GREMLIN Database
RHAA - L-rhamnose isomerase
UniProt: P32170 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11867
Length: 419 (413)
Sequences: 334 (166)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_A238_T5.0841.00
236_S291_V4.7130.99
9_W23_V4.6540.99
152_D156_Q4.5300.99
70_R74_E4.3400.99
82_A86_I4.3160.98
135_C162_C4.2850.98
390_M394_R4.2500.98
80_E125_N4.0410.98
169_S182_M3.5060.94
81_Q84_R3.4550.94
206_A210_E3.4230.94
170_A174_E3.3580.93
204_L245_Y3.2940.92
160_D164_A3.1920.91
312_I321_V3.1850.91
368_D371_A3.1680.91
409_A413_E3.1290.90
42_G338_W3.0800.89
91_R178_T3.0710.89
46_S68_K3.0560.89
24_E394_R2.9560.87
205_L252_R2.8880.86
116_K120_E2.7650.83
31_D395_H2.7430.83
140_L154_I2.6920.82
184_I212_I2.6430.80
182_M221_H2.5950.79
209_D248_Y2.5120.77
108_D160_D2.4980.76
82_A339_V2.4560.75
148_S239_V2.4280.74
100_E117_N2.4020.73
26_A353_L2.3620.72
37_M342_T2.3610.72
49_E107_R2.3380.71
99_L110_I2.3160.70
362_K366_A2.2980.70
33_L318_F2.2890.69
270_S304_E2.2860.69
207_A211_V2.1750.65
103_T113_E2.1650.65
34_P91_R2.1070.63
24_E390_M2.1060.63
42_G75_L2.0900.62
144_G238_T2.0290.60
86_I339_V2.0070.59
260_A308_I1.9880.58
346_K391_Y1.9780.58
273_I283_L1.9710.57
257_C284_L1.9600.57
216_L220_H1.9380.56
200_P203_R1.9360.56
260_A288_S1.9240.55
257_C364_E1.9220.55
56_T141_S1.9150.55
19_V379_Q1.8690.53
8_A386_A1.8600.53
284_L364_E1.8030.50
260_A269_I1.7930.50
309_A345_M1.7780.49
171_Y175_Q1.7700.49
368_D408_R1.7190.47
145_F150_A1.7050.46
222_I282_Q1.6930.46
386_A389_E1.6930.46
301_L351_R1.6820.45
119_V171_Y1.6450.44
25_E28_R1.6240.43
181_V284_L1.6240.43
371_A408_R1.6010.42
173_G324_G1.5870.41
166_R223_D1.5690.41
119_V175_Q1.5440.40
116_K175_Q1.5200.39
30_L349_L1.5160.39
268_V304_E1.4990.38
6_E10_E1.4960.38
379_Q382_L1.4950.38
212_I254_T1.4940.38
55_L137_S1.4790.37
282_Q322_H1.4670.37
302_D305_T1.4660.37
186_I204_L1.4650.37
159_I206_A1.4420.36
181_V364_E1.4370.36
21_I26_A1.4210.35
83_M92_L1.4180.35
129_L172_F1.4150.35
128_G176_L1.4110.35
336_A370_T1.3900.34
263_F269_I1.3860.34
173_G220_H1.3850.34
313_V318_F1.3780.33
166_R173_G1.3630.33
336_A340_I1.3600.33
194_T197_R1.3600.33
96_A110_I1.3500.32
49_E91_R1.3500.32
181_V257_C1.3470.32
110_I164_A1.3430.32
14_Q387_V1.3430.32
204_L225_V1.3410.32
112_P172_F1.3350.32
340_I373_L1.3080.31
242_N246_M1.3010.31
35_V90_K1.2990.31
106_S164_A1.2890.30
75_L338_W1.2880.30
144_G234_A1.2840.30
287_V325_L1.2670.29
164_A167_R1.2630.29
90_K391_Y1.2600.29
112_P171_Y1.2570.29
202_Q206_A1.2520.29
160_D163_K1.2440.29
21_I379_Q1.2420.29
247_G276_A1.2380.28
336_A403_W1.2300.28
34_P178_T1.2290.28
81_Q406_S1.2220.28
