GREMLIN Database
YIIM - Protein YiiM
UniProt: P32157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11870
Length: 224 (204)
Sequences: 1638 (1175)
Seq/√Len: 82.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_I112_Q4.5311.00
110_L163_V3.1321.00
98_V104_F2.8441.00
31_E155_S2.8271.00
110_L150_A2.7991.00
59_H146_Y2.7761.00
55_R145_L2.6991.00
36_E151_P2.6871.00
71_E135_L2.5391.00
105_R161_E2.5051.00
94_T97_N2.4781.00
105_R150_A2.4571.00
106_W160_L2.4011.00
12_I43_E2.1181.00
181_M184_D2.0031.00
34_L39_L1.9831.00
99_Y170_T1.9541.00
202_T206_Q1.9441.00
34_L109_A1.9391.00
124_N133_A1.9221.00
155_S158_A1.8941.00
109_A154_V1.8871.00
162_L165_R1.8821.00
11_K43_E1.8651.00
112_Q149_I1.8641.00
33_M40_E1.7751.00
59_H90_T1.7701.00
173_E190_R1.7511.00
60_Y68_W1.7261.00
34_L154_V1.7221.00
8_Y89_S1.6991.00
112_Q147_S1.6801.00
103_I149_I1.6671.00
96_S172_Q1.6531.00
63_E92_G1.6341.00
105_R163_V1.6321.00
88_L154_V1.6301.00
206_Q210_L1.6271.00
57_L111_I1.5991.00
37_L47_K1.5901.00
106_W111_I1.5801.00
22_A43_E1.5691.00
114_S147_S1.5601.00
4_P88_L1.5551.00
9_T28_V1.5511.00
185_D189_H1.5330.99
113_V146_Y1.4770.99
108_E158_A1.4750.99
54_D147_S1.4730.99
110_L149_I1.4690.99
54_D199_K1.4600.99
19_K121_Y1.4580.99
24_A126_H1.4510.99
46_E49_V1.4500.99
69_A75_Q1.4460.99
127_F132_I1.4370.99
31_E153_K1.4150.99
13_Q24_A1.4110.99
14_A20_P1.3940.99
45_A122_K1.3870.99
21_S24_A1.3640.99
72_F79_F1.3610.99
34_L111_I1.3580.99
61_P64_H1.3460.99
63_E90_T1.3410.99
55_R118_S1.3410.99
102_D165_R1.3380.99
64_H139_T1.3280.99
58_C136_M1.2910.98
57_L154_V1.2890.98
105_R110_L1.2880.98
108_E153_K1.2880.98
88_L106_W1.2840.98
99_Y168_D1.2590.98
36_E53_P1.2580.98
106_W154_V1.2540.98
39_L57_L1.2440.98
33_M153_K1.2390.98
12_I20_P1.2110.97
99_Y102_D1.2000.97
13_Q26_I1.1710.97
184_D187_Q1.1670.97
100_M174_A1.1660.97
35_T40_E1.1530.96
23_I85_G1.1490.96
109_A151_P1.1420.96
103_I110_L1.1250.96
177_I191_L1.1180.96
61_P95_E1.1060.95
99_Y165_R1.1050.95
169_V194_A1.1050.95
12_I22_A1.1040.95
33_M108_E1.0950.95
100_M171_V1.0920.95
64_H95_E1.0870.95
67_Y71_E1.0820.95
112_Q196_G1.0810.95
5_V91_D1.0740.95
124_N131_D1.0730.95
115_Q198_S1.0730.95
8_Y82_P1.0590.94
123_L136_M1.0570.94
131_D135_L1.0500.94
33_M151_P1.0400.94
176_A181_M1.0390.94
129_I135_L1.0150.93
104_F146_Y1.0120.93
134_Q138_N1.0060.93
22_A45_A1.0040.92
62_R66_L1.0000.92
108_E150_A0.9910.92
30_G156_A0.9760.91
100_M116_P0.9740.91
32_L39_L0.9680.91
61_P94_T0.9580.91
55_R115_Q0.9560.91
99_Y167_S0.9520.90
98_V146_Y0.9480.90
111_I146_Y0.9410.90
174_A191_L0.9260.89
82_P145_L0.9240.89
56_A148_V0.9160.89
65_Y89_S0.9020.88
38_G56_A0.9000.88
83_A127_F0.8970.87
35_T151_P0.8900.87
93_L104_F0.8880.87
112_Q164_S0.8860.87
188_Y205_M0.8850.87
10_G22_A0.8830.87
104_F162_L0.8830.87
67_Y141_K0.8820.87
44_Q47_K0.8790.86
169_V173_E0.8660.86
12_I45_A0.8660.86
63_E91_D0.8660.86
74_E129_I0.8640.85
199_K203_R0.8590.85
176_A184_D0.8590.85
140_G175_A0.8430.84
63_E94_T0.8420.84
107_G158_A0.8360.84
118_S137_Q0.8360.84
37_L44_Q0.8330.83
104_F160_L0.8320.83
199_K206_Q0.8310.83
4_P106_W0.8220.83
121_Y125_Y0.8200.82
189_H193_S0.8150.82
60_Y64_H0.8150.82
183_F188_Y0.8000.81
4_P109_A0.8000.81
15_Y19_K0.7950.80
5_V81_A0.7940.80
55_R114_S0.7920.80
173_E187_Q0.7900.80
59_H88_L0.7890.80
14_A18_G0.7860.80
90_T160_L0.7810.79
112_Q174_A0.7700.78
