GREMLIN Database
YIHR - Uncharacterized protein YihR
UniProt: P32139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11844
Length: 308 (281)
Sequences: 6047 (4631)
Seq/√Len: 276.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_G90_I3.1031.00
98_A130_Y2.9411.00
239_I270_L2.8921.00
78_C85_E2.7761.00
111_S121_T2.6151.00
217_K222_T2.5641.00
30_A42_L2.5561.00
123_F135_A2.5201.00
161_A292_E2.4981.00
280_N284_S2.3961.00
24_A29_H2.3621.00
123_F133_M2.2331.00
29_H43_T2.2151.00
119_T139_V2.1961.00
249_S304_Y2.1921.00
192_Y227_T2.1561.00
21_V118_V2.1421.00
21_V110_I2.1341.00
133_M159_T2.1251.00
119_T137_Q2.0591.00
153_A296_P2.0391.00
106_R122_A2.0341.00
41_E48_H1.9751.00
151_E298_R1.9711.00
33_V40_A1.9691.00
117_S141_S1.9541.00
121_T137_Q1.9291.00
151_E300_F1.9111.00
149_S300_F1.9031.00
259_V270_L1.8971.00
122_A127_S1.8771.00
30_A39_L1.8641.00
32_I120_L1.8511.00
22_S31_T1.8501.00
137_Q153_A1.8491.00
34_T107_D1.8281.00
292_E295_K1.8191.00
193_A203_L1.8161.00
143_N147_G1.8011.00
141_S151_E1.7811.00
31_T41_E1.7711.00
82_Q161_A1.7671.00
238_T247_S1.7601.00
147_G302_N1.7521.00
37_A120_L1.7511.00
207_D214_T1.7461.00
30_A148_L1.7271.00
121_T135_A1.7231.00
155_Q296_P1.7181.00
80_R85_E1.7041.00
163_P290_L1.7001.00
28_Y42_L1.6951.00
78_C87_Q1.6871.00
114_T117_S1.6851.00
153_A298_R1.6631.00
111_S119_T1.6381.00
175_N241_H1.6271.00
20_T33_V1.6261.00
89_P128_Y1.6131.00
75_A280_N1.5891.00
66_V138_V1.5851.00
149_S302_N1.5781.00
20_T31_T1.5671.00
37_A66_V1.5631.00
134_L164_Y1.5611.00
147_G304_Y1.5531.00
241_H246_L1.5411.00
81_Y290_L1.5241.00
251_C304_Y1.5161.00
274_P301_F1.5101.00
183_L216_A1.5081.00
103_L136_S1.4831.00
72_N258_Q1.4621.00
143_N149_S1.4621.00
185_Q238_T1.4581.00
20_T40_A1.4571.00
183_L240_T1.4561.00
124_L127_S1.4501.00
19_Q34_T1.4491.00
42_L305_G1.4491.00
238_T249_S1.4481.00
103_L122_A1.4481.00
139_V153_A1.4411.00
50_V170_P1.4351.00
32_I118_V1.4341.00
82_Q160_V1.4301.00
22_S29_H1.4071.00
96_K197_H1.3981.00
67_L167_G1.3831.00
92_E97_A1.3781.00
70_W282_F1.3491.00
213_F217_K1.3441.00
165_G277_C1.3411.00
84_Q160_V1.3361.00
193_A204_H1.3231.00
185_Q216_A1.3201.00
254_Q299_L1.3131.00
190_Q205_H1.3111.00
112_E117_S1.3091.00
135_A155_Q1.3071.00
141_S149_S1.2971.00
254_Q277_C1.2891.00
253_D299_L1.2781.00
70_W289_L1.2701.00
117_S139_V1.2561.00
218_K221_A1.2501.00
39_L148_L1.2481.00
183_L242_P1.2391.00
28_Y44_F1.2331.00
280_N283_N1.2301.00
277_C289_L1.2281.00
217_K221_A1.2251.00
161_A293_S1.2141.00
156_N293_S1.2141.00
109_Q121_T1.2111.00
35_V107_D1.2051.00
39_L50_V1.1851.00
191_V204_H1.1621.00
23_L142_L1.1441.00
62_H104_A1.1391.00
28_Y142_L1.1261.00
263_E267_R1.1261.00
257_V272_V1.1181.00
111_S137_Q1.1111.00
194_V198_A1.1111.00
184_F239_I1.1061.00
154_S164_Y1.0941.00
262_G265_L1.0941.00
251_C302_N1.0831.00
227_T258_Q1.0821.00
227_T256_W1.0811.00
164_Y297_H1.0791.00
76_N97_A1.0791.00
241_H244_Q1.0751.00
161_A290_L1.0751.00
112_E119_T1.0521.00
77_G87_Q1.0451.00
25_A142_L1.0321.00
33_V38_G1.0321.00
87_Q90_I1.0251.00
76_N96_K1.0241.00
