GREMLIN Database
MOBA - Molybdenum cofactor guanylyltransferase
UniProt: P32173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11829
Length: 194 (179)
Sequences: 4733 (3847)
Seq/√Len: 287.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_K41_D5.6881.00
20_M28_L3.2761.00
10_V86_V3.2691.00
26_G100_C3.2341.00
34_P37_Q3.2231.00
104_Y190_W2.5691.00
28_L187_L2.4301.00
9_G43_L2.3531.00
9_G47_L2.2351.00
96_L110_A2.2271.00
49_H67_K2.1531.00
33_K38_H2.1491.00
88_Q147_L2.1401.00
90_E95_F2.0561.00
33_K37_Q2.0311.00
156_R159_V2.0081.00
8_T92_G1.9871.00
8_T49_H1.9801.00
10_V95_F1.9231.00
122_V164_A1.8551.00
8_T90_E1.8231.00
183_T186_E1.7851.00
94_W137_L1.7471.00
83_M97_F1.7101.00
87_M95_F1.6991.00
131_D168_A1.6721.00
71_D81_A1.6421.00
37_Q41_D1.6301.00
43_L98_C1.5561.00
84_L88_Q1.5521.00
13_A52_V1.5501.00
20_M184_P1.5271.00
99_P102_T1.5171.00
94_W139_N1.4991.00
11_V40_A1.4831.00
181_V190_W1.4741.00
23_V28_L1.4651.00
77_P155_R1.4561.00
121_P165_G1.4301.00
30_L35_L1.4151.00
53_N86_V1.3911.00
179_V190_W1.3691.00
83_M157_V1.3561.00
51_V69_I1.3531.00
102_T135_I1.3531.00
40_A66_L1.3171.00
109_L177_A1.3091.00
145_L164_A1.3081.00
105_I135_I1.2981.00
30_L190_W1.2881.00
23_V184_P1.2801.00
29_E32_G1.2781.00
149_Y160_F1.2721.00
106_P109_L1.2631.00
84_L147_L1.2571.00
126_H129_E1.2551.00
98_C105_I1.2531.00
37_Q64_S1.2501.00
17_A23_V1.2431.00
145_L163_L1.2191.00
69_I85_S1.2151.00
142_I145_L1.2101.00
96_L137_L1.1901.00
10_V97_F1.1881.00
77_P81_A1.1881.00
73_L77_P1.1811.00
142_I164_A1.1811.00
7_I114_N1.1721.00
122_V125_V1.1671.00
31_N38_H1.1651.00
154_E159_V1.1491.00
181_V187_L1.1441.00
126_H170_D1.1411.00
98_C110_A1.1321.00
17_A26_G1.1231.00
35_L181_V1.1181.00
126_H131_D1.1151.00
121_P139_N1.1051.00
8_T51_V1.1011.00
62_Q70_E1.0811.00
160_F164_A1.0811.00
122_V161_M1.0621.00
11_V39_V1.0541.00
35_L39_V1.0531.00
29_E34_P1.0501.00
24_D27_L1.0501.00
149_Y154_E1.0501.00
11_V36_W1.0491.00
121_P141_A1.0471.00
140_R143_E1.0461.00
106_P177_A1.0321.00
7_I94_W1.0321.00
40_A50_V1.0151.00
16_K75_D1.0011.00
29_E33_K0.9961.00
116_Q167_H0.9931.00
159_V162_R0.9831.00
54_A68_V0.9821.00
34_P38_H0.9801.00
145_L160_F0.9781.00
120_A167_H0.9641.00
38_H42_A0.9631.00
20_M23_V0.9581.00
147_L151_Q0.9561.00
39_V42_A0.9441.00
149_Y159_V0.9431.00
46_Q111_A0.9371.00
93_E140_R0.9361.00
52_V66_L0.9151.00
45_T107_P0.9151.00
113_L137_L0.9151.00
73_L84_L0.9111.00
47_L96_L0.9091.00
114_N137_L0.9041.00
186_E189_R0.9011.00
148_E152_A0.9001.00
10_V53_N0.8961.00
81_A85_S0.8961.00
71_D85_S0.8921.00
99_P135_I0.8861.00
179_V189_R0.8811.00
104_Y179_V0.8721.00
14_G82_G0.8701.00
124_W131_D0.8691.00
138_V146_L0.8671.00
17_A24_D0.8661.00
77_P153_G0.8651.00
67_K89_Q0.8581.00
87_M143_E0.8571.00
126_H168_A0.8571.00
145_L148_E0.8461.00
51_V89_Q0.8411.00
127_D132_H0.8391.00
78_G81_A0.8371.00
80_L146_L0.8261.00
54_A70_E0.8201.00
14_G79_P0.8191.00
81_A84_L0.8151.00
59_E62_Q0.8070.99
57_H60_I0.8070.99
