GREMLIN Database
SQUS - Sulfoquinovose isomerase
UniProt: P32140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11845
Length: 413 (366)
Sequences: 1645 (1153)
Seq/√Len: 60.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_D225_N6.1291.00
365_D369_K4.6881.00
57_L78_G4.3591.00
37_G41_Q4.1311.00
76_D128_H3.5671.00
202_S206_H3.3441.00
14_E18_D3.2991.00
25_K74_L3.2021.00
76_D80_K3.1481.00
91_Y160_E3.0671.00
311_R366_A3.0201.00
103_V106_A2.9911.00
335_R339_T2.9271.00
322_M348_C2.8731.00
80_K84_G2.7611.00
50_L86_L2.7071.00
148_S151_E2.5591.00
106_A160_E2.4961.00
64_A72_Y2.4211.00
291_A313_R2.4111.00
87_R137_Y2.3561.00
23_F40_G2.3401.00
61_S75_V2.2551.00
83_N134_L2.2521.00
286_V340_W2.2441.00
283_N336_Q2.2201.00
21_F63_A2.2011.00
253_G282_F2.1691.00
114_F180_A2.1161.00
16_E22_D2.1141.00
132_R136_D2.0971.00
72_Y76_D2.0631.00
198_I263_L2.0631.00
303_D307_K2.0421.00
50_L112_Q2.0401.00
88_D108_K2.0081.00
291_A296_D1.9721.00
329_Y338_E1.9471.00
282_F340_W1.9411.00
205_I277_D1.9021.00
133_K137_Y1.8971.00
260_H331_V1.8881.00
65_A126_T1.8561.00
176_H179_E1.8491.00
93_G108_K1.8261.00
115_F251_E1.8251.00
186_D262_A1.8181.00
140_E192_K1.8151.00
111_Y172_N1.8001.00
83_N130_E1.7700.99
69_P73_S1.7620.99
33_F78_G1.7420.99
29_V74_L1.7310.99
297_G313_R1.7270.99
51_W112_Q1.7200.99
299_V313_R1.7170.99
152_Q199_R1.7150.99
347_Y368_N1.7120.99
354_D375_W1.7040.99
94_W116_A1.6970.99
65_A122_S1.6960.99
340_W343_T1.6880.99
201_A259_I1.6760.99
216_V252_W1.6510.99
124_V132_R1.6510.99
64_A75_V1.6480.99
16_E19_R1.6470.99
279_K328_L1.6460.99
198_I271_P1.6320.99
143_E196_R1.6300.99
147_W199_R1.6260.99
47_G97_C1.6220.99
300_Y310_V1.6180.99
148_S155_L1.6100.99
115_F175_M1.5880.99
76_D129_P1.5690.99
185_Y194_L1.5610.99
62_V122_S1.5490.98
283_N337_Y1.5400.98
57_L61_S1.5390.98
179_E255_L1.5170.98
312_E371_T1.5130.98
13_L16_E1.5130.98
153_M203_V1.4970.98
342_Q346_E1.4950.98
56_M380_D1.4870.98
47_G104_V1.4820.98
61_S123_A1.4780.98
88_D91_Y1.4640.98
111_Y115_F1.4510.98
15_Q19_R1.4490.98
279_K334_D1.4430.98
97_C104_V1.4210.97
57_L79_I1.4140.97
63_A71_A1.4050.97
172_N179_E1.3930.97
143_E154_C1.3810.97
76_D123_A1.3770.97
108_K113_H1.3760.97
34_G42_I1.3470.96
65_A125_T1.3430.96
284_A287_R1.3420.96
123_A131_A1.3360.96
111_Y176_H1.3260.96
117_L184_V1.3140.96
332_T337_Y1.3130.96
111_Y179_E1.2970.95
50_L82_M1.2960.95
248_H383_H1.2950.95
88_D95_Y1.2900.95
282_F325_A1.2890.95
75_V123_A1.2860.95
64_A126_T1.2790.95
125_T186_D1.2790.95
364_L368_N1.2760.95
244_G249_W1.2730.95
79_I123_A1.2680.95
30_P48_T1.2620.95
185_Y188_T1.2480.94
312_E363_E1.2440.94
86_L98_V1.2410.94
117_L135_L1.2320.94
291_A297_G1.2280.94
194_L198_I1.2090.93
33_F57_L1.2050.93
94_W138_T1.1930.93
129_P133_K1.1900.93
315_R379_Q1.1880.93
54_A119_G1.1800.93
159_D164_K1.1770.92
390_I393_I1.1760.92
23_F36_L1.1760.92
122_S183_I1.1680.92
25_K60_Y1.1670.92
210_R217_N1.1670.92
176_H251_E1.1650.92
