.62
125_V132_V0.8070.62
197_N222_G0.8030.61
85_A117_V0.8020.61
75_Y90_A0.8020.61
236_I329_V0.7970.61
84_S121_K0.7940.60
168_W183_I0.7910.60
175_G179_M0.7910.60
59_D62_V0.7880.60
68_M106_A0.7870.60
107_L140_I0.7830.59
180_L203_F0.7820.59
6_Q9_K0.7810.59
7_I115_I0.7800.59
21_H78_Y0.7770.59
86_L280_M0.7670.58
207_C212_V0.7650.58
301_W306_V0.7650.58
179_M183_I0.7650.58
220_A301_W0.7580.57
148_G152_W0.7570.57
120_L138_I0.7540.56
23_I133_M0.7540.56
132_V137_I0.7480.56
122_K238_R0.7460.56
239_K338_A0.7440.55
214_T294_G0.7440.55
188_L222_G0.7420.55
78_Y86_L0.7420.55
225_I327_T0.7410.55
42_K45_V0.7400.55
232_L235_L0.7400.55
63_A94_W0.7390.55
81_A90_A0.7380.55
185_G222_G0.7330.54
245_E335_K0.7330.54
8_L11_T0.7270.54
214_T290_A0.7260.54
188_L224_C0.7230.53
95_V155_G0.7230.53
236_I332_N0.7160.53
189_A192_M0.7160.53
46_P50_A0.7160.53
295_A319_A0.7140.52
99_F155_G0.7130.52
115_I118_H0.7120.52
171_G174_Q0.7100.52
63_A66_T0.7090.52
29_G64_G0.7090.52
328_A331_V0.7070.52
27_V83_R0.7060.52
279_I327_T0.7050.52
223_I258_V0.7020.51
101_A155_G0.7000.51
23_I27_V0.6990.51
224_C304_L0.6970.51
100_G159_G0.6970.51
228_L257_C0.6960.51
177_I214_T0.6950.50
170_Q212_V0.6940.50
220_A305_I0.6930.50
165_L183_I0.6930.50
123_I141_V0.6910.50
112_I149_I0.6910.50
187_M200_A0.6910.50
94_W98_S0.6890.50
206_I212_V0.6890.50
123_I145_I0.6830.49
118_H121_K0.6830.49
182_V185_G0.6810.49
316_Y320_V0.6810.49
19_V26_V0.6790.49
67_L90_A0.6790.49
208_V216_V0.6790.49
310_V316_Y0.6720.48
159_G167_Q0.6720.48
86_L90_A0.6680.48
161_L196_V0.6660.48
321_A324_A0.6640.47
87_A335_K0.6630.47
192_M227_P0.6620.47
299_A306_V0.6610.47
230_M279_I0.6570.47
279_I283_S0.6540.46
217_A224_C0.6530.46
21_H83_R0.6510.46
203_F207_C0.6500.46
108_I141_V0.6500.46
141_V144_L0.6480.46
25_F71_F0.6440.45
278_S327_T0.6430.45
245_E331_V0.6430.45
37_V301_W0.6410.45
289_T318_A0.6410.45
33_L58_F0.6400.45
131_S252_A0.6380.45
44_A47_D0.6360.44
295_A309_V0.6350.44
245_E270_A0.6340.44
42_K67_L0.6330.44
235_L250_K0.6320.44
167_Q170_Q0.6320.44
185_G316_Y0.6310.44
36_S43_G0.6300.44
213_Y296_Q0.6290.44
308_P317_I0.6280.44
13_Q79_S0.6260.43
187_M197_N0.6260.43
125_V137_I0.6260.43
157_P215_V0.6230.43
206_I209_A0.6230.43
244_E247_E0.6220.43
329_V332_N0.6200.43
39_L44_A0.6170.43
55_K58_F0.6170.43
72_L192_M0.6150.42
237_G241_F0.6140.42
81_A84_S0.6130.42
87_A142_G0.6130.42
319_A326_V0.6120.42
302_G306_V0.6090.42
162_T252_A0.6090.42
97_N100_G0.6080.42
44_A50_A0.6070.42
11_T111_I0.6030.41
298_Y309_V0.6000.41
90_A168_W0.6000.41
227_P252_A0.6000.41
112_I154_L0.5980.41
207_C215_V0.5980.41
236_I328_A0.5980.41
35_V39_L0.5970.41
173_Q176_S0.5970.41
92_G113_G0.5960.41
192_M225_I0.5960.41
43_G54_L0.5960.41
315_G322_V0.5950.40
83_R133_M0.5950.40
321_A325_V0.5940.40
223_I301_W0.5920.40
140_I144_L0.5920.40
63_A95_V0.5920.40
217_A305_I0.5920.40
6_Q10_N0.5920.40
216_V301_W0.5920.40
156_E159_G0.5910.40
