GREMLIN Database
RHAB - L-Rhamnulokinase
UniProt: P32171 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11868
Length: 489 (466)
Sequences: 12522 (8540)
Seq/√Len: 395.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_E204_K4.2801.00
110_L145_E3.8511.00
22_R26_E3.6201.00
18_V63_G3.3921.00
113_Q145_E3.3551.00
380_A384_H2.8661.00
186_N189_S2.8411.00
380_A475_V2.8331.00
126_R193_D2.8291.00
387_A419_I2.8031.00
96_V150_L2.7851.00
411_Q415_D2.7601.00
355_E367_L2.7421.00
325_L366_E2.7171.00
185_V210_P2.7011.00
171_K209_R2.6751.00
396_Q422_I2.6621.00
445_N449_D2.6191.00
20_L67_V2.5751.00
42_L98_L2.5541.00
446_N449_D2.5451.00
97_G147_Q2.5291.00
212_H215_N2.5131.00
57_E167_R2.5091.00
91_Q155_A2.4541.00
54_D167_R2.4311.00
90_D153_H2.4311.00
191_D204_K2.3651.00
197_L204_K2.3481.00
186_N193_D2.3221.00
314_D317_A2.2861.00
420_R462_T2.2251.00
380_A472_A2.2201.00
37_R62_L2.1921.00
37_R66_K2.1691.00
194_E198_A2.1651.00
19_M430_T2.1431.00
9_V60_I2.1301.00
235_S240_S2.1151.00
165_S234_A2.1111.00
156_H172_M2.0691.00
302_L371_I2.0671.00
54_D94_Q2.0131.00
113_Q117_Q2.0051.00
464_T467_P2.0021.00
363_S366_E1.9871.00
169_T230_V1.9771.00
330_F366_E1.9671.00
45_Q48_Y1.9561.00
7_V64_L1.9511.00
122_D125_Q1.9451.00
418_G468_D1.9431.00
387_A393_D1.9021.00
66_K70_E1.8981.00
261_S299_G1.8981.00
221_I224_Q1.8891.00
324_A365_A1.8861.00
399_I410_N1.8851.00
6_C438_L1.8801.00
317_A320_S1.8451.00
7_V18_V1.8431.00
11_L16_G1.8401.00
141_R145_E1.8351.00
475_V479_H1.8101.00
211_T215_N1.7931.00
306_V371_I1.7921.00
5_N20_L1.7771.00
415_D467_P1.7471.00
122_D126_R1.7461.00
126_R195_S1.7371.00
173_N211_T1.7301.00
93_G166_Y1.7271.00
122_D195_S1.7121.00
216_V231_V1.7091.00
35_I66_K1.7061.00
90_D94_Q1.6951.00
88_L143_L1.6951.00
112_A116_Q1.6781.00
40_N55_S1.6661.00
231_V440_T1.6601.00
222_C226_N1.6591.00
115_Q120_K1.6581.00
252_A396_Q1.6581.00
407_T461_T1.6531.00
216_V219_H1.6281.00
304_Q308_Q1.6041.00
109_G113_Q1.6011.00
15_S36_H1.5981.00
321_A365_A1.5881.00
6_C443_E1.5771.00
88_L206_W1.5671.00
321_A324_A1.5661.00
87_V160_M1.5641.00
188_N270_P1.5571.00
33_R70_E1.5551.00
352_A359_P1.5531.00
468_D472_A1.5511.00
219_H227_E1.5461.00
121_R125_Q1.5261.00
68_C71_G1.4941.00
384_H387_A1.4911.00
149_E152_P1.4851.00
268_Q288_E1.4711.00
52_D55_S1.4681.00
320_S324_A1.4611.00
23_Y443_E1.4581.00
165_S217_I1.4561.00
384_H479_H1.4431.00
216_V229_P1.4261.00
54_D58_S1.4161.00
322_T408_L1.4151.00
438_L444_L1.4031.00