220_F224_W1.1640.92
319_V387_C1.1640.92
125_T187_V1.1620.92
95_Y108_K1.1610.92
250_I298_I1.1570.92
183_I186_D1.1560.92
263_L271_P1.1520.92
359_S375_W1.1250.91
33_F74_L1.1230.91
172_N382_Y1.1100.90
282_F324_T1.1040.90
88_D93_G1.0970.89
321_A344_W1.0960.89
96_A112_Q1.0940.89
95_Y103_V1.0930.89
91_Y108_K1.0840.89
122_S125_T1.0810.89
204_I216_V1.0800.89
178_V201_A1.0770.89
111_Y248_H1.0760.89
142_I177_A1.0680.88
111_Y251_E1.0670.88
48_T81_A1.0670.88
215_R288_D1.0660.88
175_M246_P1.0630.88
322_M387_C1.0630.88
133_K136_D1.0550.88
57_L123_A1.0520.87
92_G137_Y1.0500.87
288_D306_G1.0490.87
258_H390_I1.0390.87
75_V128_H1.0370.87
18_D68_R1.0360.87
279_K283_N1.0350.87
203_V207_D1.0350.87
140_E144_K1.0320.86
35_W374_V1.0300.86
176_H255_L1.0250.86
322_M341_Y1.0200.86
25_K70_G1.0180.86
59_V385_L1.0160.85
35_W43_K1.0110.85
221_D227_L1.0060.85
58_H122_S1.0050.85
191_K195_D1.0040.85
24_G381_I1.0020.85
363_E371_T1.0020.85
170_G219_H0.9990.85
206_H277_D0.9960.84
339_T342_Q0.9950.84
175_M218_E0.9910.84
210_R213_H0.9900.84
178_V259_I0.9900.84
29_V77_H0.9860.84
284_A288_D0.9850.84
55_R383_H0.9830.84
15_Q22_D0.9770.83
375_W379_Q0.9680.83
81_A86_L0.9680.83
172_N176_H0.9670.83
117_L142_I0.9660.82
134_L137_Y0.9660.82
319_V348_C0.9650.82
179_E382_Y0.9650.82
351_Y368_N0.9540.82
194_L197_A0.9510.81
279_K337_Y0.9510.81
24_G60_Y0.9490.81
58_H386_H0.9490.81
209_A281_L0.9450.81
176_H382_Y0.9430.81
259_I263_L0.9410.81
115_F248_H0.9390.81
125_T393_I0.9360.80
252_W281_L0.9350.80
250_I321_A0.9340.80
81_A85_A0.9300.80
330_T338_E0.9290.80
172_N255_L0.9220.79
120_A134_L0.9170.79
135_L184_V0.9090.78
201_A256_M0.9080.78
38_N376_D0.9080.78
171_G252_W0.9070.78
330_T394_P0.9060.78
153_M156_E0.9040.78
110_G146_F0.9040.78
140_E190_D0.9040.78
218_E246_P0.9030.78
247_G316_W0.9000.78
113_H141_I0.8900.77
111_Y255_L0.8850.77
349_I355_Y0.8820.76
326_Y391_P0.8810.76
56_M381_I0.8780.76
182_L262_A0.8770.76
338_E342_Q0.8760.76
79_I131_A0.8740.76
290_W297_G0.8730.76
248_H251_E0.8710.75
298_I344_W0.8700.75
198_I274_L0.8660.75
10_N22_D0.8600.74
50_L94_W0.8530.74
99_N103_V0.8500.74
38_N357_N0.8500.74
314_V362_Q0.8460.73
23_F127_G0.8430.73
82_M116_A0.8430.73
359_S379_Q0.8380.73
117_L139_I0.8350.72
287_R292_P0.8320.72
286_V298_I0.8320.72
115_F176_H0.8300.72
191_K194_L0.8290.72
136_D140_E0.8250.71
209_A277_D0.8190.71
275_L331_V0.8180.71
136_D188_T0.8180.71
336_Q340_W0.8130.70
175_M251_E0.8110.70
80_K130_E0.8080.70
327_A390_I0.8070.70
59_V63_A0.8050.70
188_T193_W0.8050.70
302_V306_G0.7990.69
315_R359_S0.7880.68
62_V65_A0.7860.68
34_G49_H0.7850.68
115_F383_H0.7820.67
179_E251_E0.7800.67
11_R349_I0.7800.67
186_D189_H0.7770.67
272_A276_E0.7760.67
373_K376_D0.7740.66
115_F255_L0.7700.66
15_Q263_L0.7680.66
55_R248_H0.7680.66
175_M252_W0.7670.66
13_L341_Y0.7660.66
295_A366_A0.7650.66
261_A327_A0.7640.65
175_M248_H0.7630.65
95_Y106_A0.7630.65
90_K160_E0.7600.65
354_D357_N0.7590.65