11_V43_L0.8060.99
99_P138_V0.8050.99
65_G68_V0.8030.99
158_M162_R0.8020.99
49_H53_N0.7980.99
124_W168_A0.7970.99
35_L100_C0.7960.99
79_P82_G0.7880.99
42_A107_P0.7770.99
71_D74_A0.7720.99
43_L46_Q0.7700.99
9_G39_V0.7700.99
17_A187_L0.7680.99
60_I63_A0.7610.99
90_E140_R0.7570.99
20_M181_V0.7560.99
93_E139_N0.7540.99
146_L160_F0.7530.99
166_G170_D0.7520.99
185_E189_R0.7380.99
51_V90_E0.7340.99
72_S88_Q0.7330.99
124_W136_A0.7280.99
136_A161_M0.7260.99
55_N74_A0.7260.99
95_F143_E0.7230.99
185_E188_A0.7150.99
127_D130_R0.7140.99
184_P188_A0.7130.99
39_V98_C0.7100.99
17_A20_M0.7070.99
36_W40_A0.7040.99
133_P136_A0.7040.99
15_G19_R0.7030.99
69_I86_V0.7010.99
125_V171_F0.7000.99
80_L160_F0.6970.98
24_D56_R0.6960.98
171_F178_F0.6960.98
46_Q110_A0.6850.98
44_M65_G0.6790.98
10_V51_V0.6710.98
69_I89_Q0.6700.98
40_A64_S0.6680.98
71_D82_G0.6620.98
144_P147_L0.6610.98
14_G99_P0.6590.98
120_A139_N0.6590.98
10_V90_E0.6570.98
109_L113_L0.6560.98
122_V166_G0.6560.98
107_P111_A0.6550.98
97_F138_V0.6500.98
49_H92_G0.6450.98
104_Y181_V0.6330.97
124_W166_G0.6320.97
47_L110_A0.6320.97
28_L184_P0.6280.97
27_L64_S0.6240.97
30_L38_H0.6230.97
31_N190_W0.6230.97
96_L114_N0.6230.97
167_H170_D0.6220.97
148_E151_Q0.6210.97
26_G36_W0.6200.97
119_D139_N0.6170.97
29_E187_L0.6150.97
117_R120_A0.6140.97
161_M166_G0.6110.97
86_V95_F0.6100.97
35_L190_W0.6070.96
80_L84_L0.6070.96
112_R116_Q0.6040.96
118_K121_P0.5970.96
83_M99_P0.5950.96
73_L81_A0.5940.96
72_S84_L0.5940.96
152_A163_L0.5930.96
36_W52_V0.5920.96
42_A46_Q0.5920.96
53_N69_I0.5900.96
131_D158_M0.5850.96
88_Q143_E0.5840.96
79_P132_H0.5820.95
120_A165_G0.5800.95
35_L187_L0.5710.95
20_M24_D0.5650.95
111_A115_H0.5590.94
134_T157_V0.5550.94
24_D55_N0.5550.94
121_P166_G0.5540.94
128_G133_P0.5530.94
20_M186_E0.5500.94
55_N78_G0.5480.94
27_L61_Y0.5480.94
56_R60_I0.5470.94
149_Y163_L0.5440.94
102_T134_T0.5430.94
14_G134_T0.5410.93
55_N61_Y0.5410.93
167_H171_F0.5400.93
124_W161_M0.5390.93
7_I137_L0.5370.93
83_M138_V0.5370.93
144_P148_E0.5360.93
95_F140_R0.5330.93
40_A44_M0.5300.93
130_R135_I0.5300.93
178_F182_N0.5290.93
49_H91_A0.5280.93
111_A114_N0.5260.92
56_R61_Y0.5250.92
79_P182_N0.5250.92
53_N82_G0.5230.92
134_T138_V0.5220.92
117_R167_H0.5220.92
41_D45_T0.5220.92
140_R144_P0.5190.92
20_M183_T0.5180.92
122_V138_V0.5180.92
80_L157_V0.5150.92
53_N56_R0.5110.91
127_D171_F0.5100.91
11_V50_V0.5040.91
9_G96_L0.5030.91
20_M187_L0.5030.91
26_G35_L0.5000.90
104_Y176_D0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5kA 1 0.9691 100 0.234 Contact Map
2e8bA 1 0.9021 100 0.319 Contact Map
3ngwA 2 0.9278 100 0.335 Contact Map
2weeA 1 0.9485 100 0.351 Contact Map
2wawA 1 0.9485 100 0.365 Contact Map
3d5nA 2 0.8866 100 0.394 Contact Map
3rsbA 1 0.8454 99.9 0.495 Contact Map
2xmeA 3 0.9124 99.9 0.496 Contact Map
2px7A 2 0.8918 99.9 0.499 Contact Map
4mndA 2 0.933 99.9 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.