FRVX - ECOLI - GREMLIN Contacts

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FRVX - Putative aminopeptidase FrvX

UniProt:	P32153	Sequences: MNIELLQQLCEASAVSGDEQEVRDILINTLEPCVNEITFDGLGSFVARKGNKGPKVAVVGHMDEVGFMVTHIDESGFLRFTTIGGWWNQSMLNHRVTIRTHKGVKIPGVIGSVAPHALTEKQKQQPLSFDEMFIDIGANSREEVEKRGVEIGNFISPEANFACWGEDKVVGKALDNRIGCAMMAELLQTVNNPEITLYGVGSVEEEVGLRGAQTSAEHIKPDVVIVLDTAVAGDVPGIDNIKYPLKLGQGPGLMLFDKRYFPNQKLVAALKSCAAHNDLPLQFSTMKTGATDGGRYNVMGGGRPVVALCLPTRYLHANSGMISKADYEALLTLIRGFLTTLTAEKVNAFSQFRQVD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11862
Length:	356 (334)
Sequences:	2577 (1701)
Seq/√Len:	93.1

ECOLI - FRVX SGCX YPDE
BACSU - YSDC YTOP YHFE
HALSA - Q9HPS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_R	145_E	4.831	1.00
12_A	25_I	3.472	1.00
168_K	323_S	3.173	1.00
80_F	134_I	2.782	1.00
329_A	332_T	2.779	1.00
15_V	83_I	2.736	1.00
246_K	249_Q	2.641	1.00
10_C	171_G	2.620	1.00
7_Q	11_E	2.599	1.00
266_L	306_V	2.559	1.00
185_E	188_Q	2.536	1.00
99_R	156_S	2.522	1.00
138_A	144_V	2.510	1.00
59_V	202_S	2.433	1.00
277_N	336_G	2.420	1.00
73_D	79_R	2.407	1.00
56_V	338_L	2.397	1.00
276_H	340_T	2.393	1.00
27_I	31_E	2.285	1.00
55_K	198_Y	2.233	1.00
78_L	98_I	2.222	1.00
27_I	39_F	2.153	1.00
280_P	329_A	2.124	1.00
108_G	134_I	2.111	1.00
16_S	83_I	2.084	1.00
272_S	276_H	2.079	1.00
48_R	196_T	2.069	1.00
64_E	172_K	2.060	1.00
336_G	339_T	2.040	1.00
189_T	335_R	2.039	1.00
270_L	306_V	2.008	1.00
78_L	155_I	2.001	1.00
167_D	325_A	1.993	1.00
328_E	332_T	1.986	1.00
142_E	146_K	1.971	1.00
251_P	329_A	1.954	1.00
270_L	337_F	1.944	1.00
8_Q	29_T	1.932	1.00
142_E	145_E	1.916	1.00
18_D	154_F	1.894	1.00
136_I	149_V	1.887	1.00
187_L	199_G	1.880	1.00
26_L	180_C	1.877	1.00
69_V	155_I	1.875	1.00
74_E	141_R	1.875	1.00
193_P	339_T	1.875	1.00
28_N	31_E	1.860	1.00
220_K	300_G	1.852	1.00
8_Q	25_I	1.851	1.00
48_R	198_Y	1.847	1.00
97_T	105_K	1.820	1.00
50_G	196_T	1.750	1.00
8_Q	28_N	1.737	1.00
136_I	144_V	1.723	1.00
217_E	300_G	1.711	1.00
14_A	22_V	1.711	1.00
55_K	196_T	1.674	1.00
322_I	327_Y	1.673	1.00
96_V	134_I	1.666	1.00
98_I	134_I	1.656	1.00
60_G	183_M	1.653	1.00
255_L	283_F	1.651	1.00
36_E	48_R	1.644	1.00
73_D	77_F	1.644	1.00
178_I	327_Y	1.596	1.00
23_R	62_M	1.587	1.00
113_V	122_Q	1.584	1.00
21_E	105_K	1.565	1.00
27_I	45_F	1.524	1.00
57_A	296_Y	1.511	1.00
44_S	214_T	1.509	1.00
80_F	132_M	1.505	1.00
253_L	281_L	1.502	1.00
51_N	196_T	1.485	1.00
169_V	174_L	1.472	1.00
34_V	47_A	1.470	1.00
150_E	153_N	1.468	1.00
150_E	275_A	1.462	1.00
14_A	177_R	1.457	1.00
