GREMLIN Database
FRVX - Putative aminopeptidase FrvX
UniProt: P32153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11862
Length: 356 (334)
Sequences: 2577 (1701)
Seq/√Len: 93.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_R145_E4.8311.00
12_A25_I3.4721.00
168_K323_S3.1731.00
80_F134_I2.7821.00
329_A332_T2.7791.00
15_V83_I2.7361.00
246_K249_Q2.6411.00
10_C171_G2.6201.00
7_Q11_E2.5991.00
266_L306_V2.5591.00
185_E188_Q2.5361.00
99_R156_S2.5221.00
138_A144_V2.5101.00
59_V202_S2.4331.00
277_N336_G2.4201.00
73_D79_R2.4071.00
56_V338_L2.3971.00
276_H340_T2.3931.00
27_I31_E2.2851.00
55_K198_Y2.2331.00
78_L98_I2.2221.00
27_I39_F2.1531.00
280_P329_A2.1241.00
108_G134_I2.1111.00
16_S83_I2.0841.00
272_S276_H2.0791.00
48_R196_T2.0691.00
64_E172_K2.0601.00
336_G339_T2.0401.00
189_T335_R2.0391.00
270_L306_V2.0081.00
78_L155_I2.0011.00
167_D325_A1.9931.00
328_E332_T1.9861.00
142_E146_K1.9711.00
251_P329_A1.9541.00
270_L337_F1.9441.00
8_Q29_T1.9321.00
142_E145_E1.9161.00
18_D154_F1.8941.00
136_I149_V1.8871.00
187_L199_G1.8801.00
26_L180_C1.8771.00
69_V155_I1.8751.00
74_E141_R1.8751.00
193_P339_T1.8751.00
28_N31_E1.8601.00
220_K300_G1.8521.00
8_Q25_I1.8511.00
48_R198_Y1.8471.00
97_T105_K1.8201.00
50_G196_T1.7501.00
8_Q28_N1.7371.00
136_I144_V1.7231.00
217_E300_G1.7111.00
14_A22_V1.7111.00
55_K196_T1.6741.00
322_I327_Y1.6731.00
96_V134_I1.6661.00
98_I134_I1.6561.00
60_G183_M1.6531.00
255_L283_F1.6511.00
36_E48_R1.6441.00
73_D77_F1.6441.00
178_I327_Y1.5961.00
23_R62_M1.5871.00
113_V122_Q1.5841.00
21_E105_K1.5651.00
27_I45_F1.5241.00
57_A296_Y1.5111.00
44_S214_T1.5091.00
80_F132_M1.5051.00
253_L281_L1.5021.00
51_N196_T1.4851.00
169_V174_L1.4721.00
34_V47_A1.4701.00
150_E153_N1.4681.00
150_E275_A1.4621.00
14_A177_R1.4571.00
59_V292_D1.4501.00
107_P162_A1.4451.00
213_Q295_R1.4441.00
58_V338_L1.4421.00
273_C277_N1.4250.99
29_T188_Q1.4220.99
269_A340_T1.4180.99
4_E8_Q1.4160.99
37_I45_F1.4100.99
4_E7_Q1.4090.99
189_T332_T1.4000.99
68_M81_T1.3810.99
29_T32_P1.3770.99
86_W157_P1.3680.99
180_C201_G1.3630.99
30_L184_A1.3530.99
57_A215_S1.3480.99
80_F155_I1.3450.99
205_E316_H1.3340.99
163_C324_K1.3280.99
7_Q161_F1.3170.99
57_A200_V1.3120.99
69_V78_L1.3010.99
138_A147_R1.3010.99
72_I144_V1.2940.99
100_T103_G1.2910.99
182_M330_L1.2830.99
145_E150_E1.2800.99
26_L184_A1.2790.99
57_A221_P1.2700.99
15_V66_G1.2650.99
269_A337_F1.2620.99
224_V296_Y1.2590.99
271_K281_L1.2580.99
26_L201_G1.2560.99
312_T315_L1.2550.99
5_L25_I1.2470.99
226_V293_G1.2460.99
167_D323_S1.2440.99
67_F91_M1.2320.98
16_S66_G1.2130.98
38_T218_H1.2100.98
24_D28_N1.2050.98
206_E316_H1.2050.98
186_L335_R1.2050.98
