GREMLIN Database
YIHM - Uncharacterized protein YihM
UniProt: P32134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11839
Length: 326 (250)
Sequences: 1026 (809)
Seq/√Len: 51.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_G80_R4.6041.00
230_P233_A3.8531.00
265_R269_E3.1491.00
207_D225_G3.1371.00
42_D82_L3.1241.00
267_E270_D2.7101.00
174_S201_T2.5691.00
73_S107_K2.5581.00
147_T201_T2.5321.00
41_L82_L2.5051.00
194_K237_H2.4571.00
163_S167_E2.3561.00
141_Y148_F2.3261.00
138_R173_L2.3081.00
103_A144_S2.2681.00
149_T201_T2.2541.00
131_A167_E2.2501.00
51_G246_P2.2461.00
79_A86_I2.2411.00
98_I137_V2.2371.00
147_T174_S2.2131.00
188_H191_D2.1991.00
78_K82_L2.1301.00
263_A270_D2.0791.00
149_T176_L2.0571.00
139_E170_M2.0241.00
42_D78_K2.0081.00
139_E142_Q1.9961.00
153_H206_K1.9470.99
192_A196_M1.9240.99
207_D227_G1.9110.99
18_P85_D1.8690.99
102_V144_S1.8450.99
38_A78_K1.8030.99
99_D140_T1.7880.99
76_G108_T1.7850.99
36_L39_D1.7840.99
263_A266_F1.7790.99
106_L144_S1.7610.99
135_A169_E1.7410.99
178_D250_A1.7360.99
51_G84_L1.7080.99
203_V238_L1.7060.99
128_S167_E1.6930.99
263_A267_E1.6630.98
128_S132_N1.6600.98
74_A77_D1.6600.98
264_F267_E1.6420.98
266_F269_E1.6350.98
264_F270_D1.6000.98
236_T240_C1.5920.98
191_D194_K1.5810.98
96_A99_D1.5790.98
266_F270_D1.5760.98
261_A265_R1.5760.98
99_D143_D1.5670.98
127_L163_S1.5320.97
268_D272_N1.5170.97
77_D81_R1.5000.97
44_A52_V1.4980.97
149_T174_S1.4960.97
41_L79_A1.4740.96
111_S147_T1.4650.96
42_D46_E1.4570.96
115_F137_V1.4430.96
162_V195_T1.4380.96
221_A224_S1.4330.96
262_P265_R1.4250.96
131_A168_S1.4230.96
271_D274_W1.4000.95
105_A110_A1.3650.95
264_F268_D1.3630.94
102_V141_Y1.3410.94
38_A74_A1.3340.94
235_L247_Q1.3210.94
180_A206_K1.3200.93
142_Q172_S1.3140.93
20_Y51_G1.3110.93
163_S166_K1.2970.93
256_E259_Y1.2930.93
221_A225_G1.2930.93
216_G221_A1.2760.92
205_I247_Q1.2660.92
102_V140_T1.2520.92
140_T144_S1.2480.91
152_Q161_L1.2420.91
115_F141_Y1.2280.91
92_A96_A1.2220.91
151_E250_A1.2190.90
138_R170_M1.2070.90
270_D274_W1.1950.90
135_A168_S1.1930.89
217_L223_I1.1930.89
114_R206_K1.1770.89
45_S83_N1.1740.89
216_G223_I1.1710.89
95_K136_Y1.1690.88
179_F234_L1.1680.88
99_D136_Y1.1660.88
217_L221_A1.1450.87
269_E273_P1.1320.87
193_L237_H1.1290.87
96_A100_E1.1180.86
114_R153_H1.1130.86
259_Y265_R1.1110.86
142_Q171_E1.1060.86
153_H252_G1.1020.85
77_D96_A1.0780.84
74_A81_R1.0710.84
260_Y267_E1.0670.83
181_N224_S1.0640.83
51_G87_H1.0630.83
162_V165_V1.0620.83
85_D205_I1.0570.83
262_P266_F1.0530.83
22_H25_A1.0490.82
141_Y173_L1.0470.82
242_G245_E1.0390.82
131_A135_A1.0370.82
91_S95_K1.0280.81
269_E274_W1.0270.81
233_A236_T1.0220.81
232_K236_T1.0220.81
229_M234_L1.0180.80
103_A106_L1.0140.80
