GREMLIN Database
GPH - Phosphoglycolate phosphatase
UniProt: P32662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11871
Length: 252 (208)
Sequences: 27998 (21937)
Seq/√Len: 1521.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R186_Q4.0601.00
146_E151_A2.7541.00
175_L179_R2.7231.00
165_N169_H2.6461.00
200_A207_S2.5921.00
191_G196_D2.4751.00
138_T142_A2.4451.00
121_G153_Y2.3801.00
9_G182_I2.3781.00
129_P155_S2.3181.00
7_I206_P2.3061.00
117_A121_G2.2971.00
35_A97_L2.1871.00
131_G156_V2.1591.00
175_L178_E2.1351.00
138_T162_D2.1331.00
12_F130_L2.1111.00
201_K226_D2.0431.00
230_Q234_D2.0391.00
177_A187_M2.0131.00
134_T141_V2.0121.00
133_V172_P1.9951.00
197_I207_S1.9801.00
156_V179_R1.9511.00
165_N171_D1.9141.00
183_A186_Q1.9011.00
206_P226_D1.8311.00
198_Q202_A1.8101.00
122_A126_K1.7921.00
31_M101_Y1.7751.00
124_Q153_Y1.7741.00
10_V128_L1.7601.00
122_A236_L1.7291.00
11_A189_F1.7191.00
188_L208_V1.6941.00
42_G45_R1.6931.00
177_A205_C1.6771.00
124_Q155_S1.6391.00
116_V232_I1.6251.00
7_I188_L1.5761.00
211_T230_Q1.5551.00
189_F200_A1.5531.00
130_L154_F1.5461.00
177_A184_P1.5151.00
11_A176_V1.5071.00
11_A133_V1.4951.00
9_G180_M1.4951.00
142_A151_A1.4731.00
113_F212_Y1.4381.00
36_L97_L1.4181.00
182_I187_M1.4051.00
10_V190_V1.3881.00
10_V123_L1.3851.00
131_G180_M1.3791.00
119_T232_I1.3691.00
208_V229_Y1.3641.00
211_T228_I1.3391.00
35_A101_Y1.3221.00
101_Y104_E1.3031.00
194_R198_Q1.2981.00
170_P174_L1.2791.00
231_S234_D1.2771.00
14_L19_V1.2721.00
208_V227_V1.2661.00
122_A125_A1.2621.00
17_T190_V1.2451.00
18_L116_V1.2361.00
93_I97_L1.2251.00
97_L100_R1.2181.00
14_L132_L1.2111.00
90_Q93_I1.2091.00
14_L141_V1.2071.00
142_A146_E1.2041.00
115_H118_D1.1881.00
119_T236_L1.1881.00
173_L189_F1.1841.00
141_V159_G1.1831.00
158_I179_R1.1681.00
187_M205_C1.1261.00
112_L150_I1.1221.00
11_A187_M1.1211.00
217_G221_D1.1161.00
173_L199_A1.1071.00
118_D233_N1.1031.00
9_G129_P1.0991.00
32_A36_L1.0991.00
31_M35_A1.0931.00
56_V59_E1.0881.00
31_M105_V1.0851.00
158_I176_V1.0771.00
173_L205_C1.0711.00
9_G187_M1.0551.00
97_L101_Y1.0551.00
43_E47_I1.0541.00
14_L136_K1.0531.00
174_L178_E1.0511.00
149_D152_K1.0451.00
101_Y105_V1.0451.00
133_V176_V1.0431.00
121_G125_A1.0421.00
124_Q130_L1.0361.00
171_D175_L1.0301.00
15_D21_S1.0261.00
27_A31_M1.0211.00
201_K207_S1.0211.00
96_K100_R1.0171.00
27_A105_V1.0161.00
132_L154_F1.0121.00
171_D174_L0.9941.00
34_Y40_V0.9881.00
117_A153_Y0.9831.00
174_L203_A0.9801.00
31_M34_Y0.9761.00
107_E143_P0.9641.00
27_A30_D0.9601.00
176_V180_M0.9601.00
206_P227_V0.9551.00
163_V175_L0.9501.00
100_R104_E0.9501.00
199_A203_A0.9441.00
15_D136_K0.9431.00
189_F205_C0.9421.00
115_H231_S0.9411.00
120_L154_F0.9411.00
143_P147_A0.9351.00
197_I225_P0.9331.00
156_V180_M0.9321.00
138_T159_G0.9291.00
9_G131_G0.9291.00
30_D34_Y0.9171.00
141_V144_L0.9131.00
59_E63_T0.9081.00
143_P146_E0.9031.00
195_N198_Q0.8981.00
118_D121_G0.8961.00
201_K224_Q0.8961.00
134_T159_G0.8951.00
55_D59_E0.8951.00
164_Q171_D0.8921.00
112_L117_A0.8901.00
11_A205_C0.8901.00
234_D237_P0.8861.00
52_N56_V0.8861.00
113_F210_L0.8861.00
113_F116_V0.8811.00
229_Y235_L0.8741.00
174_L184_P0.8701.00
27_A109_G0.8681.00
92_R96_K0.8651.00
207_S226_D0.8601.00
173_L191_G0.8601.00
11_A180_M0.8571.00
115_H233_N0.8561.00
121_G152_K0.8551.00
136_K141_V0.8531.00
138_T161_D0.8531.00
217_G230_Q0.8461.00
53_G56_V0.8421.00
131_G176_V0.8411.00
98_F102_Y0.8391.00
158_I175_L0.8341.00
95_R99_D0.8341.00