59_V	292_D	1.450	1.00
107_P	162_A	1.445	1.00
213_Q	295_R	1.444	1.00
58_V	338_L	1.442	1.00
273_C	277_N	1.425	0.99
29_T	188_Q	1.422	0.99
269_A	340_T	1.418	0.99
4_E	8_Q	1.416	0.99
37_I	45_F	1.410	0.99
4_E	7_Q	1.409	0.99
189_T	332_T	1.400	0.99
68_M	81_T	1.381	0.99
29_T	32_P	1.377	0.99
86_W	157_P	1.368	0.99
180_C	201_G	1.363	0.99
30_L	184_A	1.353	0.99
57_A	215_S	1.348	0.99
80_F	155_I	1.345	0.99
205_E	316_H	1.334	0.99
163_C	324_K	1.328	0.99
7_Q	161_F	1.317	0.99
57_A	200_V	1.312	0.99
69_V	78_L	1.301	0.99
138_A	147_R	1.301	0.99
72_I	144_V	1.294	0.99
100_T	103_G	1.291	0.99
182_M	330_L	1.283	0.99
145_E	150_E	1.280	0.99
26_L	184_A	1.279	0.99
57_A	221_P	1.270	0.99
15_V	66_G	1.265	0.99
269_A	337_F	1.262	0.99
224_V	296_Y	1.259	0.99
271_K	281_L	1.258	0.99
26_L	201_G	1.256	0.99
312_T	315_L	1.255	0.99
5_L	25_I	1.247	0.99
226_V	293_G	1.246	0.99
167_D	323_S	1.244	0.99
67_F	91_M	1.232	0.98
16_S	66_G	1.213	0.98
38_T	218_H	1.210	0.98
24_D	28_N	1.205	0.98
206_E	316_H	1.205	0.98
186_L	335_R	1.205	0.98
225_I	270_L	1.202	0.98
186_L	334_I	1.201	0.98
13_S	97_T	1.191	0.98
331_L	335_R	1.186	0.98
248_G	323_S	1.167	0.98
230_A	252_G	1.167	0.98
10_C	161_F	1.165	0.98
139_N	143_E	1.162	0.98
96_V	110_I	1.161	0.98
178_I	322_I	1.158	0.98
78_L	136_I	1.158	0.98
293_G	305_V	1.127	0.97
71_H	79_R	1.127	0.97
57_A	219_I	1.126	0.97
23_R	39_F	1.119	0.97
188_Q	192_N	1.117	0.97
98_I	155_I	1.116	0.97
269_A	273_C	1.108	0.97
140_S	143_E	1.102	0.97
95_R	162_A	1.101	0.97
62_M	180_C	1.099	0.97
5_L	184_A	1.092	0.97
186_L	331_L	1.091	0.97
120_E	123_K	1.090	0.97
253_L	267_V	1.089	0.97
251_P	330_L	1.088	0.97
13_S	99_R	1.086	0.96
198_Y	219_I	1.082	0.96
5_L	29_T	1.082	0.96
271_K	283_F	1.081	0.96
101_H	153_N	1.073	0.96
200_V	215_S	1.071	0.96
30_L	47_A	1.069	0.96
251_P	308_L	1.066	0.96
229_T	315_L	1.062	0.96
185_E	189_T	1.057	0.96
82_T	88_N	1.056	0.96
95_R	158_E	1.052	0.96
181_A	327_Y	1.051	0.96
275_A	281_L	1.048	0.96
83_I	154_F	1.046	0.96
101_H	268_A	1.043	0.96
183_M	227_L	1.034	0.95
12_A	21_E	1.032	0.95
267_V	271_K	1.031	0.95
24_D	27_I	1.029	0.95
308_L	330_L	1.027	0.95
25_I	29_T	1.013	0.95
98_I	153_N	1.004	0.95
251_P	333_L	1.000	0.94
226_V	296_Y	0.996	0.94
181_A	331_L	0.996	0.94
46_V	200_V	0.995	0.94
30_L	187_L	0.994	0.94
230_A	284_S	0.993	0.94
33_C	188_Q	0.992	0.94
97_T	158_E	0.991	0.94
216_A	296_Y	0.989	0.94
124_Q	128_S	0.983	0.94
52_K	196_T	0.981	0.94
144_V	149_V	0.980	0.94
325_A	328_E	0.977	0.94
175_D	316_H	0.975	0.94
277_N	340_T	0.975	0.94
279_L	333_L	0.972	0.94
335_R	339_T	0.971	0.94
230_A	309_C	0.969	0.93