229_L263_F1.2190.28
124_A127_L1.2170.28
84_R126_Q1.2160.28
122_A129_L1.2160.28
336_A404_L1.2110.28
25_E29_Q1.1990.27
109_Q113_E1.1970.27
33_L309_A1.1900.27
174_E220_H1.1860.27
170_A220_H1.1760.26
85_L398_P1.1750.26
60_Q271_D1.1740.26
169_S221_H1.1720.26
346_K408_R1.1700.26
287_V324_G1.1630.26
205_L251_S1.1610.26
76_R121_W1.1580.26
33_L353_L1.1570.26
287_V345_M1.1450.25
378_E400_G1.1410.25
212_I223_D1.1390.25
390_M393_Q1.1350.25
61_A305_T1.1310.25
61_A254_T1.1300.25
402_E412_K1.1270.25
28_R32_R1.1270.25
149_H154_I1.1230.25
277_M317_L1.1230.25
273_I312_I1.1160.25
49_E61_A1.1150.24
186_I245_Y1.1080.24
273_I321_V1.0960.24
391_Y395_H1.0960.24
170_A175_Q1.0950.24
17_A23_V1.0950.24
204_L223_D1.0890.24
61_A330_A1.0880.24
263_F270_S1.0880.24
389_E399_A1.0880.24
163_K210_E1.0870.24
61_A238_T1.0850.24
200_P336_A1.0800.23
336_A373_L1.0780.23
65_Y411_E1.0760.23
60_Q182_M1.0730.23
30_L72_A1.0690.23
225_V245_Y1.0650.23
242_N288_S1.0610.23
116_K119_V1.0560.23
164_A403_W1.0510.23
269_I385_Q1.0500.23
363_L371_A1.0400.22
90_K300_L1.0380.22
97_I373_L1.0360.22
249_A256_L1.0350.22
232_I273_I1.0250.22
203_R370_T1.0250.22
200_P237_Y1.0200.22
96_A243_E1.0190.22
252_R323_I1.0160.22
11_L386_A1.0160.22
145_F246_M1.0100.21
23_V149_H1.0030.21
108_D163_K1.0000.21
121_W166_R0.9990.21
60_Q101_S0.9900.21
202_Q278_L0.9860.21
238_T271_D0.9780.21
170_A216_L0.9720.20
222_I327_F0.9710.20
200_P403_W0.9590.20
275_A345_M0.9550.20
242_N384_W0.9550.20
106_S279_Y0.9510.20
13_K23_V0.9470.20
119_V172_F0.9460.20
216_L221_H0.9450.20
357_T364_E0.9440.20
42_G388_W0.9430.20
194_T376_L0.9420.20
214_E253_Q0.9400.20
147_L207_A0.9400.20
34_P107_R0.9400.20
52_E153_S0.9390.19
79_L92_L0.9390.19
91_R176_L0.9380.19
50_N56_T0.9360.19
318_F335_I0.9350.19
107_R317_L0.9260.19
133_P200_P0.9250.19
56_T59_I0.9250.19
21_I213_S0.9220.19
317_L321_V0.9180.19
103_T111_K0.9180.19
76_R100_E0.9140.19
124_A413_E0.9110.19
331_S376_L0.9100.19
195_V364_E0.9080.19
140_L153_S0.9070.19
203_R336_A0.9060.19
5_L390_M0.9050.19
147_L204_L0.9050.19
304_E344_N0.9020.19
181_V322_H0.9000.18
163_K302_D0.9000.18
247_G275_A0.8960.18
49_E178_T0.8940.18
247_G280_V0.8940.18
23_V210_E0.8910.18
141_S367_G0.8900.18
50_N104_P0.8890.18
21_I64_N0.8850.18
393_Q400_G0.8850.18
71_N74_E0.8820.18
145_F190_M0.8730.18
339_V391_Y0.8710.18
355_E364_E0.8710.18
35_V127_L0.8700.18
35_V342_T0.8640.18
316_D319_D0.8640.18
68_K301_L0.8610.18
173_G223_D0.8590.17
414_I417_R0.8560.17
193_I300_L0.8560.17
15_R400_G0.8550.17
218_P322_H0.8540.17
215_K254_T0.8530.17
22_D387_V0.8500.17
273_I305_T0.8480.17
288_S305_T0.8470.17
268_V344_N0.8460.17
