GREMLIN Database
YIIX - Uncharacterized protein YiiX
UniProt: P32167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11882
Length: 202 (177)
Sequences: 328 (244)
Seq/√Len: 18.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_I86_Y3.7341.00
64_E72_T3.2860.99
51_G62_V3.0850.99
148_Q183_A3.0740.99
151_K174_L2.9160.99
116_D130_E2.4810.96
137_Q143_R2.4700.96
89_R192_T2.2850.94
121_W134_K2.1960.93
53_L60_P2.1540.92
69_V131_V2.1330.92
50_T132_V2.1210.91
161_Q165_K2.0150.89
64_E89_R2.0050.89
52_M135_V1.9560.88
152_E161_Q1.9370.87
77_W81_G1.8970.86
43_T180_S1.8550.85
180_S185_F1.8500.84
69_V130_E1.8220.84
72_T116_D1.7780.82
152_E178_V1.7670.82
36_S40_Q1.7360.80
152_E165_K1.7170.80
161_Q178_V1.7150.80
29_Q64_E1.7130.79
45_T185_F1.7130.79
20_Q188_P1.7090.79
75_K193_V1.7090.79
74_L78_I1.6990.79
72_T80_H1.6830.78
64_E116_D1.6810.78
179_V183_A1.6550.77
101_Q146_E1.6490.77
54_V71_Y1.6350.76
92_E191_T1.6180.75
110_Y126_Q1.6070.75
71_Y108_K1.5220.71
182_Q185_F1.5140.70
123_D134_K1.5120.70
74_L112_G1.5110.70
66_V119_F1.5030.70
36_S39_I1.4860.69
145_G180_S1.4590.67
75_K79_A1.4320.66
63_F111_L1.4230.65
23_T54_V1.4200.65
43_T90_R1.4080.64
64_E80_H1.4040.64
92_E188_P1.3900.63
165_K178_V1.3810.63
31_S48_S1.3660.62
180_S183_A1.3630.62
91_V187_A1.3160.59
49_H128_C1.2860.57
73_P76_Q1.2800.57
90_R193_V1.2790.57
63_F135_V1.2670.56
127_Y178_V1.2610.56
151_K175_E1.2530.55
42_A164_L1.2360.54
119_F164_L1.2320.54
28_F115_Y1.2180.53
24_G111_L1.1880.51
27_I53_L1.1840.51
145_G178_V1.1760.50
145_G182_Q1.1740.50
145_G149_K1.1720.50
125_R138_N1.1700.50
55_I60_P1.1660.50
89_R185_F1.1610.50
56_R71_Y1.1150.47
126_Q132_V1.1130.47
70_K83_K1.1130.47
163_K166_E1.1110.46
63_F107_A1.1040.46
150_L182_Q1.1000.46
94_G97_V1.0960.46
149_K152_E1.0960.46
88_V97_V1.0890.45
71_Y107_A1.0640.44
38_A42_A1.0580.43
42_A179_V1.0560.43
26_I172_I1.0540.43
53_L98_E1.0540.43
130_E164_L1.0430.42
50_T184_V1.0400.42
164_L172_I1.0330.42
31_S119_F1.0220.41
21_P156_S1.0210.41
114_P129_S1.0200.41
150_L180_S1.0170.41
161_Q175_E1.0060.40
48_S129_S0.9830.39
127_Y130_E0.9750.38
27_I96_S0.9530.37
76_Q191_T0.9520.37
101_Q105_Q0.9370.36
38_A65_A0.9300.36
188_P191_T0.9280.36
179_V184_V0.9270.35
65_A127_Y0.9170.35
106_T113_K0.9150.35
27_I88_V0.9140.35
149_K180_S0.9140.35
132_V138_N0.9120.35
48_S134_K0.9080.34
93_G191_T0.9020.34
86_Y186_D0.9000.34
63_F131_V0.8960.34
162_A195_K0.8960.34
144_V187_A0.8920.33
63_F69_V0.8910.33
22_Q57_N0.8890.33
53_L86_Y0.8870.33
51_G68_P0.8860.33
86_Y91_V0.8820.33
29_Q164_L0.8770.33
173_P184_V0.8740.32
89_R116_D0.8720.32
57_N83_K0.8660.32
71_Y111_L0.8630.32
48_S133_W0.8630.32
26_I188_P0.8580.32
145_G161_Q0.8560.32
40_Q48_S0.8510.31
76_Q188_P0.8480.31
31_S77_W0.8480.31
42_A151_K0.8390.31
92_E187_A0.8350.30
169_G194_A0.8300.30
25_D28_F0.8200.30
33_S48_S0.8170.29
59_K74_L0.8150.29
118_S168_Y0.8140.29
48_S123_D0.8120.29
23_T55_I0.8100.29
79_A166_E0.8080.29
36_S183_A0.8040.29
78_I156_S0.8030.29
117_F150_L0.8000.29