36_E	50_G	0.967	0.93
121_K	124_Q	0.966	0.93
80_F	110_I	0.966	0.93
194_E	278_D	0.966	0.93
185_E	327_Y	0.964	0.93
164_W	170_V	0.962	0.93
263_N	304_P	0.958	0.93
96_V	108_G	0.957	0.93
250_G	326_D	0.945	0.93
268_A	272_S	0.941	0.92
128_S	131_E	0.940	0.92
30_L	201_G	0.939	0.92
20_Q	265_K	0.929	0.92
23_R	45_F	0.929	0.92
35_N	47_A	0.928	0.92
26_L	62_M	0.926	0.92
143_E	146_K	0.926	0.92
164_W	321_M	0.922	0.92
121_K	125_Q	0.922	0.92
170_V	321_M	0.919	0.92
265_K	304_P	0.917	0.91
40_D	44_S	0.906	0.91
91_M	110_I	0.902	0.91
254_M	286_M	0.901	0.91
254_M	284_S	0.898	0.91
176_N	179_G	0.897	0.91
227_L	334_I	0.895	0.90
47_A	201_G	0.892	0.90
294_G	297_N	0.892	0.90
43_G	203_V	0.887	0.90
183_M	199_G	0.886	0.90
107_P	158_E	0.886	0.90
175_D	205_E	0.879	0.90
249_Q	280_P	0.878	0.90
220_K	301_G	0.875	0.89
182_M	331_L	0.873	0.89
336_G	340_T	0.863	0.89
18_D	99_R	0.861	0.89
78_L	144_V	0.858	0.88
225_I	334_I	0.858	0.88
53_G	196_T	0.857	0.88
21_E	99_R	0.856	0.88
229_T	312_T	0.853	0.88
15_V	154_F	0.853	0.88
27_I	37_I	0.852	0.88
260_Y	307_A	0.846	0.88
250_G	282_Q	0.841	0.87
6_L	181_A	0.840	0.87
95_R	319_S	0.840	0.87
62_M	201_G	0.839	0.87
106_I	136_I	0.839	0.87
55_K	222_D	0.838	0.87
253_L	306_V	0.838	0.87
81_T	256_F	0.828	0.87
204_E	209_L	0.823	0.86
185_E	331_L	0.822	0.86
56_V	197_L	0.818	0.86
189_T	331_L	0.814	0.86
11_E	161_F	0.813	0.86
88_N	91_M	0.813	0.86
20_Q	24_D	0.808	0.85
67_F	155_I	0.807	0.85
271_K	275_A	0.806	0.85
169_V	324_K	0.806	0.85
85_G	316_H	0.806	0.85
228_D	284_S	0.803	0.85
37_I	47_A	0.803	0.85
64_E	173_A	0.799	0.85
106_I	149_V	0.798	0.85
299_M	303_R	0.797	0.84
209_L	294_G	0.796	0.84
234_D	313_R	0.795	0.84
38_T	48_R	0.794	0.84
174_L	322_I	0.791	0.84
85_G	205_E	0.790	0.84
209_L	295_R	0.789	0.84
175_D	206_E	0.788	0.84
92_L	132_M	0.785	0.84
273_C	340_T	0.783	0.83
289_G	315_L	0.782	0.83
161_F	171_G	0.779	0.83
245_L	252_G	0.777	0.83
49_K	187_L	0.775	0.83
310_L	330_L	0.770	0.82
48_R	55_K	0.769	0.82
161_F	169_V	0.769	0.82
12_A	22_V	0.769	0.82
60_G	176_N	0.764	0.82
247_L	311_P	0.763	0.82
98_I	136_I	0.763	0.82
176_N	229_T	0.758	0.81
332_T	336_G	0.756	0.81
231_V	315_L	0.750	0.81
182_M	327_Y	0.750	0.81
100_T	148_G	0.747	0.80
296_Y	303_R	0.747	0.80
226_V	305_V	0.743	0.80
225_I	306_V	0.742	0.80
30_L	34_V	0.740	0.80
136_I	147_R	0.739	0.80
262_P	307_A	0.737	0.80
145_E	275_A	0.737	0.80
70_T	81_T	0.735	0.79
77_F	236_P	0.732	0.79
171_G	174_L	0.732	0.79
61_H	205_E	0.732	0.79
270_L	308_L	0.730	0.79
119_T	122_Q	0.728	0.79
22_V	62_M	0.726	0.79
7_Q	163_C	0.725	0.78
325_A	329_A	0.725	0.78
