GREMLIN Database
YIIG - Uncharacterized protein YiiG
UniProt: P32151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11860
Length: 351 (303)
Sequences: 169 (132)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_K245_A4.8700.99
229_R344_V3.6800.95
176_E179_K3.5290.93
99_Y190_H3.2550.90
169_M194_L3.0230.86
84_C131_C2.8230.82
337_L341_N2.7330.80
77_K143_P2.6590.78
226_I247_Q2.5450.75
148_I343_M2.5330.74
172_Y181_D2.4710.72
298_E313_S2.4120.70
251_L255_D2.3850.70
224_K228_E2.3200.67
185_K189_L2.2860.66
162_L200_F2.2660.65
11_I15_M2.2130.63
261_A265_K2.1900.63
161_A192_T2.1200.60
146_Q151_V2.0960.59
177_N180_D2.0290.56
248_I252_I2.0270.56
262_A303_V2.0100.56
21_G256_K1.9780.54
190_H193_F1.9710.54
170_D174_T1.8750.50
88_L155_Y1.8690.50
78_M242_M1.8500.49
152_A211_I1.8410.49
124_S127_N1.8010.47
110_P162_L1.8010.47
111_T114_E1.7990.47
142_T299_A1.7790.46
183_F186_G1.7750.46
78_M278_E1.7290.44
337_L340_Y1.7120.44
136_K286_F1.7090.44
292_A305_R1.6720.42
156_I182_A1.6600.42
245_A278_E1.6590.42
297_L300_K1.6490.41
82_I348_N1.6360.41
137_S339_E1.6240.40
77_K149_D1.5890.39
207_Y210_A1.5880.39
102_W109_G1.5860.39
200_F232_K1.5850.39
270_E304_R1.5780.39
79_D86_N1.5760.39
222_E344_V1.5680.38
104_K295_Y1.5650.38
183_F187_K1.5580.38
306_I320_L1.5420.37
82_I86_N1.5290.37
183_F189_L1.5200.36
186_G223_L1.5070.36
331_D343_M1.4970.36
167_N208_H1.4920.35
158_A201_E1.4590.34
211_I281_K1.4560.34
136_K156_I1.4530.34
220_L274_A1.4490.34
242_M344_V1.4490.34
74_F78_M1.4490.34
178_Y334_P1.4180.33
183_F223_L1.4110.33
220_L344_V1.4110.33
77_K86_N1.4100.33
258_D265_K1.4050.32
236_Y240_A1.4030.32
277_K306_I1.3780.31
266_V283_G1.3740.31
173_Y183_F1.3700.31
205_E266_V1.3640.31
185_K267_S1.3640.31
260_E271_T1.3630.31
276_A292_A1.3620.31
162_L196_N1.3610.31
145_L148_I1.3610.31
155_Y258_D1.3470.30
137_S209_A1.3330.30
109_G155_Y1.3310.30
11_I16_S1.3300.30
18_G24_D1.3270.30
215_N348_N1.3250.30
190_H236_Y1.3230.30
211_I286_F1.3160.29
298_E339_E1.3050.29
180_D245_A1.3040.29
304_R307_R1.2990.29
183_F244_S1.2950.29
299_A336_A1.2930.29
305_R331_D1.2730.28
96_L207_Y1.2690.28
203_V287_S1.2630.28
309_K333_F1.2610.28
122_G254_Q1.2420.27
14_I29_T1.2300.27
93_Q188_T1.2250.26
313_S316_D1.2210.26
153_V168_E1.2140.26
75_D249_N1.2140.26
69_D228_E1.2130.26
103_L272_L1.2100.26
10_I152_A1.2040.26
86_N149_D1.2020.26
192_T274_A1.1940.25
171_K273_V1.1900.25
95_S102_W1.1850.25
77_K242_M1.1840.25
149_D239_L1.1780.25
339_E346_D1.1680.25