318_L368_A1.4031.00
203_N206_W1.4021.00
369_R373_D1.4001.00
407_T423_A1.3991.00
57_E61_R1.3931.00
469_S472_A1.3661.00
418_G472_A1.3581.00
250_S268_Q1.3551.00
319_I323_Q1.3521.00
76_S437_Q1.3471.00
163_Y167_R1.3441.00
122_D199_W1.3441.00
142_A146_Q1.3411.00
408_L412_L1.3401.00
89_L158_L1.3381.00
321_A364_D1.3341.00
9_V64_L1.3291.00
257_S413_C1.3271.00
377_L474_Y1.3181.00
396_Q420_R1.3121.00
176_Y190_D1.3121.00
376_A412_L1.3111.00
108_N112_A1.3051.00
253_A394_F1.3021.00
332_I477_Q1.2961.00
169_T218_G1.2951.00
83_G236_H1.2941.00
110_L141_R1.2911.00
197_L207_F1.2871.00
376_A416_A1.2781.00
16_G60_I1.2761.00
358_Q362_E1.2651.00
249_G451_R1.2631.00
376_A413_C1.2621.00
211_T217_I1.2591.00
255_L413_C1.2571.00
16_G59_A1.2471.00
35_I38_F1.2421.00
137_L200_S1.2411.00
313_N317_A1.2341.00
165_S173_N1.2341.00
144_T151_I1.2301.00
42_L55_S1.2241.00
85_D99_P1.2221.00
5_N73_R1.2181.00
93_G172_M1.2171.00
123_I131_F1.2131.00
405_Q426_V1.2111.00
171_K211_T1.2071.00
235_S436_I1.1981.00
249_G252_A1.1951.00
415_D464_T1.1951.00
195_S198_A1.1931.00
58_S62_L1.1901.00
319_I407_T1.1891.00
147_Q150_L1.1861.00
117_Q199_W1.1861.00
62_L66_K1.1781.00
317_A321_A1.1761.00
380_A417_C1.1751.00
412_L416_A1.1741.00
449_D452_Q1.1731.00
52_D98_L1.1701.00
471_I474_Y1.1701.00
356_T481_T1.1621.00
334_P339_F1.1601.00
381_D479_H1.1561.00
9_V18_V1.1421.00
50_T98_L1.1391.00
328_C331_I1.1321.00
35_I67_V1.1291.00
173_N217_I1.1281.00
60_I164_F1.1231.00
53_V87_V1.1221.00
331_I334_P1.1201.00
319_I406_N1.1181.00
310_Q367_L1.1141.00
320_S323_Q1.1141.00
125_Q272_T1.1141.00
109_G112_A1.1121.00
158_L172_M1.1101.00
149_E153_H1.1081.00
316_P319_I1.1061.00
420_R464_T1.1031.00
88_L154_I1.1001.00
353_C358_Q1.0981.00
151_I154_I1.0951.00
398_H422_I1.0931.00
176_Y185_V1.0931.00
176_Y210_P1.0921.00
216_V440_T1.0911.00
97_G150_L1.0801.00
249_G448_D1.0801.00
21_A434_I1.0741.00
219_H229_P1.0721.00
252_A398_H1.0711.00
477_Q480_S1.0701.00
111_M131_F1.0691.00
6_C441_L1.0601.00
88_L140_L1.0601.00
435_G450_F1.0591.00
77_I228_I1.0581.00
56_L160_M1.0581.00
79_I165_S1.0551.00
384_H475_V1.0531.00
112_A115_Q1.0491.00
76_S441_L1.0491.00
251_R395_S1.0461.00
321_A368_A1.0441.00
154_I206_W1.0431.00
197_L202_A1.0351.00
76_S231_V1.0331.00
110_L146_Q1.0311.00
334_P355_E1.0301.00
253_A265_F1.0271.00
375_L403_G1.0261.00
232_A235_S1.0261.00
106_R142_A1.0221.00
211_T232_A1.0191.00
362_E366_E1.0161.00
377_L416_A1.0151.00
5_N32_L1.0151.00