87_R134_L0.7570.65
216_V249_W0.7560.65
80_K129_P0.7520.64
354_D361_W0.7520.64
115_F172_N0.7510.64
87_R94_W0.7430.63
58_H63_A0.7420.63
278_A331_V0.7410.63
80_K83_N0.7400.63
271_P274_L0.7370.63
62_V389_V0.7370.63
41_Q350_K0.7360.63
391_P395_L0.7350.62
139_I196_R0.7320.62
139_I192_K0.7210.61
50_L98_V0.7200.61
82_M94_W0.7180.61
20_I384_L0.7180.61
77_H81_A0.7160.60
216_V244_G0.7160.60
24_G254_R0.7160.60
260_H275_L0.7130.60
351_Y364_L0.7120.60
285_T289_A0.7100.60
255_L382_Y0.7100.60
21_F71_A0.7060.59
315_R384_L0.7050.59
198_I202_S0.7040.59
315_R386_H0.7030.59
21_F60_Y0.7030.59
185_Y262_A0.7000.59
300_Y375_W0.6960.58
362_Q375_W0.6950.58
254_R323_G0.6930.58
185_Y189_H0.6920.58
359_S378_K0.6910.58
113_H146_F0.6870.57
314_V318_I0.6860.57
111_Y383_H0.6850.57
318_I348_C0.6840.57
49_H109_Q0.6830.57
246_P289_A0.6830.57
326_Y338_E0.6820.57
313_R347_Y0.6810.57
323_G386_H0.6800.56
91_Y334_D0.6800.56
121_A124_V0.6800.56
248_H254_R0.6790.56
118_L176_H0.6780.56
291_A366_A0.6780.56
251_E360_W0.6780.56
334_D346_E0.6750.56
53_T86_L0.6740.56
298_I321_A0.6740.56
75_V126_T0.6730.56
143_E192_K0.6730.56
108_K160_E0.6700.55
111_Y382_Y0.6690.55
214_Y280_G0.6690.55
78_G82_M0.6690.55
164_K167_E0.6680.55
62_V66_M0.6670.55
204_I208_V0.6660.55
63_A66_M0.6650.55
245_T378_K0.6640.55
217_N226_P0.6630.55
357_N361_W0.6630.55
303_D309_V0.6620.54
134_L138_T0.6610.54
27_S30_P0.6580.54
129_P195_D0.6580.54
65_A393_I0.6570.54
132_R184_V0.6560.54
54_A116_A0.6560.54
34_G314_V0.6540.54
157_S166_E0.6540.54
191_K287_R0.6540.54
82_M197_A0.6520.53
52_I380_D0.6510.53
279_K332_T0.6490.53
130_E133_K0.6460.53
327_A394_P0.6440.52
57_L119_G0.6430.52
376_D379_Q0.6430.52
335_R346_E0.6420.52
111_Y252_W0.6420.52
83_N137_Y0.6410.52
109_Q377_G0.6410.52
68_R71_A0.6400.52
61_S122_S0.6380.52
205_I274_L0.6370.52
249_W323_G0.6370.52
48_T379_Q0.6360.52
128_H133_K0.6340.51
12_W16_E0.6330.51
133_K140_E0.6320.51
251_E255_L0.6320.51
118_L175_M0.6310.51
217_N304_W0.6310.51
192_K195_D0.6310.51
365_D371_T0.6300.51
328_L337_Y0.6270.51
60_Y253_G0.6270.51
297_G347_Y0.6260.50
86_L95_Y0.6250.50
121_A183_I0.6250.50
109_Q112_Q0.6240.50
251_E383_H0.6230.50
73_S76_D0.6230.50
254_R386_H0.6230.50
18_D145_Y0.6220.50
318_I323_G0.6220.50
49_H56_M0.6210.50
381_I385_L0.6180.50
300_Y317_P0.6180.50
27_S36_L0.6170.49
308_P311_R0.6170.49
66_M393_I0.6170.49
282_F328_L0.6130.49
70_G129_P0.6120.49
287_R369_K0.6120.49
123_A128_H0.6110.49
49_H378_K0.6110.49
250_I285_T0.6100.49
314_V317_P0.6090.49
68_R72_Y0.6090.49
254_R390_I0.6080.48
142_I154_C0.6080.48
378_K386_H0.6070.48
60_Y177_A0.6050.48
21_F385_L0.6030.48
245_T301_T0.6030.48
81_A98_V0.6010.48
181_F184_V0.6010.48
72_Y75_V0.5990.47
73_S80_K0.5970.47
92_G358_G0.5950.47
31_T80_K0.5940.47
218_E252_W0.5930.47
94_W112_Q0.5920.47
133_K334_D0.5920.47
93_G162_F0.5900.46
195_D199_R0.5900.46
354_D359_S0.5900.46
258_H261_A0.5900.46
245_T386_H0.5890.46
79_I120_A0.5870.46