155_Y207_Y1.1640.25
84_C257_F1.1620.24
82_I99_Y1.1600.24
217_K224_K1.1570.24
18_G82_I1.1560.24
225_N294_Q1.1550.24
186_G189_L1.1510.24
215_N222_E1.1500.24
101_D178_Y1.1430.24
89_Q278_E1.1400.24
269_L299_A1.1380.24
193_F331_D1.1370.24
14_I17_L1.1260.23
252_I257_F1.1220.23
94_R205_E1.1210.23
251_L332_S1.1170.23
193_F230_E1.1170.23
20_T133_K1.1140.23
145_L344_V1.1120.23
114_E340_Y1.1110.23
90_I250_N1.1100.23
311_P343_M1.1090.23
141_L157_D1.1060.23
262_A302_Y1.1030.23
84_C143_P1.1020.23
313_S327_W1.0990.23
190_H269_L1.0970.23
127_N209_A1.0950.23
122_G199_A1.0940.23
168_E344_V1.0920.22
101_D111_T1.0900.22
258_D275_Q1.0870.22
135_V176_E1.0860.22
99_Y269_L1.0840.22
107_K242_M1.0740.22
293_G303_V1.0680.22
152_A233_T1.0650.22
240_A246_K1.0630.22
18_G267_S1.0620.22
14_I315_W1.0610.22
185_K274_A1.0490.21
157_D296_Q1.0470.21
104_K157_D1.0440.21
139_V163_G1.0380.21
149_D159_A1.0340.21
99_Y180_D1.0340.21
258_D276_A1.0340.21
207_Y211_I1.0250.21
173_Y245_A1.0220.21
223_L231_G1.0220.21
136_K147_P1.0180.20
135_V320_L1.0170.20
180_D186_G1.0150.20
159_A304_R1.0130.20
159_A214_I1.0060.20
110_P173_Y1.0050.20
308_D315_W1.0050.20
74_F303_V0.9950.20
86_N224_K0.9940.20
149_D162_L0.9830.20
155_Y204_A0.9820.20
23_D220_L0.9800.20
230_E344_V0.9780.19
142_T246_K0.9750.19
207_Y342_E0.9670.19
169_M175_Q0.9580.19
66_P137_S0.9570.19
11_I68_V0.9560.19
183_F224_K0.9550.19
117_V168_E0.9510.19
325_S328_M0.9460.19
143_P189_L0.9430.19
333_F343_M0.9400.19
102_W119_G0.9400.19
84_C135_V0.9370.18
262_A277_K0.9360.18
200_F246_K0.9350.18
223_L299_A0.9350.18
71_Q161_A0.9340.18
136_K186_G0.9330.18
20_T24_D0.9330.18
65_Q177_N0.9240.18
305_R320_L0.9190.18
157_D334_P0.9170.18
246_K299_A0.9100.18
106_F206_S0.9090.18
247_Q252_I0.9020.18
152_A156_I0.9020.18
11_I26_K0.8990.18
109_G200_F0.8960.17
166_I226_I0.8960.17
106_F159_A0.8920.17
200_F226_I0.8910.17
292_A309_K0.8900.17
187_K190_H0.8890.17
218_R275_Q0.8890.17
211_I277_K0.8880.17
14_I23_D0.8870.17
165_T295_Y0.8860.17
94_R202_P0.8850.17
125_E336_A0.8850.17
336_A343_M0.8820.17
240_A300_K0.8810.17
91_P110_P0.8770.17
241_V259_A0.8750.17
86_N152_A0.8740.17
136_K160_V0.8640.17
27_A182_A0.8630.17
152_A159_A0.8630.17
76_E150_G0.8600.17
138_A266_V0.8590.17
178_Y255_D0.8520.17
173_Y186_G0.8490.16
21_G221_A0.8420.16
235_H283_G0.8390.16
110_P180_D0.8390.16
311_P323_A0.8360.16
155_Y327_W0.8350.16
226_I338_R0.8350.16
214_I217_K0.8350.16
154_S206_S0.8300.16
182_A228_E0.8290.16