61_R65_N1.0071.00
383_L417_C1.0061.00
439_M450_F1.0051.00
60_I64_L0.9981.00
140_L157_A0.9981.00
75_D441_L0.9971.00
18_V67_V0.9961.00
296_N378_L0.9961.00
32_L35_I0.9931.00
166_Y172_M0.9931.00
220_W228_I0.9931.00
110_L113_Q0.9921.00
125_Q188_N0.9881.00
49_V103_R0.9851.00
65_N69_E0.9841.00
6_C76_S0.9841.00
369_R408_L0.9831.00
380_A416_A0.9831.00
55_S58_S0.9811.00
41_G51_W0.9781.00
94_Q167_R0.9771.00
467_P471_I0.9761.00
66_K69_E0.9741.00
123_I183_Q0.9741.00
113_Q116_Q0.9711.00
438_L443_E0.9711.00
249_G395_S0.9691.00
461_T465_P0.9651.00
137_L183_Q0.9621.00
21_A431_L0.9601.00
7_V20_L0.9591.00
74_I228_I0.9531.00
254_Y400_V0.9491.00
323_Q408_L0.9481.00
80_D429_S0.9461.00
263_M383_L0.9441.00
20_L74_I0.9431.00
88_L157_A0.9431.00
472_A476_A0.9421.00
231_V441_L0.9421.00
403_G409_L0.9381.00
150_L153_H0.9351.00
464_T468_D0.9331.00
143_L150_L0.9321.00
154_I157_A0.9221.00
148_P152_P0.9221.00
284_E289_G0.9211.00
174_W179_A0.9151.00
68_C74_I0.9141.00
315_L318_L0.9131.00
119_G199_W0.9131.00
410_N461_T0.9101.00
35_I63_G0.9091.00
190_D212_H0.9041.00
417_C420_R0.9011.00
325_L328_C0.8931.00
338_R355_E0.8931.00
185_V189_S0.8921.00
7_V74_I0.8911.00
141_R144_T0.8901.00
86_F157_A0.8881.00
119_G122_D0.8871.00
261_S379_Y0.8861.00
113_Q141_R0.8851.00
97_G143_L0.8811.00
435_G454_V0.8801.00
465_P468_D0.8801.00
473_H476_A0.8791.00
170_G221_I0.8771.00
33_R67_V0.8761.00
162_D174_W0.8751.00
275_T388_Q0.8721.00
79_I164_F0.8711.00
188_N272_T0.8711.00
397_L417_C0.8681.00
355_E371_I0.8681.00
191_D209_R0.8681.00
155_A205_A0.8661.00
328_C373_D0.8571.00
109_G146_Q0.8571.00
377_L475_V0.8561.00
439_M447_V0.8531.00
179_A192_W0.8521.00
173_N209_R0.8521.00
11_L164_F0.8511.00
358_Q367_L0.8501.00
77_I220_W0.8501.00
384_H388_Q0.8461.00
313_N364_D0.8461.00
444_L450_F0.8451.00
268_Q290_R0.8381.00
176_Y212_H0.8371.00
241_A400_V0.8361.00
84_V181_T0.8361.00
111_M138_Y0.8361.00
11_L60_I0.8351.00
174_W208_G0.8341.00
24_E453_V0.8321.00
111_M133_P0.8291.00
79_I168_L0.8261.00
322_T369_R0.8251.00
64_L68_C0.8251.00
312_I318_L0.8241.00
305_R308_Q0.8231.00
351_A354_R0.8221.00
137_L184_L0.8191.00
78_G231_V0.8191.00
192_W207_F0.8181.00
469_S473_H0.8181.00
372_F412_L0.8111.00
176_Y284_E0.8111.00
424_G456_T0.8101.00
89_L93_G0.8091.00
222_C227_E0.8091.00
265_F386_L0.8031.00
463_F467_P0.8031.00
238_T262_L0.8001.00
307_L315_L0.8001.00
76_S229_P0.7981.00
383_L387_A0.7981.00
328_C332_I0.7971.00
105_S132_L0.7961.00
439_M446_N0.7901.00