186_L259_V1.0211.00
73_R99_I1.0211.00
124_L133_M1.0191.00
236_E252_S1.0191.00
42_L172_L1.0191.00
240_T247_S1.0181.00
69_P124_L1.0171.00
206_V214_T1.0151.00
110_I118_V1.0131.00
90_I96_K1.0071.00
235_W251_C1.0011.00
44_F49_L0.9971.00
256_W278_P0.9961.00
127_S133_M0.9901.00
48_H52_P0.9881.00
51_I269_G0.9851.00
27_D45_Q0.9821.00
211_L226_H0.9821.00
38_G65_K0.9761.00
75_A195_D0.9641.00
164_Y291_L0.9611.00
262_G269_G0.9601.00
70_W98_A0.9541.00
138_V150_V0.9541.00
25_A146_T0.9531.00
248_V305_G0.9461.00
82_Q292_E0.9441.00
66_V168_I0.9411.00
184_F213_F0.9351.00
291_L296_P0.9351.00
70_W74_I0.9341.00
184_F259_V0.9331.00
80_R83_G0.9321.00
39_L170_P0.9251.00
281_A289_L0.9221.00
74_I88_L0.9221.00
178_S181_E0.9191.00
75_A199_N0.9191.00
26_G144_A0.9181.00
125_P133_M0.9171.00
250_L274_P0.9161.00
183_L218_K0.9111.00
25_A144_A0.9091.00
53_H63_L0.9021.00
180_D267_R0.9021.00
150_V168_I0.9011.00
139_V151_E0.8971.00
140_Y150_V0.8921.00
62_H99_I0.8871.00
169_H273_E0.8841.00
100_H169_H0.8821.00
182_Y241_H0.8791.00
136_S166_V0.8781.00
224_I228_F0.8771.00
163_P282_F0.8661.00
116_T141_S0.8631.00
43_T48_H0.8611.00
235_W238_T0.8581.00
75_A283_N0.8491.00
185_Q240_T0.8441.00
66_V140_Y0.8431.00
62_H105_W0.8351.00
97_A197_H0.8311.00
92_E95_S0.8250.99
82_Q290_L0.8250.99
185_Q215_Q0.8240.99
42_L50_V0.8200.99
166_V297_H0.8190.99
79_Y86_Y0.8150.99
219_I270_L0.8150.99
187_P235_W0.8140.99
189_N214_T0.8140.99
106_R127_S0.8080.99
138_V152_I0.8080.99
136_S154_S0.8070.99
163_P288_L0.8030.99
100_H273_E0.7980.99
120_L140_Y0.7970.99
69_P134_L0.7960.99
108_W136_S0.7950.99
181_E218_K0.7950.99
235_W249_S0.7940.99
256_W287_D0.7910.99
186_L237_M0.7800.99
186_L257_V0.7720.99
49_L305_G0.7710.99
237_M257_V0.7700.99
90_I98_A0.7670.99
274_P299_L0.7610.99
206_V209_L0.7590.99
21_V120_L0.7550.99
78_C283_N0.7540.99
250_L272_V0.7510.99
103_L134_L0.7500.99
152_I166_V0.7430.99
42_L49_L0.7400.99
68_I136_S0.7380.99
211_L228_F0.7360.99
110_I120_L0.7320.99
31_T40_A0.7310.99
92_E264_K0.7290.99
184_F272_V0.7250.99
108_W138_V0.7180.99
39_L168_I0.7180.99
156_N291_L0.7170.99
44_F246_L0.7140.99
68_I103_L0.7140.99
88_L98_A0.7130.99
191_V211_L0.7130.99
172_L303_I0.7120.99
66_V152_I0.7100.98
92_E99_I0.7100.98
193_A201_T0.7100.98
186_L213_F0.7040.98
224_I259_V0.7030.98
98_A101_G0.7000.98
278_P287_D0.6950.98
174_C182_Y0.6940.98
277_C281_A0.6930.98
236_E249_S0.6930.98
76_N197_H0.6890.98
21_V34_T0.6890.98
220_A223_K0.6850.98
89_P98_A0.6840.98
259_V272_V0.6840.98
70_W163_P0.6840.98
72_N227_T0.6820.98
152_I167_G0.6810.98
175_N242_P0.6800.98
39_L42_L0.6800.98
134_L162_A0.6790.98
216_A240_T0.6780.98
46_G246_L0.6770.98
227_T275_M0.6770.98
239_I272_V0.6730.98
233_D302_N0.6690.98
63_L265_L0.6650.98
230_T234_L0.6640.98
50_V172_L0.6630.98
81_Y132_F0.6610.98
41_E52_P0.6600.98
152_I301_F0.6590.98
67_L71_P0.6580.98
75_A284_S0.6570.97
79_Y88_L0.6570.97
52_P173_T0.6570.97
103_L124_L0.6550.97
180_D223_K0.6550.97
24_A45_Q0.6540.97
265_L271_A0.6530.97
31_T43_T0.6530.97
76_N90_I0.6510.97
70_W281_A0.6500.97