151_E204_H1.0060.80
128_S191_D0.9990.79
81_R103_A0.9970.79
53_K89_E0.9930.79
260_Y264_F0.9860.78
134_I148_F0.9780.78
91_S94_D0.9660.77
51_G85_D0.9630.77
53_K204_H0.9620.76
206_K251_Y0.9610.76
102_V148_F0.9590.76
81_R166_K0.9550.76
39_D42_D0.9550.76
103_A140_T0.9530.76
181_N206_K0.9510.76
230_P254_E0.9380.75
154_E184_N0.9290.74
270_D273_P0.9270.74
174_S199_H0.9250.74
105_A146_L0.9210.73
112_S149_T0.9080.72
93_S244_D0.9080.72
138_R172_S0.9040.72
142_Q170_M0.9020.72
149_T207_D0.9010.72
49_L249_T0.8980.71
159_H195_T0.8980.71
263_A269_E0.8970.71
151_E252_G0.8900.71
65_G69_D0.8890.71
37_P41_L0.8880.70
168_S173_L0.8880.70
52_V161_L0.8850.70
221_A253_L0.8770.70
218_G221_A0.8760.69
216_G219_H0.8750.69
20_Y248_V0.8730.69
130_I164_L0.8720.69
23_A202_Q0.8710.69
162_V196_M0.8680.69
184_N229_M0.8590.68
115_F134_I0.8540.67
193_L196_M0.8520.67
92_A194_K0.8470.67
104_I211_V0.8430.66
197_A241_L0.8410.66
269_E272_N0.8380.66
78_K258_D0.8380.66
165_V175_L0.8340.66
72_L107_K0.8310.65
45_S82_L0.8310.65
152_Q182_M0.8300.65
53_K252_G0.8280.65
221_A252_G0.8260.65
116_Y153_H0.8230.65
155_D204_H0.8230.65
125_D128_S0.8230.65
265_R268_D0.8210.64
95_K99_D0.8130.64
162_V199_H0.8100.63
76_G107_K0.8090.63
21_L26_F0.8030.63
41_L52_V0.8020.63
178_D204_H0.8000.62
157_K160_E0.7930.62
80_R109_G0.7910.61
61_R64_L0.7900.61
237_H241_L0.7830.61
138_R142_Q0.7830.61
43_I47_N0.7760.60
17_L247_Q0.7710.60
181_N196_M0.7700.59
185_A193_L0.7690.59
166_K240_C0.7640.59
77_D80_R0.7610.58
194_K240_C0.7600.58
150_I162_V0.7570.58
124_R244_D0.7560.58
114_R202_Q0.7550.58
38_A77_D0.7520.58
68_D71_E0.7520.58
206_K221_A0.7480.57
127_L164_L0.7380.56
258_D263_A0.7360.56
115_F150_I0.7350.56
18_P228_D0.7310.55
260_Y265_R0.7230.55
154_E181_N0.7220.55
64_L67_M0.7220.55
99_D144_S0.7190.54
62_F65_G0.7190.54
152_Q200_I0.7160.54
73_S240_C0.7150.54
93_S96_A0.7140.54
46_E146_L0.7100.53
255_E258_D0.7070.53
38_A42_D0.7060.53
158_S187_E0.7050.53
35_V150_I0.7040.53
77_D143_D0.7040.53
151_E181_N0.7030.53
83_N145_G0.7030.53
100_E128_S0.7030.53
230_P238_L0.7020.52
39_D43_I0.7000.52
168_S229_M0.6970.52
124_R163_S0.6970.52
237_H240_C0.6960.52
18_P239_I0.6920.51
116_Y154_E0.6830.50
260_Y270_D0.6800.50
129_I167_E0.6790.50
125_D129_I0.6780.50
141_Y229_M0.6780.50
103_A107_K0.6720.49
108_T146_L0.6700.49
206_K252_G0.6670.49
73_S190_I0.6660.49
54_I88_I0.6620.48
22_H252_G0.6600.48
135_A173_L0.6600.48
90_T204_H0.6570.48
140_T143_D0.6570.48
122_N125_D0.6550.48
234_L237_H0.6530.47
145_G172_S0.6530.47
161_L175_L0.6530.47
154_E206_K0.6510.47
87_H246_P0.6480.47
259_Y264_F0.6480.47
83_N86_I0.6470.47
180_A252_G0.6470.47
25_A154_E0.6460.47
41_L238_L0.6460.47
162_V166_K0.6450.47
261_A264_F0.6450.47
73_S166_K0.6440.46
74_A86_I0.6410.46
