GREMLIN Database
SQUT - Sulfofructosephosphate aldolase
UniProt: P32141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11846
Length: 292 (259)
Sequences: 690 (449)
Seq/√Len: 27.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_L183_E5.4711.00
222_W246_A4.1741.00
160_P180_A4.1691.00
239_R286_E3.9951.00
265_N268_M3.9521.00
54_K266_E3.8061.00
183_E186_D3.4211.00
231_E279_Q3.3941.00
51_N269_L3.1271.00
267_L271_D2.9281.00
158_I189_A2.9111.00
142_V184_L2.6931.00
236_R239_R2.5440.99
182_K213_R2.4760.99
275_P279_Q2.4080.99
209_C213_R2.4070.99
274_A278_Q2.3530.99
99_I137_Q2.2770.98
112_P123_L2.2000.98
28_R69_F2.1270.97
282_D286_E2.1010.97
204_Q208_L2.0970.97
107_D110_I2.0610.97
117_Q188_G2.0580.97
175_Q179_D2.0560.97
232_K236_R2.0370.97
18_M250_L1.9920.96
178_I217_H1.9650.96
90_A145_F1.9480.96
26_A257_A1.8620.94
136_Q140_D1.8520.94
33_A261_G1.8170.94
56_L228_G1.8070.94
182_K186_D1.7920.93
60_A277_L1.7840.93
55_A266_E1.7570.93
175_Q178_I1.7520.92
50_V54_K1.7370.92
186_D215_N1.7300.92
19_L60_A1.6710.91
142_V158_I1.6680.90
19_L52_A1.6610.90
205_Q272_V1.6440.90
278_Q282_D1.6310.89
165_P168_G1.6280.89
54_K270_R1.6170.89
100_P141_M1.5870.88
41_A44_V1.5850.88
129_W184_L1.5640.87
134_D160_P1.5610.87
71_Y118_D1.5480.87
130_R176_A1.5430.87
123_L158_I1.5430.87
139_L184_L1.5230.86
27_M73_Q1.5170.86
157_I284_V1.5150.86
86_M121_K1.4850.84
123_L145_F1.4800.84
205_Q209_C1.4690.84
54_K78_N1.4480.83
174_E200_G1.4480.83
45_L69_F1.4110.81
56_L63_I1.4110.81
30_M228_G1.4110.81
233_L236_R1.3970.80
179_D182_K1.3930.80
143_K147_E1.3740.79
235_P283_I1.3710.79
147_E232_K1.3550.78
26_A161_V1.3480.78
129_W183_E1.3390.78
55_A270_R1.3170.76
224_I246_A1.3160.76
209_C212_Q1.2960.75
137_Q239_R1.2930.75
97_N139_L1.2860.75
232_K282_D1.2770.74
47_D50_V1.2750.74
129_W135_A1.2740.74
258_S262_L1.2560.73
236_R240_V1.2520.73
16_F250_L1.2460.72
54_K205_Q1.2410.72
50_V78_N1.2360.72
231_E235_P1.2360.72
62_A161_V1.2270.71
79_A195_E1.2150.70
17_A285_D1.1990.69
195_E255_V1.1880.68
50_V212_Q1.1850.68
100_P133_E1.1810.68
208_L244_A1.1600.67
16_F115_I1.1600.67
88_V185_G1.1580.66
40_V44_V1.1560.66
239_R243_T1.1540.66
228_G257_A1.1400.65
96_G133_E1.1390.65
100_P145_F1.1360.65
259_V272_V1.1250.64
258_S272_V1.1170.64
232_K239_R1.1150.63
178_I210_A1.1140.63
80_I121_K1.1100.63
32_A42_D1.1060.63
262_L272_V1.1040.63
43_S209_C1.0960.62
140_D143_K1.0870.61
272_V275_P1.0650.60
231_E276_K1.0650.60
258_S276_K1.0640.60
195_E277_L1.0570.59
127_V156_S1.0560.59
19_L30_M1.0550.59
50_V72_R1.0510.59
52_A259_V1.0400.58
116_K154_L1.0390.58
26_A34_A1.0390.58
48_F144_E1.0310.57
113_L152_H1.0290.57
109_K136_Q1.0250.57
52_A273_C1.0170.56
70_C94_I1.0070.55
125_L160_P1.0050.55
181_A194_V0.9970.55
34_A257_A0.9860.54
107_D145_F0.9830.54
15_G285_D0.9810.54
12_A43_S0.9770.53
136_Q205_Q0.9730.53
