GREMLIN Database
SQUV - Sulfofructose kinase
UniProt: P32143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11848
Length: 298 (278)
Sequences: 22519 (16694)
Seq/√Len: 1001.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A252_V3.0701.00
134_L158_V2.7391.00
71_L86_R2.5881.00
213_Q219_D2.5341.00
56_D80_N2.5131.00
220_W264_V2.4991.00
253_A258_G2.3591.00
5_A130_W2.3321.00
259_D262_E2.3061.00
218_C246_F2.2191.00
148_T174_L2.1281.00
68_N86_R2.0921.00
202_Q221_L2.0461.00
48_A53_A2.0141.00
60_R87_Y1.9931.00
50_R77_W1.9731.00
158_V251_A1.9641.00
182_E213_Q1.9541.00
150_A155_V1.9411.00
6_C45_A1.9401.00
253_A266_F1.9251.00
227_Q261_A1.9221.00
245_V270_V1.8851.00
286_D289_Q1.8651.00
147_F157_T1.8491.00
46_V77_W1.8331.00
132_V156_M1.8081.00
220_W227_Q1.8051.00
258_G262_E1.7991.00
60_R121_W1.7971.00
179_A247_H1.7911.00
156_M176_D1.7751.00
176_D207_G1.7621.00
75_E81_T1.7611.00
47_A248_G1.7611.00
256_T287_C1.7491.00
198_L221_L1.7261.00
218_C268_S1.7031.00
73_E76_S1.6731.00
132_V158_V1.6651.00
242_A275_C1.6561.00
219_D228_H1.6501.00
271_A275_C1.6391.00
71_L75_E1.6351.00
250_L263_S1.6231.00
261_A265_R1.6221.00
213_Q228_H1.6191.00
72_A76_S1.6181.00
144_K170_E1.6051.00
249_A270_V1.5981.00
177_H208_H1.5961.00
277_R289_Q1.5891.00
145_K148_T1.5861.00
232_F269_G1.5651.00
200_Q204_L1.5561.00
210_Y250_L1.5411.00
149_L153_A1.5271.00
10_T59_G1.5091.00
48_A252_V1.4911.00
208_H222_E1.4901.00
186_A192_K1.4891.00
132_V251_A1.4821.00
200_Q203_T1.4771.00
220_W260_L1.4771.00
68_N72_A1.4711.00
35_E69_S1.4641.00
238_D279_G1.4621.00
63_D68_N1.4561.00
213_Q216_A1.4551.00
222_E225_G1.4401.00
4_V48_A1.4351.00
229_Q264_V1.4241.00
145_K149_L1.4241.00
249_A266_F1.4191.00
37_G70_L1.4101.00
90_A116_L1.4061.00
151_R176_D1.3971.00
195_A199_K1.3721.00
193_E196_S1.3721.00
144_K148_T1.3661.00
160_D212_T1.3561.00
161_G180_F1.3531.00
149_L152_Q1.3481.00
42_A74_L1.3391.00
232_F265_R1.3321.00
175_S178_A1.3271.00
191_V200_Q1.3261.00
12_M69_S1.3241.00
229_Q268_S1.3201.00
156_M177_H1.3191.00
151_R174_L1.3171.00
199_K203_T1.3141.00
195_A226_R1.3101.00
127_F130_W1.3091.00
63_D86_R1.3081.00
54_Q80_N1.2921.00
67_G92_S1.2791.00
14_R33_Y1.2691.00
71_L84_T1.2661.00
169_S204_L1.2641.00
128_S153_A1.2521.00
234_V276_T1.2371.00
249_A267_A1.2301.00
208_H254_L1.2241.00
73_E77_W1.2231.00
218_C264_V1.2211.00
37_G73_E1.2161.00
252_V256_T1.2161.00
156_M207_G1.2101.00
118_D121_W1.2091.00
213_Q217_G1.2011.00
250_L254_L1.1891.00
87_Y90_A1.1871.00
208_H260_L1.1781.00
179_A212_T1.1771.00
212_T246_F1.1711.00
119_A145_K1.1701.00
202_Q223_N1.1661.00
253_A263_S1.1651.00
208_H250_L1.1601.00
232_F268_S1.1571.00
14_R35_E1.1541.00
199_K221_L1.1511.00
234_V275_C1.1491.00
262_E265_R1.1441.00
191_V196_S1.1411.00
69_S72_A1.1361.00
49_A79_V1.1311.00
51_L249_A1.1301.00
68_N71_L1.1281.00
250_L267_A1.1251.00
236_V275_C1.1221.00
65_D68_N1.1221.00
135_A157_T1.1171.00
53_A255_A1.1151.00
273_L276_T1.1131.00
72_A75_E1.1001.00
133_V150_A1.0991.00
185_L211_V1.0881.00
