GREMLIN Database
FDHD - Protein FdhD
UniProt: P32177 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11859
Length: 277 (250)
Sequences: 2267 (1566)
Seq/√Len: 99.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_Y204_Q4.2031.00
37_V247_V4.1761.00
47_Y70_S4.0321.00
64_Y186_H3.5631.00
67_L82_I3.5121.00
229_A255_L3.5081.00
237_F261_C3.4631.00
177_L181_E3.4631.00
199_L231_C2.9451.00
76_I82_I2.7621.00
258_V261_C2.6651.00
214_V228_S2.6271.00
61_D64_Y2.6211.00
184_G201_R2.5731.00
55_M65_F2.5421.00
229_A253_C2.5281.00
201_R205_E2.4761.00
216_V224_M2.4681.00
71_L203_S2.4361.00
216_V236_L2.3941.00
251_E271_H2.2081.00
184_G198_L2.0611.00
176_M182_L1.9921.00
67_L204_Q1.9671.00
78_S81_D1.9141.00
241_A260_F1.8901.00
35_D267_T1.8881.00
175_W202_R1.8741.00
82_I98_I1.8501.00
43_V57_A1.8291.00
46_V95_E1.8191.00
236_L255_L1.8041.00
186_H201_R1.8011.00
235_I256_T1.7821.00
152_D156_H1.7661.00
199_L233_V1.7561.00
45_L66_A1.7301.00
133_G252_R1.7141.00
258_V268_V1.6491.00
66_A96_V1.6401.00
35_D260_F1.6331.00
83_F99_E1.6181.00
150_L237_F1.6121.00
77_E81_D1.6111.00
175_W212_G1.6051.00
244_T248_E1.5811.00
71_L199_L1.5701.00
63_E204_Q1.5541.00
38_A170_T1.5381.00
260_F269_Y1.5231.00
81_D104_R1.5171.00
168_G269_Y1.5021.00
208_S211_Q1.4991.00
173_A216_V1.4961.00
104_R107_G1.4921.00
145_F235_I1.4801.00
251_E270_T1.4751.00
61_D186_H1.4681.00
41_V94_L1.4211.00
174_A182_L1.4131.00
224_M236_L1.4041.00
220_A238_A1.4041.00
154_L261_C1.3920.99
168_G260_F1.3890.99
202_R209_W1.3750.99
43_V62_L1.3680.99
35_D269_Y1.3660.99
63_E85_M1.3640.99
177_L183_V1.3480.99
150_L261_C1.3470.99
160_F182_L1.3300.99
116_A120_G1.3100.99
247_V257_L1.2990.99
151_D264_G1.2820.99
248_E252_R1.2790.99
255_L271_H1.2590.99
173_A194_A1.2480.99
64_Y201_R1.2460.99
146_D149_K1.2350.99
85_M98_I1.2330.99
35_D168_G1.2310.99
145_F213_A1.2270.99
39_E244_T1.2200.99
52_H115_L1.2190.99
70_S98_I1.2140.99
147_L266_A1.2120.99
82_I85_M1.1840.98
153_A213_A1.1760.98
149_K152_D1.1720.98
57_A62_L1.1650.98
173_A195_L1.1600.98
176_M213_A1.1580.98
47_Y98_I1.1550.98
214_V233_V1.1430.98
256_T274_R1.1400.98
258_V275_L1.1390.98
195_L216_V1.1330.98
129_L133_G1.1280.98
164_G260_F1.1280.98
222_Y226_Q1.1280.98
225_V236_L1.1250.98
36_E166_L1.1230.98
63_E96_V1.1210.98
53_V69_F1.1100.97
238_A259_G1.1020.97
162_P185_G1.1020.97
259_G269_Y1.1020.97
67_L85_M1.0940.97
42_P54_V1.0920.97
45_L98_I1.0870.97
83_F102_S1.0660.97
260_F267_T1.0640.97
201_R207_E1.0480.96
49_G97_Q1.0470.96
76_I203_S1.0470.96
268_V275_L1.0470.96
216_V238_A1.0410.96
225_V255_L1.0410.96
84_G99_E1.0380.96
67_L79_P1.0340.96
69_F115_L1.0160.96
43_V66_A1.0060.95
156_H159_D1.0050.95
76_I100_L1.0030.95
35_D259_G0.9930.95
157_L217_S0.9850.95
161_Q172_A0.9810.95
