GREMLIN Database
MENA - 1,4-dihydroxy-2-naphthoate octaprenyltransferase
UniProt: P32166 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11880
Length: 308 (277)
Sequences: 9210 (6558)
Seq/√Len: 394.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_Y92_Q3.7601.00
69_A92_Q3.6961.00
59_L103_V3.2961.00
223_V227_R3.1111.00
93_Q97_R3.0041.00
66_Y96_K2.9731.00
91_T94_E2.8791.00
11_A89_V2.8271.00
78_R81_P2.5251.00
205_I209_R2.3661.00
206_N209_R2.3201.00
32_T46_A2.2201.00
14_E89_V2.1931.00
268_R272_R2.1351.00
265_K269_Y2.1181.00
62_L102_T2.0641.00
21_L54_G2.0341.00
12_W94_E2.0321.00
275_D278_A2.0191.00
100_I104_V2.0091.00
114_V117_A1.9701.00
48_L109_S1.9701.00
71_K213_K1.9661.00
224_N227_R1.9471.00
67_G143_V1.9061.00
55_L105_L1.9051.00
10_Q14_E1.8961.00
56_L106_I1.8651.00
115_A118_C1.8371.00
264_V268_R1.8071.00
290_A294_N1.7821.00
227_R231_C1.7671.00
220_L224_N1.7631.00
286_T290_A1.7611.00
97_R101_I1.7531.00
90_I95_M1.7281.00
114_V118_C1.7101.00
209_R218_V1.7051.00
48_L112_A1.6601.00
130_L134_S1.6481.00
62_L98_A1.6401.00
66_Y95_M1.6381.00
179_I182_L1.6161.00
29_I50_L1.6151.00
42_D45_V1.6151.00
287_V290_A1.6051.00
217_V225_A1.5961.00
12_W16_L1.5711.00
13_L16_L1.5671.00
283_L287_V1.5531.00
264_V267_A1.5501.00
284_E288_K1.5471.00
58_I102_T1.5461.00
205_I222_E1.5401.00
152_G219_R1.5211.00
55_L102_T1.4841.00
12_W98_A1.4791.00
237_L259_A1.4601.00
55_L106_I1.4411.00
23_L196_V1.4301.00
266_Q269_Y1.4191.00
73_S86_Q1.4181.00
285_R289_G1.4171.00
92_Q96_K1.4081.00
111_L116_V1.3721.00
63_A99_L1.3701.00
16_L62_L1.3471.00
275_D279_M1.3441.00
168_M186_A1.3441.00
62_L99_L1.3411.00
224_N228_Y1.3291.00
234_M238_V1.3211.00
267_A271_M1.3201.00
279_M283_L1.3081.00
276_P279_M1.3071.00
96_K100_I1.3061.00
16_L102_T1.3031.00
205_I218_V1.2921.00
289_G293_T1.2891.00
263_L266_Q1.2831.00
262_L269_Y1.2821.00
74_D211_N1.2771.00
93_Q96_K1.2701.00
262_L265_K1.2691.00
171_W182_L1.2541.00
69_A73_S1.2511.00
148_Y151_I1.2491.00
283_L290_A1.2451.00
108_L112_A1.2331.00
52_T109_S1.2291.00
16_L58_I1.2271.00
13_L18_P1.2261.00
250_S253_G1.2261.00
98_A102_T1.2231.00
137_A161_F1.2221.00
285_R288_K1.2181.00
9_T13_L1.2151.00
214_N219_R1.2141.00
283_L286_T1.2071.00
261_P265_K1.2051.00
34_L171_W1.2011.00
47_L51_I1.2011.00
129_I133_L1.1991.00
250_S254_W1.1961.00
68_D150_Y1.1881.00
278_A282_M1.1841.00
15_S95_M1.1831.00
171_W175_A1.1811.00
188_A239_C1.1771.00
281_P285_R1.1761.00
71_K150_Y1.1671.00
263_L267_A1.1571.00
195_A232_L1.1571.00
66_Y99_L1.1531.00
28_I53_A1.1491.00
290_A293_T1.1421.00
149_G213_K1.1361.00
278_A281_P1.1321.00
222_E226_R1.1291.00
288_K292_L1.1251.00
140_T157_S1.1191.00
178_L183_I1.1171.00
16_L98_A1.1151.00
280_R283_L1.1071.00
191_L232_L1.1031.00
286_T294_N1.1021.00
287_V291_L1.1001.00
155_D215_T1.0921.00
252_W256_F1.0911.00
32_T174_Q1.0901.00
244_N254_W1.0891.00
256_F300_G1.0811.00
183_I187_T1.0801.00
131_G134_S1.0791.00
75_K207_S1.0761.00
268_R271_M1.0751.00
107_C111_L1.0721.00
41_F46_A1.0701.00
285_R290_A1.0691.00