45_A55_V1.0841.00
48_A55_V1.0811.00
177_H250_L1.0691.00
44_A134_L1.0671.00
232_F272_A1.0651.00
273_L277_R1.0611.00
63_D89_Q1.0591.00
134_L251_A1.0571.00
185_L197_A1.0481.00
236_V239_T1.0441.00
196_S199_K1.0441.00
46_V50_R1.0391.00
253_A256_T1.0341.00
177_H254_L1.0311.00
106_I109_N1.0311.00
198_L211_V1.0271.00
53_A256_T1.0251.00
148_T152_Q1.0171.00
182_E216_A1.0171.00
221_L226_R1.0141.00
10_T70_L1.0061.00
208_H220_W0.9991.00
268_S271_A0.9981.00
47_A245_V0.9961.00
56_D83_Y0.9931.00
87_Y116_L0.9921.00
105_R109_N0.9891.00
245_V274_K0.9861.00
159_L175_S0.9771.00
189_T197_A0.9771.00
179_A250_L0.9761.00
250_L260_L0.9741.00
56_D130_W0.9741.00
134_L247_H0.9691.00
207_G223_N0.9651.00
49_A78_G0.9651.00
141_D145_K0.9631.00
133_V155_V0.9621.00
37_G69_S0.9591.00
6_C41_A0.9591.00
15_I36_V0.9591.00
61_V67_G0.9571.00
265_R269_G0.9561.00
69_S73_E0.9561.00
231_A268_S0.9511.00
64_D92_S0.9501.00
199_K226_R0.9471.00
263_S267_A0.9451.00
16_Y96_A0.9431.00
48_A248_G0.9411.00
123_E145_K0.9401.00
252_V287_C0.9401.00
5_A58_I0.9361.00
62_G92_S0.9311.00
51_L270_V0.9291.00
81_T84_T0.9281.00
61_V71_L0.9271.00
14_R66_T0.9251.00
135_A147_F0.9161.00
111_P114_D0.9141.00
10_T42_A0.9131.00
252_V266_F0.9121.00
130_W155_V0.9101.00
258_G266_F0.9071.00
71_L81_T0.9021.00
107_I110_Y0.8991.00
182_E186_A0.8971.00
236_V276_T0.8971.00
49_A54_Q0.8971.00
7_V133_V0.8911.00
61_V84_T0.8901.00
10_T57_F0.8901.00
181_S184_G0.8891.00
14_R94_Q0.8881.00
216_A228_H0.8721.00
225_G261_A0.8711.00
229_Q265_R0.8681.00
237_V278_P0.8631.00
148_T170_E0.8621.00
235_D276_T0.8561.00
254_L263_S0.8551.00
217_G231_A0.8551.00
127_F155_V0.8521.00
71_L85_K0.8511.00
56_D126_D0.8461.00
180_F185_L0.8401.00
259_D263_S0.8381.00
160_D179_A0.8361.00
172_V175_S0.8241.00
42_A281_R0.8231.00
106_I110_Y0.8211.00
246_F268_S0.8171.00
60_R85_K0.8171.00
44_A247_H0.8081.00
245_V249_A0.8061.00
11_V93_S0.8061.00
170_E173_A0.8061.00
199_K202_Q0.8051.00
5_A56_D0.8051.00
249_A253_A0.8051.00
198_L209_V0.8031.00
229_Q261_A0.8021.00
30_A108_I0.8021.00
223_N226_R0.7981.00
70_L92_S0.7911.00
245_V271_A0.7911.00
196_S200_Q0.7901.00
160_D180_F0.7901.00
227_Q264_V0.7871.00
61_V86_R0.7831.00
4_V255_A0.7761.00
158_V179_A0.7741.00
198_L202_Q0.7731.00
13_D38_G0.7661.00
104_E107_I0.7651.00
234_V272_A0.7641.00
135_A143_A0.7551.00
49_A55_V0.7511.00
45_A57_F0.7491.00
12_M66_T0.7481.00
197_A201_A0.7471.00
142_G146_A0.7441.00
222_E260_L0.7441.00
268_S272_A0.7421.00
132_V255_A0.7371.00
85_K121_W0.7371.00
269_G273_L0.7341.00
35_E66_T0.7341.00
56_D82_R0.7311.00
12_M35_E0.7301.00
46_V281_R0.7261.00
7_V146_A0.7261.00
64_D67_G0.7241.00
173_A204_L0.7241.00
51_L252_V0.7201.00
121_W124_E0.7201.00
271_A274_K0.7191.00
137_V159_L0.7121.00
273_L289_Q0.6991.00
266_F287_C0.6971.00
158_V177_H0.6931.00
144_K174_L0.6931.00
100_D104_E0.6871.00
195_A228_H0.6861.00
202_Q222_E0.6851.00
114_D117_P0.6851.00
51_L266_F0.6821.00
97_I107_I0.6801.00
246_F264_V0.6781.00
66_T94_Q0.6771.00
210_Y220_W0.6731.00
104_E110_Y0.6731.00