70_P265_I0.5900.40
230_M275_V0.5890.40
225_I279_I0.5890.40
45_V51_D0.5890.40
237_G336_S0.5880.40
87_A207_C0.5880.40
188_L304_L0.5860.40
225_I229_G0.5850.39
35_V318_A0.5850.39
69_V171_G0.5840.39
281_V285_C0.5830.39
90_A142_G0.5830.39
274_R278_S0.5830.39
72_L76_I0.5830.39
14_H111_I0.5820.39
226_P283_S0.5820.39
224_C287_A0.5820.39
39_L56_K0.5820.39
80_I118_H0.5800.39
68_M73_A0.5790.39
107_L111_I0.5770.39
307_L317_I0.5760.39
104_F283_S0.5750.38
163_N166_T0.5750.38
37_V223_I0.5730.38
281_V326_V0.5720.38
89_C96_G0.5720.38
285_C328_A0.5720.38
161_L168_W0.5720.38
307_L310_V0.5720.38
83_R256_G0.5700.38
107_L269_A0.5690.38
53_N57_L0.5660.38
286_G290_A0.5650.37
259_G305_I0.5630.37
47_D50_A0.5630.37
40_Y51_D0.5610.37
297_C316_Y0.5610.37
218_I223_I0.5590.37
63_A106_A0.5580.37
193_G197_N0.5560.37
48_A51_D0.5560.37
254_V280_M0.5550.37
45_V50_A0.5540.36
19_V205_L0.5540.36
64_G80_I0.5530.36
46_P49_V0.5510.36
41_G51_D0.5510.36
157_P261_T0.5500.36
42_K48_A0.5490.36
44_A48_A0.5480.36
220_A297_C0.5480.36
121_K138_I0.5470.36
172_M210_Q0.5460.36
293_V319_A0.5460.36
87_A140_I0.5420.35
157_P160_A0.5420.35
37_V259_G0.5410.35
181_A288_V0.5380.35
93_A106_A0.5380.35
107_L288_V0.5370.35
39_L42_K0.5370.35
221_V316_Y0.5370.35
149_I196_V0.5370.35
108_I149_I0.5370.35
10_N115_I0.5370.35
95_V238_R0.5360.35
157_P206_I0.5360.35
46_P51_D0.5350.35
298_Y311_E0.5350.35
87_A215_V0.5350.35
259_G301_W0.5320.34
64_G117_V0.5310.34
132_V215_V0.5280.34
35_V38_M0.5280.34
226_P261_T0.5270.34
9_K13_Q0.5260.34
56_K85_A0.5260.34
223_I304_L0.5240.34
240_N330_C0.5240.34
116_V122_K0.5230.34
31_I270_A0.5220.33
223_I305_I0.5210.33
11_T115_I0.5200.33
248_T278_S0.5200.33
296_Q319_A0.5190.33
233_A327_T0.5180.33
207_C213_Y0.5180.33
181_A221_V0.5170.33
220_A304_L0.5170.33
27_V248_T0.5170.33
145_I154_L0.5170.33
82_E171_G0.5160.33
39_L321_A0.5160.33
223_I287_A0.5130.33
25_F231_G0.5120.33
12_R111_I0.5120.33
131_S261_T0.5120.33
153_G157_P0.5110.32
38_M299_A0.5110.32
91_I143_T0.5100.32
180_L254_V0.5100.32
120_L141_V0.5100.32
166_T173_Q0.5100.32
15_L206_I0.5100.32
290_A297_C0.5070.32
175_G240_N0.5070.32
259_G287_A0.5070.32
83_R134_P0.5060.32
136_F258_V0.5050.32
201_Y219_A0.5050.32
86_L155_G0.5050.32
31_I38_M0.5040.32
333_V337_L0.5040.32
201_Y259_G0.5030.32
12_R17_T0.5030.32
29_G264_A0.5030.32
282_G323_G0.5020.32
229_G328_A0.5000.32
71_F86_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9777 100 0.686 Contact Map
2kncA 1 0.1337 64.7 0.968 Contact Map
4r0cA 3 0.4262 62.1 0.969 Contact Map
3b9wA 3 0.5097 43.3 0.972 Contact Map
4j05A 3 0.9025 31.3 0.974 Contact Map
4r1iA 2 0.4457 27.6 0.975 Contact Map
1ldfA 3 0.5404 23.1 0.976 Contact Map
4ezcA 3 0.8273 21.4 0.976 Contact Map
1u7gA 3 0.5292 20.8 0.976 Contact Map
2b2hA 3 0.5905 18.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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