181_E243_Q0.6480.97
152_I299_L0.6460.97
213_F216_A0.6440.97
252_S301_F0.6440.97
28_Y45_Q0.6430.97
28_Y146_T0.6430.97
179_V270_L0.6430.97
32_I39_L0.6420.97
23_L118_V0.6400.97
101_G130_Y0.6380.97
192_Y278_P0.6370.97
143_N146_T0.6360.97
28_Y49_L0.6280.97
109_Q123_F0.6260.97
146_T304_Y0.6240.97
184_F219_I0.6230.97
73_R273_E0.6220.97
144_A147_G0.6220.97
191_V226_H0.6220.97
99_I104_A0.6220.97
291_L295_K0.6210.96
253_D300_F0.6170.96
65_K104_A0.6160.96
71_P275_M0.6140.96
69_P128_Y0.6140.96
134_L154_S0.6140.96
222_T225_D0.6120.96
156_N161_A0.6120.96
156_N162_A0.6100.96
38_G59_P0.6070.96
25_A28_Y0.6040.96
27_D146_T0.6030.96
74_I282_F0.6020.96
154_S297_H0.6010.96
231_A234_L0.6010.96
73_R100_H0.5990.96
32_I148_L0.5960.96
69_P101_G0.5940.95
179_V219_I0.5930.95
113_L118_V0.5920.95
180_D183_L0.5920.95
137_Q155_Q0.5920.95
75_A197_H0.5910.95
191_V228_F0.5910.95
34_T109_Q0.5900.95
47_C245_A0.5890.95
136_S152_I0.5880.95
67_L104_A0.5870.95
64_G168_I0.5870.95
77_G98_A0.5850.95
42_L148_L0.5790.95
71_P277_C0.5760.95
113_L117_S0.5760.95
37_A140_Y0.5760.95
154_S166_V0.5760.95
103_L108_W0.5710.94
187_P234_L0.5710.94
32_I140_Y0.5710.94
198_A264_K0.5690.94
122_A128_Y0.5690.94
181_E220_A0.5670.94
258_Q275_M0.5670.94
23_L30_A0.5660.94
187_P236_E0.5640.94
179_V182_Y0.5640.94
27_D144_A0.5630.94
81_Y88_L0.5630.94
260_Y264_K0.5620.94
102_L105_W0.5610.94
59_P104_A0.5600.94
66_V136_S0.5590.94
232_N235_W0.5520.93
78_C90_I0.5520.93
281_A287_D0.5510.93
203_L286_I0.5510.93
74_I79_Y0.5500.93
34_T110_I0.5500.93
224_I227_T0.5480.93
108_W122_A0.5470.93
179_V261_S0.5460.93
228_F259_V0.5440.93
99_I279_P0.5430.93
71_P165_G0.5420.93
182_Y239_I0.5420.93
26_G146_T0.5400.93
177_T241_H0.5390.93
217_K223_K0.5380.92
229_K233_D0.5380.92
38_G105_W0.5370.92
79_Y283_N0.5370.92
35_V38_G0.5360.92
80_R283_N0.5350.92
50_V63_L0.5310.92
289_L297_H0.5290.92
113_L119_T0.5290.92
239_I259_V0.5280.92
29_H41_E0.5270.92
80_R86_Y0.5260.92
53_H59_P0.5250.92
56_E107_D0.5250.92
160_V293_S0.5240.92
81_Y86_Y0.5240.92
152_I254_Q0.5220.91
73_R169_H0.5190.91
132_F162_A0.5190.91
164_Y299_L0.5190.91
168_I301_F0.5180.91
40_A63_L0.5160.91
90_I95_S0.5160.91
34_T120_L0.5150.91
38_G60_L0.5140.91
194_V227_T0.5120.91
179_V221_A0.5110.90
110_I113_L0.5100.90
170_P274_P0.5090.90
190_Q193_A0.5080.90
219_I222_T0.5080.90
74_I77_G0.5060.90
130_Y162_A0.5060.90
197_H200_P0.5060.90
175_N243_Q0.5030.90
73_R77_G0.5030.90
175_N246_L0.5030.90
178_S268_Q0.5020.90
25_A143_N0.5010.90
162_A291_L0.5010.90
32_I37_A0.5000.90
76_N92_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z45A 2 0.9805 100 0.194 Contact Map
1snzA 1 0.9773 100 0.211 Contact Map
1ygaA 2 0.9383 100 0.216 Contact Map
3imhA 3 0.961 100 0.222 Contact Map
1lurA 1 0.9318 100 0.223 Contact Map
4rnlA 1 0.974 100 0.225 Contact Map
1nsxA 2 0.9545 100 0.226 Contact Map
3nreA 1 0.9123 100 0.269 Contact Map
3mwxA 1 0.9578 100 0.287 Contact Map
3os7A 2 0.9805 100 0.295 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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