35_A171_W1.0641.00
223_V226_R1.0631.00
202_L225_A1.0581.00
148_Y157_S1.0561.00
44_L48_L1.0561.00
110_G114_V1.0451.00
85_M95_M1.0431.00
202_L224_N1.0311.00
216_L220_L1.0271.00
51_I109_S1.0261.00
259_A262_L1.0231.00
205_I217_V1.0161.00
178_L182_L1.0071.00
135_I139_I1.0031.00
136_I140_T1.0011.00
260_A263_L0.9921.00
139_I143_V0.9891.00
227_R230_A0.9821.00
15_S62_L0.9821.00
25_F29_I0.9791.00
42_D174_Q0.9771.00
198_N228_Y0.9751.00
289_G295_L0.9741.00
31_G35_A0.9741.00
288_K294_N0.9741.00
262_L266_Q0.9671.00
28_I49_A0.9631.00
111_L115_A0.9601.00
94_E97_R0.9551.00
243_F252_W0.9521.00
293_T296_L0.9501.00
109_S113_L0.9481.00
206_N210_E0.9481.00
62_L95_M0.9421.00
204_D208_D0.9401.00
267_A270_V0.9381.00
201_N217_V0.9381.00
130_L133_L0.9301.00
295_L298_V0.9281.00
289_G294_N0.9221.00
70_V74_D0.9181.00
284_E287_V0.9161.00
266_Q270_V0.9131.00
163_G193_A0.9081.00
165_L169_G0.9081.00
48_L113_L0.9061.00
44_L47_L0.9041.00
62_L90_I0.9031.00
140_T148_Y0.9011.00
226_R230_A0.9001.00
130_L169_G0.8961.00
132_G136_I0.8961.00
69_A85_M0.8951.00
187_T239_C0.8941.00
261_P268_R0.8921.00
230_A234_M0.8891.00
187_T191_L0.8861.00
221_G225_A0.8841.00
110_G131_G0.8841.00
60_S138_A0.8841.00
284_E290_A0.8821.00
25_F50_L0.8811.00
84_G88_G0.8751.00
115_A129_I0.8741.00
43_P47_L0.8711.00
171_W179_I0.8661.00
277_V281_P0.8631.00
291_L295_L0.8581.00
24_A57_Q0.8451.00
90_I98_A0.8421.00
158_V197_L0.8401.00
293_T298_V0.8401.00
166_S169_G0.8341.00
164_W186_A0.8321.00
36_W41_F0.8281.00
161_F186_A0.8261.00
279_M282_M0.8261.00
270_V273_E0.8241.00
206_N222_E0.8161.00
68_D71_K0.8091.00
293_T297_F0.8091.00
265_K268_R0.8021.00
288_K291_L0.8011.00
26_A294_N0.7981.00
33_A36_W0.7971.00
56_L130_L0.7971.00
114_V128_L0.7911.00
142_T150_Y0.7891.00
202_L222_E0.7841.00
259_A266_Q0.7801.00
94_E98_A0.7791.00
163_G190_G0.7761.00
177_T181_A0.7751.00
162_F193_A0.7751.00
30_V185_P0.7721.00
180_P183_I0.7701.00
103_V135_I0.7691.00
70_V92_Q0.7621.00
51_I55_L0.7621.00
283_L289_G0.7611.00
68_D213_K0.7601.00
283_L294_N0.7551.00
71_K211_N0.7551.00
55_L109_S0.7551.00
104_V108_L0.7501.00
253_G256_F0.7501.00
112_A116_V0.7481.00
282_M287_V0.7461.00
249_H252_W0.7451.00
163_G189_C0.7441.00
236_S240_L0.7411.00
101_I105_L0.7411.00
39_G42_D0.7391.00
260_A264_V0.7381.00
195_A233_L0.7361.00
179_I183_I0.7351.00
255_L259_A0.7341.00
194_T232_L0.7331.00
189_C193_A0.7331.00
149_G155_D0.7331.00
80_G83_R0.7331.00
86_Q95_M0.7321.00
266_Q271_M0.7291.00
264_V272_R0.7281.00
68_D142_T0.7271.00
66_Y85_M0.7271.00
202_L226_R0.7231.00
148_Y152_G0.7221.00
59_L102_T0.7191.00
63_A139_I0.7181.00
263_L268_R0.7151.00
33_A298_V0.7141.00
253_G257_L0.7111.00
67_G142_T0.7111.00
292_L296_L0.7091.00
63_A67_G0.7091.00
229_H286_T0.7081.00
160_V190_G0.7061.00
235_G239_C0.7061.00
257_L261_P0.7041.00
85_M90_I0.7011.00
41_F174_Q0.6991.00
159_L164_W0.6991.00
96_K99_L0.6981.00
84_G89_V0.6941.00
40_H44_L0.6941.00
282_M286_T0.6931.00
240_L256_F0.6870.99
262_L270_V0.6850.99
281_P284_E0.6840.99
29_I46_A0.6820.99