186_G291_S0.8290.16
26_K65_Q0.8220.16
167_N248_I0.8220.16
231_G278_E0.8220.16
261_A296_Q0.8210.16
112_G230_E0.8170.16
258_D316_D0.8160.16
269_L303_V0.8160.16
163_G250_N0.8160.16
220_L224_K0.8150.16
78_M256_K0.8130.16
138_A164_N0.8120.16
100_A103_L0.8120.16
27_A107_K0.8120.16
155_Y275_Q0.8120.16
18_G21_G0.8110.16
262_A293_G0.8110.16
258_D261_A0.8100.16
65_Q70_E0.8090.16
279_A282_G0.8070.16
267_S274_A0.8050.15
188_T281_K0.8040.15
77_K348_N0.8000.15
129_A243_I0.8000.15
84_C265_K0.7990.15
143_P298_E0.7960.15
191_Q203_V0.7940.15
156_I297_L0.7920.15
180_D215_N0.7850.15
155_Y295_Y0.7790.15
23_D117_V0.7780.15
19_L79_D0.7780.15
228_E330_E0.7710.15
149_D172_Y0.7690.15
94_R211_I0.7680.15
344_V348_N0.7670.15
11_I256_K0.7620.15
61_E65_Q0.7610.15
190_H331_D0.7610.15
86_N267_S0.7560.15
24_D135_V0.7550.14
170_D271_T0.7540.14
169_M173_Y0.7530.14
81_Y152_A0.7520.14
79_D147_P0.7510.14
90_I272_L0.7510.14
186_G299_A0.7430.14
190_H230_E0.7400.14
123_I127_N0.7390.14
97_A108_Q0.7330.14
246_K347_Y0.7310.14
16_S82_I0.7310.14
238_S295_Y0.7300.14
143_P245_A0.7290.14
152_A329_V0.7280.14
242_M254_Q0.7250.14
83_K283_G0.7220.14
154_S295_Y0.7210.14
176_E207_Y0.7200.14
275_Q344_V0.7200.14
141_L244_S0.7150.14
231_G340_Y0.7130.14
159_A166_I0.7100.14
230_E341_N0.7090.14
131_C178_Y0.7080.14
255_D332_S0.7070.14
175_Q180_D0.7040.14
19_L122_G0.7030.13
69_D221_A0.7010.13
111_T258_D0.6960.13
161_A199_A0.6950.13
121_Y336_A0.6920.13
182_A189_L0.6920.13
188_T344_V0.6910.13
217_K292_A0.6910.13
152_A249_N0.6900.13
86_N348_N0.6890.13
135_V167_N0.6880.13
109_G162_L0.6880.13
12_V260_E0.6870.13
188_T242_M0.6850.13
224_K259_A0.6820.13
165_T247_Q0.6780.13
81_Y207_Y0.6760.13
81_Y155_Y0.6750.13
302_Y305_R0.6720.13
261_A264_K0.6710.13
103_L204_A0.6710.13
236_Y246_K0.6710.13
257_F335_R0.6690.13
197_L217_K0.6670.13
145_L217_K0.6640.13
97_A205_E0.6640.13
209_A249_N0.6620.13
242_M245_A0.6610.13
81_Y180_D0.6610.13
166_I241_V0.6590.13
78_M215_N0.6580.13
247_Q326_S0.6570.13
219_Q345_D0.6500.13
73_V146_Q0.6490.13
211_I218_R0.6450.12
161_A281_K0.6450.12
148_I151_V0.6440.12
234_F282_G0.6420.12
78_M187_K0.6410.12
75_D79_D0.6410.12
234_F272_L0.6390.12
200_F222_E0.6390.12
143_P155_Y0.6380.12
302_Y306_I0.6380.12
251_L298_E0.6370.12
242_M278_E0.6350.12
89_Q204_A0.6340.12
138_A165_T0.6340.12
210_A344_V0.6340.12
81_Y99_Y0.6300.12
155_Y340_Y0.6290.12
246_K261_A0.6290.12
101_D258_D0.6280.12
248_I343_M0.6270.12
132_E325_S0.6270.12
135_V159_A0.6270.12
