GREMLIN Database
RHAD - Rhamnulose-1-phosphate aldolase
UniProt: P32169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11866
Length: 274 (207)
Sequences: 1418 (889)
Seq/√Len: 61.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_K100_A5.0991.00
236_Q240_K4.0041.00
181_G204_H3.8531.00
253_R257_I3.4591.00
146_N240_K3.3821.00
83_Q89_N3.3391.00
60_Q63_P2.9721.00
40_A44_P2.7201.00
154_L247_M2.6991.00
58_L61_P2.6551.00
58_L63_P2.6131.00
219_P223_E2.4871.00
138_V221_L2.3791.00
149_A240_K2.1791.00
153_V244_M2.1761.00
70_F122_F2.1401.00
131_A217_S2.0881.00
232_E236_Q2.0751.00
137_R220_T2.0541.00
184_P210_P2.0371.00
59_S63_P2.0351.00
216_G228_I2.0081.00
199_Q202_Q2.0021.00
56_I59_S1.9511.00
206_L231_A1.9291.00
155_E242_Y1.9261.00
146_N236_Q1.9001.00
140_M224_T1.8991.00
82_V89_N1.8841.00
128_R131_A1.8761.00
257_I261_K1.8451.00
197_T209_W1.8321.00
254_E258_A1.8201.00
150_L235_A1.8171.00
252_S255_E1.7500.99
140_M228_I1.7370.99
147_L231_A1.7100.99
177_P257_I1.6980.99
154_L249_Q1.6160.99
147_L214_V1.6110.99
73_T125_H1.6080.99
71_I92_I1.5700.99
43_A47_D1.4930.98
239_V244_M1.4690.98
206_L216_G1.4620.98
71_I90_L1.4400.98
41_D222_D1.4390.98
241_V248_K1.4280.98
144_A147_L1.4060.97
66_A69_P1.4040.97
153_V239_V1.3880.97
41_D44_P1.3800.97
154_L210_P1.3700.97
47_D53_P1.3670.97
69_P92_I1.3670.97
124_S201_M1.3530.97
170_T176_F1.3500.97
77_K89_N1.3450.97
96_D126_C1.3250.96
127_E198_A1.3210.96
171_E174_V1.3100.96
146_N232_E1.3080.96
143_H212_H1.3000.96
152_Y168_G1.2890.96
191_D195_Q1.2870.96
239_V243_S1.2780.95
214_V231_A1.2720.95
261_K265_V1.2630.95
147_L208_L1.2520.95
169_S172_C1.2360.94
96_D100_A1.2310.94
43_A46_H1.2280.94
73_T221_L1.1820.93
56_I61_P1.1800.93
148_I169_S1.1710.93
120_A215_F1.1530.92
175_V178_D1.1370.92
44_P47_D1.1320.91
39_D43_A1.1200.91
148_I151_T1.1170.91
150_L242_Y1.1110.91
156_N182_I1.1000.90
125_H139_I1.0890.90
171_E176_F1.0890.90
205_S219_P1.0840.90
146_N239_V1.0810.89
42_I47_D1.0780.89
81_N89_N1.0670.89
117_E193_I1.0620.89
48_N51_Q1.0560.88
93_V122_F1.0550.88
253_R256_L1.0500.88
220_T223_E1.0400.87
196_A199_Q1.0300.87
171_E230_T1.0010.85
240_K243_S1.0000.85
72_V76_G0.9960.85
115_T189_G0.9880.85
73_T90_L0.9840.84
195_Q199_Q0.9810.84
145_T240_K0.9790.84
144_A228_I0.9730.84
191_D223_E0.9730.84
233_K236_Q0.9650.83
142_C228_I0.9590.83
43_A87_A0.9560.83
61_P64_L0.9490.82
144_A232_E0.9440.82
58_L79_F0.9380.81
257_I260_G0.9290.81
210_P249_Q0.9250.81
176_F256_L0.9240.80
239_V253_R0.9090.79
36_R68_T0.9020.79
74_G77_K0.8900.78
239_V242_Y0.8870.78
221_L224_T0.8700.76
39_D87_A0.8690.76
70_F93_V0.8650.76
42_I60_Q0.8600.75
191_D194_G0.8570.75
77_K82_V0.8510.75
108_L111_E0.8430.74
95_V126_C0.8400.74
178_D257_I0.8380.74
38_D41_D0.8310.73
251_I259_L0.8310.73
70_F187_V0.8300.73
93_V115_T0.8290.73
227_L230_T0.8280.73
192_E195_Q0.8270.73
108_L139_I0.8250.72
169_S173_L0.8250.72
45_Y48_N0.8180.72
193_I215_F0.8150.71
230_T263_F0.8100.71
258_A262_R0.8080.71
123_L195_Q0.8060.71
92_I108_L0.8010.70
93_V118_L0.7980.70
68_T129_I0.7960.70
255_E258_A0.7900.69
39_D44_P0.7880.69
251_I256_L0.7870.69
123_L127_E0.7860.69
252_S258_A0.7810.68
206_L227_L0.7800.68
254_E261_K0.7790.68
153_V248_K0.7740.68
44_P48_N0.7740.68
40_A45_Y0.7730.67
43_A90_L0.7730.67
174_V263_F0.7720.67
175_V251_I0.7650.67
49_F53_P0.7610.66
206_L214_V0.7590.66
153_V242_Y0.7570.66
205_S217_S0.7570.66
127_E202_Q0.7560.66
58_L64_L0.7550.66
249_Q261_K0.7530.65
170_T173_L0.7480.65
