GREMLIN Database
YIHW - Uncharacterized HTH-type transcriptional regulator YihW
UniProt: P32144 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11849
Length: 261 (249)
Sequences: 7677 (5666)
Seq/√Len: 359.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_S172_Y3.3361.00
89_A92_D3.0601.00
111_V210_V2.9411.00
141_E148_T2.7341.00
173_L204_A2.6221.00
103_T197_V2.3991.00
18_L33_L2.3451.00
213_H236_D2.2671.00
201_M225_G2.2261.00
113_R133_I2.2221.00
232_A255_I2.1691.00
208_L232_A2.0871.00
95_P98_S2.0781.00
166_A199_T2.0771.00
172_Y208_L2.0451.00
18_L22_R2.0361.00
14_Q17_M2.0241.00
101_F170_A2.0091.00
84_K110_H1.9981.00
88_E114_A1.9841.00
201_M207_I1.9531.00
223_E226_N1.9421.00
102_I108_V1.9261.00
163_S166_A1.9151.00
239_P244_K1.8951.00
172_Y206_N1.8621.00
101_F200_M1.8491.00
244_K248_Q1.7731.00
206_N232_A1.7721.00
124_I170_A1.7641.00
110_H113_R1.7581.00
96_D119_N1.7431.00
90_V174_V1.6981.00
89_A255_I1.6921.00
226_N229_Q1.6601.00
170_A200_M1.6521.00
163_S167_D1.6461.00
90_V210_V1.5931.00
144_V156_I1.5831.00
162_A195_N1.5791.00
145_P164_F1.5771.00
199_T202_A1.5671.00
171_D205_R1.5481.00
79_Q214_T1.5331.00
131_A144_V1.5321.00
111_V174_V1.5281.00
186_L209_L1.5231.00
166_A202_A1.5151.00
186_L230_V1.5071.00
36_V41_V1.4951.00
245_S249_D1.4941.00
91_A114_A1.4751.00
87_A114_A1.4531.00
24_Y62_G1.4511.00
30_L41_V1.4391.00
12_H51_Q1.4381.00
145_P156_I1.4301.00
161_A196_V1.4251.00
84_K114_A1.4211.00
15_L30_L1.4211.00
18_L25_M1.4171.00
8_G12_H1.4051.00
45_I61_A1.3981.00
123_I134_L1.3981.00
13_D17_M1.3931.00
199_T203_H1.3901.00
79_Q82_E1.3891.00
55_T64_A1.3821.00
22_R29_E1.3821.00
149_L156_I1.3801.00
93_Y208_L1.3741.00
14_Q18_L1.3731.00
104_I155_G1.3691.00
20_A63_R1.3571.00
240_P243_L1.3551.00
98_S171_D1.3541.00
213_H238_L1.3541.00
82_E236_D1.3501.00
209_L230_V1.3501.00
96_D118_H1.3461.00
93_Y234_F1.3431.00
148_T192_N1.3251.00
28_D38_T1.3091.00
57_H60_G1.3061.00
80_T110_H1.3021.00
12_H47_K1.2941.00
96_D120_H1.2931.00
123_I140_F1.2811.00
16_L53_L1.2671.00
97_G120_H1.2661.00
180_I216_Y1.2531.00
94_I115_L1.2511.00
26_N29_E1.2511.00
225_G229_Q1.2501.00
145_P161_A1.2481.00
83_K106_T1.2471.00
241_A245_S1.2451.00
206_N231_T1.2411.00
84_K113_R1.2361.00
89_A93_Y1.2361.00
93_Y255_I1.2191.00
14_Q33_L1.2091.00
39_Q43_R1.2011.00
122_R143_M1.1911.00
202_A229_Q1.1821.00
101_F203_H1.1691.00
245_S248_Q1.1671.00
177_V211_A1.1561.00
14_Q34_L1.1521.00
112_A134_L1.1411.00
216_Y239_P1.1281.00
80_T84_K1.1261.00
19_I54_I1.1261.00
17_M21_E1.1251.00
22_R33_L1.1221.00
81_E84_K1.1221.00
46_R50_E1.1181.00
82_E213_H1.1141.00
174_V208_L1.1101.00
122_R141_E1.1101.00
162_A196_V1.1071.00
177_V224_I1.0991.00
160_S164_F1.0951.00
95_P172_Y1.0941.00