15_D134_T0.8301.00
26_A30_D0.8221.00
188_L206_P0.8211.00
209_G228_I0.8201.00
14_L144_L0.8151.00
10_V188_L0.8121.00
123_L128_L0.8091.00
218_E221_D0.7971.00
59_E91_V0.7971.00
120_L153_Y0.7961.00
8_R128_L0.7931.00
123_L130_L0.7931.00
52_N60_R0.7931.00
19_V144_L0.7861.00
7_I128_L0.7851.00
197_I209_G0.7821.00
184_P205_C0.7791.00
11_A131_G0.7691.00
208_V235_L0.7681.00
15_D192_D0.7681.00
190_V208_V0.7681.00
33_L38_L0.7621.00
105_V108_E0.7591.00
44_E48_T0.7571.00
159_G162_D0.7551.00
15_D144_L0.7551.00
8_R129_P0.7541.00
212_Y232_I0.7531.00
209_G220_I0.7511.00
102_Y106_A0.7491.00
130_L153_Y0.7471.00
56_V60_R0.7471.00
117_A149_D0.7471.00
19_V148_L0.7451.00
63_T66_R0.7321.00
182_I186_Q0.7291.00
117_A152_K0.7231.00
210_L232_I0.7191.00
96_K99_D0.7071.00
135_N166_K0.7071.00
7_I186_Q0.7061.00
94_L98_F0.6991.00
141_V157_V0.6951.00
30_D43_E0.6931.00
112_L148_L0.6931.00
16_G22_A0.6901.00
28_A32_A0.6891.00
60_R63_T0.6861.00
118_D122_A0.6841.00
184_P187_M0.6791.00
198_Q201_K0.6741.00
60_R64_W0.6741.00
36_L93_I0.6731.00
47_I50_I0.6731.00
145_L151_A0.6691.00
190_V235_L0.6661.00
17_T196_D0.6611.00
133_V189_F0.6611.00
172_P176_V0.6591.00
162_D179_R0.6571.00
34_Y39_P0.6541.00
232_I236_L0.6541.00
54_A57_L0.6501.00
170_P202_A0.6471.00
189_F196_D0.6461.00
28_A101_Y0.6451.00
129_P182_I0.6421.00
172_P199_A0.6391.00
229_Y232_I0.6381.00
30_D40_V0.6381.00
158_I172_P0.6361.00
156_V176_V0.6341.00
94_L97_L0.6341.00
8_R182_I0.6301.00
142_A157_V0.6281.00
173_L196_D0.6281.00
25_L98_F0.6251.00
20_D111_F0.6221.00
60_R65_A0.6191.00
57_L60_R0.6171.00
177_A182_I0.6171.00
23_P111_F0.6141.00
45_R48_T0.6131.00
19_V110_T0.6111.00
116_V120_L0.6101.00
103_G139_P0.6091.00
189_F199_A0.6071.00
130_L155_S0.6021.00
160_G172_P0.6011.00
154_F157_V0.6011.00
89_E93_I0.6001.00
115_H212_Y0.5961.00
137_P140_F0.5941.00
44_E47_I0.5921.00
209_G225_P0.5921.00
93_I96_K0.5911.00
99_D103_G0.5901.00
163_V172_P0.5901.00
121_G124_Q0.5891.00
174_L177_A0.5871.00
177_A203_A0.5851.00
21_S136_K0.5841.00
32_A97_L0.5841.00
135_N168_P0.5831.00
124_Q152_K0.5811.00
216_Y219_A0.5811.00
107_E147_A0.5791.00
17_T210_L0.5791.00
62_L66_R0.5771.00
229_Y236_L0.5761.00
198_Q223_S0.5761.00
36_L94_L0.5731.00
233_N236_L0.5731.00
20_D113_F0.5701.00
112_L116_V0.5691.00
195_N199_A0.5691.00
105_V109_G0.5691.00
116_V119_T0.5661.00
100_R103_G0.5651.00
114_P233_N0.5651.00
135_N195_N0.5621.00
133_V158_I0.5581.00
61_A64_W0.5551.00
141_V145_L0.5551.00
23_P27_A0.5541.00
24_G110_T0.5541.00
115_H119_T0.5531.00
25_L29_V0.5501.00
12_F119_T0.5471.00
54_A58_M0.5471.00
26_A46_V0.5421.00
114_P231_S0.5401.00
62_L65_A0.5321.00
146_E152_K0.5311.00
136_K140_F0.5281.00
95_R98_F0.5281.00
119_T190_V0.5241.00
20_D23_P0.5231.00
136_K191_G0.5221.00
11_A173_L0.5221.00
135_N160_G0.5221.00
25_L136_K0.5211.00
173_L200_A0.5201.00
18_L132_L0.5201.00
119_T122_A0.5181.00
132_L145_L0.5131.00
46_V50_I0.5111.00
150_I153_Y0.5101.00
10_V130_L0.5071.00
18_L120_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iruA 4 0.9683 100 0.327 Contact Map
1swvA 2 0.9167 100 0.328 Contact Map
3s6jA 2 0.873 100 0.332 Contact Map
1te2A 2 0.8611 100 0.332 Contact Map
4eekA 2 0.8849 100 0.333 Contact Map
4uw9A 1 0.8452 100 0.339 Contact Map
3d6jA 1 0.8333 100 0.342 Contact Map
3l5kA 1 0.881 100 0.349 Contact Map
3mc1A 2 0.8611 100 0.351 Contact Map
3sd7A 1 0.8492 100 0.351 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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