GREMLIN Database
RHAM - L-rhamnose mutarotase
UniProt: P32156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11865
Length: 104 (101)
Sequences: 879 (578)
Seq/√Len: 57.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_N57_E3.6001.00
72_V75_R2.9191.00
19_Q23_N2.4001.00
5_A53_F2.3851.00
31_A35_S2.3691.00
40_N55_M2.3301.00
25_I30_E2.2791.00
3_R99_E2.2221.00
10_V15_H1.9781.00
87_N91_S1.9561.00
9_Q85_P1.9151.00
7_V51_L1.8200.99
17_E20_R1.7270.99
21_R83_V1.7270.99
6_F54_A1.7090.99
28_E72_V1.7010.99
31_A34_K1.6660.99
39_H59_E1.6360.99
15_H50_N1.6290.99
42_A55_M1.5880.98
11_N85_P1.5570.98
70_T73_C1.4870.98
3_R42_A1.4740.98
99_E102_Y1.4530.97
58_I64_W1.4500.97
15_H47_K1.3850.96
40_N102_Y1.3560.96
7_V46_D1.3180.95
20_R24_P1.2930.95
36_H66_A1.2920.95
74_Q78_K1.2810.94
42_A102_Y1.2800.94
9_Q51_L1.2640.94
21_R80_M1.2620.94
26_W72_V1.2540.94
34_K39_H1.2520.94
19_Q98_Q1.2380.93
3_R57_E1.2350.93
36_H67_V1.2290.93
47_K98_Q1.2290.93
33_L38_A1.2200.93
17_E21_R1.2110.93
47_K50_N1.1810.92
11_N14_A1.1730.91
73_C77_W1.1630.91
3_R102_Y1.1600.91
46_D49_R1.1460.90
7_V49_R1.1140.89
32_V67_V1.1130.89
66_A69_S1.1130.89
30_E101_F1.1090.89
45_L52_L1.1090.89
52_L100_V1.0840.88
78_K90_N1.0770.87
21_R79_Y1.0750.87
30_E103_L1.0440.86
32_V70_T0.9890.82
38_A56_V0.9870.82
78_K86_A0.9850.82
33_L72_V0.9800.82
67_V73_C0.9690.81
32_V36_H0.9600.80
33_L67_V0.9440.79
65_N68_A0.9410.79
34_K59_E0.9310.78
5_A43_I0.9290.78
19_Q47_K0.9200.78
58_I62_E0.9150.77
7_V53_F0.9120.77
46_D51_L0.9020.76
61_E74_Q0.8930.75
44_Y57_E0.8550.72
2_I96_E0.8470.72
36_H70_T0.8320.70
4_K61_E0.8140.68
4_K64_W0.8100.68
56_V64_W0.8090.68
4_K56_V0.7850.66
38_A67_V0.7700.64
35_S70_T0.7630.63
35_S66_A0.7620.63
19_Q100_V0.7560.63
65_N69_S0.7560.63
14_A83_V0.7550.63
20_R65_N0.7410.61
32_V35_S0.7400.61
32_V73_C0.7400.61
4_K44_Y0.7220.59
44_Y99_E0.7170.59
60_S65_N0.7160.59
56_V70_T0.7160.59
6_F56_V0.7140.58
80_M83_V0.7130.58
42_A57_E0.7020.57
46_D50_N0.7010.57
78_K81_T0.6890.56
3_R55_M0.6860.55
21_R52_L0.6840.55
33_L36_H0.6830.55
25_I29_L0.6740.54
58_I63_R0.6620.53
22_H76_W0.6620.53
39_H103_L0.6600.52
46_D89_D0.6570.52
29_L32_V0.6520.52
61_E65_N0.6500.51
3_R44_Y0.6370.50
33_L77_W0.6350.50
69_S74_Q0.6330.49
34_K103_L0.6250.49
71_D95_S0.6240.48
5_A38_A0.6190.48
41_Y101_F0.6190.48
4_K58_I0.6130.47
74_Q77_W0.6100.47
62_E66_A0.6090.47
39_H102_Y0.6060.47
57_E99_E0.6040.46
36_H63_R0.5990.46
58_I94_S0.5940.45
2_I62_E0.5870.44
79_Y83_V0.5840.44
25_I103_L0.5760.43
54_A73_C0.5740.43
59_E63_R0.5710.43
36_H58_I0.5690.43
7_V95_S0.5680.42
36_H73_C0.5660.42
2_I58_I0.5650.42
57_E102_Y0.5580.41
15_H98_Q0.5530.41
64_W73_C0.5510.41
37_G80_M0.5480.40
92_P96_E0.5410.40
3_R40_N0.5410.40
44_Y55_M0.5400.39
33_L56_V0.5400.39
8_M93_V0.5350.39
38_A43_I0.5340.39
15_H19_Q0.5330.39
36_H56_V0.5310.38
45_L50_N0.5310.38
89_D93_V0.5300.38
9_Q50_N0.5300.38
8_M80_M0.5290.38
54_A83_V0.5200.37
3_R58_I0.5190.37
27_P31_A0.5190.37
29_L67_V0.5170.37
81_T85_P0.5160.37
24_P69_S0.5100.36
77_W92_P0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlwA 3 1 100 0.131 Contact Map
1x8dA 2 1 100 0.134 Contact Map
4dpoA 2 0.8942 96.3 0.844 Contact Map
4dn9A 3 0.9231 95.5 0.854 Contact Map
4hl9A 2 0.8942 95.2 0.856 Contact Map
1y0hA 2 0.9231 94.7 0.861 Contact Map
1x7vA 5 0.8942 94.3 0.864 Contact Map
3gz7A 2 0.9038 93.5 0.868 Contact Map
4fvcA 1 0.8269 93.1 0.87 Contact Map
2gffA 2 0.9327 93 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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