189_H209_R0.7680.78
68_W141_K0.7640.78
188_Y192_L0.7610.77
98_V144_W0.7600.77
34_L57_L0.7600.77
137_Q175_A0.7560.77
7_V39_L0.7460.76
68_W84_F0.7450.76
67_Y70_R0.7440.76
64_H96_S0.7400.75
142_V175_A0.7390.75
58_C123_L0.7350.75
168_D173_E0.7340.75
115_Q201_W0.7320.75
59_H111_I0.7310.74
84_F136_M0.7290.74
124_N132_I0.7230.74
129_I132_I0.7220.74
200_S204_T0.7210.73
98_V113_V0.7190.73
4_P158_A0.7180.73
15_Y22_A0.7110.72
59_H144_W0.7100.72
82_P126_H0.7060.72
58_C175_A0.6990.71
30_G155_S0.6950.71
60_Y84_F0.6950.71
102_D162_L0.6940.71
73_P79_F0.6940.71
99_Y169_V0.6920.70
39_L106_W0.6920.70
44_Q133_A0.6860.70
147_S191_L0.6860.70
174_A201_W0.6800.69
186_D189_H0.6780.69
12_I44_Q0.6760.69
174_A205_M0.6750.69
39_L154_V0.6730.68
100_M198_S0.6700.68
184_D189_H0.6700.68
15_Y125_Y0.6690.68
193_S206_Q0.6680.68
133_A137_Q0.6630.67
43_E47_K0.6590.67
7_V32_L0.6580.67
58_C127_F0.6580.67
203_R206_Q0.6580.67
100_M170_T0.6570.66
21_S67_Y0.6530.66
54_D146_Y0.6500.66
104_F111_I0.6460.65
49_V55_R0.6450.65
191_L205_M0.6450.65
166_V196_G0.6440.65
37_L53_P0.6420.65
22_A25_K0.6420.65
99_Y166_V0.6400.64
123_L137_Q0.6370.64
5_V8_Y0.6370.64
90_T146_Y0.6370.64
103_I164_S0.6360.64
176_A187_Q0.6330.64
167_S193_S0.6270.63
102_D166_V0.6250.63
19_K125_Y0.6220.62
62_R89_S0.6180.62
190_R193_S0.6140.61
37_L151_P0.6110.61
5_V62_R0.6090.61
177_I187_Q0.6090.61
44_Q122_K0.6080.60
172_Q176_A0.6080.60
118_S179_W0.6030.60
187_Q190_R0.6020.60
20_P195_A0.6010.60
62_R65_Y0.5970.59
44_Q55_R0.5940.59
60_Y65_Y0.5890.58
204_T208_R0.5880.58
116_P121_Y0.5870.58
25_K44_Q0.5860.58
95_E102_D0.5850.58
58_C144_W0.5850.58
15_Y21_S0.5830.57
68_W135_L0.5830.57
6_D89_S0.5820.57
116_P198_S0.5820.57
9_T57_L0.5790.57
84_F205_M0.5780.57
30_G35_T0.5760.56
90_T93_L0.5750.56
99_Y104_F0.5710.56
116_P179_W0.5670.55
134_Q137_Q0.5650.55
21_S90_T0.5640.55
144_W169_V0.5640.55
44_Q115_Q0.5640.55
124_N127_F0.5620.55
121_Y169_V0.5600.54
54_D198_S0.5580.54
116_P174_A0.5580.54
64_H94_T0.5580.54
192_L195_A0.5540.54
82_P88_L0.5540.54
36_E138_N0.5540.54
72_F129_I0.5530.53
106_W158_A0.5520.53
23_I58_C0.5520.53
46_E121_Y0.5490.53
129_I133_A0.5480.53
95_E144_W0.5440.52
109_A153_K0.5430.52
137_Q179_W0.5390.52
32_L56_A0.5390.52
5_V89_S0.5390.52
22_A37_L0.5340.51
123_L132_I0.5330.51
12_I38_G0.5330.51
191_L194_A0.5290.50
136_M175_A0.5280.50
10_G13_Q0.5270.50
98_V102_D0.5250.50
32_L41_G0.5240.50
131_D138_N0.5240.50
170_T173_E0.5220.49
170_T175_A0.5200.49
22_A208_R0.5180.49
38_G57_L0.5180.49
22_A131_D0.5180.49
122_K127_F0.5180.49
93_L97_N0.5170.49
95_E98_V0.5160.49
188_Y209_R0.5150.48
15_Y24_A0.5140.48
121_Y124_N0.5140.48
48_K176_A0.5100.48
66_L70_R0.5100.48
118_S123_L0.5090.48
64_H68_W0.5060.47
20_P45_A0.5060.47
29_D156_A0.5050.47
60_Y139_T0.5040.47
140_G150_A0.5040.47
72_F135_L0.5020.47
47_K88_L0.5000.46
46_E51_G0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o65A 1 0.942 100 0.273 Contact Map
1oruA 2 0.6875 100 0.57 Contact Map
1y8oB 1 0.4196 45 0.958 Contact Map
3crkC 1 0.3705 27.6 0.962 Contact Map
2kccA 1 0.3661 16.4 0.966 Contact Map
1k8mA 1 0.3795 14.5 0.967 Contact Map
1pmrA 1 0.3482 13.3 0.968 Contact Map
1z6hA 1 0.3125 12.5 0.968 Contact Map
2mkxA 1 0.2277 12 0.968 Contact Map
2d5dA 1 0.3036 11.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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