GREMLIN Database
FSAB - Fructose-6-phosphate aldolase 2
UniProt: P32669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11905
Length: 220 (208)
Sequences: 3868 (2069)
Seq/√Len: 143.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_K102_E5.9041.00
64_D67_G4.8901.00
44_P48_K2.9361.00
205_E209_H2.6601.00
9_N35_S2.5541.00
96_I108_G2.5211.00
69_V98_I2.5191.00
15_R192_Q2.4461.00
150_Q162_V2.4241.00
150_Q154_E2.4221.00
30_S210_D2.3991.00
117_G149_L2.2801.00
88_V111_V2.2571.00
23_A122_L2.2181.00
97_K101_K2.2151.00
202_S206_K2.1391.00
98_I102_E2.1311.00
189_D193_Q2.0341.00
94_A97_K2.0141.00
209_H213_A1.9621.00
65_A94_A1.9291.00
45_R48_K1.8681.00
70_E74_R1.7871.00
97_K126_K1.7171.00
128_V153_L1.7151.00
72_A76_R1.6871.00
11_A14_E1.6751.00
86_I99_L1.6661.00
114_A152_L1.6521.00
126_K161_M1.6431.00
66_Q70_E1.6311.00
14_E18_R1.5921.00
86_I96_I1.5441.00
69_V95_A1.5401.00
72_A99_L1.5321.00
148_E178_L1.5301.00
62_S67_G1.5281.00
32_I39_I1.5121.00
63_R91_E1.4971.00
209_H212_N1.4701.00
100_K126_K1.4561.00
73_K98_I1.4431.00
121_A156_H1.4411.00
63_R204_I1.4341.00
65_A98_I1.4241.00
58_A75_L1.4151.00
57_F107_L1.4141.00
116_Q200_V1.4131.00
135_V140_G1.4051.00
65_A91_E1.4001.00
75_L78_A1.3991.00
141_D144_R1.3891.00
40_W74_R1.3691.00
206_K209_H1.3581.00
63_R208_E1.3551.00
173_A190_V1.3511.00
12_E188_L1.3461.00
202_S205_E1.3411.00
201_E205_E1.3401.00
9_N12_E1.3351.00
105_T126_K1.3131.00
144_R148_E1.3131.00
147_Q151_T1.3071.00
15_R19_I1.3051.00
37_E42_V1.2891.00
164_A167_F1.2811.00
114_A148_E1.2791.00
106_T126_K1.2641.00
161_M183_S1.2581.00
74_R77_D1.2571.00
107_L129_A1.2471.00
73_K104_I1.2381.00
14_E45_R1.2331.00
59_Q131_Y1.2201.00
100_K124_G1.2111.00
16_L188_L1.2101.00
60_T68_M1.2081.00
93_L119_L1.2001.00
65_A69_V1.1881.00
118_L152_L1.1851.00
197_T201_E1.1681.00
61_M208_E1.1621.00
72_A86_I1.1400.99
46_L50_I1.1380.99
56_L79_I1.1370.99
88_V108_G1.1330.99
186_L191_A1.1330.99
18_R94_A1.1330.99
38_S41_E1.1080.99
68_M86_I1.1030.99
91_E94_A1.0740.99
90_S195_L1.0700.99
121_A153_L1.0690.99
73_K77_D1.0640.99
10_V42_V1.0620.99
39_I211_W1.0570.99
68_M72_A1.0530.99
152_L156_H1.0440.99
199_A203_A1.0340.99
163_L183_S1.0300.99
43_L82_I1.0300.99
151_T155_M1.0220.99
5_L191_A1.0200.99
43_L58_A1.0130.99
66_Q98_I1.0130.99
110_A203_A1.0090.99
76_R104_I1.0050.99
72_A84_V0.9960.99
22_I191_A0.9940.98
121_A152_L0.9900.98
70_E73_K0.9890.98
69_V99_L0.9850.98
33_A213_A0.9760.98
199_A202_S0.9750.98
74_R78_A0.9730.98
122_L158_P0.9710.98
65_A95_A0.9670.98
193_Q196_N0.9640.98
34_A189_D0.9560.98
42_V45_R0.9550.98
164_A176_C0.9520.98
173_A186_L0.9450.98
170_P193_Q0.9430.98
83_V127_Y0.9370.98
110_A131_Y0.9360.98
143_I176_C0.9360.98
147_Q179_A0.9350.98
96_I106_T0.9350.98
58_A82_I0.9330.98
67_G70_E0.9240.98
37_E45_R0.9220.98
133_N168_K0.9210.98
69_V73_K0.9200.97
69_V72_A0.9170.97
40_W44_P0.9110.97
114_A118_L0.9080.97
16_L192_Q0.9060.97
76_R105_T0.8970.97
36_K42_V0.8920.97
205_E208_E0.8910.97
203_A207_F0.8870.97
107_L110_A0.8820.97
88_V96_I0.8810.97
144_R147_Q0.8750.97
107_L131_Y0.8690.96
198_P202_S0.8690.96
64_D72_A0.8680.96
111_V153_L0.8650.96
5_L16_L0.8650.96
188_L192_Q0.8650.96
192_Q196_N0.8640.96
32_I42_V0.8640.96
206_K210_D0.8630.96
41_E79_I0.8550.96
98_I101_K0.8510.96
12_E192_Q0.8440.96
39_I43_L0.8390.96
72_A78_A0.8370.96
208_E212_N0.8370.96
72_A77_D0.8370.96
47_Q56_L0.8330.96
90_S192_Q0.8320.95
14_E49_A0.8270.95