97_I240_T0.6711.00
222_E227_Q0.6671.00
73_E281_R0.6661.00
215_S233_K0.6611.00
185_L201_A0.6611.00
38_G43_T0.6601.00
158_V247_H0.6571.00
54_Q131_D0.6531.00
146_A150_A0.6491.00
246_F271_A0.6471.00
147_F174_L0.6471.00
34_T278_P0.6451.00
258_G263_S0.6451.00
195_A221_L0.6401.00
246_F267_A0.6381.00
21_L106_I0.6381.00
217_G228_H0.6361.00
120_E123_E0.6351.00
194_M213_Q0.6351.00
65_D69_S0.6321.00
24_E104_E0.6321.00
40_P162_D0.6311.00
169_S173_A0.6281.00
117_P122_L0.6271.00
16_Y30_A0.6251.00
45_A79_V0.6221.00
194_M197_A0.6191.00
264_V268_S0.6101.00
141_D144_K0.6081.00
77_W286_D0.6071.00
131_D155_V0.6061.00
111_P115_L0.6051.00
59_G84_T0.6031.00
98_M106_I0.6021.00
83_Y86_R0.6001.00
9_I138_R0.5991.00
42_A57_F0.5991.00
166_Q169_S0.5981.00
98_M108_I0.5981.00
248_G252_V0.5961.00
144_K147_F0.5961.00
257_S263_S0.5951.00
194_M198_L0.5931.00
191_V197_A0.5931.00
4_V53_A0.5901.00
229_Q232_F0.5891.00
195_A219_D0.5871.00
132_V177_H0.5861.00
5_A8_G0.5851.00
157_T175_S0.5821.00
90_A113_P0.5801.00
48_A251_A0.5791.00
117_P121_W0.5791.00
218_C229_Q0.5761.00
202_Q205_T0.5761.00
178_A209_V0.5741.00
44_A251_A0.5711.00
16_Y33_Y0.5701.00
210_Y246_F0.5701.00
119_A142_G0.5691.00
179_A210_Y0.5691.00
113_P116_L0.5681.00
124_E149_L0.5681.00
65_D72_A0.5681.00
195_A198_L0.5641.00
51_L248_G0.5641.00
119_A123_E0.5631.00
24_E100_D0.5621.00
37_G281_R0.5601.00
68_N75_E0.5591.00
202_Q224_G0.5581.00
262_E266_F0.5581.00
27_K40_P0.5581.00
119_A141_D0.5561.00
93_S114_D0.5551.00
40_P138_R0.5541.00
105_R110_Y0.5541.00
133_V146_A0.5521.00
240_T280_G0.5511.00
185_L194_M0.5501.00
260_L263_S0.5491.00
87_Y121_W0.5471.00
22_P26_G0.5451.00
120_E124_E0.5431.00
150_A157_T0.5431.00
215_S236_V0.5431.00
74_L79_V0.5411.00
63_D87_Y0.5371.00
182_E214_G0.5361.00
54_Q255_A0.5341.00
132_V254_L0.5321.00
9_I162_D0.5321.00
183_P187_R0.5311.00
222_E226_R0.5311.00
125_I128_S0.5301.00
180_F212_T0.5291.00
123_E126_D0.5261.00
44_A248_G0.5211.00
140_H167_D0.5211.00
49_A77_W0.5211.00
160_D244_D0.5201.00
212_T244_D0.5191.00
189_T200_Q0.5181.00
260_L264_V0.5151.00
176_D208_H0.5151.00
55_V79_V0.5151.00
198_L201_A0.5141.00
214_G239_T0.5121.00
254_L257_S0.5111.00
143_A146_A0.5101.00
131_D156_M0.5101.00
202_Q209_V0.5101.00
43_T280_G0.5101.00
185_L221_L0.5091.00
126_D130_W0.5081.00
42_A46_V0.5071.00
151_R154_G0.5071.00
4_V132_V0.5061.00
219_D226_R0.5041.00
147_F171_L0.5041.00
95_S109_N0.5031.00
197_A200_Q0.5031.00
41_A45_A0.5021.00
167_D170_E0.5021.00
112_S115_L0.5021.00
150_A154_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 1 100 0.126 Contact Map
3ry7A 2 0.9832 100 0.159 Contact Map
4xdaA 2 1 100 0.162 Contact Map
2fv7A 2 0.9899 100 0.166 Contact Map
1rkdA 2 1 100 0.173 Contact Map
1vm7A 2 0.9765 100 0.173 Contact Map
3ljsA 2 0.9732 100 0.174 Contact Map
3ikhA 2 0.943 100 0.179 Contact Map
3vasA 1 0.9664 100 0.18 Contact Map
3iq0A 2 0.9832 100 0.182 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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