450_F454_V0.7901.00
39_N59_A0.7891.00
316_P320_S0.7891.00
75_D443_E0.7881.00
159_L182_T0.7861.00
404_C426_V0.7851.00
22_R25_R0.7851.00
376_A409_L0.7831.00
115_Q131_F0.7821.00
352_A356_T0.7811.00
140_L184_L0.7781.00
348_E351_A0.7781.00
306_V367_L0.7781.00
96_V153_H0.7781.00
424_G455_S0.7771.00
249_G452_Q0.7731.00
185_V190_D0.7731.00
188_N269_T0.7721.00
53_V98_L0.7711.00
454_V457_T0.7711.00
217_I232_A0.7711.00
190_D284_E0.7681.00
224_Q227_E0.7681.00
83_G178_N0.7651.00
177_T283_N0.7641.00
61_R224_Q0.7641.00
399_I413_C0.7621.00
311_Q364_D0.7621.00
191_D194_E0.7611.00
399_I423_A0.7611.00
255_L261_S0.7591.00
44_S48_Y0.7591.00
253_A397_L0.7561.00
325_L365_A0.7551.00
325_L330_F0.7541.00
112_A350_Q0.7541.00
141_R201_G0.7531.00
470_E473_H0.7531.00
424_G457_T0.7521.00
55_S59_A0.7521.00
438_L442_D0.7521.00
32_L38_F0.7501.00
255_L379_Y0.7491.00
219_H226_N0.7481.00
126_R186_N0.7471.00
385_E388_Q0.7461.00
109_G145_E0.7461.00
174_W210_P0.7431.00
245_S254_Y0.7421.00
468_D471_I0.7391.00
11_L59_A0.7391.00
54_D163_Y0.7391.00
90_D96_V0.7371.00
198_A204_K0.7371.00
13_A101_A0.7361.00
161_P234_A0.7351.00
190_D289_G0.7311.00
195_S199_W0.7311.00
89_L172_M0.7291.00
334_P371_I0.7261.00
90_D155_A0.7261.00
21_A425_P0.7241.00
407_T463_F0.7241.00
423_A461_T0.7241.00
381_D475_V0.7241.00
306_V368_A0.7231.00
71_G74_I0.7211.00
372_F406_N0.7191.00
8_A78_G0.7181.00
245_S400_V0.7171.00
444_L453_V0.7171.00
64_L67_V0.7161.00
449_D453_V0.7161.00
404_C410_N0.7161.00
102_Y260_W0.7151.00
241_A429_S0.7141.00
88_L96_V0.7121.00
325_L329_R0.7121.00
322_T368_A0.7111.00
91_Q153_H0.7111.00
323_Q411_Q0.7101.00
57_E224_Q0.7081.00
165_S169_T0.7071.00
476_A479_H0.7071.00
463_F468_D0.7071.00
198_A203_N0.7071.00
177_T235_S0.7071.00
326_P329_R0.7051.00
473_H477_Q0.7051.00
58_S61_R0.7031.00
61_R167_R0.7031.00
193_D196_L0.7021.00
466_N469_S0.7021.00
247_L254_Y0.7011.00
123_I196_L0.7001.00
332_I362_E0.7001.00
152_P156_H0.6971.00
342_P345_M0.6931.00
418_G465_P0.6921.00
474_Y477_Q0.6921.00
163_Y166_Y0.6891.00
77_I230_V0.6870.99
399_I421_V0.6870.99
38_F304_Q0.6870.99
397_L419_I0.6860.99
344_T347_S0.6860.99
212_H284_E0.6860.99
83_G294_L0.6850.99
255_L397_L0.6850.99
323_Q407_T0.6840.99
304_Q315_L0.6820.99
322_T325_L0.6810.99
93_G155_A0.6800.99
21_A30_L0.6800.99
186_N191_D0.6760.99
334_P337_D0.6760.99
6_C75_D0.6740.99
463_F466_N0.6730.99
291_Y295_K0.6730.99
395_S419_I0.6700.99
21_A430_T0.6700.99
334_P370_C0.6700.99