38_A163_V0.9760.95
63_E87_V0.9630.94
44_A51_S0.9580.94
35_D167_T0.9480.94
27_D264_G0.9460.94
216_V255_L0.9450.94
213_A235_I0.9420.94
50_I109_K0.9360.93
156_H181_E0.9310.93
71_L76_I0.9280.93
160_F185_G0.9260.93
167_T260_F0.9230.93
190_G193_V0.9220.93
50_I112_R0.9180.93
67_L76_I0.9180.93
35_D164_G0.9150.93
224_M243_T0.9120.92
79_P203_S0.9120.92
220_A260_F0.9100.92
77_E107_G0.9080.92
196_D227_K0.8980.92
250_A257_L0.8980.92
76_I85_M0.8960.92
83_F101_S0.8960.92
139_L255_L0.8920.92
182_L185_G0.8870.91
101_S104_R0.8840.91
195_L224_M0.8830.91
162_P166_L0.8810.91
149_K180_G0.8790.91
120_G125_G0.8770.91
138_P141_F0.8730.91
62_L96_V0.8730.91
168_G241_A0.8660.90
149_K153_A0.8650.90
57_A65_F0.8620.90
254_N271_H0.8620.90
150_L258_V0.8620.90
150_L266_A0.8560.90
172_A217_S0.8560.90
51_S114_A0.8510.90
92_N130_N0.8490.89
61_D201_R0.8480.89
175_W198_L0.8420.89
178_P181_E0.8320.89
35_D217_S0.8300.88
79_P206_G0.8260.88
195_L214_V0.8240.88
189_V243_T0.8240.88
248_E251_E0.8220.88
79_P204_Q0.8190.88
30_Q266_A0.8110.87
158_N165_Q0.8110.87
120_G216_V0.8110.87
88_V97_Q0.8100.87
80_R206_G0.7980.86
156_H160_F0.7970.86
164_G267_T0.7960.86
220_A259_G0.7960.86
48_N100_L0.7950.86
67_L203_S0.7920.86
56_M123_V0.7890.86
100_L108_L0.7860.86
171_H219_R0.7800.85
143_Q235_I0.7700.84
55_M117_G0.7630.84
59_P197_K0.7610.84
42_P122_G0.7560.83
164_G168_G0.7560.83
195_L198_L0.7560.83
259_G267_T0.7520.83
163_V170_T0.7510.83
83_F97_Q0.7410.82
73_E121_C0.7380.82
168_G259_G0.7370.82
32_P137_Q0.7360.82
27_D34_L0.7360.82
175_W233_V0.7360.82
220_A246_A0.7350.82
66_A94_L0.7350.82
167_T170_T0.7310.81
155_R158_N0.7290.81
235_I274_R0.7290.81
164_G169_C0.7270.81
168_G265_R0.7270.81
183_V213_A0.7260.81
88_V95_E0.7250.81
169_C260_F0.7190.80
220_A225_V0.7170.80
105_F109_K0.7130.80
189_V225_V0.7110.79
124_C161_Q0.7100.79
217_S267_T0.7090.79
213_A237_F0.7080.79
195_L221_S0.7080.79
171_H191_R0.7020.78
166_L183_V0.7000.78
26_R29_L0.7000.78
216_V220_A0.6980.78
198_L214_V0.6960.78
132_I135_P0.6950.78
74_G230_M0.6940.78
56_M125_G0.6920.77
177_L180_G0.6880.77
258_V266_A0.6850.77
168_G217_S0.6850.77
184_G207_E0.6830.77
72_S230_M0.6820.76
145_F237_F0.6820.76
149_K176_M0.6810.76
44_A54_V0.6800.76
52_H75_I0.6750.76
87_V96_V0.6720.75
56_M120_G0.6680.75
214_V231_C0.6640.75
191_R219_R0.6640.75
134_K230_M0.6620.74
202_R217_S0.6610.74
78_S206_G0.6600.74
56_M161_Q0.6590.74
47_Y52_H0.6590.74
254_N270_T0.6580.74
162_P165_Q0.6540.73
234_E254_N0.6520.73
116_A126_V0.6480.73
249_V252_R0.6470.73
167_T241_A0.6420.72
186_H238_A0.6390.72
222_Y246_A0.6390.72
69_F173_A0.6360.71
171_H190_G0.6350.71
226_Q249_V0.6350.71
62_L94_L0.6340.71
64_Y184_G0.6340.71
113_R124_C0.6330.71
66_A98_I0.6330.71
124_C226_Q0.6320.71