78_L	106_I	0.724	0.78
290_A	294_G	0.724	0.78
182_M	186_L	0.724	0.78
103_G	106_I	0.723	0.78
259_R	294_G	0.722	0.78
197_L	338_L	0.721	0.78
71_H	235_V	0.718	0.78
257_D	289_G	0.711	0.77
97_T	107_P	0.711	0.77
262_P	267_V	0.709	0.77
230_A	245_L	0.709	0.77
218_H	301_G	0.709	0.77
108_G	136_I	0.708	0.77
12_A	29_T	0.705	0.77
233_G	244_P	0.705	0.77
87_W	90_S	0.705	0.77
190_V	197_L	0.704	0.76
181_A	185_E	0.704	0.76
106_I	138_A	0.701	0.76
6_L	174_L	0.697	0.76
284_S	309_C	0.694	0.75
150_E	271_K	0.693	0.75
93_N	318_N	0.693	0.75
74_E	121_K	0.686	0.75
34_V	37_I	0.684	0.74
182_M	227_L	0.683	0.74
224_V	303_R	0.683	0.74
208_G	290_A	0.677	0.74
56_V	223_V	0.677	0.74
327_Y	331_L	0.676	0.73
312_T	322_I	0.672	0.73
163_C	167_D	0.671	0.73
26_L	45_F	0.669	0.73
85_G	290_A	0.669	0.73
262_P	289_G	0.666	0.72
273_C	336_G	0.665	0.72
315_L	320_G	0.665	0.72
189_T	193_P	0.665	0.72
254_M	307_A	0.653	0.71
67_F	80_F	0.650	0.71
85_G	206_E	0.649	0.70
273_C	279_L	0.648	0.70
264_Q	304_P	0.647	0.70
33_C	191_N	0.645	0.70
258_K	290_A	0.642	0.70
274_A	333_L	0.641	0.69
257_D	294_G	0.640	0.69
100_T	153_N	0.640	0.69
204_E	207_V	0.637	0.69
291_T	316_H	0.637	0.69
35_N	49_K	0.637	0.69
25_I	28_N	0.636	0.69
10_C	172_K	0.633	0.69
51_N	195_I	0.633	0.69
269_A	272_S	0.632	0.68
98_I	149_V	0.630	0.68
272_S	275_A	0.630	0.68
226_V	229_T	0.628	0.68
217_E	301_G	0.627	0.68
54_P	222_D	0.627	0.68
275_A	278_D	0.625	0.68
277_N	332_T	0.622	0.67
39_F	45_F	0.621	0.67
77_F	133_F	0.621	0.67
176_N	228_D	0.620	0.67
57_A	224_V	0.620	0.67
11_E	160_N	0.618	0.67
252_G	309_C	0.618	0.67
186_L	338_L	0.618	0.67
183_M	186_L	0.616	0.66
216_A	299_M	0.615	0.66
264_Q	268_A	0.614	0.66
208_G	257_D	0.613	0.66
41_G	304_P	0.613	0.66
100_T	106_I	0.611	0.66
245_L	284_S	0.607	0.65
255_L	267_V	0.606	0.65
21_E	28_N	0.605	0.65
223_V	337_F	0.605	0.65
18_D	21_E	0.604	0.65
111_G	314_Y	0.602	0.65
73_D	133_F	0.602	0.65
58_V	334_I	0.597	0.64
228_D	291_T	0.597	0.64
289_G	307_A	0.595	0.64
119_T	123_K	0.594	0.64
13_S	21_E	0.593	0.64
38_T	198_Y	0.593	0.64
240_N	248_G	0.592	0.63
20_Q	23_R	0.591	0.63
9_L	22_V	0.590	0.63
56_V	225_I	0.588	0.63
71_H	74_E	0.588	0.63
212_A	216_A	0.587	0.63
101_H	272_S	0.585	0.62
297_N	305_V	0.585	0.62
204_E	210_R	0.584	0.62
44_S	200_V	0.584	0.62
59_V	226_V	0.583	0.62
61_H	206_E	0.583	0.62
30_L	37_I	0.582	0.62
6_L	169_V	0.582	0.62
46_V	215_S	0.580	0.62
15_V	156_S	0.578	0.62
72_I	271_K	0.576	0.61
176_N	205_E	0.576	0.61
64_E	111_G	0.576	0.61
35_N	187_L	0.575	0.61
229_T	284_S	0.573	0.61
137_G	250_G	0.572	0.61
68_M	83_I	0.570	0.60