238_S271_T0.6260.12
123_I189_L0.6220.12
85_Y155_Y0.6220.12
218_R305_R0.6190.12
118_Y180_D0.6180.12
207_Y247_Q0.6170.12
214_I341_N0.6140.12
221_A281_K0.6070.12
207_Y294_Q0.6070.12
231_G267_S0.6060.12
79_D192_T0.6060.12
108_Q228_E0.6060.12
265_K296_Q0.6050.12
92_V123_I0.6010.12
303_V309_K0.6000.12
98_R102_W0.6000.12
23_D226_I0.5990.12
78_M84_C0.5990.12
221_A268_E0.5980.12
11_I148_I0.5980.12
219_Q239_L0.5970.12
111_T294_Q0.5960.12
103_L344_V0.5950.12
13_A23_D0.5920.12
215_N246_K0.5910.12
154_S229_R0.5900.12
211_I327_W0.5890.12
190_H231_G0.5870.11
11_I297_L0.5850.11
24_D66_P0.5820.11
19_L162_L0.5810.11
146_Q278_E0.5800.11
80_V299_A0.5800.11
241_V308_D0.5790.11
198_E209_A0.5780.11
79_D168_E0.5780.11
62_T282_G0.5760.11
207_Y275_Q0.5760.11
248_I261_A0.5760.11
120_I256_K0.5740.11
288_F342_E0.5740.11
140_A152_A0.5730.11
155_Y261_A0.5700.11
161_A336_A0.5690.11
113_E179_K0.5680.11
186_G214_I0.5670.11
18_G30_E0.5670.11
220_L243_I0.5660.11
169_M305_R0.5650.11
229_R323_A0.5640.11
171_K346_D0.5630.11
220_L229_R0.5610.11
82_I158_A0.5600.11
175_Q305_R0.5560.11
237_Y246_K0.5540.11
99_Y131_C0.5520.11
87_K164_N0.5500.11
187_K309_K0.5490.11
139_V153_V0.5470.11
162_L245_A0.5470.11
88_L99_Y0.5460.11
265_K275_Q0.5460.11
80_V193_F0.5450.11
87_K133_K0.5450.11
81_Y236_Y0.5440.11
89_Q96_L0.5430.11
149_D186_G0.5400.11
132_E327_W0.5370.11
131_C329_V0.5370.11
223_L252_I0.5370.11
123_I152_A0.5370.11
226_I341_N0.5360.11
22_C81_Y0.5350.11
79_D148_I0.5340.11
275_Q278_E0.5320.11
312_Y326_S0.5320.11
152_A179_K0.5320.11
160_V225_N0.5290.11
13_A232_K0.5290.11
148_I155_Y0.5290.11
129_A205_E0.5290.11
336_A341_N0.5270.11
89_Q296_Q0.5250.11
210_A277_K0.5200.10
333_F344_V0.5190.10
112_G257_F0.5190.10
160_V211_I0.5170.10
136_K342_E0.5150.10
157_D344_V0.5130.10
68_V262_A0.5120.10
293_G297_L0.5110.10
132_E272_L0.5080.10
223_L244_S0.5080.10
135_V335_R0.5070.10
105_D343_M0.5050.10
246_K333_F0.5030.10
309_K330_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ieeA 1 0.7009 97.6 0.9 Contact Map
3rh3A 1 0.6524 97.2 0.906 Contact Map
4yjwA 1 0.3989 95.7 0.921 Contact Map
1ez3A 1 0.2963 59.7 0.952 Contact Map
2ap3A 1 0.5328 48.2 0.955 Contact Map
4jwoA 1 0.6952 43.9 0.956 Contact Map
3b55A 1 0.6695 31.7 0.959 Contact Map
1fioA 1 0.2963 25.3 0.961 Contact Map
3zbiC 1 0.0798 24.5 0.962 Contact Map
4mfiA 1 0.6182 23.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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