GREMLIN Database
YIIS - UPF0381 protein YiiS
UniProt: P32162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11876
Length: 99 (89)
Sequences: 131 (80)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A55_S5.0431.00
37_R41_E4.7560.99
31_S75_E2.9930.89
37_R69_D2.7960.85
24_D34_F2.4340.76
70_L75_E2.3000.71
19_T25_N2.1820.67
64_A81_T1.9270.57
25_N55_S1.7440.49
18_G93_L1.6700.46
34_F43_F1.6190.44
49_E53_A1.5500.41
8_C13_C1.5270.40
28_S92_E1.4680.38
36_T39_E1.4470.37
53_A89_I1.4040.35
9_S39_E1.3980.35
36_T71_E1.3860.35
7_K65_Y1.3770.34
30_F47_L1.3750.34
88_M95_L1.3050.32
31_S77_D1.2980.31
43_F46_K1.2590.30
60_G63_V1.2530.30
86_A90_I1.2330.29
30_F53_A1.2250.29
29_K79_A1.2160.29
35_A83_S1.2150.29
24_D88_M1.2080.28
20_V49_E1.1750.27
33_F38_E1.1670.27
15_I19_T1.1600.27
21_I75_E1.1400.26
38_E65_Y1.1360.26
59_E71_E1.1360.26
12_G17_I1.1290.26
67_I78_A1.1190.25
21_I83_S1.1140.25
7_K21_I1.1080.25
35_A54_T1.1010.25
47_L80_F1.1010.25
23_N95_L1.0920.24
17_I93_L1.0730.24
19_T96_R1.0400.23
44_M78_A1.0300.23
63_V80_F1.0110.22
11_K65_Y1.0050.22
23_N59_E1.0010.22
66_K77_D0.9990.22
54_T94_S0.9920.22
34_F46_K0.9780.21
30_F33_F0.9280.20
69_D88_M0.9260.20
30_F34_F0.9020.19
37_R67_I0.8910.19
10_T14_A0.8830.19
12_G73_Q0.8820.19
85_Q89_I0.8790.18
29_K88_M0.8650.18
59_E83_S0.8620.18
81_T95_L0.8620.18
21_I93_L0.8610.18
39_E45_T0.8570.18
6_D11_K0.8520.18
55_S61_A0.8520.18
38_E83_S0.8370.17
20_V93_L0.8190.17
6_D15_I0.8180.17
45_T68_K0.8090.17
58_D73_Q0.7980.16
32_R38_E0.7850.16
44_M48_K0.7800.16
55_S92_E0.7740.16
48_K61_A0.7670.16
25_N29_K0.7660.16
11_K15_I0.7610.16
92_E95_L0.7540.15
87_E91_F0.7320.15
24_D83_S0.7300.15
37_R77_D0.7110.15
27_T79_A0.7090.15
33_F72_G0.7070.14
21_I54_T0.7050.14
14_A89_I0.7000.14
17_I94_S0.6970.14
45_T74_V0.6930.14
19_T23_N0.6880.14
46_K68_K0.6870.14
67_I74_V0.6710.14
64_A77_D0.6700.14
52_A61_A0.6690.14
13_C95_L0.6680.14
34_F78_A0.6620.14
24_D85_Q0.6620.14
21_I24_D0.6580.13
19_T89_I0.6570.13
62_S66_K0.6510.13
36_T67_I0.6490.13
28_S75_E0.6460.13
20_V27_T0.6360.13
37_R54_T0.6330.13
46_K54_T0.6320.13
50_L54_T0.6290.13
28_S95_L0.6200.13
64_A68_K0.6180.13
31_S52_A0.6180.13
66_K78_A0.6110.13
45_T48_K0.6090.13
31_S45_T0.6070.13
49_E62_S0.6070.13
16_D23_N0.5940.12
60_G73_Q0.5880.12
49_E72_G0.5870.12
13_C53_A0.5760.12
7_K86_A0.5750.12
34_F75_E0.5710.12
93_L96_R0.5690.12
7_K48_K0.5630.12
30_F78_A0.5620.12
12_G50_L0.5490.11
87_E90_I0.5490.11
52_A63_V0.5400.11
6_D71_E0.5350.11
7_K77_D0.5280.11
55_S63_V0.5280.11
33_F47_L0.5180.11
32_R75_E0.5170.11
20_V32_R0.5100.11
33_F70_L0.5040.11
65_Y77_D0.5030.11
15_I23_N0.5020.11
18_G28_S0.5020.11
35_A77_D0.5010.11
69_D83_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k3iA 1 1 100 0.182 Contact Map
2khdA 1 0.9495 100 0.32 Contact Map
2jz5A 1 0.8182 100 0.363 Contact Map
4xesA 1 0.899 4.7 0.953 Contact Map
2z1dA 1 0.4949 4.3 0.954 Contact Map
1xakA 1 0.5758 4 0.955 Contact Map
2o7aA 1 0.5253 3.7 0.956 Contact Map
2xsaA 2 0.8182 2.8 0.958 Contact Map
1jhnA 1 0.4242 2.7 0.959 Contact Map
2d9qB 1 0.3636 2.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.