406_S413_E0.8440.17
156_Q160_D0.8430.17
91_R322_H0.8420.17
287_V323_I0.8320.17
307_A310_S0.8300.17
176_L243_E0.8300.17
173_G221_H0.8290.17
196_D199_A0.8290.17
322_H364_E0.8270.17
50_N154_I0.8270.17
182_M238_T0.8240.17
8_A11_L0.8240.17
190_M370_T0.8230.17
298_V332_I0.8230.17
145_F284_L0.8230.17
92_L282_Q0.8230.17
242_N275_A0.8220.17
37_M119_V0.8180.17
107_R301_L0.8170.17
258_L263_F0.8160.16
80_E124_A0.8160.16
331_S381_S0.8120.16
387_V406_S0.8110.16
257_C263_F0.8100.16
275_A358_A0.8090.16
90_K140_L0.8090.16
91_R107_R0.8080.16
229_L372_R0.8060.16
186_I208_L0.8050.16
309_A348_A0.8010.16
89_P126_Q0.8010.16
200_P370_T0.8010.16
324_G345_M0.8000.16
165_S290_P0.7990.16
37_M86_I0.7950.16
52_E145_F0.7940.16
275_A335_I0.7920.16
284_L307_A0.7880.16
338_W388_W0.7880.16
272_K392_C0.7850.16
68_K107_R0.7830.16
86_I378_E0.7820.16
55_L172_F0.7790.16
50_N53_G0.7780.16
144_G327_F0.7780.16
264_H272_K0.7730.16
163_K310_S0.7710.15
148_S254_T0.7690.15
167_R323_I0.7670.15
106_S221_H0.7670.15
92_L127_L0.7610.15
164_A200_P0.7590.15
102_D180_S0.7580.15
406_S409_A0.7570.15
204_L242_N0.7550.15
373_L386_A0.7510.15
128_G133_P0.7460.15
381_S384_W0.7460.15
83_M247_G0.7450.15
229_L234_A0.7430.15
23_V387_V0.7420.15
229_L342_T0.7410.15
121_W223_D0.7400.15
257_C355_E0.7370.15
61_A116_K0.7370.15
210_E213_S0.7360.15
87_P264_H0.7340.15
299_V308_I0.7340.15
184_I309_A0.7310.15
30_L127_L0.7280.15
160_D384_W0.7240.14
222_I322_H0.7240.14
169_S346_K0.7230.14
54_S238_T0.7220.14
204_L258_L0.7220.14
359_E362_K0.7220.14
187_P281_P0.7190.14
333_N411_E0.7190.14
56_T290_P0.7140.14
182_M216_L0.7110.14
217_N305_T0.7110.14
53_G68_K0.7090.14
121_W372_R0.7090.14
45_V335_I0.7080.14
413_E417_R0.7080.14
71_N283_L0.7070.14
17_A387_V0.7050.14
257_C307_A0.7040.14
364_E372_R0.7040.14
325_L345_M0.7020.14
284_L355_E0.7020.14
51_P407_V0.7020.14
306_Q351_R0.7010.14
141_S154_I0.7010.14
218_P254_T0.7000.14
17_A27_L0.6990.14
301_L348_A0.6960.14
224_A257_C0.6940.14
336_A344_N0.6940.14
186_I301_L0.6910.14
117_N171_Y0.6900.14
80_E254_T0.6900.14
95_H98_Y0.6890.14
246_M273_I0.6890.14
24_E358_A0.6880.14
270_S302_D0.6860.14
122_A172_F0.6860.14
105_V232_I0.6860.14
91_R171_Y0.6850.14
275_A280_V0.6840.14
182_M305_T0.6830.14
54_S61_A0.6830.14
227_S264_H0.6830.14
60_Q238_T0.6830.14
238_T254_T0.6820.14
245_Y324_G0.6820.14
74_E236_S0.6790.14
320_R352_A0.6770.14
34_P50_N0.6760.14
105_V306_Q0.6760.14
26_A320_R0.6750.14
225_V249_A0.6750.14
73_S113_E0.6750.14
170_A384_W0.6720.13
190_M203_R0.6720.13
26_A350_L0.6720.13
135_C331_S0.6720.13
108_D335_I0.6720.13
73_S92_L0.6710.13
27_L274_S0.6700.13
101_S169_S0.6680.13
