GREMLIN Database
NUDC - NADH pyrophosphatase
UniProt: P32664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11702
Length: 257 (227)
Sequences: 2168 (1562)
Seq/√Len: 103.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_H222_E5.0531.00
176_M182_K4.3521.00
242_R246_E3.8421.00
185_N207_E3.5781.00
137_R140_S3.4651.00
167_L202_T3.3141.00
134_A141_I3.0491.00
184_K209_D2.8681.00
103_H117_S2.7531.00
105_M114_M2.6931.00
98_C101_C2.5911.00
101_C116_C2.5471.00
98_C116_C2.5051.00
172_A186_L2.4931.00
167_L204_F2.4661.00
106_Y117_S2.4611.00
169_Q172_A2.4581.00
182_K209_D2.4431.00
135_I175_V2.3731.00
145_Q221_L2.3641.00
84_R112_W2.2511.00
144_A157_L2.2461.00
108_S115_L2.2151.00
141_I245_I2.1211.00
135_I206_A2.1171.00
203_A240_V2.0961.00
92_Y114_M2.0471.00
140_S227_R1.9931.00
234_L242_R1.9711.00
179_S223_A1.9351.00
101_C119_C1.9251.00
161_V167_L1.8911.00
184_K207_E1.8681.00
189_V247_D1.8311.00
172_A184_K1.7961.00
157_L179_S1.7961.00
75_D78_L1.7891.00
246_E250_A1.7691.00
94_S100_Y1.7491.00
103_H118_H1.7241.00
56_L89_A1.7041.00
132_I240_V1.6801.00
215_I223_A1.6761.00
146_H155_T1.6631.00
130_C239_T1.6581.00
179_S220_L1.6531.00
137_R211_G1.6511.00
228_Y248_T1.5261.00
208_Y211_G1.5181.00
116_C119_C1.5181.00
115_L122_R1.5051.00
213_I223_A1.5031.00
146_H149_H1.4711.00
143_L226_Y1.4711.00
171_V183_V1.4651.00
167_L200_L1.4611.00
156_V244_L1.4481.00
32_E35_N1.4421.00
67_S70_Q1.4151.00
181_I208_Y1.4101.00
133_V206_A1.3901.00
98_C119_C1.3811.00
156_V203_A1.3671.00
139_D228_Y1.3651.00
133_V157_L1.3080.99
187_R207_E1.3080.99
160_F197_P1.2990.99
147_T221_L1.2860.99
234_L245_I1.2750.99
139_D229_D1.2690.99
144_A223_A1.2630.99
142_L181_I1.2510.99
189_V244_L1.2340.99
151_N221_L1.2310.99
144_A179_S1.2250.99
227_R230_D1.2250.99
144_A220_L1.2190.99
31_G35_N1.2120.99
190_T240_V1.1980.99
145_Q222_E1.1980.99
161_V170_A1.1910.99
90_E94_S1.1900.99
189_V205_M1.1750.99
96_K104_E1.1740.98
232_P249_V1.1730.98
139_D227_R1.1610.98
95_H123_Y1.1300.98
95_H105_M1.1290.98
149_H155_T1.1260.98
30_Y35_N1.1210.98
28_L31_G1.1200.98
217_P220_L1.1000.98
145_Q150_R1.0820.97
168_E191_S1.0710.97
113_A122_R1.0600.97
29_P32_E1.0550.97
96_K114_M1.0450.97
136_R207_E1.0440.97
134_A156_V1.0410.97
132_I171_V1.0410.97
32_E36_F1.0170.96
131_I170_A1.0090.96
99_G119_C1.0040.96
205_M247_D0.9960.96
58_Q93_R0.9850.96
102_G105_M0.9790.95
132_I203_A0.9770.95
86_V90_E0.9710.95
92_Y107_P0.9640.95
235_P241_A0.9520.95
190_T243_R0.9500.95
58_Q89_A0.9450.94
135_I156_V0.9400.94