263_A268_D0.6390.46
84_L103_A0.6380.46
107_K128_S0.6370.46
255_E267_E0.6350.46
116_Y254_E0.6300.45
40_L153_H0.6280.45
77_D195_T0.6280.45
53_K202_Q0.6230.44
190_I194_K0.6130.43
248_V253_L0.6100.43
42_D167_E0.6090.43
165_V196_M0.6070.43
46_E110_A0.6070.43
18_P246_P0.6060.43
219_H222_C0.6030.42
132_N136_Y0.6030.42
238_L241_L0.6030.42
24_Y206_K0.6020.42
43_I46_E0.6010.42
202_Q206_K0.6000.42
21_L153_H0.6000.42
126_V163_S0.5960.42
99_D134_I0.5960.42
152_Q181_N0.5960.42
151_E178_D0.5920.41
203_V235_L0.5900.41
138_R168_S0.5890.41
95_K140_T0.5890.41
119_Y122_N0.5890.41
127_L131_A0.5880.41
36_L46_E0.5880.41
139_E172_S0.5860.41
257_V266_F0.5850.40
80_R241_L0.5850.40
96_A169_E0.5840.40
138_R157_K0.5840.40
236_T239_I0.5840.40
22_H55_H0.5830.40
21_L44_A0.5830.40
41_L75_F0.5810.40
95_K133_D0.5800.40
146_L159_H0.5800.40
116_Y252_G0.5790.40
36_L198_P0.5750.39
181_N219_H0.5740.39
53_K246_P0.5730.39
141_Y243_D0.5730.39
189_P235_L0.5720.39
128_S244_D0.5690.39
169_E236_T0.5680.39
168_S171_E0.5650.38
81_R128_S0.5650.38
78_K83_N0.5630.38
112_S147_T0.5630.38
145_G189_P0.5620.38
164_L269_E0.5610.38
36_L164_L0.5590.38
188_H197_A0.5550.37
262_P273_P0.5550.37
40_L150_I0.5550.37
55_H153_H0.5530.37
73_S76_G0.5530.37
180_A253_L0.5520.37
127_L167_E0.5500.37
93_S132_N0.5480.37
132_N171_E0.5480.37
121_G171_E0.5460.37
109_G145_G0.5450.37
166_K191_D0.5440.36
182_M192_A0.5420.36
139_E143_D0.5400.36
216_G225_G0.5400.36
162_V175_L0.5390.36
46_E66_N0.5390.36
46_E144_S0.5390.36
76_G131_A0.5380.36
131_A170_M0.5370.36
73_S269_E0.5360.36
169_E187_E0.5360.36
41_L242_G0.5350.36
97_S105_A0.5340.35
90_T176_L0.5330.35
51_G248_V0.5330.35
267_E273_P0.5330.35
114_R152_Q0.5310.35
179_F183_I0.5300.35
98_I235_L0.5300.35
181_N186_N0.5280.35
159_H163_S0.5270.35
121_G128_S0.5270.35
176_L231_F0.5250.35
40_L204_H0.5250.35
115_F148_F0.5240.35
259_Y263_A0.5220.34
126_V150_I0.5210.34
67_M251_Y0.5190.34
169_E226_Q0.5180.34
46_E236_T0.5180.34
80_R83_N0.5180.34
181_N205_I0.5160.34
258_D266_F0.5160.34
158_S162_V0.5150.34
248_V252_G0.5150.34
158_S195_T0.5100.33
103_A238_L0.5070.33
200_I240_C0.5060.33
169_E189_P0.5060.33
261_A268_D0.5040.33
77_D142_Q0.5040.33
55_H253_L0.5040.33
55_H116_Y0.5010.32
42_D86_I0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ovxA 1 0.7638 100 0.451 Contact Map
3u0hA 3 0.7791 100 0.465 Contact Map
2zdsA 5 0.7853 100 0.468 Contact Map
1i60A 1 0.7853 100 0.471 Contact Map
3tvaA 1 0.7822 100 0.471 Contact Map
3cnyA 1 0.7945 100 0.473 Contact Map
3cqjA 2 0.7761 100 0.476 Contact Map
3dx5A 2 0.7577 100 0.477 Contact Map
3p6lA 2 0.7669 100 0.478 Contact Map
3wqoA 2 0.7515 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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