167_V170_S0.6800.99
153_L220_L0.6800.99
192_L236_S0.6780.99
155_D201_N0.6780.99
168_M182_L0.6750.99
90_I94_E0.6720.99
287_V293_T0.6700.99
83_R86_Q0.6670.99
57_Q61_N0.6650.99
197_L200_N0.6650.99
244_N253_G0.6640.99
137_A160_V0.6630.99
32_T41_F0.6620.99
137_A157_S0.6610.99
45_V113_L0.6590.99
23_L27_A0.6580.99
99_L103_V0.6570.99
258_L261_P0.6560.99
232_L235_G0.6540.99
78_R82_L0.6510.99
230_A271_M0.6500.99
103_V106_I0.6490.99
105_L109_S0.6490.99
208_D215_T0.6470.99
82_L89_V0.6470.99
88_G94_E0.6470.99
15_S90_I0.6460.99
267_A272_R0.6440.99
294_N298_V0.6440.99
296_L300_G0.6410.99
258_L262_L0.6400.99
83_R88_G0.6390.99
58_I62_L0.6390.99
131_G135_I0.6380.99
108_L111_L0.6380.99
263_L270_V0.6380.99
128_L132_G0.6360.99
259_A268_R0.6350.99
290_A295_L0.6340.99
113_L117_A0.6330.99
198_N225_A0.6330.99
244_N251_L0.6330.99
52_T110_G0.6280.99
231_C235_G0.6280.99
276_P280_R0.6250.99
132_G135_I0.6220.99
32_T49_A0.6220.99
118_C128_L0.6210.99
243_F253_G0.6120.99
264_V271_M0.6110.99
241_A245_L0.6100.99
287_V294_N0.6100.99
44_L112_A0.6090.99
282_M290_A0.6080.99
58_I98_A0.6070.99
59_L99_L0.6070.99
196_V200_N0.6050.99
36_W174_Q0.6050.99
36_W39_G0.6040.99
110_G118_C0.6040.99
287_V298_V0.6010.99
32_T36_W0.5970.99
12_W15_S0.5970.99
261_P264_V0.5930.98
66_Y69_A0.5890.98
201_N215_T0.5890.98
14_E19_K0.5850.98
71_K74_D0.5820.98
226_R229_H0.5810.98
199_I270_V0.5810.98
59_L139_I0.5790.98
30_V189_C0.5770.98
168_M178_L0.5760.98
24_A27_A0.5760.98
291_L294_N0.5740.98
129_I132_G0.5730.98
51_I105_L0.5700.98
110_G115_A0.5700.98
21_L50_L0.5690.98
64_N142_T0.5680.98
181_A246_F0.5670.98
282_M285_R0.5670.98
229_H233_L0.5650.98
292_L298_V0.5640.98
171_W177_T0.5610.98
10_Q13_L0.5560.98
256_F259_A0.5560.98
286_T291_L0.5560.98
259_A263_L0.5560.98
86_Q89_V0.5540.98
153_L219_R0.5530.98
214_N218_V0.5520.98
230_A267_A0.5490.98
200_N203_R0.5460.97
117_A172_Y0.5460.97
243_F248_L0.5450.97
239_C242_L0.5450.97
241_A244_N0.5420.97
265_K272_R0.5400.97
298_V301_I0.5380.97
59_L106_I0.5370.97
12_W90_I0.5360.97
20_T61_N0.5310.97
264_V269_Y0.5300.97
56_L138_A0.5290.97
159_L187_T0.5260.97
70_V73_S0.5250.97
283_L291_L0.5240.97
49_A53_A0.5230.97
220_L228_Y0.5170.96
233_L236_S0.5150.96
52_T106_I0.5140.96
188_A240_L0.5140.96
249_H253_G0.5130.96
32_T35_A0.5090.96
57_Q200_N0.5090.96
290_A296_L0.5080.96
33_A302_F0.5070.96
287_V292_L0.5070.96
292_L295_L0.5050.96
269_Y272_R0.5040.96
298_V302_F0.5020.96
78_R206_N0.5020.96
49_A174_Q0.5010.96
20_T57_Q0.5010.96
65_D84_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8571 100 0.339 Contact Map
4tq3A 1 0.9026 100 0.352 Contact Map
2cfqA 1 0.8701 14.3 0.951 Contact Map
2xq2A 2 0.7435 14.3 0.951 Contact Map
4xnjA 1 0.5942 8.2 0.956 Contact Map
3ze3A 4 0.3377 7.2 0.957 Contact Map
3o7qA 1 0.8182 6.5 0.958 Contact Map
4n7wA 2 0.6494 6.1 0.959 Contact Map
2onkC 2 0.25 4 0.962 Contact Map
4uisB 1 0.1169 3.8 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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