81_T178_N0.6690.99
319_I408_L0.6690.99
448_D451_R0.6660.99
397_L421_V0.6660.99
100_V106_R0.6630.99
50_T106_R0.6630.99
213_P234_A0.6620.99
267_S271_F0.6620.99
62_L65_N0.6610.99
54_D95_R0.6590.99
396_Q419_I0.6590.99
114_A200_S0.6590.99
341_N345_M0.6580.99
435_G453_V0.6570.99
388_Q479_H0.6570.99
299_G375_L0.6560.99
237_D259_T0.6560.99
60_I63_G0.6550.99
450_F453_V0.6550.99
87_V99_P0.6500.99
89_L156_H0.6500.99
229_P441_L0.6500.99
32_L37_R0.6500.99
34_E38_F0.6500.99
465_P469_S0.6490.99
219_H222_C0.6480.99
380_A479_H0.6470.99
303_L319_I0.6460.99
118_L196_L0.6420.99
184_L207_F0.6410.99
327_A470_E0.6400.99
140_L206_W0.6380.99
319_I322_T0.6380.99
141_R151_I0.6370.99
127_S196_L0.6360.99
144_T201_G0.6360.99
246_P451_R0.6320.99
162_D172_M0.6320.99
462_T465_P0.6320.99
346_C381_D0.6310.99
89_L166_Y0.6310.99
86_F136_T0.6300.99
121_R124_Y0.6290.99
472_A475_V0.6280.99
138_Y183_Q0.6270.99
36_H39_N0.6250.99
89_L163_Y0.6250.99
247_L252_A0.6230.99
23_Y75_D0.6230.99
416_A471_I0.6230.99
226_N229_P0.6210.99
114_A138_Y0.6210.99
306_V310_Q0.6210.99
470_E474_Y0.6200.99
439_M444_L0.6190.99
141_R200_S0.6180.99
435_G439_M0.6170.99
373_D412_L0.6170.99
463_F471_I0.6150.99
333_N477_Q0.6130.99
216_V441_L0.6130.99
161_P178_N0.6130.99
53_V99_P0.6130.99
54_D98_L0.6130.99
61_R64_L0.6110.99
309_E363_S0.6110.99
34_E37_R0.6100.99
423_A463_F0.6090.99
377_L471_I0.6080.99
244_A428_A0.6060.99
5_N72_I0.6060.99
467_P470_E0.6060.99
236_H239_A0.6050.99
153_H156_H0.6040.99
411_Q414_A0.6030.99
407_T411_Q0.6020.99
151_I155_A0.6020.99
81_T160_M0.6020.99
177_T213_P0.6010.99
346_C479_H0.6010.99
406_N409_L0.6000.99
54_D57_E0.6000.99
261_S413_C0.6000.99
131_F183_Q0.6000.99
82_W102_Y0.5980.99
93_G156_H0.5960.99
108_N133_P0.5940.99
129_I135_N0.5930.99
451_R454_V0.5930.99
198_A201_G0.5900.98
182_T192_W0.5890.98
123_I200_S0.5890.98
410_N423_A0.5890.98
135_N181_T0.5870.98
411_Q461_T0.5870.98
107_T138_Y0.5860.98
295_K298_M0.5840.98
238_T256_S0.5840.98
315_L319_I0.5830.98
83_G181_T0.5830.98
328_C369_R0.5820.98
333_N355_E0.5810.98
412_L467_P0.5810.98
319_I372_F0.5810.98
6_C444_L0.5810.98
94_Q153_H0.5800.98
451_R455_S0.5790.98
448_D452_Q0.5790.98
467_P472_A0.5790.98
214_G440_T0.5780.98
369_R412_L0.5780.98
411_Q464_T0.5770.98
338_R342_P0.5760.98
252_A395_S0.5750.98
257_S399_I0.5740.98
353_C356_T0.5740.98
23_Y438_L0.5740.98
334_P374_S0.5730.98
327_A331_I0.5720.98
263_M382_V0.5720.98
209_R215_N0.5710.98
50_T97_G0.5700.98