225_I270_L1.2020.98
186_L334_I1.2010.98
13_S97_T1.1910.98
331_L335_R1.1860.98
248_G323_S1.1670.98
230_A252_G1.1670.98
10_C161_F1.1650.98
139_N143_E1.1620.98
96_V110_I1.1610.98
178_I322_I1.1580.98
78_L136_I1.1580.98
293_G305_V1.1270.97
71_H79_R1.1270.97
57_A219_I1.1260.97
23_R39_F1.1190.97
188_Q192_N1.1170.97
98_I155_I1.1160.97
269_A273_C1.1080.97
140_S143_E1.1020.97
95_R162_A1.1010.97
62_M180_C1.0990.97
5_L184_A1.0920.97
186_L331_L1.0910.97
120_E123_K1.0900.97
253_L267_V1.0890.97
251_P330_L1.0880.97
13_S99_R1.0860.96
198_Y219_I1.0820.96
5_L29_T1.0820.96
271_K283_F1.0810.96
101_H153_N1.0730.96
200_V215_S1.0710.96
30_L47_A1.0690.96
251_P308_L1.0660.96
229_T315_L1.0620.96
185_E189_T1.0570.96
82_T88_N1.0560.96
95_R158_E1.0520.96
181_A327_Y1.0510.96
275_A281_L1.0480.96
83_I154_F1.0460.96
101_H268_A1.0430.96
183_M227_L1.0340.95
12_A21_E1.0320.95
267_V271_K1.0310.95
24_D27_I1.0290.95
308_L330_L1.0270.95
25_I29_T1.0130.95
98_I153_N1.0040.95
251_P333_L1.0000.94
226_V296_Y0.9960.94
181_A331_L0.9960.94
46_V200_V0.9950.94
30_L187_L0.9940.94
230_A284_S0.9930.94
33_C188_Q0.9920.94
97_T158_E0.9910.94
216_A296_Y0.9890.94
124_Q128_S0.9830.94
52_K196_T0.9810.94
144_V149_V0.9800.94
325_A328_E0.9770.94
175_D316_H0.9750.94
277_N340_T0.9750.94
279_L333_L0.9720.94
335_R339_T0.9710.94
230_A309_C0.9690.93
36_E50_G0.9670.93
121_K124_Q0.9660.93
80_F110_I0.9660.93
194_E278_D0.9660.93
185_E327_Y0.9640.93
164_W170_V0.9620.93
263_N304_P0.9580.93
96_V108_G0.9570.93
250_G326_D0.9450.93
268_A272_S0.9410.92
128_S131_E0.9400.92
30_L201_G0.9390.92
20_Q265_K0.9290.92
23_R45_F0.9290.92
35_N47_A0.9280.92
26_L62_M0.9260.92
143_E146_K0.9260.92
164_W321_M0.9220.92
121_K125_Q0.9220.92
170_V321_M0.9190.92
265_K304_P0.9170.91
40_D44_S0.9060.91
91_M110_I0.9020.91
254_M286_M0.9010.91
254_M284_S0.8980.91
176_N179_G0.8970.91
227_L334_I0.8950.90
47_A201_G0.8920.90
294_G297_N0.8920.90
43_G203_V0.8870.90
183_M199_G0.8860.90
107_P158_E0.8860.90
175_D205_E0.8790.90
249_Q280_P0.8780.90
220_K301_G0.8750.89
182_M331_L0.8730.89
336_G340_T0.8630.89
18_D99_R0.8610.89
78_L144_V0.8580.88
225_I334_I0.8580.88
53_G196_T0.8570.88
21_E99_R0.8560.88
229_T312_T0.8530.88
15_V154_F0.8530.88
27_I37_I0.8520.88
260_Y307_A0.8460.88
250_G282_Q0.8410.87
6_L181_A0.8400.87
95_R319_S0.8400.87
62_M201_G0.8390.87
106_I136_I0.8390.87
55_K222_D0.8380.87
253_L306_V0.8380.87
81_T256_F0.8280.87
204_E209_L0.8230.86
185_E331_L0.8220.86
56_V197_L0.8180.86
189_T331_L0.8140.86
11_E161_F0.8130.86
88_N91_M0.8130.86
20_Q24_D0.8080.85
67_F155_I0.8070.85
271_K275_A0.8060.85
169_V324_K0.8060.85
85_G316_H0.8060.85
228_D284_S0.8030.85
37_I47_A0.8030.85