76_R372_R0.6670.13
276_A284_L0.6670.13
149_H186_I0.6660.13
52_E414_I0.6660.13
33_L313_V0.6660.13
121_W247_G0.6650.13
323_I349_L0.6640.13
222_I255_A0.6630.13
238_T242_N0.6610.13
363_L368_D0.6610.13
110_I229_L0.6590.13
107_R312_I0.6580.13
276_A317_L0.6560.13
53_G270_S0.6560.13
53_G56_T0.6560.13
264_H392_C0.6560.13
300_L373_L0.6540.13
344_N378_E0.6530.13
166_R324_G0.6530.13
218_P391_Y0.6530.13
45_V69_A0.6530.13
133_P257_C0.6510.13
15_R19_V0.6510.13
256_L364_E0.6510.13
251_S387_V0.6460.13
162_C382_L0.6450.13
274_S374_A0.6440.13
96_A196_D0.6440.13
121_W173_G0.6420.13
24_E109_Q0.6420.13
91_R280_V0.6420.13
227_S265_P0.6400.13
283_L320_R0.6400.13
68_K220_H0.6400.13
300_L345_M0.6380.13
181_V282_Q0.6380.13
10_E413_E0.6380.13
167_R220_H0.6380.13
151_D253_Q0.6370.13
23_V92_L0.6360.13
13_K117_N0.6360.13
24_E28_R0.6350.13
234_A271_D0.6350.13
249_A252_R0.6340.13
290_P302_D0.6330.13
45_V93_N0.6320.13
375_L379_Q0.6320.13
249_A280_V0.6310.13
23_V26_A0.6310.13
39_C95_H0.6310.13
256_L284_L0.6300.13
187_P208_L0.6290.13
164_A202_Q0.6280.13
204_L208_L0.6280.13
171_Y361_R0.6270.13
338_W370_T0.6260.13
162_C211_V0.6250.13
274_S311_E0.6240.13
166_R212_I0.6240.13
287_V344_N0.6230.13
112_P169_S0.6230.13
257_C357_T0.6220.13
69_A78_D0.6210.13
154_I180_S0.6210.13
260_A263_F0.6200.12
104_P186_I0.6200.12
83_M279_Y0.6200.12
22_D25_E0.6190.12
83_M125_N0.6190.12
72_A318_F0.6180.12
107_R321_V0.6170.12
167_R214_E0.6170.12
97_I300_L0.6150.12
166_R220_H0.6140.12
224_A310_S0.6140.12
164_A315_H0.6130.12
100_E415_L0.6130.12
69_A75_L0.6090.12
307_A364_E0.6090.12
166_R372_R0.6090.12
273_I363_L0.6070.12
169_S216_L0.6050.12
395_H399_A0.6050.12
358_A391_Y0.6050.12
187_P222_I0.6050.12
71_N318_F0.6050.12
24_E287_V0.6040.12
238_T330_A0.6030.12
181_V256_L0.6030.12
6_E24_E0.6030.12
223_D327_F0.6000.12
333_N418_R0.5990.12
16_F99_L0.5980.12
26_A33_L0.5980.12
5_L46_S0.5960.12
134_S306_Q0.5940.12
5_L306_Q0.5940.12
142_A154_I0.5940.12
169_S184_I0.5940.12
246_M275_A0.5940.12
99_L227_S0.5920.12
90_K288_S0.5900.12
335_I374_A0.5900.12
173_G208_L0.5900.12
263_F319_D0.5890.12
180_S283_L0.5880.12
300_L305_T0.5850.12
108_D157_F0.5840.12
148_S160_D0.5840.12
56_T105_V0.5830.12
24_E413_E0.5830.12
197_R225_V0.5820.12
128_G196_D0.5790.12
264_H292_R0.5760.12
17_A22_D0.5750.12
220_H223_D0.5750.12
72_A302_D0.5740.12
195_V353_L0.5730.12
124_A249_A0.5730.12
110_I160_D0.5710.12
149_H229_L0.5690.12
55_L171_Y0.5680.12
10_E358_A0.5670.12
247_G372_R0.5660.12
150_A307_A0.5650.12
145_F390_M0.5650.12
250_T320_R0.5640.12
34_P349_L0.5630.11
97_I134_S0.5630.11
362_K409_A0.5630.11
374_A404_L0.5630.11