201_M240_V0.9350.94
130_C199_S0.9310.94
146_H220_L0.9300.94
149_H153_V0.9280.94
150_R153_V0.9240.94
87_Q198_Q0.9220.94
133_V171_V0.9220.94
224_N230_D0.9210.94
133_V175_V0.9160.93
38_L41_Q0.9100.93
48_E51_G0.8990.93
175_V183_V0.8950.93
182_K210_S0.8780.92
188_Y191_S0.8760.92
215_I218_K0.8740.92
154_H226_Y0.8650.91
151_N233_L0.8640.91
72_I238_G0.8590.91
25_K64_D0.8570.91
131_I171_V0.8570.91
131_I193_P0.8550.91
129_P202_T0.8510.91
80_Q169_Q0.8390.90
187_R205_M0.8380.90
143_L231_L0.8330.90
71_V74_L0.8290.89
45_Q48_E0.8290.89
141_I156_V0.8280.89
105_M123_Y0.8270.89
90_E93_R0.8260.89
220_L223_A0.8250.89
136_R205_M0.8250.89
107_P114_M0.8240.89
99_G105_M0.8210.89
228_Y249_V0.8190.89
95_H114_M0.8160.89
214_V217_P0.8120.89
163_V198_Q0.8070.88
229_D232_P0.8060.88
145_Q151_N0.8040.88
154_H224_N0.7970.88
72_I130_C0.7970.88
246_E249_V0.7940.87
37_D60_Q0.7880.87
92_Y105_M0.7850.87
87_Q163_V0.7770.86
111_E128_A0.7630.85
31_G34_A0.7610.85
45_Q55_W0.7610.85
28_L32_E0.7600.85
205_M251_M0.7600.85
79_F83_G0.7570.85
130_C204_F0.7560.85
171_V204_F0.7470.84
126_Q162_E0.7460.84
71_V79_F0.7440.84
140_S211_G0.7410.83
183_V206_A0.7370.83
39_V43_A0.7360.83
145_Q223_A0.7340.83
95_H99_G0.7330.83
164_G191_S0.7330.83
146_H221_L0.7320.83
156_V239_T0.7280.82
80_Q83_G0.7260.82
135_I157_L0.7260.82
30_Y33_A0.7250.82
106_Y115_L0.7240.82
201_M241_A0.7230.82
172_A182_K0.7130.81
50_Q62_R0.7110.81
30_Y34_A0.7090.81
167_L191_S0.7040.80
109_K122_R0.7020.80
44_L88_L0.7010.80
145_Q152_G0.6990.80
145_Q149_H0.6970.80
91_F123_Y0.6970.80
152_G233_L0.6960.80
243_R247_D0.6920.79
97_Y104_E0.6910.79
88_L92_Y0.6910.79
28_L35_N0.6870.79
190_T239_T0.6820.78
94_S198_Q0.6810.78
27_E30_Y0.6800.78
237_P246_E0.6800.78
131_I166_T0.6800.78
104_E117_S0.6770.78
132_I183_V0.6770.78
161_V204_F0.6770.78
168_E188_Y0.6740.77
99_G123_Y0.6740.77
108_S113_A0.6730.77
153_V233_L0.6720.77
128_A199_S0.6710.77
34_A37_D0.6650.76
128_A198_Q0.6650.76
34_A40_G0.6630.76
41_Q61_R0.6630.76
247_D250_A0.6610.76
235_P242_R0.6550.75
166_T190_T0.6530.75
189_V243_R0.6530.75
156_V226_Y0.6510.75
127_I163_V0.6500.75
130_C156_V0.6470.74
57_V76_V0.6470.74
89_A93_R0.6470.74
45_Q49_W0.6460.74
37_D40_G0.6460.74
27_E32_E0.6450.74
40_G43_A0.6430.74
132_I241_A0.6430.74
170_A249_V0.6420.74
137_R210_S0.6390.73
113_A130_C0.6350.73
33_A43_A0.6320.73
29_P33_A0.6310.73
99_G245_I0.6280.72
134_A244_L0.6260.72
183_V186_L0.6250.72
130_C161_V0.6250.72
232_P245_I0.6190.71
29_P34_A0.6190.71
65_M89_A0.6190.71
99_G121_E0.6180.71
