GREMLIN Database
PTFA - Fructose-like phosphotransferase enzyme IIA component
UniProt: P32155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11864
Length: 148 (137)
Sequences: 6782 (5120)
Seq/√Len: 437.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_N131_Q3.3211.00
6_A136_D2.5721.00
23_K42_L2.2661.00
26_A42_L2.1911.00
27_T31_Q2.1481.00
36_T71_K2.1131.00
128_H132_Q2.0011.00
15_G24_Q2.0001.00
80_K97_W1.9911.00
25_L99_C1.9841.00
10_D28_I1.9061.00
45_L99_C1.8831.00
14_Q81_A1.8711.00
30_L35_I1.8481.00
17_G20_S1.8181.00
40_Q69_C1.7601.00
34_F72_Q1.7591.00
8_C32_N1.7531.00
83_A95_N1.7511.00
12_N81_A1.7511.00
15_G21_V1.6971.00
13_I78_A1.6841.00
34_F74_F1.6521.00
12_N79_R1.6501.00
74_F101_G1.6311.00
7_S32_N1.6201.00
36_T40_Q1.6181.00
43_Q47_L1.5891.00
19_Y49_E1.5701.00
25_L78_A1.5671.00
134_D137_Q1.5211.00
73_P103_P1.5191.00
70_V101_G1.5121.00
41_F101_G1.5041.00
16_N20_S1.4271.00
21_V97_W1.4171.00
133_G138_V1.4161.00
6_A139_L1.4021.00
47_L50_K1.4001.00
44_T65_G1.3941.00
23_K46_L1.3881.00
59_G95_N1.3781.00
11_L79_R1.3391.00
85_D93_D1.3341.00
10_D24_Q1.3331.00
44_T47_L1.3331.00
80_K83_A1.3261.00
22_L45_L1.3131.00
136_D140_A1.3031.00
19_Y46_L1.2931.00
133_G137_Q1.2901.00
68_A104_Q1.2861.00
28_I31_Q1.2741.00
58_S127_I1.2571.00
28_I32_N1.2021.00
26_A45_L1.1991.00
77_F138_V1.1841.00
94_V97_W1.1661.00
127_I131_Q1.1561.00
5_T8_C1.1301.00
129_Q141_L1.1251.00
13_I24_Q1.1081.00
86_W97_W1.0951.00
42_L46_L1.0781.00
139_L143_N1.0781.00
133_G141_L1.0371.00
120_K126_F1.0341.00
96_C131_Q1.0191.00
9_I138_V1.0181.00
83_A93_D1.0071.00
47_L51_M1.0061.00
73_P102_V1.0051.00
10_D13_I1.0021.00
18_A87_K1.0021.00
22_L42_L0.9981.00
14_Q82_Q0.9981.00
15_G80_K0.9911.00
24_Q28_I0.9861.00
11_L138_V0.9791.00
35_I41_F0.9781.00
30_L39_H0.9761.00
49_E54_T0.9731.00
115_G119_R0.9721.00
19_Y23_K0.9691.00
137_Q140_A0.9591.00
28_I76_L0.9481.00
20_S23_K0.9471.00
123_H126_F0.9421.00
20_S24_Q0.9391.00
29_A101_G0.9261.00
27_T30_L0.9151.00
26_A99_C0.9131.00
129_Q132_Q0.9111.00
29_A76_L0.9101.00
36_T69_C0.9041.00
33_G71_K0.9031.00
75_V113_I0.8951.00
80_K95_N0.8901.00
16_N82_Q0.8851.00
77_F96_C0.8851.00
44_T69_C0.8831.00
41_F45_L0.8621.00
85_D91_G0.8581.00
39_H43_Q0.8541.00
110_Q114_I0.8511.00
118_C122_I0.8371.00
21_V80_K0.8311.00
79_R138_V0.8301.00
62_V114_I0.8171.00
24_Q27_T0.8151.00
102_V113_I0.8121.00
78_A99_C0.8091.00
30_L42_L0.8071.00
73_P109_D0.8021.00
79_R96_C0.8011.00
55_G89_S0.7951.00
126_F141_L0.7931.00
117_L121_I0.7931.00
23_K43_Q0.7921.00
140_A143_N0.7911.00
44_T67_S0.7821.00
40_Q44_T0.7781.00
115_G118_C0.7711.00
80_K84_I0.7581.00
5_T72_Q0.7551.00
8_C34_F0.7511.00
24_Q78_A0.7471.00
111_V115_G0.7301.00
23_K27_T0.7261.00
48_R54_T0.7251.00
46_L50_K0.7221.00
21_V84_I0.7191.00
27_T42_L0.7151.00
29_A74_F0.7141.00
25_L76_L0.7111.00
82_Q95_N0.7101.00
48_R63_P0.7061.00
15_G78_A0.7051.00
77_F98_I0.7011.00
129_Q137_Q0.6991.00
5_T32_N0.6991.00
60_V121_I0.6911.00
120_K142_L0.6891.00
59_G131_Q0.6871.00
57_G60_V0.6851.00
104_Q109_D0.6781.00
22_L46_L0.6691.00
76_L99_C0.6651.00
60_V127_I0.6641.00
124_K128_H0.6591.00
9_I139_L0.6561.00
5_T139_L0.6551.00
14_Q24_Q0.6510.99
104_Q108_E0.6480.99
48_R51_M0.6430.99
87_K92_E0.6400.99
98_I117_L0.6340.99
67_S70_V0.6310.99
111_V114_I0.6250.99
13_I81_A0.6120.99
26_A30_L0.6110.99
76_L101_G0.6060.99
55_G90_D0.6050.99
75_V98_I0.5990.99
119_R123_H0.5980.99
23_K39_H0.5970.99
29_A41_F0.5950.99
118_C121_I0.5950.99
40_Q43_Q0.5940.99
129_Q133_G0.5930.99
41_F99_C0.5900.99
12_N134_D0.5880.99
116_T120_K0.5850.99
19_Y50_K0.5840.99
18_A22_L0.5830.99
58_S92_E0.5830.99
3_A113_I0.5780.99
110_Q118_C0.5740.99
53_S87_K0.5730.99
52_H55_G0.5720.99
79_R134_D0.5710.99
70_V74_F0.5700.99
126_F129_Q0.5600.98
88_A91_G0.5570.98
10_D78_A0.5570.98
128_H131_Q0.5550.98
102_V110_Q0.5540.98
29_A35_I0.5520.98
125_E129_Q0.5510.98
5_T34_F0.5500.98
79_R130_L0.5450.98
130_L138_V0.5410.98
61_A94_V0.5400.98
41_F65_G0.5360.98
18_A46_L0.5290.98
88_A94_V0.5290.98
66_K102_V0.5230.98
4_L77_F0.5220.98
22_L86_W0.5140.97
56_F118_C0.5110.97
88_A93_D0.5050.97
75_V117_L0.5040.97
114_I118_C0.5040.97
21_V78_A0.5030.97
125_E128_H0.5030.97
108_E112_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a6jA 4 0.973 100 0.166 Contact Map
4m62S 1 0.973 100 0.177 Contact Map
2a0jA 1 0.9527 100 0.186 Contact Map
3urrA 2 0.9797 100 0.195 Contact Map
3oxpA 2 0.9527 100 0.196 Contact Map
1a3aA 2 0.9527 100 0.2 Contact Map
2oq3A 1 0.9459 100 0.216 Contact Map
2oqtA 2 0.9595 100 0.228 Contact Map
3bjvA 2 0.9595 100 0.229 Contact Map
3t43A 2 0.8716 100 0.24 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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