31_S35_Q0.7950.28
68_P139_A0.7950.28
48_S130_E0.7930.28
147_Q183_A0.7900.28
142_M172_I0.7830.28
21_P97_V0.7810.28
126_Q131_V0.7780.27
149_K177_T0.7750.27
122_S134_K0.7730.27
147_Q179_V0.7720.27
27_I71_Y0.7660.27
114_P149_K0.7630.27
50_T114_P0.7620.27
94_G112_G0.7610.27
36_S48_S0.7600.27
152_E174_L0.7590.27
47_Y87_V0.7490.26
55_I104_A0.7490.26
119_F179_V0.7450.26
69_V164_L0.7400.26
44_H120_S0.7390.26
151_K182_Q0.7380.26
150_L178_V0.7360.25
145_G152_E0.7300.25
133_W148_Q0.7290.25
38_A131_V0.7290.25
31_S130_E0.7260.25
20_Q109_R0.7250.25
145_G150_L0.7250.25
28_F50_T0.7210.25
145_G165_K0.7150.24
136_Y158_P0.7140.24
27_I143_R0.7100.24
35_Q119_F0.7030.24
35_Q121_W0.6900.23
62_V184_V0.6870.23
27_I182_Q0.6870.23
150_L161_Q0.6800.23
133_W153_F0.6790.23
121_W147_Q0.6780.23
52_M132_V0.6770.23
134_K168_Y0.6760.23
26_I194_A0.6760.23
131_V136_Y0.6750.23
52_M126_Q0.6740.23
39_I163_K0.6730.23
54_V61_Y0.6690.22
139_A144_V0.6680.22
148_Q184_V0.6540.22
62_V133_W0.6520.22
44_H57_N0.6500.22
69_V127_Y0.6500.22
116_D192_T0.6500.22
79_A191_T0.6450.21
63_F91_V0.6420.21
31_S134_K0.6350.21
77_W149_K0.6350.21
18_A56_R0.6350.21
44_H176_E0.6300.21
149_K178_V0.6270.21
126_Q159_Q0.6250.21
29_Q130_E0.6230.21
136_Y157_S0.6220.20
41_L101_Q0.6210.20
40_Q119_F0.6210.20
39_I180_S0.6210.20
45_T116_D0.6210.20
52_M110_Y0.6150.20
64_E130_E0.6120.20
21_P26_I0.6070.20
18_A97_V0.6040.20
147_Q154_D0.6020.20
42_A183_A0.6010.20
37_K144_V0.5990.20
88_V104_A0.5980.20
153_F178_V0.5940.19
51_G60_P0.5930.19
23_T60_P0.5930.19
54_V108_K0.5910.19
123_D130_E0.5910.19
128_C181_P0.5840.19
49_H181_P0.5840.19
121_W179_V0.5830.19
105_Q188_P0.5830.19
37_K195_K0.5830.19
50_T115_Y0.5780.19
40_Q179_V0.5750.19
35_Q130_E0.5740.19
56_R88_V0.5730.19
88_V109_R0.5720.19
33_S45_T0.5700.18
106_T135_V0.5660.18
42_A174_L0.5650.18
107_A135_V0.5600.18
34_S41_L0.5590.18
96_S167_R0.5590.18
26_I159_Q0.5560.18
155_L176_E0.5560.18
113_K124_D0.5530.18
99_Q153_F0.5530.18
84_G123_D0.5500.18
21_P53_L0.5450.18
21_P25_D0.5420.17
114_P135_V0.5410.17
30_I33_S0.5400.17
45_T179_V0.5380.17
118_S170_K0.5350.17
59_K132_V0.5350.17
25_D90_R0.5310.17
49_H129_S0.5250.17
38_A127_Y0.5250.17
62_V92_E0.5240.17
20_Q97_V0.5230.17
61_Y75_K0.5210.17
109_R138_N0.5170.17
80_H139_A0.5160.17
96_S190_L0.5140.16
88_V93_G0.5120.16
18_A32_R0.5110.16
145_G179_V0.5080.16
127_Y169_G0.5080.16
116_D134_K0.5080.16
119_F139_A0.5050.16
38_A114_P0.5010.16
66_V118_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2if6A 1 0.901 100 0.361 Contact Map
3kw0A 3 0.8267 100 0.589 Contact Map
4dotA 1 0.495 99.2 0.813 Contact Map
4dpzX 1 0.4851 98.7 0.845 Contact Map
2lktA 1 0.505 98.4 0.858 Contact Map
4q95A 3 0.5396 98.3 0.862 Contact Map
4q68A 1 0.4158 97.6 0.882 Contact Map
4fdyA 1 0.3861 97.4 0.886 Contact Map
2im9A 1 0.4851 97.2 0.891 Contact Map
4hpeA 1 0.3812 97.1 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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