255_L263_M0.5700.98
87_V95_R0.5670.98
48_Y106_R0.5660.98
375_L409_L0.5640.98
6_C23_Y0.5640.98
242_V282_T0.5630.98
52_D58_S0.5630.98
133_P349_I0.5620.98
270_P279_A0.5580.98
100_V143_L0.5570.98
65_N68_C0.5550.98
19_M30_L0.5550.98
394_F419_I0.5530.98
373_D377_L0.5530.98
246_P454_V0.5530.98
446_N450_F0.5510.98
32_L39_N0.5510.98
330_F361_P0.5510.98
243_I435_G0.5510.98
304_Q307_L0.5500.98
19_M431_L0.5500.98
95_R98_L0.5490.98
38_F307_L0.5480.98
431_L435_G0.5470.97
196_L200_S0.5460.97
242_V264_G0.5440.97
331_I362_E0.5440.97
439_M442_D0.5430.97
85_D101_A0.5420.97
14_S17_R0.5420.97
303_L318_L0.5420.97
328_C474_Y0.5420.97
158_L166_Y0.5410.97
404_C423_A0.5410.97
151_I201_G0.5410.97
294_L297_I0.5400.97
59_A62_L0.5400.97
301_W304_Q0.5390.97
37_R59_A0.5390.97
170_G223_P0.5390.97
106_R146_Q0.5390.97
56_L99_P0.5380.97
340_I360_I0.5370.97
171_K219_H0.5370.97
202_A207_F0.5370.97
34_E66_K0.5360.97
229_P232_A0.5350.97
306_V311_Q0.5350.97
413_C417_C0.5340.97
414_A421_V0.5330.97
212_H287_A0.5330.97
327_A369_R0.5310.97
221_I227_E0.5310.97
43_H49_V0.5290.97
395_S420_R0.5290.97
159_L178_N0.5270.97
213_P235_S0.5260.97
412_L471_I0.5260.97
88_L97_G0.5230.97
48_Y100_V0.5220.97
13_A102_Y0.5220.97
379_Y413_C0.5210.97
263_M379_Y0.5200.97
183_Q200_S0.5200.97
430_T433_N0.5190.97
268_Q289_G0.5190.97
339_F355_E0.5190.97
84_V102_Y0.5190.97
165_S230_V0.5190.97
49_V101_A0.5170.97
162_D208_G0.5170.97
261_S297_I0.5170.97
39_N51_W0.5170.97
256_S400_V0.5160.96
117_Q141_R0.5150.96
35_I70_E0.5140.96
177_T239_A0.5140.96
38_F41_G0.5130.96
259_T301_W0.5130.96
5_N22_R0.5130.96
267_S293_V0.5130.96
84_V260_W0.5110.96
176_Y213_P0.5110.96
37_R63_G0.5100.96
299_G302_L0.5090.96
214_G439_M0.5080.96
39_N42_L0.5080.96
33_R38_F0.5070.96
377_L477_Q0.5070.96
253_A263_M0.5070.96
329_R366_E0.5060.96
86_F143_L0.5040.96
265_F394_F0.5030.96
256_S262_L0.5030.96
16_G39_N0.5020.96
181_T236_H0.5020.96
318_L408_L0.5010.96
82_W236_H0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9755 100 0.129 Contact Map
3ezwA 3 0.9816 100 0.149 Contact Map
2itmA 2 0.9489 100 0.15 Contact Map
3hz6A 1 0.9673 100 0.152 Contact Map
3h3nX 3 0.9796 100 0.153 Contact Map
3g25A 3 0.9796 100 0.155 Contact Map
3ifrA 2 0.9632 100 0.156 Contact Map
3wxlA 2 0.9816 100 0.157 Contact Map
2d4wA 2 0.9755 100 0.16 Contact Map
2w40A 3 0.9775 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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