35_N	48_R	0.567	0.60
137_G	249_Q	0.565	0.60
250_G	313_R	0.564	0.60
178_I	331_L	0.563	0.60
147_R	165_G	0.563	0.60
65_V	320_G	0.562	0.59
13_S	156_S	0.561	0.59
99_R	155_I	0.561	0.59
223_V	304_P	0.561	0.59
88_N	129_F	0.560	0.59
46_V	198_Y	0.559	0.59
257_D	307_A	0.559	0.59
141_R	144_V	0.558	0.59
86_W	115_P	0.557	0.59
99_R	105_K	0.556	0.59
26_L	47_A	0.555	0.58
282_Q	326_D	0.553	0.58
120_E	124_Q	0.553	0.58
169_V	322_I	0.552	0.58
290_A	316_H	0.551	0.58
31_E	37_I	0.550	0.58
226_V	334_I	0.550	0.58
200_V	224_V	0.548	0.57
61_H	316_H	0.546	0.57
35_N	191_N	0.546	0.57
205_E	291_T	0.545	0.57
67_F	157_P	0.545	0.57
110_I	132_M	0.545	0.57
88_N	127_L	0.545	0.57
209_L	290_A	0.542	0.57
139_N	325_A	0.541	0.57
23_R	43_G	0.541	0.57
223_V	266_L	0.538	0.56
171_G	321_M	0.537	0.56
190_V	338_L	0.537	0.56
45_F	184_A	0.535	0.56
5_L	185_E	0.535	0.56
41_G	222_D	0.535	0.56
34_V	187_L	0.534	0.56
29_T	184_A	0.534	0.56
268_A	271_K	0.533	0.55
195_I	339_T	0.532	0.55
247_L	323_S	0.532	0.55
71_H	151_I	0.531	0.55
307_A	315_L	0.531	0.55
259_R	290_A	0.529	0.55
59_V	266_L	0.529	0.55
251_P	332_T	0.529	0.55
14_A	172_K	0.528	0.55
211_G	214_T	0.528	0.55
178_I	310_L	0.528	0.55
194_E	276_H	0.527	0.55
58_V	183_M	0.526	0.54
273_C	337_F	0.525	0.54
167_D	324_K	0.524	0.54
324_K	328_E	0.524	0.54
79_R	274_A	0.524	0.54
257_D	315_L	0.523	0.54
70_T	80_F	0.522	0.54
82_T	129_F	0.521	0.54
273_C	276_H	0.521	0.54
323_S	327_Y	0.521	0.54
5_L	188_Q	0.520	0.54
279_L	336_G	0.519	0.53
18_D	83_I	0.519	0.53
214_T	302_G	0.518	0.53
313_R	326_D	0.518	0.53
226_V	230_A	0.518	0.53
143_E	166_E	0.518	0.53
289_G	294_G	0.516	0.53
65_V	206_E	0.516	0.53
120_E	126_P	0.515	0.53
35_N	50_G	0.515	0.53
86_W	118_L	0.509	0.52
254_M	309_C	0.509	0.52
260_Y	293_G	0.509	0.52
253_L	271_K	0.507	0.52
67_F	86_W	0.505	0.52
231_V	284_S	0.505	0.52
17_G	154_F	0.505	0.52
210_R	261_F	0.504	0.51
260_Y	297_N	0.503	0.51
166_E	323_S	0.503	0.51
66_G	83_I	0.503	0.51
168_K	321_M	0.502	0.51
138_A	143_E	0.501	0.51
215_S	296_Y	0.500	0.51
30_L	33_C	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wwvA	4	0.986	100	0.407	Contact Map
1y0yA	5	0.9326	100	0.418	Contact Map
3wt4A	4	0.9466	100	0.427	Contact Map
2wznA	4	0.9326	100	0.43	Contact Map
2wyrA	4	0.9045	100	0.434	Contact Map
2fvgA	1	0.868	100	0.436	Contact Map
3vatA	4	0.9803	100	0.436	Contact Map
2gljA	6	0.941	100	0.441	Contact Map
2glfA	4	0.9354	100	0.453	Contact Map
1y7eA	4	0.8371	100	0.464	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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