64_E173_A0.7990.85
106_I149_V0.7980.85
299_M303_R0.7970.84
209_L294_G0.7960.84
234_D313_R0.7950.84
38_T48_R0.7940.84
174_L322_I0.7910.84
85_G205_E0.7900.84
209_L295_R0.7890.84
175_D206_E0.7880.84
92_L132_M0.7850.84
273_C340_T0.7830.83
289_G315_L0.7820.83
161_F171_G0.7790.83
245_L252_G0.7770.83
49_K187_L0.7750.83
310_L330_L0.7700.82
48_R55_K0.7690.82
161_F169_V0.7690.82
12_A22_V0.7690.82
60_G176_N0.7640.82
247_L311_P0.7630.82
98_I136_I0.7630.82
176_N229_T0.7580.81
332_T336_G0.7560.81
231_V315_L0.7500.81
182_M327_Y0.7500.81
100_T148_G0.7470.80
296_Y303_R0.7470.80
226_V305_V0.7430.80
225_I306_V0.7420.80
30_L34_V0.7400.80
136_I147_R0.7390.80
262_P307_A0.7370.80
145_E275_A0.7370.80
70_T81_T0.7350.79
77_F236_P0.7320.79
171_G174_L0.7320.79
61_H205_E0.7320.79
270_L308_L0.7300.79
119_T122_Q0.7280.79
22_V62_M0.7260.79
7_Q163_C0.7250.78
325_A329_A0.7250.78
78_L106_I0.7240.78
290_A294_G0.7240.78
182_M186_L0.7240.78
103_G106_I0.7230.78
259_R294_G0.7220.78
197_L338_L0.7210.78
71_H235_V0.7180.78
257_D289_G0.7110.77
97_T107_P0.7110.77
262_P267_V0.7090.77
230_A245_L0.7090.77
218_H301_G0.7090.77
108_G136_I0.7080.77
12_A29_T0.7050.77
233_G244_P0.7050.77
87_W90_S0.7050.77
190_V197_L0.7040.76
181_A185_E0.7040.76
106_I138_A0.7010.76
6_L174_L0.6970.76
284_S309_C0.6940.75
150_E271_K0.6930.75
93_N318_N0.6930.75
74_E121_K0.6860.75
34_V37_I0.6840.74
182_M227_L0.6830.74
224_V303_R0.6830.74
208_G290_A0.6770.74
56_V223_V0.6770.74
327_Y331_L0.6760.73
312_T322_I0.6720.73
163_C167_D0.6710.73
26_L45_F0.6690.73
85_G290_A0.6690.73
262_P289_G0.6660.72
273_C336_G0.6650.72
315_L320_G0.6650.72
189_T193_P0.6650.72
254_M307_A0.6530.71
67_F80_F0.6500.71
85_G206_E0.6490.70
273_C279_L0.6480.70
264_Q304_P0.6470.70
33_C191_N0.6450.70
258_K290_A0.6420.70
274_A333_L0.6410.69
257_D294_G0.6400.69
100_T153_N0.6400.69
204_E207_V0.6370.69
291_T316_H0.6370.69
35_N49_K0.6370.69
25_I28_N0.6360.69
10_C172_K0.6330.69
51_N195_I0.6330.69
269_A272_S0.6320.68
98_I149_V0.6300.68
272_S275_A0.6300.68
226_V229_T0.6280.68
217_E301_G0.6270.68
54_P222_D0.6270.68
275_A278_D0.6250.68
277_N332_T0.6220.67
39_F45_F0.6210.67
77_F133_F0.6210.67
176_N228_D0.6200.67
57_A224_V0.6200.67
11_E160_N0.6180.67
252_G309_C0.6180.67
186_L338_L0.6180.67
183_M186_L0.6160.66
216_A299_M0.6150.66
264_Q268_A0.6140.66
208_G257_D0.6130.66
41_G304_P0.6130.66
100_T106_I0.6110.66
245_L284_S0.6070.65
255_L267_V0.6060.65
21_E28_N0.6050.65
223_V337_F0.6050.65
18_D21_E0.6040.65
111_G314_Y0.6020.65
73_D133_F0.6020.65
58_V334_I0.5970.64
228_D291_T0.5970.64
289_G307_A0.5950.64
119_T123_K0.5940.64
13_S21_E0.5930.64
38_T198_Y0.5930.64
240_N248_G0.5920.63
20_Q23_R0.5910.63