134_D239_R0.9700.53
67_Q110_I0.9600.52
149_C190_D0.9580.52
209_C271_D0.9570.52
19_L132_D0.9560.52
44_V47_D0.9480.51
21_V48_F0.9480.51
213_R286_E0.9450.51
190_D195_E0.9420.51
235_P279_Q0.9380.50
62_A250_L0.9370.50
200_G203_P0.9260.49
137_Q140_D0.9250.49
102_D163_R0.9230.49
129_W139_L0.9230.49
162_V180_A0.8990.47
58_P267_L0.8970.47
81_A84_C0.8960.47
169_D232_K0.8950.47
57_S82_K0.8950.47
19_L277_L0.8940.47
139_L186_D0.8920.47
269_L273_C0.8920.47
13_S285_D0.8890.46
55_A59_Y0.8870.46
141_M180_A0.8870.46
205_Q267_L0.8820.46
116_K151_S0.8810.46
19_L63_I0.8790.46
51_N123_L0.8750.45
169_D201_K0.8710.45
101_V133_E0.8700.45
25_E90_A0.8690.45
120_G194_V0.8680.45
58_P286_E0.8640.45
48_F133_E0.8620.44
28_R42_D0.8570.44
201_K244_A0.8530.44
33_A40_V0.8530.44
266_E270_R0.8520.44
58_P274_A0.8490.43
85_A221_P0.8480.43
112_P115_I0.8470.43
59_Y164_P0.8460.43
140_D283_I0.8450.43
42_D69_F0.8450.43
67_Q149_C0.8420.43
67_Q102_D0.8280.42
181_A207_L0.8270.42
69_F140_D0.8220.41
179_D209_C0.8080.40
138_R249_F0.8000.40
212_Q216_D0.7940.39
33_A45_L0.7940.39
271_D275_P0.7910.39
117_Q284_V0.7880.39
52_A195_E0.7880.39
129_W180_A0.7830.39
32_A260_V0.7810.38
136_Q139_L0.7790.38
47_D282_D0.7770.38
30_M56_L0.7760.38
157_I191_L0.7740.38
40_V261_G0.7720.38
201_K207_L0.7680.37
47_D286_E0.7670.37
263_P278_Q0.7660.37
203_P217_H0.7590.37
92_E99_I0.7590.37
47_D54_K0.7500.36
239_R282_D0.7500.36
169_D206_E0.7490.36
32_A40_V0.7450.36
83_S169_D0.7450.36
259_V276_K0.7440.36
97_N161_V0.7410.36
119_G197_P0.7350.35
185_G220_M0.7350.35
19_L255_V0.7350.35
74_V86_M0.7350.35
267_L270_R0.7340.35
130_R251_A0.7320.35
88_V118_D0.7300.35
81_A120_G0.7290.35
155_V220_M0.7260.35
12_A239_R0.7250.34
94_I241_A0.7250.34
24_R126_L0.7240.34
89_A237_A0.7240.34
182_K283_I0.7210.34
183_E187_S0.7200.34
44_V118_D0.7200.34
18_M122_A0.7190.34
161_V274_A0.7180.34
18_M197_P0.7160.34
26_A70_C0.7140.34
168_G283_I0.7130.34
62_A131_S0.7130.34
20_A24_R0.7050.33
45_L118_D0.7020.33
221_P256_W0.7010.33
16_F62_A0.6970.33
11_R113_L0.6930.32
251_A256_W0.6920.32
123_L149_C0.6900.32
143_K268_M0.6890.32
131_S242_M0.6850.32
272_V276_K0.6850.32
196_M229_V0.6750.31
163_R195_E0.6740.31
53_A63_I0.6700.31
149_C264_D0.6690.31
115_I120_G0.6690.31
127_V164_P0.6680.31
43_S50_V0.6670.31
56_L269_L0.6670.31
272_V285_D0.6650.30
43_S134_D0.6640.30
136_Q285_D0.6630.30
213_R268_M0.6580.30
196_M234_F0.6570.30
162_V177_I0.6520.30
43_S83_S0.6460.29
25_E28_R0.6460.29
39_P260_V0.6450.29
15_G189_A0.6440.29
222_W256_W0.6430.29
215_N224_I0.6430.29
279_Q282_D0.6410.29
98_G216_D0.6380.29
21_V63_I0.6370.29
102_D146_N0.6350.29
78_N217_H0.6340.28
27_M212_Q0.6340.28
264_D268_M0.6310.28
162_V176_A0.6270.28
126_L161_V0.6260.28
65_V102_D0.6250.28
271_D282_D0.6250.28
69_F282_D0.6240.28
195_E223_V0.6220.28
100_P142_V0.6200.28