29_P35_N0.6170.71
232_P251_M0.6130.70
188_Y216_D0.6130.70
87_Q195_P0.6130.70
84_R163_V0.6130.70
156_V181_I0.6120.70
136_R139_D0.6110.70
91_F110_T0.6100.70
100_Y121_E0.6090.70
171_V186_L0.6080.70
87_Q90_E0.6060.70
88_L163_V0.6060.70
124_Y196_F0.6060.70
149_H199_S0.6040.69
213_I217_P0.6030.69
247_D251_M0.5990.69
27_E33_A0.5980.68
97_Y102_G0.5970.68
152_G221_L0.5970.68
140_S230_D0.5950.68
186_L204_F0.5930.68
167_L193_P0.5920.68
48_E52_E0.5920.68
66_G70_Q0.5890.67
153_V226_Y0.5870.67
35_N38_L0.5850.67
77_G81_L0.5820.66
28_L36_F0.5770.66
122_R175_V0.5730.65
111_E122_R0.5720.65
126_Q132_I0.5690.65
72_I239_T0.5690.65
25_K32_E0.5670.64
84_R162_E0.5660.64
101_C210_S0.5660.64
121_E198_Q0.5650.64
43_A57_V0.5630.64
26_G40_G0.5620.64
133_V172_A0.5620.64
42_R58_Q0.5610.64
25_K29_P0.5600.63
226_Y245_I0.5600.63
103_H121_E0.5590.63
161_V188_Y0.5580.63
28_L33_A0.5540.63
200_L244_L0.5520.62
33_A37_D0.5510.62
95_H157_L0.5500.62
44_L47_G0.5490.62
157_L220_L0.5480.62
137_R207_E0.5440.61
156_V241_A0.5430.61
112_W127_I0.5430.61
56_L85_G0.5420.61
195_P199_S0.5420.61
25_K30_Y0.5400.61
37_D41_Q0.5390.61
157_L213_I0.5380.60
25_K28_L0.5380.60
112_W149_H0.5350.60
106_Y118_H0.5340.60
136_R141_I0.5300.59
134_A248_T0.5300.59
133_V179_S0.5300.59
45_Q53_P0.5300.59
113_A124_Y0.5290.59
190_T229_D0.5270.59
220_L236_P0.5270.59
87_Q196_F0.5260.59
124_Y236_P0.5240.58
99_G198_Q0.5230.58
140_S225_W0.5230.58
124_Y128_A0.5220.58
72_I166_T0.5210.58
26_G38_L0.5210.58
95_H198_Q0.5200.58
95_H196_F0.5180.58
211_G232_P0.5180.58
122_R248_T0.5180.58
131_I161_V0.5170.57
154_H225_W0.5170.57
46_I112_W0.5170.57
94_S121_E0.5140.57
144_A181_I0.5140.57
137_R208_Y0.5100.56
128_A149_H0.5100.56
87_Q199_S0.5090.56
162_E193_P0.5060.56
187_R251_M0.5060.56
58_Q153_V0.5050.56
172_A213_I0.5050.56
39_V42_R0.5050.56
116_C124_Y0.5030.55
131_I160_F0.5020.55
87_Q114_M0.5020.55
233_L242_R0.5020.55
146_H215_I0.5010.55
153_V235_P0.5010.55
126_Q240_V0.5000.55
87_Q124_Y0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vk6A 2 0.9961 100 0.364 Contact Map
3cngA 4 0.6304 100 0.688 Contact Map
2qjtB 2 0.9611 100 0.702 Contact Map
2a6tA 1 0.7549 99.9 0.739 Contact Map
3q1pA 2 0.6848 99.9 0.747 Contact Map
4hfqA 2 0.7004 99.9 0.757 Contact Map
2qjoA 3 0.9533 99.9 0.763 Contact Map
2b0vA 2 0.5136 99.8 0.774 Contact Map
3fjyA 2 0.5409 99.8 0.786 Contact Map
3gz5A 2 0.5058 99.8 0.786 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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