175_W217_S0.6310.71
157_L169_C0.6290.71
164_G239_V0.6240.70
94_L98_I0.6220.70
169_C202_R0.6220.70
112_R127_E0.6200.69
228_S233_V0.6190.69
142_T211_Q0.6180.69
195_L228_S0.6140.69
261_C266_A0.6100.68
210_Q232_G0.6100.68
184_G202_R0.6090.68
174_A215_L0.6040.67
172_A187_E0.6020.67
53_V72_S0.5980.67
164_G241_A0.5970.67
72_S116_A0.5960.66
120_G126_V0.5960.66
40_E190_G0.5950.66
139_L234_E0.5910.66
121_C190_G0.5910.66
56_M122_G0.5890.65
64_Y205_E0.5880.65
216_V247_V0.5870.65
125_G161_Q0.5860.65
90_S95_E0.5860.65
159_D165_Q0.5860.65
209_W231_C0.5850.65
164_G193_V0.5820.65
32_P148_N0.5820.65
123_V161_Q0.5810.64
241_A245_L0.5800.64
35_D220_A0.5800.64
111_R127_E0.5790.64
97_Q266_A0.5760.64
127_E130_N0.5720.63
86_D97_Q0.5720.63
113_R117_G0.5680.63
155_R263_P0.5670.63
121_C192_H0.5670.63
154_L237_F0.5660.62
118_R218_S0.5650.62
217_S260_F0.5640.62
161_Q187_E0.5630.62
117_G120_G0.5630.62
77_E137_Q0.5630.62
54_V122_G0.5600.62
106_M109_K0.5600.62
87_V93_G0.5590.61
28_D31_H0.5590.61
163_V167_T0.5580.61
174_A177_L0.5570.61
56_M244_T0.5550.61
69_F72_S0.5530.61
72_S199_L0.5520.61
59_P242_A0.5520.61
210_Q254_N0.5510.60
162_P255_L0.5500.60
194_A240_S0.5480.60
32_P85_M0.5480.60
130_N133_G0.5470.60
50_I106_M0.5460.60
26_R37_V0.5440.59
193_V234_E0.5430.59
42_P56_M0.5430.59
186_H232_G0.5420.59
174_A185_G0.5420.59
100_L104_R0.5420.59
87_V94_L0.5420.59
173_A214_V0.5410.59
171_H192_H0.5400.59
37_V244_T0.5390.59
122_G125_G0.5380.59
74_G247_V0.5360.58
58_S163_V0.5340.58
81_D103_R0.5340.58
217_S239_V0.5340.58
70_S218_S0.5320.58
147_L275_L0.5320.58
245_L249_V0.5310.58
50_I108_L0.5290.57
124_C239_V0.5290.57
69_F123_V0.5280.57
136_V229_A0.5280.57
113_R187_E0.5260.57
48_N105_F0.5240.57
52_H118_R0.5240.57
67_L205_E0.5220.56
190_G219_R0.5200.56
222_Y239_V0.5200.56
216_V223_E0.5170.56
202_R207_E0.5170.56
139_L254_N0.5170.56
67_L98_I0.5170.56
163_V169_C0.5140.55
34_L79_P0.5130.55
56_M121_C0.5110.55
76_I233_V0.5100.55
220_A236_L0.5090.54
38_A65_F0.5090.54
228_S255_L0.5080.54
100_L157_L0.5080.54
28_D148_N0.5060.54
47_Y198_L0.5050.54
142_T274_R0.5040.54
192_H219_R0.5040.54
139_L142_T0.5030.54
190_G246_A0.5020.53
149_K213_A0.5010.53
199_L218_S0.5010.53
145_F274_R0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pdeA 2 0.8809 100 0.093 Contact Map
2pw9A 2 0.8484 100 0.174 Contact Map
3mtjA 3 0.5018 50.7 0.959 Contact Map
3e96A 2 0.3863 46.1 0.96 Contact Map
2fp4A 1 0.5054 42.8 0.961 Contact Map
2yv1A 1 0.4801 40.7 0.962 Contact Map
2yv2A 1 0.4729 40.6 0.962 Contact Map
3d0cA 2 0.4007 40.5 0.962 Contact Map
3oqbA 4 0.5162 38.6 0.962 Contact Map
4ahqA 3 0.3827 34.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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