9_L22_V0.5900.63
56_V225_I0.5880.63
71_H74_E0.5880.63
212_A216_A0.5870.63
101_H272_S0.5850.62
297_N305_V0.5850.62
204_E210_R0.5840.62
44_S200_V0.5840.62
59_V226_V0.5830.62
61_H206_E0.5830.62
30_L37_I0.5820.62
6_L169_V0.5820.62
46_V215_S0.5800.62
15_V156_S0.5780.62
72_I271_K0.5760.61
176_N205_E0.5760.61
64_E111_G0.5760.61
35_N187_L0.5750.61
229_T284_S0.5730.61
137_G250_G0.5720.61
68_M83_I0.5700.60
35_N48_R0.5670.60
137_G249_Q0.5650.60
250_G313_R0.5640.60
178_I331_L0.5630.60
147_R165_G0.5630.60
65_V320_G0.5620.59
13_S156_S0.5610.59
99_R155_I0.5610.59
223_V304_P0.5610.59
88_N129_F0.5600.59
46_V198_Y0.5590.59
257_D307_A0.5590.59
141_R144_V0.5580.59
86_W115_P0.5570.59
99_R105_K0.5560.59
26_L47_A0.5550.58
282_Q326_D0.5530.58
120_E124_Q0.5530.58
169_V322_I0.5520.58
290_A316_H0.5510.58
31_E37_I0.5500.58
226_V334_I0.5500.58
200_V224_V0.5480.57
61_H316_H0.5460.57
35_N191_N0.5460.57
205_E291_T0.5450.57
67_F157_P0.5450.57
110_I132_M0.5450.57
88_N127_L0.5450.57
209_L290_A0.5420.57
139_N325_A0.5410.57
23_R43_G0.5410.57
223_V266_L0.5380.56
171_G321_M0.5370.56
190_V338_L0.5370.56
45_F184_A0.5350.56
5_L185_E0.5350.56
41_G222_D0.5350.56
34_V187_L0.5340.56
29_T184_A0.5340.56
268_A271_K0.5330.55
195_I339_T0.5320.55
247_L323_S0.5320.55
71_H151_I0.5310.55
307_A315_L0.5310.55
259_R290_A0.5290.55
59_V266_L0.5290.55
251_P332_T0.5290.55
14_A172_K0.5280.55
211_G214_T0.5280.55
178_I310_L0.5280.55
194_E276_H0.5270.55
58_V183_M0.5260.54
273_C337_F0.5250.54
167_D324_K0.5240.54
324_K328_E0.5240.54
79_R274_A0.5240.54
257_D315_L0.5230.54
70_T80_F0.5220.54
82_T129_F0.5210.54
273_C276_H0.5210.54
323_S327_Y0.5210.54
5_L188_Q0.5200.54
279_L336_G0.5190.53
18_D83_I0.5190.53
214_T302_G0.5180.53
313_R326_D0.5180.53
226_V230_A0.5180.53
143_E166_E0.5180.53
289_G294_G0.5160.53
65_V206_E0.5160.53
120_E126_P0.5150.53
35_N50_G0.5150.53
86_W118_L0.5090.52
254_M309_C0.5090.52
260_Y293_G0.5090.52
253_L271_K0.5070.52
67_F86_W0.5050.52
231_V284_S0.5050.52
17_G154_F0.5050.52
210_R261_F0.5040.51
260_Y297_N0.5030.51
166_E323_S0.5030.51
66_G83_I0.5030.51
168_K321_M0.5020.51
138_A143_E0.5010.51
215_S296_Y0.5000.51
30_L33_C0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.986 100 0.407 Contact Map
1y0yA 5 0.9326 100 0.418 Contact Map
3wt4A 4 0.9466 100 0.427 Contact Map
2wznA 4 0.9326 100 0.43 Contact Map
2wyrA 4 0.9045 100 0.434 Contact Map
2fvgA 1 0.868 100 0.436 Contact Map
3vatA 4 0.9803 100 0.436 Contact Map
2gljA 6 0.941 100 0.441 Contact Map
2glfA 4 0.9354 100 0.453 Contact Map
1y7eA 4 0.8371 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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