16_L19_I1.0841.00
55_T62_G1.0821.00
232_A253_E1.0781.00
179_A187_M1.0771.00
19_I63_R1.0731.00
207_I230_V1.0591.00
208_L234_F1.0541.00
54_I61_A1.0431.00
143_M148_T1.0411.00
8_G47_K1.0291.00
27_I45_I1.0261.00
91_A94_I1.0191.00
47_K51_Q1.0191.00
124_I168_F1.0011.00
31_A38_T0.9951.00
90_V111_V0.9901.00
94_I174_V0.9881.00
91_A111_V0.9821.00
145_P165_V0.9761.00
102_I111_V0.9751.00
243_L246_R0.9701.00
10_P14_Q0.9651.00
112_A133_I0.9651.00
82_E86_I0.9651.00
160_S168_F0.9561.00
87_A91_A0.9461.00
180_I211_A0.9441.00
105_G108_V0.9421.00
46_R49_S0.9391.00
162_A199_T0.9391.00
108_V130_V0.9391.00
93_Y232_A0.9371.00
216_Y233_L0.9361.00
195_N198_K0.9351.00
178_G188_E0.9351.00
72_F106_T0.9331.00
181_E184_G0.9311.00
173_L200_M0.9271.00
18_L21_E0.9251.00
84_K88_E0.9251.00
107_T212_D0.9251.00
177_V209_L0.9231.00
228_A250_S0.9221.00
244_K254_I0.9201.00
194_A222_V0.9151.00
111_V114_A0.9051.00
181_E219_S0.8971.00
167_D198_K0.8971.00
29_E33_L0.8961.00
47_K50_E0.8951.00
31_A41_V0.8921.00
108_V111_V0.8911.00
86_I107_T0.8891.00
83_K215_K0.8881.00
129_R154_S0.8871.00
169_R205_R0.8871.00
79_Q212_D0.8851.00
83_K107_T0.8831.00
87_A111_V0.8721.00
107_T215_K0.8691.00
25_M61_A0.8691.00
87_A110_H0.8651.00
25_M30_L0.8591.00
246_R249_D0.8531.00
142_V149_L0.8521.00
135_Y154_S0.8491.00
48_L53_L0.8451.00
112_A130_V0.8341.00
116_L133_I0.8341.00
16_L20_A0.8291.00
205_R219_S0.8281.00
127_S130_V0.8271.00
160_S167_D0.8251.00
116_L137_N0.8171.00
165_V200_M0.8161.00
188_E194_A0.8141.00
153_N178_G0.8121.00
10_P13_D0.8111.00
174_V210_V0.8061.00
207_I231_T0.8001.00
168_F191_V0.7991.00
17_M20_A0.7961.00
169_R219_S0.7871.00
85_A88_E0.7861.00
165_V199_T0.7791.00
169_R223_E0.7791.00
75_R178_G0.7771.00
90_V234_F0.7771.00
180_I186_L0.7741.00
133_I136_H0.7711.00
79_Q213_H0.7701.00
191_V222_V0.7681.00
108_V210_V0.7681.00
46_R56_R0.7671.00
29_E32_N0.7671.00
101_F165_V0.7641.00
182_S185_A0.7601.00
116_L119_N0.7531.00
109_E133_I0.7441.00
7_T24_Y0.7421.00
132_H154_S0.7381.00
102_I112_A0.7381.00
167_D223_E0.7351.00
23_G63_R0.7331.00
102_I123_I0.7331.00
184_G219_S0.7301.00
169_R184_G0.7291.00
187_M219_S0.7291.00
177_V186_L0.7281.00
120_H139_R0.7261.00
81_E85_A0.7251.00
106_T215_K0.7220.99
239_P243_L0.7210.99
150_R193_E0.7200.99
10_P24_Y0.7200.99
12_H16_L0.7200.99
169_R203_H0.7190.99
239_P254_I0.7160.99
110_H114_A0.7160.99
7_T10_P0.7150.99
45_I56_R0.7090.99
131_A156_I0.7080.99
182_S246_R0.7030.99
131_A149_L0.7030.99
104_I153_N0.7000.99
71_A74_Q0.7000.99
146_G161_A0.6980.99
150_R157_I0.6930.99
201_M224_I0.6910.99
186_L224_I0.6910.99
173_L207_I0.6880.99
188_E224_I0.6870.99
180_I227_V0.6790.99
170_A204_A0.6760.99
28_D32_N0.6750.99
146_G164_F0.6740.99
117_N137_N0.6690.99