169_S237_V0.7470.65
37_L42_I0.7450.65
120_A124_S0.7450.65
138_V224_T0.7440.64
89_N112_A0.7400.64
75_S113_V0.7390.64
157_D235_A0.7390.64
57_P75_S0.7380.64
186_M196_A0.7300.63
83_Q88_A0.7290.63
255_E259_L0.7280.63
42_I71_I0.7280.63
40_A52_Q0.7270.63
242_Y245_G0.7240.62
137_R219_P0.7220.62
175_V230_T0.7220.62
181_G208_L0.7190.62
75_S189_G0.7190.62
250_T256_L0.7180.62
142_C214_V0.7150.61
218_G223_E0.7150.61
41_D220_T0.7140.61
205_S227_L0.7110.61
115_T119_P0.7110.61
184_P199_Q0.7080.61
140_M206_L0.7050.60
157_D215_F0.7020.60
181_G207_V0.6980.59
59_S64_L0.6950.59
69_P108_L0.6930.59
41_D49_F0.6910.59
242_Y246_G0.6880.58
201_M217_S0.6860.58
56_I63_P0.6860.58
145_T236_Q0.6830.58
77_K112_A0.6800.58
45_Y52_Q0.6800.58
169_S174_V0.6790.57
75_S116_S0.6780.57
129_I177_P0.6760.57
57_P63_P0.6750.57
186_M209_W0.6730.57
131_A137_R0.6720.57
197_T207_V0.6710.56
117_E194_G0.6630.56
174_V178_D0.6630.56
72_V115_T0.6620.55
42_I209_W0.6580.55
116_S120_A0.6580.55
173_L251_I0.6550.55
94_K97_S0.6550.55
183_L200_E0.6510.54
180_V244_M0.6480.54
184_P196_A0.6460.54
147_L228_I0.6460.54
70_F118_L0.6440.53
153_V246_G0.6430.53
176_F253_R0.6400.53
194_G225_F0.6400.53
238_L242_Y0.6360.53
62_M138_V0.6360.53
119_P194_G0.6340.52
171_E233_K0.6340.52
59_S73_T0.6320.52
149_A239_V0.6310.52
171_E263_F0.6300.52
116_S189_G0.6260.51
75_S115_T0.6260.51
208_L214_V0.6230.51
38_D51_Q0.6210.51
178_D264_G0.6190.51
129_I137_R0.6170.50
44_P51_Q0.6160.50
211_F248_K0.6110.50
75_S114_P0.6100.50
172_C175_V0.6060.49
216_G242_Y0.6050.49
139_I217_S0.6030.49
40_A43_A0.6020.49
170_T175_V0.6020.49
138_V193_I0.6000.48
126_C194_G0.5980.48
36_R39_D0.5980.48
115_T190_T0.5970.48
170_T185_W0.5950.48
200_E207_V0.5930.48
177_P206_L0.5910.47
218_G221_L0.5910.47
194_G230_T0.5890.47
119_P123_L0.5820.46
60_Q140_M0.5790.46
41_D88_A0.5770.46
157_D234_S0.5750.46
62_M190_T0.5750.46
248_K256_L0.5740.45
263_F267_P0.5730.45
42_I46_H0.5700.45
40_A87_A0.5690.45
144_A169_S0.5680.45
43_A97_S0.5650.44
150_L238_L0.5630.44
150_L210_P0.5610.44
140_M184_P0.5590.44
45_Y49_F0.5580.44
211_F249_Q0.5560.43
190_T258_A0.5530.43
217_S224_T0.5530.43
41_D48_N0.5530.43
95_V122_F0.5530.43
43_A48_N0.5520.43
60_Q64_L0.5510.43
97_S122_F0.5470.42
138_V209_W0.5460.42
117_E170_T0.5430.42
183_L210_P0.5410.42
38_D53_P0.5410.42
55_Y230_T0.5400.42
206_L228_I0.5390.42
117_E121_H0.5380.41
249_Q252_S0.5380.41
141_H212_H0.5370.41
73_T117_E0.5330.41
120_A191_D0.5320.41
177_P254_E0.5310.41
223_E259_L0.5300.41
153_V241_V0.5280.40
117_E189_G0.5270.40
74_G89_N0.5250.40
119_P191_D0.5250.40
171_E188_P0.5240.40
120_A193_I0.5230.40
51_Q87_A0.5230.40
96_D191_D0.5210.40
129_I146_N0.5190.39
225_F229_D0.5180.39
186_M193_I0.5170.39
48_N52_Q0.5130.39
67_N96_D0.5110.39
147_L235_A0.5110.39
79_F170_T0.5110.39
67_N95_V0.5100.38
83_Q93_V0.5080.38
241_V244_M0.5070.38
74_G111_E0.5060.38
113_V195_Q0.5060.38
152_Y248_K0.5060.38
141_H213_G0.5020.38
79_F142_C0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v9lA 3 0.9818 100 0.263 Contact Map
4c24A 3 0.7591 100 0.375 Contact Map
1pvtA 3 0.8175 100 0.378 Contact Map
3ocrA 4 0.8212 100 0.382 Contact Map
1e4cP 3 0.7482 100 0.39 Contact Map
2opiA 3 0.7555 100 0.405 Contact Map
4xxfA 3 0.792 100 0.413 Contact Map
1k0wA 3 0.7591 100 0.416 Contact Map
2z7bA 3 0.792 100 0.422 Contact Map
4m6rA 3 0.7445 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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