11_A15_R0.8270.95
149_L153_L0.8250.95
68_M95_A0.8210.95
59_Q129_A0.8190.95
164_A179_A0.8170.95
17_A43_L0.8150.95
57_F129_A0.8130.95
130_P149_L0.7980.94
108_G125_A0.7880.94
134_R166_S0.7870.94
136_D142_G0.7840.94
76_R82_I0.7810.94
12_E15_R0.7770.94
170_P190_V0.7750.93
166_S185_T0.7750.93
63_R72_A0.7710.93
132_V142_G0.7710.93
10_V45_R0.7700.93
135_V145_T0.7700.93
71_E78_A0.7610.93
85_K185_T0.7560.93
34_A206_K0.7470.92
150_Q182_E0.7450.92
71_E75_L0.7430.92
122_L156_H0.7420.92
59_Q107_L0.7380.92
100_K105_T0.7350.92
67_G71_E0.7350.92
111_V128_V0.7230.91
89_T204_I0.7230.91
64_D68_M0.7160.90
13_V46_L0.7110.90
8_A27_T0.7090.90
140_G171_R0.7080.90
88_V93_L0.7070.90
129_A203_A0.7050.90
148_E151_T0.7020.90
20_F192_Q0.6950.89
28_N109_T0.6940.89
77_D102_E0.6910.89
20_F195_L0.6860.88
19_I191_A0.6780.88
152_L155_M0.6770.88
90_S119_L0.6760.88
65_A72_A0.6760.88
66_Q77_D0.6740.88
125_A156_H0.6730.88
30_S34_A0.6700.87
15_R18_R0.6700.87
151_T178_L0.6620.87
150_Q179_A0.6580.86
25_V46_L0.6550.86
37_E41_E0.6540.86
57_F131_Y0.6530.86
164_A184_I0.6530.86
12_E19_I0.6510.86
86_I95_A0.6480.85
47_Q79_I0.6450.85
99_L102_E0.6450.85
105_T127_Y0.6420.85
32_I43_L0.6420.85
55_I83_V0.6400.85
85_K109_T0.6380.85
118_L156_H0.6380.85
32_I37_E0.6370.85
110_A129_A0.6330.84
153_L160_S0.6270.84
73_K76_R0.6240.83
32_I35_S0.6230.83
10_V37_E0.6220.83
71_E74_R0.6180.83
120_A125_A0.6130.82
145_T149_L0.6130.82
112_Y203_A0.6100.82
121_A158_P0.6100.82
64_D71_E0.6090.82
66_Q102_E0.6050.81
27_T31_I0.6010.81
3_L194_M0.5970.81
24_G29_P0.5910.80
136_D139_G0.5890.80
151_T154_E0.5870.79
199_A207_F0.5870.79
59_Q203_A0.5860.79
118_L155_M0.5850.79
212_N215_F0.5840.79
89_T92_G0.5820.79
66_Q72_A0.5820.79
143_I177_L0.5800.79
135_V138_Q0.5800.79
19_I195_L0.5790.78
76_R80_P0.5780.78
83_V106_T0.5770.78
68_M71_E0.5750.78
89_T98_I0.5720.78
169_T172_Q0.5720.78
143_I179_A0.5710.78
44_P47_Q0.5700.77
176_C181_C0.5690.77
76_R84_V0.5670.77
68_M77_D0.5650.77
47_Q82_I0.5630.77
19_I192_Q0.5620.76
65_A77_D0.5590.76
109_T165_A0.5570.76
16_L22_I0.5550.76
4_Y107_L0.5550.76
53_E79_I0.5550.76
30_S33_A0.5540.75
211_W215_F0.5540.75
26_T185_T0.5530.75
196_N201_E0.5530.75
200_V203_A0.5500.75
108_G120_A0.5500.75
45_R49_A0.5490.75
132_V145_T0.5480.75
35_S42_V0.5470.74
63_R68_M0.5460.74
112_Y131_Y0.5440.74
33_A210_D0.5420.74
6_D26_T0.5410.74
28_N165_A0.5400.74
17_A49_A0.5390.73
131_Y168_K0.5360.73
59_Q110_A0.5330.73
10_V56_L0.5330.73
107_L203_A0.5320.72
109_T131_Y0.5320.72
207_F214_A0.5310.72
153_L158_P0.5300.72
4_Y83_V0.5270.72
173_A184_I0.5260.72
139_G171_R0.5240.71
15_R90_S0.5220.71
75_L82_I0.5200.71
55_I105_T0.5170.70
131_Y203_A0.5170.70
72_A75_L0.5160.70
32_I214_A0.5150.70
176_C211_W0.5150.70
17_A22_I0.5140.70
117_G153_L0.5130.70
57_F110_A0.5100.69
83_V105_T0.5100.69
10_V13_V0.5050.69
132_V164_A0.5040.68
197_T200_V0.5020.68
73_K99_L0.5010.68
192_Q195_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l6wA 6 1 100 0.033 Contact Map
1wx0A 6 0.9182 100 0.039 Contact Map
3r8rA 5 0.9591 100 0.041 Contact Map
3s1xA 6 0.9909 100 0.043 Contact Map
1vpxA 6 0.9818 100 0.045 Contact Map
3cwnA 2 0.9636 100 0.201 Contact Map
3cq0A 2 0.9636 100 0.207 Contact Map
3m16A 2 0.9636 100 0.21 Contact Map
3tkfA 2 0.9636 100 0.21 Contact Map
3hjzA 1 0.9636 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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