45_E100_D0.5860.46
326_Y341_Y0.5860.46
14_E80_K0.5840.46
178_V200_V0.5840.46
315_R376_D0.5820.46
172_N252_W0.5810.45
365_D368_N0.5800.45
50_L119_G0.5800.45
109_Q173_A0.5790.45
108_K162_F0.5790.45
162_F361_W0.5790.45
41_Q272_A0.5780.45
93_G141_I0.5770.45
32_G48_T0.5760.45
178_V203_V0.5760.45
171_G390_I0.5750.45
257_L275_L0.5740.45
292_P311_R0.5740.45
156_E220_F0.5730.45
379_Q384_L0.5730.45
72_Y126_T0.5720.44
17_T385_L0.5690.44
362_Q378_K0.5690.44
115_F179_E0.5670.44
31_T48_T0.5660.44
75_V78_G0.5650.44
31_T339_T0.5650.44
154_C177_A0.5640.44
110_G142_I0.5630.43
90_K150_E0.5620.43
348_C353_M0.5610.43
170_G243_G0.5610.43
117_L335_R0.5590.43
168_Y227_L0.5580.43
293_D296_D0.5580.43
96_A109_Q0.5580.43
32_G40_G0.5570.43
136_D193_W0.5560.43
293_D311_R0.5560.43
53_T56_M0.5550.43
52_I378_K0.5540.42
120_A131_A0.5530.42
50_L54_A0.5530.42
136_D190_D0.5520.42
223_Q292_P0.5510.42
93_G113_H0.5510.42
144_K288_D0.5500.42
93_G382_Y0.5490.42
131_A134_L0.5480.42
339_T350_K0.5480.42
137_Y140_E0.5480.42
130_E283_N0.5470.42
67_G346_E0.5460.42
51_W54_A0.5460.42
291_A299_V0.5450.41
30_P291_A0.5450.41
58_H345_W0.5450.41
362_Q377_G0.5440.41
141_I145_Y0.5440.41
379_Q386_H0.5440.41
277_D280_G0.5420.41
315_R362_Q0.5420.41
70_G338_E0.5400.41
192_K196_R0.5390.41
72_Y129_P0.5390.41
130_E134_L0.5390.41
329_Y332_T0.5390.41
384_L388_L0.5380.41
136_D192_K0.5370.41
172_N249_W0.5370.41
174_N224_W0.5370.41
33_F77_H0.5370.41
374_V377_G0.5360.40
145_Y162_F0.5360.40
152_Q165_T0.5350.40
300_Y312_E0.5340.40
104_V356_E0.5330.40
325_A328_L0.5330.40
194_L263_L0.5320.40
100_D187_V0.5310.40
49_H362_Q0.5300.40
171_G176_H0.5300.40
295_A367_D0.5290.40
99_N104_V0.5260.39
315_R375_W0.5260.39
377_G380_D0.5250.39
11_R14_E0.5250.39
82_M87_R0.5230.39
282_F337_Y0.5230.39
176_H248_H0.5220.39
293_D313_R0.5220.39
263_L277_D0.5220.39
10_N14_E0.5220.39
155_L165_T0.5220.39
19_R334_D0.5180.39
176_H383_H0.5180.39
52_I56_M0.5180.39
29_V61_S0.5180.39
10_N287_R0.5180.39
14_E264_E0.5170.38
158_W165_T0.5150.38
118_L382_Y0.5140.38
31_T73_S0.5120.38
111_Y175_M0.5110.38
223_Q339_T0.5110.38
316_W320_E0.5090.38
54_A110_G0.5090.38
40_G152_Q0.5080.37
33_F191_K0.5080.37
363_E377_G0.5060.37
130_E308_P0.5060.37
41_Q150_E0.5050.37
260_H264_E0.5050.37
66_M69_P0.5050.37
67_G70_G0.5050.37
175_M383_H0.5050.37
261_A331_V0.5040.37
215_R284_A0.5030.37
118_L179_E0.5020.37
176_H180_A0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zblA 5 0.9976 100 0.35 Contact Map
3gt5A 1 0.9298 100 0.447 Contact Map
3vw5A 1 0.8838 100 0.476 Contact Map
3wkgA 1 0.9225 100 0.478 Contact Map
2gz6A 2 0.8765 100 0.492 Contact Map
1fp3A 2 0.9177 100 0.504 Contact Map
4v1sA 1 0.7337 99.9 0.784 Contact Map
4mu9A 1 0.7361 99.9 0.802 Contact Map
3k11A 3 0.8039 99.8 0.823 Contact Map
5agdA 1 0.7119 99.8 0.823 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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