42_G370_T0.5620.11
316_D399_A0.5610.11
79_L177_G0.5600.11
223_D245_Y0.5600.11
275_A350_L0.5590.11
135_C142_A0.5580.11
177_G407_V0.5570.11
370_T403_W0.5560.11
227_S304_E0.5560.11
184_I301_L0.5560.11
141_S146_T0.5550.11
369_Y409_A0.5550.11
72_A336_A0.5540.11
39_C98_Y0.5540.11
14_Q319_D0.5540.11
238_T331_S0.5520.11
190_M346_K0.5520.11
16_F277_M0.5520.11
27_L388_W0.5520.11
13_K70_R0.5520.11
402_E405_E0.5510.11
149_H258_L0.5510.11
198_L278_L0.5500.11
90_K154_I0.5500.11
49_E68_K0.5490.11
317_L364_E0.5490.11
61_A391_Y0.5490.11
236_S381_S0.5490.11
176_L180_S0.5490.11
65_Y415_L0.5460.11
119_V310_S0.5460.11
34_P49_E0.5440.11
242_N245_Y0.5430.11
147_L186_I0.5410.11
93_N197_R0.5400.11
135_C149_H0.5400.11
216_L219_A0.5380.11
248_Y252_R0.5380.11
166_R204_L0.5380.11
344_N370_T0.5370.11
140_L380_K0.5370.11
163_K335_I0.5350.11
125_N269_I0.5340.11
133_P187_P0.5340.11
196_D349_L0.5340.11
75_L78_D0.5340.11
69_A93_N0.5340.11
15_R18_A0.5330.11
71_N75_L0.5310.11
312_I335_I0.5300.11
371_A404_L0.5300.11
165_S211_V0.5290.11
135_C141_S0.5280.11
224_A340_I0.5270.11
60_Q232_I0.5250.11
274_S340_I0.5250.11
335_I415_L0.5240.11
372_R376_L0.5240.11
60_Q107_R0.5220.11
391_Y405_E0.5220.11
133_P203_R0.5200.11
123_K184_I0.5200.11
163_K290_P0.5190.11
112_P237_Y0.5180.11
150_A276_A0.5170.11
170_A305_T0.5170.11
79_L83_M0.5170.11
288_S322_H0.5170.11
64_N334_R0.5160.11
258_L273_I0.5150.11
141_S260_A0.5150.11
222_I281_P0.5150.11
21_I336_A0.5150.11
54_S234_A0.5150.11
99_L102_D0.5140.11
112_P119_V0.5130.11
26_A359_E0.5130.11
81_Q269_I0.5120.11
208_L324_G0.5110.11
301_L306_Q0.5110.11
223_D324_G0.5110.11
351_R381_S0.5110.11
133_P162_C0.5110.11
9_W321_V0.5110.11
194_T237_Y0.5100.11
180_S222_I0.5100.11
270_S338_W0.5100.11
257_C351_R0.5080.11
7_Q10_E0.5080.11
71_N313_V0.5080.11
325_L378_E0.5080.11
181_V199_A0.5070.11
150_A203_R0.5070.11
50_N107_R0.5070.11
209_D354_L0.5070.11
78_D93_N0.5060.11
257_C322_H0.5060.11
405_E408_R0.5060.11
152_D219_A0.5050.11
79_L404_L0.5050.11
135_C181_V0.5050.11
351_R364_E0.5040.11
139_P389_E0.5030.11
305_T321_V0.5020.11
142_A162_C0.5000.10
49_E166_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d8wA 4 0.9642 100 0.328 Contact Map
3p14A 2 0.9594 100 0.536 Contact Map
3m0mA 4 0.9189 100 0.768 Contact Map
1a0cA 4 0.926 100 0.881 Contact Map
1muwA 4 0.8473 99.9 0.896 Contact Map
3ktcA 4 0.7566 99.8 0.919 Contact Map
1xlaA 4 0.7852 98.2 0.961 Contact Map
1ximA 4 0.8138 98.1 0.962 Contact Map
1bxbA 4 0.8067 97.7 0.965 Contact Map
3tc3A 1 0.6611 97.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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