243_T271_D0.6200.28
25_E94_I0.6180.27
169_D199_Y0.6180.27
174_E255_V0.6180.27
201_K212_Q0.6180.27
54_K275_P0.6170.27
43_S282_D0.6170.27
128_L228_G0.6160.27
94_I128_L0.6160.27
22_D49_K0.6150.27
91_D190_D0.6150.27
251_A280_L0.6120.27
71_Y125_L0.6100.27
27_M123_L0.6090.27
93_F128_L0.6080.27
19_L59_Y0.6080.27
79_A261_G0.6080.27
101_V250_L0.6070.27
109_K151_S0.6060.27
212_Q245_G0.6060.27
174_E195_E0.6050.27
88_V125_L0.6050.27
234_F250_L0.6050.27
79_A109_K0.6000.26
228_G245_G0.5990.26
110_I153_G0.5970.26
21_V65_V0.5960.26
181_A223_V0.5960.26
132_D148_L0.5950.26
132_D179_D0.5950.26
182_K245_G0.5950.26
33_A263_P0.5930.26
132_D280_L0.5890.26
210_A213_R0.5880.26
119_G245_G0.5870.26
167_R205_Q0.5860.26
11_R145_F0.5800.25
177_I195_E0.5790.25
46_T271_D0.5790.25
131_S265_N0.5740.25
206_E271_D0.5740.25
127_V135_A0.5740.25
185_G189_A0.5730.25
63_I67_Q0.5730.25
22_D193_K0.5720.25
48_F68_Q0.5720.25
163_R273_C0.5700.25
58_P182_K0.5670.24
43_S47_D0.5650.24
71_Y88_V0.5640.24
34_A44_V0.5620.24
208_L239_R0.5610.24
19_L257_A0.5590.24
27_M228_G0.5580.24
200_G205_Q0.5570.24
25_E174_E0.5570.24
175_Q232_K0.5550.24
57_S273_C0.5530.24
26_A167_R0.5520.24
101_V190_D0.5500.24
108_R141_M0.5490.23
90_A156_S0.5490.23
82_K282_D0.5470.23
42_D46_T0.5470.23
89_A158_I0.5420.23
80_I120_G0.5420.23
147_E283_I0.5400.23
248_G252_G0.5380.23
159_E225_L0.5380.23
159_E248_G0.5380.23
225_L252_G0.5380.23
225_L248_G0.5380.23
159_E252_G0.5380.23
42_D180_A0.5380.23
99_I239_R0.5380.23
186_D263_P0.5380.23
71_Y74_V0.5360.23
14_G153_G0.5350.23
41_A97_N0.5330.23
68_Q223_V0.5320.23
102_D244_A0.5320.23
93_F227_S0.5320.23
86_M271_D0.5290.22
92_E102_D0.5280.22
26_A95_P0.5240.22
23_Q27_M0.5240.22
11_R17_A0.5240.22
169_D286_E0.5230.22
22_D64_L0.5220.22
87_I122_A0.5220.22
115_I123_L0.5200.22
186_D262_L0.5190.22
136_Q206_E0.5170.22
53_A73_Q0.5170.22
72_R132_D0.5160.22
137_Q199_Y0.5150.22
131_S232_K0.5140.22
201_K243_T0.5120.21
182_K215_N0.5120.21
97_N260_V0.5110.21
283_I286_E0.5110.21
185_G219_N0.5090.21
141_M145_F0.5090.21
164_P201_K0.5080.21
100_P144_E0.5070.21
32_A39_P0.5070.21
141_M222_W0.5070.21
63_I119_G0.5070.21
108_R147_E0.5060.21
95_P148_L0.5060.21
196_M237_A0.5050.21
167_R200_G0.5030.21
48_F260_V0.5020.21
47_D209_C0.5010.21
95_P227_S0.5010.21
47_D136_Q0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1to3A 2 0.9863 100 0.423 Contact Map
3iv3A 2 0.9829 100 0.438 Contact Map
3fokA 3 0.8562 100 0.649 Contact Map
4mozA 5 0.9178 99.9 0.725 Contact Map
3glcA 6 0.8219 99.7 0.813 Contact Map
1w8sA 4 0.8459 99.6 0.818 Contact Map
2qjgA 6 0.8562 99.2 0.855 Contact Map
3r12A 2 0.7774 97.6 0.912 Contact Map
3oa3A 2 0.774 97.6 0.912 Contact Map
3ngjA 4 0.7432 97.2 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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