36_V39_Q0.6690.99
126_N200_M0.6680.99
99_T124_I0.6680.99
88_E92_D0.6680.99
211_A233_L0.6680.99
198_K202_A0.6650.99
188_E193_E0.6640.99
100_I172_Y0.6600.99
49_S56_R0.6600.99
212_D215_K0.6580.99
100_I123_I0.6570.99
16_L48_L0.6560.99
137_N140_F0.6560.99
166_A203_H0.6540.99
85_A89_A0.6530.99
208_L231_T0.6520.99
246_R250_S0.6510.99
241_A244_K0.6510.99
76_E109_E0.6490.99
163_S195_N0.6480.99
136_H154_S0.6480.99
27_I41_V0.6460.99
158_G161_A0.6450.99
30_L45_I0.6450.99
57_H62_G0.6430.99
9_N12_H0.6430.99
125_T131_A0.6430.99
39_Q127_S0.6400.99
128_L156_I0.6400.99
119_N139_R0.6380.99
175_T204_A0.6370.99
69_N75_R0.6360.99
86_I210_V0.6270.99
168_F222_V0.6260.99
19_I25_M0.6260.99
206_N253_E0.6220.98
178_G220_A0.6200.98
49_S54_I0.6190.98
242_A246_R0.6180.98
109_E129_R0.6180.98
225_G230_V0.6150.98
159_P163_S0.6140.98
204_A207_I0.6130.98
159_P195_N0.6110.98
34_L41_V0.6080.98
120_H141_E0.6020.98
128_L144_V0.6010.98
7_T57_H0.6010.98
11_R44_D0.5970.98
124_I221_A0.5960.98
194_A224_I0.5950.98
213_H239_P0.5880.98
94_I111_V0.5880.98
105_G176_S0.5850.98
103_T108_V0.5850.98
150_R190_D0.5840.98
76_E110_H0.5810.98
189_F220_A0.5800.98
129_R132_H0.5780.98
159_P162_A0.5760.98
192_N195_N0.5750.98
161_A164_F0.5750.98
128_L132_H0.5740.97
162_A166_A0.5720.97
178_G193_E0.5710.97
243_L247_L0.5710.97
99_T221_A0.5660.97
127_S193_E0.5620.97
175_T224_I0.5610.97
178_G189_F0.5600.97
100_I174_V0.5570.97
159_P192_N0.5570.97
15_L34_L0.5530.97
75_R193_E0.5520.97
186_L225_G0.5500.97
124_I143_M0.5490.97
82_E238_L0.5480.97
100_I111_V0.5480.97
85_A237_E0.5470.97
197_V224_I0.5470.97
176_S188_E0.5460.97
207_I229_Q0.5410.96
196_V199_T0.5410.96
101_F173_L0.5410.96
216_Y243_L0.5400.96
175_T207_I0.5400.96
69_N150_R0.5390.96
83_K212_D0.5370.96
105_G178_G0.5360.96
39_Q178_G0.5360.96
32_N35_D0.5340.96
73_E76_E0.5330.96
43_R180_I0.5320.96
163_S198_K0.5300.96
181_E187_M0.5300.96
155_G193_E0.5270.96
216_Y235_T0.5260.96
179_A218_A0.5240.96
178_G197_V0.5220.96
105_G127_S0.5210.96
188_E197_V0.5190.95
182_S243_L0.5190.95
179_A220_A0.5170.95
175_T201_M0.5150.95
101_F124_I0.5110.95
102_I130_V0.5110.95
156_I164_F0.5100.95
160_S163_S0.5090.95
27_I31_A0.5080.95
238_L244_K0.5070.95
241_A248_Q0.5020.95
143_M160_S0.5020.95
82_E85_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.931 100 0.518 Contact Map
3rrlB 1 0.6628 100 0.536 Contact Map
2w48A 3 0.9693 100 0.585 Contact Map
3l7oA 2 0.5939 100 0.616 Contact Map
1o8bA 2 0.5824 100 0.626 Contact Map
1uj6A 2 0.6015 100 0.63 Contact Map
1lk5A 4 0.6015 100 0.631 Contact Map
1m0sA 2 0.6054 100 0.631 Contact Map
3uw1A 2 0.613 100 0.635 Contact Map
3ixqA 4 0.6169 100 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.